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MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2)

Identity

Alias_namesPRKM8IPL
PRKM8 interacting protein-like
Alias_symbol (synonym)IB2
JIP2
Other aliasIB-2
HGNC (Hugo) MAPK8IP2
LocusID (NCBI) 23542
Atlas_Id 49912
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50600685 and ends at 50611551 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LOC100506548 (5p13.1) / MAPK8IP2 (22q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAPK8IP2   6883
Cards
Entrez_Gene (NCBI)MAPK8IP2  23542  mitogen-activated protein kinase 8 interacting protein 2
AliasesIB-2; IB2; JIP2; PRKM8IPL
GeneCards (Weizmann)MAPK8IP2
Ensembl hg19 (Hinxton)ENSG00000008735 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008735 [Gene_View]  chr22:50600685-50611551 [Contig_View]  MAPK8IP2 [Vega]
ICGC DataPortalENSG00000008735
TCGA cBioPortalMAPK8IP2
AceView (NCBI)MAPK8IP2
Genatlas (Paris)MAPK8IP2
WikiGenes23542
SOURCE (Princeton)MAPK8IP2
Genetics Home Reference (NIH)MAPK8IP2
Genomic and cartography
GoldenPath hg38 (UCSC)MAPK8IP2  -     chr22:50600685-50611551 +  22q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAPK8IP2  -     22q13.33   [Description]    (hg19-Feb_2009)
EnsemblMAPK8IP2 - 22q13.33 [CytoView hg19]  MAPK8IP2 - 22q13.33 [CytoView hg38]
Mapping of homologs : NCBIMAPK8IP2 [Mapview hg19]  MAPK8IP2 [Mapview hg38]
OMIM607755   
Gene and transcription
Genbank (Entrez)AF136382 AF218778 AK293580 AK294265 AL021708
RefSeq transcript (Entrez)NM_012324 NM_016431 NM_139124
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAPK8IP2
Cluster EST : UnigeneHs.558180 [ NCBI ]
CGAP (NCI)Hs.558180
Alternative Splicing GalleryENSG00000008735
Gene ExpressionMAPK8IP2 [ NCBI-GEO ]   MAPK8IP2 [ EBI - ARRAY_EXPRESS ]   MAPK8IP2 [ SEEK ]   MAPK8IP2 [ MEM ]
Gene Expression Viewer (FireBrowse)MAPK8IP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23542
GTEX Portal (Tissue expression)MAPK8IP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13387   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13387  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13387
Splice isoforms : SwissVarQ13387
PhosPhoSitePlusQ13387
Domaine pattern : Prosite (Expaxy)PID (PS01179)    SH3 (PS50002)   
Domains : Interpro (EBI)PH_dom-like    PTB/PI_dom    SH3_domain   
Domain families : Pfam (Sanger)PID (PF00640)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00640    pfam14604   
Domain families : Smart (EMBL)PTB (SM00462)  SH3 (SM00326)  
Conserved Domain (NCBI)MAPK8IP2
DMDM Disease mutations23542
Blocks (Seattle)MAPK8IP2
SuperfamilyQ13387
Human Protein AtlasENSG00000008735
Peptide AtlasQ13387
HPRD09674
IPIIPI00031777   IPI00221227   IPI00221228   IPI00221229   IPI00910494   IPI00910776   IPI00953197   
Protein Interaction databases
DIP (DOE-UCLA)Q13387
IntAct (EBI)Q13387
FunCoupENSG00000008735
BioGRIDMAPK8IP2
STRING (EMBL)MAPK8IP2
ZODIACMAPK8IP2
Ontologies - Pathways
QuickGOQ13387
Ontology : AmiGObeta-amyloid binding  behavioral fear response  MAP-kinase scaffold activity  structural molecule activity  protein binding  cytoplasm  signal complex assembly  JNK cascade  mating behavior  regulation of receptor activity  postsynaptic density  kinesin binding  protein kinase binding  protein complex binding  positive regulation of stress-activated MAPK cascade  social behavior  neuronal cell body  protein complex  regulation of JNK cascade  nonassociative learning  dendrite morphogenesis  regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  regulation of NMDA receptor activity  regulation of AMPA receptor activity  
Ontology : EGO-EBIbeta-amyloid binding  behavioral fear response  MAP-kinase scaffold activity  structural molecule activity  protein binding  cytoplasm  signal complex assembly  JNK cascade  mating behavior  regulation of receptor activity  postsynaptic density  kinesin binding  protein kinase binding  protein complex binding  positive regulation of stress-activated MAPK cascade  social behavior  neuronal cell body  protein complex  regulation of JNK cascade  nonassociative learning  dendrite morphogenesis  regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  regulation of NMDA receptor activity  regulation of AMPA receptor activity  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAPK8IP2
Atlas of Cancer Signalling NetworkMAPK8IP2
Wikipedia pathwaysMAPK8IP2
Orthology - Evolution
OrthoDB23542
GeneTree (enSembl)ENSG00000008735
Phylogenetic Trees/Animal Genes : TreeFamMAPK8IP2
HOVERGENQ13387
HOGENOMQ13387
Homologs : HomoloGeneMAPK8IP2
Homology/Alignments : Family Browser (UCSC)MAPK8IP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAPK8IP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPK8IP2
dbVarMAPK8IP2
ClinVarMAPK8IP2
1000_GenomesMAPK8IP2 
Exome Variant ServerMAPK8IP2
ExAC (Exome Aggregation Consortium)MAPK8IP2 (select the gene name)
Genetic variants : HAPMAP23542
Genomic Variants (DGV)MAPK8IP2 [DGVbeta]
DECIPHERMAPK8IP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAPK8IP2 
Mutations
ICGC Data PortalMAPK8IP2 
TCGA Data PortalMAPK8IP2 
Broad Tumor PortalMAPK8IP2
OASIS PortalMAPK8IP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAPK8IP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAPK8IP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAPK8IP2
DgiDB (Drug Gene Interaction Database)MAPK8IP2
DoCM (Curated mutations)MAPK8IP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAPK8IP2 (select a term)
intoGenMAPK8IP2
Cancer3DMAPK8IP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607755   
Orphanet
MedgenMAPK8IP2
Genetic Testing Registry MAPK8IP2
NextProtQ13387 [Medical]
TSGene23542
GENETestsMAPK8IP2
Target ValidationMAPK8IP2
Huge Navigator MAPK8IP2 [HugePedia]
snp3D : Map Gene to Disease23542
BioCentury BCIQMAPK8IP2
ClinGenMAPK8IP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23542
Chemical/Pharm GKB GenePA30627
Clinical trialMAPK8IP2
Miscellaneous
canSAR (ICR)MAPK8IP2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAPK8IP2
EVEXMAPK8IP2
GoPubMedMAPK8IP2
iHOPMAPK8IP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:06:20 CEST 2017

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