Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1)

Identity

Alias_namesPRKM8IP
Alias_symbol (synonym)IB1
JIP-1
JIP1
Other alias
HGNC (Hugo) MAPK8IP1
LocusID (NCBI) 9479
Atlas_Id 46440
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 45885496 and ends at 45906465 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAPK8IP1 (11p11.2) / CPSF7 (11q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAPK8IP1   6882
Cards
Entrez_Gene (NCBI)MAPK8IP1  9479  mitogen-activated protein kinase 8 interacting protein 1
AliasesIB1; JIP-1; JIP1; PRKM8IP
GeneCards (Weizmann)MAPK8IP1
Ensembl hg19 (Hinxton)ENSG00000121653 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121653 [Gene_View]  ENSG00000121653 [Sequence]  chr11:45885496-45906465 [Contig_View]  MAPK8IP1 [Vega]
ICGC DataPortalENSG00000121653
TCGA cBioPortalMAPK8IP1
AceView (NCBI)MAPK8IP1
Genatlas (Paris)MAPK8IP1
WikiGenes9479
SOURCE (Princeton)MAPK8IP1
Genetics Home Reference (NIH)MAPK8IP1
Genomic and cartography
GoldenPath hg38 (UCSC)MAPK8IP1  -     chr11:45885496-45906465 +  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAPK8IP1  -     11p11.2   [Description]    (hg19-Feb_2009)
MAPK8IP1 - 11p11.2 [CytoView hg19]  MAPK8IP1 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIMAPK8IP1 [Mapview hg19]  MAPK8IP1 [Mapview hg38]
OMIM125853   604641   
Gene and transcription
Genbank (Entrez)AB209720 AF007134 AF074091 AK293637 AK295942
RefSeq transcript (Entrez)NM_005456
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAPK8IP1
Cluster EST : UnigeneHs.234249 [ NCBI ]
CGAP (NCI)Hs.234249
Alternative Splicing GalleryENSG00000121653
Gene ExpressionMAPK8IP1 [ NCBI-GEO ]   MAPK8IP1 [ EBI - ARRAY_EXPRESS ]   MAPK8IP1 [ SEEK ]   MAPK8IP1 [ MEM ]
Gene Expression Viewer (FireBrowse)MAPK8IP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9479
GTEX Portal (Tissue expression)MAPK8IP1
Human Protein AtlasENSG00000121653-MAPK8IP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQF2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQF2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQF2
Splice isoforms : SwissVarQ9UQF2
PhosPhoSitePlusQ9UQF2
Domaine pattern : Prosite (Expaxy)PID (PS01179)    SH3 (PS50002)   
Domains : Interpro (EBI)JIP1_SH3    PH-like_dom_sf    PTB/PI_dom    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)PID (PF00640)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00640    pfam14604   
Domain families : Smart (EMBL)PTB (SM00462)  SH3 (SM00326)  
Conserved Domain (NCBI)MAPK8IP1
DMDM Disease mutations9479
Blocks (Seattle)MAPK8IP1
PDB (RSDB)2G01    2GMX    2H96    3OXI    3PTG    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4E73    4G1W    4H39    4HYS    4HYU    4IZY    5LW1   
PDB Europe2G01    2GMX    2H96    3OXI    3PTG    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4E73    4G1W    4H39    4HYS    4HYU    4IZY    5LW1   
PDB (PDBSum)2G01    2GMX    2H96    3OXI    3PTG    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4E73    4G1W    4H39    4HYS    4HYU    4IZY    5LW1   
PDB (IMB)2G01    2GMX    2H96    3OXI    3PTG    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4E73    4G1W    4H39    4HYS    4HYU    4IZY    5LW1   
Structural Biology KnowledgeBase2G01    2GMX    2H96    3OXI    3PTG    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4E73    4G1W    4H39    4HYS    4HYU    4IZY    5LW1   
SCOP (Structural Classification of Proteins)2G01    2GMX    2H96    3OXI    3PTG    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4E73    4G1W    4H39    4HYS    4HYU    4IZY    5LW1   
CATH (Classification of proteins structures)2G01    2GMX    2H96    3OXI    3PTG    3VUD    3VUG    3VUH    3VUI    3VUK    3VUL    3VUM    4E73    4G1W    4H39    4HYS    4HYU    4IZY    5LW1   
SuperfamilyQ9UQF2
Human Protein Atlas [tissue]ENSG00000121653-MAPK8IP1 [tissue]
Peptide AtlasQ9UQF2
HPRD05223
