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MAPK15 (mitogen-activated protein kinase 15)

Identity

Alias_symbol (synonym)ERK8
ERK7
Other alias
HGNC (Hugo) MAPK15
LocusID (NCBI) 225689
Atlas_Id 49928
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 144798507 and ends at 144804633 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MAPK15 (8q24.3) / SCRIB (8q24.3)MED25 (19q13.33) / MAPK15 (8q24.3)MED25 19q13.33 / MAPK15 8q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAPK15   24667
Cards
Entrez_Gene (NCBI)MAPK15  225689  mitogen-activated protein kinase 15
AliasesERK7; ERK8
GeneCards (Weizmann)MAPK15
Ensembl hg19 (Hinxton)ENSG00000181085 [Gene_View]  chr8:144798507-144804633 [Contig_View]  MAPK15 [Vega]
Ensembl hg38 (Hinxton)ENSG00000181085 [Gene_View]  chr8:144798507-144804633 [Contig_View]  MAPK15 [Vega]
ICGC DataPortalENSG00000181085
TCGA cBioPortalMAPK15
AceView (NCBI)MAPK15
Genatlas (Paris)MAPK15
WikiGenes225689
SOURCE (Princeton)MAPK15
Genetics Home Reference (NIH)MAPK15
Genomic and cartography
GoldenPath hg19 (UCSC)MAPK15  -     chr8:144798507-144804633 +  8q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAPK15  -     8q24.3   [Description]    (hg38-Dec_2013)
EnsemblMAPK15 - 8q24.3 [CytoView hg19]  MAPK15 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIMAPK15 [Mapview hg19]  MAPK15 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AY065978 AY994058 BC028034 BP357805 DQ891473
RefSeq transcript (Entrez)NM_139021
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NT_187571 NW_004929340
Consensus coding sequences : CCDS (NCBI)MAPK15
Cluster EST : UnigeneHs.493169 [ NCBI ]
CGAP (NCI)Hs.493169
Alternative Splicing GalleryENSG00000181085
Gene ExpressionMAPK15 [ NCBI-GEO ]   MAPK15 [ EBI - ARRAY_EXPRESS ]   MAPK15 [ SEEK ]   MAPK15 [ MEM ]
Gene Expression Viewer (FireBrowse)MAPK15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)225689
GTEX Portal (Tissue expression)MAPK15
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TD08   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TD08  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TD08
Splice isoforms : SwissVarQ8TD08
Catalytic activity : Enzyme2.7.11.24 [ Enzyme-Expasy ]   2.7.11.242.7.11.24 [ IntEnz-EBI ]   2.7.11.24 [ BRENDA ]   2.7.11.24 [ KEGG ]   
PhosPhoSitePlusQ8TD08
Domaine pattern : Prosite (Expaxy)MAPK (PS01351)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    MAP_kinase_CS    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAPK15
DMDM Disease mutations225689
Blocks (Seattle)MAPK15
SuperfamilyQ8TD08
Human Protein AtlasENSG00000181085
Peptide AtlasQ8TD08
HPRD16867
IPIIPI00935477   IPI00747020   IPI00165955   
Protein Interaction databases
DIP (DOE-UCLA)Q8TD08
IntAct (EBI)Q8TD08
FunCoupENSG00000181085
BioGRIDMAPK15
STRING (EMBL)MAPK15
ZODIACMAPK15
Ontologies - Pathways
QuickGOQ8TD08
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  MAPK cascade  MAPK cascade  positive regulation of protein phosphorylation  MAP kinase activity  protein binding  ATP binding  extracellular region  intracellular  nucleus  negative regulation of DNA replication  SH3 domain binding  positive regulation of protein ubiquitination  positive regulation of telomere maintenance via telomerase  positive regulation of telomere maintenance via telomerase  response to estradiol  positive regulation of protein catabolic process  protein autophosphorylation  positive regulation of telomerase activity  positive regulation of telomerase activity  positive regulation of telomere capping  positive regulation of telomere capping  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  MAPK cascade  MAPK cascade  positive regulation of protein phosphorylation  MAP kinase activity  protein binding  ATP binding  extracellular region  intracellular  nucleus  negative regulation of DNA replication  SH3 domain binding  positive regulation of protein ubiquitination  positive regulation of telomere maintenance via telomerase  positive regulation of telomere maintenance via telomerase  response to estradiol  positive regulation of protein catabolic process  protein autophosphorylation  positive regulation of telomerase activity  positive regulation of telomerase activity  positive regulation of telomere capping  positive regulation of telomere capping  
NDEx NetworkMAPK15
Atlas of Cancer Signalling NetworkMAPK15
Wikipedia pathwaysMAPK15
Orthology - Evolution
OrthoDB225689
GeneTree (enSembl)ENSG00000181085
Phylogenetic Trees/Animal Genes : TreeFamMAPK15
HOVERGENQ8TD08
HOGENOMQ8TD08
Homologs : HomoloGeneMAPK15
Homology/Alignments : Family Browser (UCSC)MAPK15
Gene fusions - Rearrangements
Fusion : MitelmanMED25/MAPK15 [19q13.33/8q24.3]  [t(8;19)(q24;q13)]  
Fusion: TCGAMED25 19q13.33 MAPK15 8q24.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAPK15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPK15
dbVarMAPK15
ClinVarMAPK15
1000_GenomesMAPK15 
Exome Variant ServerMAPK15
ExAC (Exome Aggregation Consortium)MAPK15 (select the gene name)
Genetic variants : HAPMAP225689
Genomic Variants (DGV)MAPK15 [DGVbeta]
DECIPHER (Syndromes)8:144798507-144804633  ENSG00000181085
CONAN: Copy Number AnalysisMAPK15 
Mutations
ICGC Data PortalMAPK15 
TCGA Data PortalMAPK15 
Broad Tumor PortalMAPK15
OASIS PortalMAPK15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAPK15  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAPK15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAPK15
DgiDB (Drug Gene Interaction Database)MAPK15
DoCM (Curated mutations)MAPK15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAPK15 (select a term)
intoGenMAPK15
Cancer3DMAPK15(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenMAPK15
Genetic Testing Registry MAPK15
NextProtQ8TD08 [Medical]
TSGene225689
GENETestsMAPK15
Huge Navigator MAPK15 [HugePedia]
snp3D : Map Gene to Disease225689
BioCentury BCIQMAPK15
ClinGenMAPK15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD225689
Chemical/Pharm GKB GenePA142671478
Clinical trialMAPK15
Miscellaneous
canSAR (ICR)MAPK15 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAPK15
EVEXMAPK15
GoPubMedMAPK15
iHOPMAPK15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:14:28 CET 2017

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