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MAPKAPK5 (mitogen-activated protein kinase-activated protein kinase 5)

Identity

Alias_symbol (synonym)PRAK
Other aliasMAPKAP-K5
MK-5
MK5
HGNC (Hugo) MAPKAPK5
LocusID (NCBI) 8550
Atlas_Id 41296
Location 12q24.12  [Link to chromosome band 12q24]
Location_base_pair Starts at 111842228 and ends at 111893424 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACAD10 (12q24.12) / MAPKAPK5 (12q24.12)MAPKAPK5 (12q24.12) / ALDH2 (12q24.12)MAPKAPK5 (12q24.12) / GAP43 (3q13.31)
MAPKAPK5 (12q24.12) / GNPTAB (12q23.2)MAPKAPK5 (12q24.12) / MAPKAPK5 (12q24.12)ROMO1 (20q11.22) / MAPKAPK5 (12q24.12)
MAPKAPK5 12q24.12 / ALDH2 12q24.12MAPKAPK5 12q24.12 / GNPTAB 12q23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(q24;q24) ACAD10/MAPKAPK5


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(3;12)(q13;q24) MAPKAPK5/GAP43
t(12;12)(q23;q24) MAPKAPK5/GNPTAB
MAPKAPK5/ALDH2 (12q24)
MAPKAPK5/ALDH2 (12q24)


