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MARCH4 (membrane associated ring-CH-type finger 4)

Identity

Alias_namesmembrane-associated ring finger (C3HC4) 4
membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
Alias_symbol (synonym)KIAA1399
MARCH-IV
RNF174
Other alias
HGNC (Hugo) 4-Mar
LocusID (NCBI) 57574
Atlas_Id 68811
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 216257862 and ends at 216372027 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AAMP (2q35) / MARCH4 (2q35)CYCS (7p15.3) / MARCH4 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)4-Mar   29269
Cards
Entrez_Gene (NCBI)MARCH4  57574  membrane associated ring-CH-type finger 4
AliasesMARCH-IV; RNF174
GeneCards (Weizmann)MARCH4
Ensembl hg19 (Hinxton)ENSG00000144583 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144583 [Gene_View]  chr2:216257862-216372027 [Contig_View]  MARCH4 [Vega]
ICGC DataPortalENSG00000144583
TCGA cBioPortalMARCH4
AceView (NCBI)MARCH4
Genatlas (Paris)MARCH4
WikiGenes57574
SOURCE (Princeton)MARCH4
Genetics Home Reference (NIH)MARCH4
Genomic and cartography
GoldenPath hg38 (UCSC)MARCH4  -     chr2:216257862-216372027 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARCH4  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblMARCH4 - 2q35 [CytoView hg19]  MARCH4 - 2q35 [CytoView hg38]
Mapping of homologs : NCBIMARCH4 [Mapview hg19]  MARCH4 [Mapview hg38]
OMIM608208   
Gene and transcription
Genbank (Entrez)AB037820 AL353945 AW051292 BC048793 BC098448
RefSeq transcript (Entrez)NM_020814
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MARCH4
Cluster EST : UnigeneHs.170388 [ NCBI ]
CGAP (NCI)Hs.170388
Alternative Splicing GalleryENSG00000144583
Gene ExpressionMARCH4 [ NCBI-GEO ]   MARCH4 [ EBI - ARRAY_EXPRESS ]   MARCH4 [ SEEK ]   MARCH4 [ MEM ]
Gene Expression Viewer (FireBrowse)MARCH4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57574
GTEX Portal (Tissue expression)MARCH4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2E8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2E8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2E8
Splice isoforms : SwissVarQ9P2E8
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ9P2E8
Domaine pattern : Prosite (Expaxy)ZF_RING_CH (PS51292)   
Domains : Interpro (EBI)MARCH-like    Znf_RING-CH    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)RINGv (PF12906)   
Domain families : Pfam (NCBI)pfam12906   
Domain families : Smart (EMBL)RINGv (SM00744)  
Conserved Domain (NCBI)MARCH4
DMDM Disease mutations57574
Blocks (Seattle)MARCH4
SuperfamilyQ9P2E8
Human Protein AtlasENSG00000144583
Peptide AtlasQ9P2E8
HPRD16299
IPIIPI00002144   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2E8
IntAct (EBI)Q9P2E8
FunCoupENSG00000144583
BioGRIDMARCH4
STRING (EMBL)MARCH4
ZODIACMARCH4
Ontologies - Pathways
QuickGOQ9P2E8
Ontology : AmiGOGolgi membrane  ubiquitin-protein transferase activity  Golgi stack  trans-Golgi network  zinc ion binding  integral component of membrane  protein ubiquitination  
Ontology : EGO-EBIGolgi membrane  ubiquitin-protein transferase activity  Golgi stack  trans-Golgi network  zinc ion binding  integral component of membrane  protein ubiquitination  
NDEx NetworkMARCH4
Atlas of Cancer Signalling NetworkMARCH4
Wikipedia pathwaysMARCH4
Orthology - Evolution
OrthoDB57574
GeneTree (enSembl)ENSG00000144583
Phylogenetic Trees/Animal Genes : TreeFam4-Mar
HOVERGENQ9P2E8
HOGENOMQ9P2E8
Homologs : HomoloGeneMARCH4
Homology/Alignments : Family Browser (UCSC)MARCH4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARCH4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARCH4
dbVarMARCH4
ClinVarMARCH4
1000_GenomesMARCH4 
Exome Variant ServerMARCH4
ExAC (Exome Aggregation Consortium)MARCH4 (select the gene name)
Genetic variants : HAPMAP57574
Genomic Variants (DGV)MARCH4 [DGVbeta]
DECIPHERMARCH4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARCH4 
Mutations
ICGC Data Portal4-Mar 
TCGA Data Portal4-Mar 
Broad Tumor Portal4-Mar
OASIS Portal4-Mar [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARCH4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMD4-Mar
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MARCH4
DgiDB (Drug Gene Interaction Database)MARCH4
DoCM (Curated mutations)MARCH4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARCH4 (select a term)
intoGenMARCH4
Cancer3DMARCH4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608208   
Orphanet
MedgenMARCH4
Genetic Testing Registry MARCH4
NextProtQ9P2E8 [Medical]
TSGene57574
GENETestsMARCH4
Target ValidationMARCH4
Huge Navigator 4-Mar [HugePedia]
snp3D : Map Gene to Disease57574
BioCentury BCIQMARCH4
ClinGenMARCH4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57574
Chemical/Pharm GKB GenePA134861849
Clinical trialMARCH4
Miscellaneous
canSAR (ICR)MARCH4 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMARCH4
EVEXMARCH4
GoPubMedMARCH4
iHOPMARCH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:25:33 CEST 2017

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