IPIIPI00023133   IPI00921980   IPI00794394   
Protein Interaction databases
DIP (DOE-UCLA)Q9UQF2
IntAct (EBI)Q9UQF2
FunCoupENSG00000121653
BioGRIDMAPK8IP1
STRING (EMBL)MAPK8IP1
ZODIACMAPK8IP1
Ontologies - Pathways
QuickGOQ9UQF2
Ontology : AmiGOprotein kinase inhibitor activity  MAP-kinase scaffold activity  protein binding  nucleus  cytoplasm  endoplasmic reticulum membrane  cytosol  plasma membrane  regulation of transcription, DNA-templated  JUN phosphorylation  JUN kinase binding  vesicle-mediated transport  kinesin binding  mitogen-activated protein kinase kinase binding  mitogen-activated protein kinase kinase kinase binding  mitochondrial membrane  negative regulation of JUN kinase activity  dendritic growth cone  axonal growth cone  cell body  dentate gyrus mossy fiber  synapse  regulation of JNK cascade  positive regulation of JNK cascade  perinuclear region of cytoplasm  regulation of CD8-positive, alpha-beta T cell proliferation  negative regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein kinase inhibitor activity  MAP-kinase scaffold activity  protein binding  nucleus  cytoplasm  endoplasmic reticulum membrane  cytosol  plasma membrane  regulation of transcription, DNA-templated  JUN phosphorylation  JUN kinase binding  vesicle-mediated transport  kinesin binding  mitogen-activated protein kinase kinase binding  mitogen-activated protein kinase kinase kinase binding  mitochondrial membrane  negative regulation of JUN kinase activity  dendritic growth cone  axonal growth cone  cell body  dentate gyrus mossy fiber  synapse  regulation of JNK cascade  positive regulation of JNK cascade  perinuclear region of cytoplasm  regulation of CD8-positive, alpha-beta T cell proliferation  negative regulation of intrinsic apoptotic signaling pathway  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAPK8IP1
Atlas of Cancer Signalling NetworkMAPK8IP1
Wikipedia pathwaysMAPK8IP1
Orthology - Evolution
OrthoDB9479
GeneTree (enSembl)ENSG00000121653
Phylogenetic Trees/Animal Genes : TreeFamMAPK8IP1
HOGENOMQ9UQF2
Homologs : HomoloGeneMAPK8IP1
Homology/Alignments : Family Browser (UCSC)MAPK8IP1
Gene fusions - Rearrangements
Fusion : QuiverMAPK8IP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAPK8IP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPK8IP1
dbVarMAPK8IP1
ClinVarMAPK8IP1
1000_GenomesMAPK8IP1 
Exome Variant ServerMAPK8IP1
ExAC (Exome Aggregation Consortium)ENSG00000121653
GNOMAD BrowserENSG00000121653
Varsome BrowserMAPK8IP1
Genetic variants : HAPMAP9479
Genomic Variants (DGV)MAPK8IP1 [DGVbeta]
DECIPHERMAPK8IP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAPK8IP1 
Mutations
ICGC Data PortalMAPK8IP1 
TCGA Data PortalMAPK8IP1 
Broad Tumor PortalMAPK8IP1
OASIS PortalMAPK8IP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAPK8IP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAPK8IP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MAPK8IP1
DgiDB (Drug Gene Interaction Database)MAPK8IP1
DoCM (Curated mutations)MAPK8IP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAPK8IP1 (select a term)
intoGenMAPK8IP1
Cancer3DMAPK8IP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125853    604641   
Orphanet
DisGeNETMAPK8IP1
MedgenMAPK8IP1
Genetic Testing Registry MAPK8IP1
NextProtQ9UQF2 [Medical]
TSGene9479
GENETestsMAPK8IP1
Target ValidationMAPK8IP1
Huge Navigator MAPK8IP1 [HugePedia]
snp3D : Map Gene to Disease9479
BioCentury BCIQMAPK8IP1
ClinGenMAPK8IP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9479
Chemical/Pharm GKB GenePA30626
Clinical trialMAPK8IP1
Miscellaneous
canSAR (ICR)MAPK8IP1 (select the gene name)
DataMed IndexMAPK8IP1
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAPK8IP1
EVEXMAPK8IP1
GoPubMedMAPK8IP1
iHOPMAPK8IP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 21 15:54:56 CET 2019
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