External links

Nomenclature
HGNC (Hugo)MAPKAPK5   6889
Cards
Entrez_Gene (NCBI)MAPKAPK5  8550  mitogen-activated protein kinase-activated protein kinase 5
AliasesMAPKAP-K5; MK-5; MK5; PRAK
GeneCards (Weizmann)MAPKAPK5
Ensembl hg19 (Hinxton)ENSG00000089022 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089022 [Gene_View]  ENSG00000089022 [Sequence]  chr12:111842228-111893424 [Contig_View]  MAPKAPK5 [Vega]
ICGC DataPortalENSG00000089022
TCGA cBioPortalMAPKAPK5
AceView (NCBI)MAPKAPK5
Genatlas (Paris)MAPKAPK5
WikiGenes8550
SOURCE (Princeton)MAPKAPK5
Genetics Home Reference (NIH)MAPKAPK5
Genomic and cartography
GoldenPath hg38 (UCSC)MAPKAPK5  -     chr12:111842228-111893424 +  12q24.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAPKAPK5  -     12q24.12   [Description]    (hg19-Feb_2009)
EnsemblMAPKAPK5 - 12q24.12 [CytoView hg19]  MAPKAPK5 - 12q24.12 [CytoView hg38]
Mapping of homologs : NCBIMAPKAPK5 [Mapview hg19]  MAPKAPK5 [Mapview hg38]
OMIM606723   
Gene and transcription
Genbank (Entrez)AK122767 AL110301 AW780199 BC000833 BC041049
RefSeq transcript (Entrez)NM_003668 NM_139078
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAPKAPK5
Cluster EST : UnigeneHs.413901 [ NCBI ]
CGAP (NCI)Hs.413901
Alternative Splicing GalleryENSG00000089022
Gene ExpressionMAPKAPK5 [ NCBI-GEO ]   MAPKAPK5 [ EBI - ARRAY_EXPRESS ]   MAPKAPK5 [ SEEK ]   MAPKAPK5 [ MEM ]
Gene Expression Viewer (FireBrowse)MAPKAPK5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8550
GTEX Portal (Tissue expression)MAPKAPK5
Human Protein AtlasENSG00000089022-MAPKAPK5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IW41   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IW41  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IW41
Splice isoforms : SwissVarQ8IW41
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8IW41
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAPKAPK5
DMDM Disease mutations8550
Blocks (Seattle)MAPKAPK5
SuperfamilyQ8IW41
Human Protein Atlas [tissue]ENSG00000089022-MAPKAPK5 [tissue]
Peptide AtlasQ8IW41
HPRD09467
IPIIPI00160672   IPI00217131   IPI01022418   IPI01021933   IPI01020822   IPI01021609   IPI01021769   IPI01021268   
Protein Interaction databases
DIP (DOE-UCLA)Q8IW41
IntAct (EBI)Q8IW41
FunCoupENSG00000089022
BioGRIDMAPKAPK5
STRING (EMBL)MAPKAPK5
ZODIACMAPKAPK5
Ontologies - Pathways
QuickGOQ8IW41
Ontology : AmiGOMAPK cascade  activation of MAPK activity  p53 binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  MAP kinase kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  regulation of translation  signal transduction  Ras protein signal transduction  Ras protein signal transduction  calcium-dependent protein serine/threonine kinase activity  peptidyl-serine phosphorylation  negative regulation of TOR signaling  positive regulation of telomere maintenance via telomerase  intracellular signal transduction  protein autophosphorylation  mitogen-activated protein kinase binding  positive regulation of telomerase activity  stress-induced premature senescence  regulation of signal transduction by p53 class mediator  positive regulation of telomere capping  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  p53 binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calmodulin-dependent protein kinase activity  MAP kinase kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  regulation of translation  signal transduction  Ras protein signal transduction  Ras protein signal transduction  calcium-dependent protein serine/threonine kinase activity  peptidyl-serine phosphorylation  negative regulation of TOR signaling  positive regulation of telomere maintenance via telomerase  intracellular signal transduction  protein autophosphorylation  mitogen-activated protein kinase binding  positive regulation of telomerase activity  stress-induced premature senescence  regulation of signal transduction by p53 class mediator  positive regulation of telomere capping  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAPKAPK5
Atlas of Cancer Signalling NetworkMAPKAPK5
Wikipedia pathwaysMAPKAPK5
Orthology - Evolution
OrthoDB8550
GeneTree (enSembl)ENSG00000089022
Phylogenetic Trees/Animal Genes : TreeFamMAPKAPK5
HOVERGENQ8IW41
HOGENOMQ8IW41
Homologs : HomoloGeneMAPKAPK5
Homology/Alignments : Family Browser (UCSC)MAPKAPK5
Gene fusions - Rearrangements
Fusion : MitelmanACAD10/MAPKAPK5 [12q24.12/12q24.12]  [t(12;12)(q24;q24)]  
Fusion : MitelmanMAPKAPK5/ALDH2 [12q24.12/12q24.12]  [t(12;12)(q24;q24)]  
Fusion : MitelmanMAPKAPK5/GAP43 [12q24.12/3q13.31]  [t(3;12)(q13;q24)]  
Fusion : MitelmanMAPKAPK5/GNPTAB [12q24.12/12q23.2]  [t(12;12)(q23;q24)]  
Fusion PortalMAPKAPK5 12q24.12 ALDH2 12q24.12 LUAD
Fusion PortalMAPKAPK5 12q24.12 GNPTAB 12q23.2 BRCA
Fusion : QuiverMAPKAPK5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAPKAPK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPKAPK5
dbVarMAPKAPK5
ClinVarMAPKAPK5
1000_GenomesMAPKAPK5 
Exome Variant ServerMAPKAPK5
ExAC (Exome Aggregation Consortium)ENSG00000089022
GNOMAD BrowserENSG00000089022
Varsome BrowserMAPKAPK5
Genetic variants : HAPMAP8550
Genomic Variants (DGV)MAPKAPK5 [DGVbeta]
DECIPHERMAPKAPK5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAPKAPK5 
Mutations
ICGC Data PortalMAPKAPK5 
TCGA Data PortalMAPKAPK5 
Broad Tumor PortalMAPKAPK5
OASIS PortalMAPKAPK5 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMAPKAPK5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAPKAPK5
DgiDB (Drug Gene Interaction Database)MAPKAPK5
DoCM (Curated mutations)MAPKAPK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAPKAPK5 (select a term)
intoGenMAPKAPK5
Cancer3DMAPKAPK5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606723   
Orphanet
DisGeNETMAPKAPK5
MedgenMAPKAPK5
Genetic Testing Registry MAPKAPK5
NextProtQ8IW41 [Medical]
TSGene8550
GENETestsMAPKAPK5
Target ValidationMAPKAPK5
Huge Navigator MAPKAPK5 [HugePedia]
snp3D : Map Gene to Disease8550
BioCentury BCIQMAPKAPK5
ClinGenMAPKAPK5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8550
Chemical/Pharm GKB GenePA30633
Clinical trialMAPKAPK5
Miscellaneous
canSAR (ICR)MAPKAPK5 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAPKAPK5
EVEXMAPKAPK5
GoPubMedMAPKAPK5
iHOPMAPKAPK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:18:57 CET 2018

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