MAPK15 (mitogen-activated protein kinase 15)

2007-12-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
ERK7,ERK8
FUSION GENES

Other Information

Locus ID:

NCBI: 225689
MIM: 618616
HGNC: 24667
Ensembl: ENSG00000181085

Variants:

dbSNP: 225689
ClinVar: 225689
TCGA: ENSG00000181085
COSMIC: MAPK15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181085ENST00000338033Q8TD08
ENSG00000181085ENST00000395107Q8TD08
ENSG00000181085ENST00000395108Q8TD08

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

References

Pubmed IDYearTitleCitations
229482272012MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.45
118750702002ERK8, a new member of the mitogen-activated protein kinase family.38
207330542010A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA.25
163362132006Characterization of the reversible phosphorylation and activation of ERK8.24
203952062010Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.24
211909362011Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.17
164842222006Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.16
191668462009Regulation of the activity and expression of ERK8 by DNA damage.15
166248052006ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.14
246188992014ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration.14

Citation

Dessen P

MAPK15 (mitogen-activated protein kinase 15)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49928/mapk15