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MARCH2 (membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase)

Identity

Alias_namesmembrane-associated ring finger (C3HC4) 2
membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
Alias_symbol (synonym)HSPC240
MARCH-II
RNF172
Other alias
HGNC (Hugo) MARCH2
LocusID (NCBI) 51257
Atlas_Id 68809
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 8478187 and ends at 8503899 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MARCH2 (19p13.2) / CERS4 (19p13.2)MARCH2 (19p13.2) / PLVAP (19p13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MARCH2   28038
Cards
Entrez_Gene (NCBI)MARCH2  51257  membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
AliasesHSPC240; MARCH-II; RNF172
GeneCards (Weizmann)MARCH2
Ensembl hg19 (Hinxton)ENSG00000099785 [Gene_View]  chr19:8478187-8503899 [Contig_View]  MARCH2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000099785 [Gene_View]  chr19:8478187-8503899 [Contig_View]  MARCH2 [Vega]
ICGC DataPortalENSG00000099785
TCGA cBioPortalMARCH2
AceView (NCBI)MARCH2
Genatlas (Paris)MARCH2
WikiGenes51257
SOURCE (Princeton)MARCH2
Genetics Home Reference (NIH)MARCH2
Genomic and cartography
GoldenPath hg19 (UCSC)MARCH2  -     chr19:8478187-8503899 +  19p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MARCH2  -     19p13.2   [Description]    (hg38-Dec_2013)
EnsemblMARCH2 - 19p13.2 [CytoView hg19]  MARCH2 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIMARCH2 [Mapview hg19]  MARCH2 [Mapview hg38]
OMIM613332   
Gene and transcription
Genbank (Entrez)AB197929 AF151074 AK130163 BC015910 BC032624
RefSeq transcript (Entrez)NM_001005415 NM_001005416 NM_016496
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929413
Consensus coding sequences : CCDS (NCBI)MARCH2
Cluster EST : UnigeneHs.631861 [ NCBI ]
CGAP (NCI)Hs.631861
Alternative Splicing GalleryENSG00000099785
Gene ExpressionMARCH2 [ NCBI-GEO ]   MARCH2 [ EBI - ARRAY_EXPRESS ]   MARCH2 [ SEEK ]   MARCH2 [ MEM ]
Gene Expression Viewer (FireBrowse)MARCH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51257
GTEX Portal (Tissue expression)MARCH2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P0N8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P0N8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P0N8
Splice isoforms : SwissVarQ9P0N8
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ9P0N8
Domaine pattern : Prosite (Expaxy)ZF_RING_CH (PS51292)   
Domains : Interpro (EBI)Znf_RING-CH    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)RINGv (PF12906)   
Domain families : Pfam (NCBI)pfam12906   
Domain families : Smart (EMBL)RINGv (SM00744)  
Conserved Domain (NCBI)MARCH2
DMDM Disease mutations51257
Blocks (Seattle)MARCH2
SuperfamilyQ9P0N8
Human Protein AtlasENSG00000099785
Peptide AtlasQ9P0N8
HPRD14361
IPIIPI00296880   IPI00470593   
Protein Interaction databases
DIP (DOE-UCLA)Q9P0N8
IntAct (EBI)Q9P0N8
FunCoupENSG00000099785
BioGRIDMARCH2
STRING (EMBL)MARCH2
ZODIACMARCH2
Ontologies - Pathways
QuickGOQ9P0N8
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  lysosomal membrane  endoplasmic reticulum  endoplasmic reticulum membrane  endocytosis  zinc ion binding  endosome membrane  integral component of membrane  protein ubiquitination  protein ubiquitination  ligase activity  cytoplasmic vesicle  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  lysosomal membrane  endoplasmic reticulum  endoplasmic reticulum membrane  endocytosis  zinc ion binding  endosome membrane  integral component of membrane  protein ubiquitination  protein ubiquitination  ligase activity  cytoplasmic vesicle  
NDEx NetworkMARCH2
Atlas of Cancer Signalling NetworkMARCH2
Wikipedia pathwaysMARCH2
Orthology - Evolution
OrthoDB51257
GeneTree (enSembl)ENSG00000099785
Phylogenetic Trees/Animal Genes : TreeFamMARCH2
HOVERGENQ9P0N8
HOGENOMQ9P0N8
Homologs : HomoloGeneMARCH2
Homology/Alignments : Family Browser (UCSC)MARCH2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARCH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARCH2
dbVarMARCH2
ClinVarMARCH2
1000_GenomesMARCH2 
Exome Variant ServerMARCH2
ExAC (Exome Aggregation Consortium)MARCH2 (select the gene name)
Genetic variants : HAPMAP51257
Genomic Variants (DGV)MARCH2 [DGVbeta]
DECIPHER (Syndromes)19:8478187-8503899  ENSG00000099785
CONAN: Copy Number AnalysisMARCH2 
Mutations
ICGC Data PortalMARCH2 
TCGA Data PortalMARCH2 
Broad Tumor PortalMARCH2
OASIS PortalMARCH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARCH2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMARCH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MARCH2
DgiDB (Drug Gene Interaction Database)MARCH2
DoCM (Curated mutations)MARCH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARCH2 (select a term)
intoGenMARCH2
Cancer3DMARCH2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613332   
Orphanet
MedgenMARCH2
Genetic Testing Registry MARCH2
NextProtQ9P0N8 [Medical]
TSGene51257
GENETestsMARCH2
Huge Navigator MARCH2 [HugePedia]
snp3D : Map Gene to Disease51257
BioCentury BCIQMARCH2
ClinGenMARCH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51257
Chemical/Pharm GKB GenePA134993565
Clinical trialMARCH2
Miscellaneous
canSAR (ICR)MARCH2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMARCH2
EVEXMARCH2
GoPubMedMARCH2
iHOPMARCH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:27:43 CET 2017

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