MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1)

2007-02-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
IB1,JIP-1,JIP1,PRKM8IP
FUSION GENES

Other Information

Locus ID:

NCBI: 9479
MIM: 604641
HGNC: 6882
Ensembl: ENSG00000121653

Variants:

dbSNP: 9479
ClinVar: 9479
TCGA: ENSG00000121653
COSMIC: MAPK8IP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121653ENST00000241014Q9UQF2
ENSG00000121653ENST00000395629E9PBB9

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010

References

Pubmed IDYearTitleCitations
172004142007Two binding partners cooperate to activate the molecular motor Kinesin-1.100
126655282003A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.56
194911042009Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.53
163013302005Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.46
128938272003Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.42
159987992005Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop.29
182862072008Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.27
125630352003JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65.24
184803792008Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.23
127838732003JNK-interacting protein 1 promotes Akt1 activation.21

Citation

Dessen P

MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46440/mapk8ip1