Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAPT (microtubule-associated protein tau)

Identity

Other namesDDPAC
FTDP-17
MAPTL
MSTD
MTBT1
MTBT2
PPND
PPP1R103
TAU
HGNC (Hugo) MAPT
LocusID (NCBI) 4137
Location 17q21.31
Location_base_pair Starts at 43971748 and ends at 44105699 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAPT   6893
Cards
Entrez_Gene (NCBI)MAPT  4137  microtubule-associated protein tau
GeneCards (Weizmann)MAPT
Ensembl hg19 (Hinxton)ENSG00000186868 [Gene_View]  chr17:43971748-44105699 [Contig_View]  MAPT [Vega]
Ensembl hg38 (Hinxton)ENSG00000186868 [Gene_View]  chr17:43971748-44105699 [Contig_View]  MAPT [Vega]
ICGC DataPortalENSG00000186868
cBioPortalMAPT
AceView (NCBI)MAPT
Genatlas (Paris)MAPT
WikiGenes4137
SOURCE (Princeton)MAPT
Genomic and cartography
GoldenPath hg19 (UCSC)MAPT  -     chr17:43971748-44105699 +  17q21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAPT  -     17q21.31   [Description]    (hg38-Dec_2013)
EnsemblMAPT - 17q21.31 [CytoView hg19]  MAPT - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIMAPT [Mapview hg19]  MAPT [Mapview hg38]
OMIM157140   168600   172700   260540   600274   601104   
Gene and transcription
Genbank (Entrez)AB073354 AF456477 AK055986 AK095802 AK226139
RefSeq transcript (Entrez)NM_001123066 NM_001123067 NM_001203251 NM_001203252 NM_005910 NM_016834 NM_016835 NM_016841
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_007398 NT_010783 NT_167251 NT_187663 NW_001838441 NW_004929407
Consensus coding sequences : CCDS (NCBI)MAPT
Cluster EST : UnigeneHs.101174 [ NCBI ]
CGAP (NCI)Hs.101174
Alternative Splicing : Fast-db (Paris)GSHG0033294
Alternative Splicing GalleryENSG00000186868
Gene ExpressionMAPT [ NCBI-GEO ]     MAPT [ SEEK ]   MAPT [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10636 (Uniprot)
NextProtP10636  [Medical]
With graphics : InterProP10636
Splice isoforms : SwissVarP10636 (Swissvar)
Domaine pattern : Prosite (Expaxy)TAU_MAP_1 (PS00229)    TAU_MAP_2 (PS51491)   
Domains : Interpro (EBI)MAP2/MAP4/Tau    MAP_tubulin-bd_rpt    Tau   
Related proteins : CluSTrP10636
Domain families : Pfam (Sanger)Tubulin-binding (PF00418)   
Domain families : Pfam (NCBI)pfam00418   
DMDM Disease mutations4137
Blocks (Seattle)P10636
PDB (SRS)1I8H    2ON9    3OVL    4FL5    4GLR    4NP8   
PDB (PDBSum)1I8H    2ON9    3OVL    4FL5    4GLR    4NP8   
PDB (IMB)1I8H    2ON9    3OVL    4FL5    4GLR    4NP8   
PDB (RSDB)1I8H    2ON9    3OVL    4FL5    4GLR    4NP8   
Human Protein AtlasENSG00000186868
Peptide AtlasP10636
HPRD01142
IPIIPI00964662   IPI00220171   IPI00293683   IPI00220173   IPI00220174   IPI00026836   IPI00220175   IPI00025499   IPI00217976   IPI00043401   IPI01010378   IPI01009823   
Protein Interaction databases
DIP (DOE-UCLA)P10636
IntAct (EBI)P10636
FunCoupENSG00000186868
BioGRIDMAPT
IntegromeDBMAPT
STRING (EMBL)MAPT
Ontologies - Pathways
QuickGOP10636
Ontology : AmiGOmicrotubule cytoskeleton organization  neuron migration  structural constituent of cytoskeleton  protein binding  cytosol  microtubule  microtubule associated complex  plasma membrane  apoptotic process  cellular component disassembly involved in execution phase of apoptosis  adult walking behavior  microtubule binding  axon cargo transport  regulation of autophagy  SH3 domain binding  enzyme binding  protein kinase binding  axon  growth cone  regulation of microtubule polymerization  positive regulation of microtubule polymerization  negative regulation of intracellular transport  apolipoprotein binding  nuclear periphery  cytoplasmic ribonucleoprotein granule  tubulin complex  positive regulation of axon extension  mitochondrion transport along microtubule  axon extension  generation of neurons  regulation of microtubule-based movement  lipoprotein particle binding  
Ontology : EGO-EBImicrotubule cytoskeleton organization  neuron migration  structural constituent of cytoskeleton  protein binding  cytosol  microtubule  microtubule associated complex  plasma membrane  apoptotic process  cellular component disassembly involved in execution phase of apoptosis  adult walking behavior  microtubule binding  axon cargo transport  regulation of autophagy  SH3 domain binding  enzyme binding  protein kinase binding  axon  growth cone  regulation of microtubule polymerization  positive regulation of microtubule polymerization  negative regulation of intracellular transport  apolipoprotein binding  nuclear periphery  cytoplasmic ribonucleoprotein granule  tubulin complex  positive regulation of axon extension  mitochondrion transport along microtubule  axon extension  generation of neurons  regulation of microtubule-based movement  lipoprotein particle binding  
Pathways : KEGGMAPK signaling pathway    Alzheimer's disease   
Protein Interaction DatabaseMAPT
DoCM (Curated mutations)MAPT
Wikipedia pathwaysMAPT
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMAPT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPT
dbVarMAPT
ClinVarMAPT
1000_GenomesMAPT 
Exome Variant ServerMAPT
SNP (GeneSNP Utah)MAPT
SNP : HGBaseMAPT
Genetic variants : HAPMAPMAPT
Genomic VariantsMAPT  MAPT [DGVbeta]
Mutations
ICGC Data PortalENSG00000186868 
Somatic Mutations in Cancer : COSMICMAPT 
CONAN: Copy Number AnalysisMAPT 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:43971748-44105699
Mutations and Diseases : HGMDMAPT
OMIM157140    168600    172700    260540    600274    601104   
MedgenMAPT
NextProtP10636 [Medical]
GENETestsMAPT
Disease Genetic AssociationMAPT
Huge Navigator MAPT [HugePedia]  MAPT [HugeCancerGEM]
snp3D : Map Gene to Disease4137
DGIdb (Drug Gene Interaction db)MAPT
General knowledge
Homologs : HomoloGeneMAPT
Homology/Alignments : Family Browser (UCSC)MAPT
Phylogenetic Trees/Animal Genes : TreeFamMAPT
Chemical/Protein Interactions : CTD4137
Chemical/Pharm GKB GenePA238
Clinical trialMAPT
Cancer Resource (Charite)ENSG00000186868
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineMAPT
GoPubMedMAPT
iHOPMAPT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 23:35:06 CET 2014
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