Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MAPKAPK3 (mitogen-activated protein kinase-activated protein kinase 3)

Identity

Alias_symbol (synonym)3pK
MAPKAP3
3PK
Other aliasMAPKAP-K3
MAPKAPK-3
MK-3
HGNC (Hugo) MAPKAPK3
LocusID (NCBI) 7867
Atlas_Id 43351
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 50654562 and ends at 50686728 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MAPKAPK3 (3p21.2) / HEMK1 (3p21.2)RPL13 (16q24.3) / MAPKAPK3 (3p21.2)MAPKAPK3 3p21.2 / HEMK1 3p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAPKAPK3   6888
Cards
Entrez_Gene (NCBI)MAPKAPK3  7867  mitogen-activated protein kinase-activated protein kinase 3
Aliases3PK; MAPKAP-K3; MAPKAP3; MAPKAPK-3; 
MK-3
GeneCards (Weizmann)MAPKAPK3
Ensembl hg19 (Hinxton)ENSG00000114738 [Gene_View]  chr3:50654562-50686728 [Contig_View]  MAPKAPK3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114738 [Gene_View]  chr3:50654562-50686728 [Contig_View]  MAPKAPK3 [Vega]
ICGC DataPortalENSG00000114738
TCGA cBioPortalMAPKAPK3
AceView (NCBI)MAPKAPK3
Genatlas (Paris)MAPKAPK3
WikiGenes7867
SOURCE (Princeton)MAPKAPK3
Genetics Home Reference (NIH)MAPKAPK3
Genomic and cartography
GoldenPath hg19 (UCSC)MAPKAPK3  -     chr3:50654562-50686728 +  3p21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAPKAPK3  -     3p21.2   [Description]    (hg38-Dec_2013)
EnsemblMAPKAPK3 - 3p21.2 [CytoView hg19]  MAPKAPK3 - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBIMAPKAPK3 [Mapview hg19]  MAPKAPK3 [Mapview hg38]
OMIM602130   
Gene and transcription
Genbank (Entrez)AB451303 AB451434 AK290969 AK313565 BC001662
RefSeq transcript (Entrez)NM_001243925 NM_001243926 NM_004635
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)MAPKAPK3
Cluster EST : UnigeneHs.735013 [ NCBI ]
CGAP (NCI)Hs.735013
Alternative Splicing GalleryENSG00000114738
Gene ExpressionMAPKAPK3 [ NCBI-GEO ]   MAPKAPK3 [ EBI - ARRAY_EXPRESS ]   MAPKAPK3 [ SEEK ]   MAPKAPK3 [ MEM ]
Gene Expression Viewer (FireBrowse)MAPKAPK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7867
GTEX Portal (Tissue expression)MAPKAPK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16644   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16644  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16644
Splice isoforms : SwissVarQ16644
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ16644
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    MAPKAPK_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAPKAPK3
DMDM Disease mutations7867
Blocks (Seattle)MAPKAPK3
PDB (SRS)3FHR    3FXW    3R1N    3SHE   
PDB (PDBSum)3FHR    3FXW    3R1N    3SHE   
PDB (IMB)3FHR    3FXW    3R1N    3SHE   
PDB (RSDB)3FHR    3FXW    3R1N    3SHE   
Structural Biology KnowledgeBase3FHR    3FXW    3R1N    3SHE   
SCOP (Structural Classification of Proteins)3FHR    3FXW    3R1N    3SHE   
CATH (Classification of proteins structures)3FHR    3FXW    3R1N    3SHE   
SuperfamilyQ16644
Human Protein AtlasENSG00000114738
Peptide AtlasQ16644
HPRD03678
IPIIPI00005777   IPI00925843   IPI00925537   IPI00925308   
Protein Interaction databases
DIP (DOE-UCLA)Q16644
IntAct (EBI)Q16644
FunCoupENSG00000114738
BioGRIDMAPKAPK3
STRING (EMBL)MAPKAPK3
ZODIACMAPKAPK3
Ontologies - Pathways
QuickGOQ16644
Ontology : AmiGOMAPK cascade  activation of MAPK activity  toll-like receptor signaling pathway  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  MAP kinase kinase activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  response to stress  signal transduction  cell surface receptor signaling pathway  Ras protein signal transduction  calcium-dependent protein serine/threonine kinase activity  peptidyl-serine phosphorylation  response to lipopolysaccharide  response to cytokine  macropinocytosis  protein autophosphorylation  vascular endothelial growth factor receptor signaling pathway  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  toll-like receptor signaling pathway  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  MAP kinase kinase activity  protein binding  calmodulin binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  response to stress  signal transduction  cell surface receptor signaling pathway  Ras protein signal transduction  calcium-dependent protein serine/threonine kinase activity  peptidyl-serine phosphorylation  response to lipopolysaccharide  response to cytokine  macropinocytosis  protein autophosphorylation  vascular endothelial growth factor receptor signaling pathway  
Pathways : BIOCARTAStress Induction of HSP Regulation [Genes]    MAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    VEGF signaling pathway   
NDEx NetworkMAPKAPK3
Atlas of Cancer Signalling NetworkMAPKAPK3
Wikipedia pathwaysMAPKAPK3
Orthology - Evolution
OrthoDB7867
GeneTree (enSembl)ENSG00000114738
Phylogenetic Trees/Animal Genes : TreeFamMAPKAPK3
HOVERGENQ16644
HOGENOMQ16644
Homologs : HomoloGeneMAPKAPK3
Homology/Alignments : Family Browser (UCSC)MAPKAPK3
Gene fusions - Rearrangements
Fusion : MitelmanMAPKAPK3/HEMK1 [3p21.2/3p21.2]  
Fusion: TCGAMAPKAPK3 3p21.2 HEMK1 3p21.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAPKAPK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPKAPK3
dbVarMAPKAPK3
ClinVarMAPKAPK3
1000_GenomesMAPKAPK3 
Exome Variant ServerMAPKAPK3
ExAC (Exome Aggregation Consortium)MAPKAPK3 (select the gene name)
Genetic variants : HAPMAP7867
Genomic Variants (DGV)MAPKAPK3 [DGVbeta]
DECIPHER (Syndromes)3:50654562-50686728  ENSG00000114738
CONAN: Copy Number AnalysisMAPKAPK3 
Mutations
ICGC Data PortalMAPKAPK3 
TCGA Data PortalMAPKAPK3 
Broad Tumor PortalMAPKAPK3
OASIS PortalMAPKAPK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAPKAPK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAPKAPK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAPKAPK3
DgiDB (Drug Gene Interaction Database)MAPKAPK3
DoCM (Curated mutations)MAPKAPK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAPKAPK3 (select a term)
intoGenMAPKAPK3
Cancer3DMAPKAPK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602130   
Orphanet
MedgenMAPKAPK3
Genetic Testing Registry MAPKAPK3
NextProtQ16644 [Medical]
TSGene7867
GENETestsMAPKAPK3
Huge Navigator MAPKAPK3 [HugePedia]
snp3D : Map Gene to Disease7867
BioCentury BCIQMAPKAPK3
ClinGenMAPKAPK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7867
Chemical/Pharm GKB GenePA30632
Clinical trialMAPKAPK3
Miscellaneous
canSAR (ICR)MAPKAPK3 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAPKAPK3
EVEXMAPKAPK3
GoPubMedMAPKAPK3
iHOPMAPKAPK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:14:31 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.