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MARCH6 (membrane associated ring-CH-type finger 6)

Identity

Alias_namesmembrane-associated ring finger (C3HC4) 6
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
Alias_symbol (synonym)TEB4
MARCH-VI
RNF176
Other aliasDOA10
HGNC (Hugo) MARCH6
LocusID (NCBI) 10299
Atlas_Id 54088
Location 5p15.2  [Link to chromosome band 5p15]
Location_base_pair Starts at 10353639 and ends at 10440388 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BNIP3 (10q26.3) / MARCH6 (5p15.2)HIBADH (7p15.2) / MARCH6 (5p15.2)MARCH6 (5p15.2) / HSPA9 (5q31.2)
MARCH6 (5p15.2) / IRX4 (5p15.33)MARCH6 (5p15.2) / ROPN1L (5p15.2)MARCH6 (5p15.2) / ZFAND3 (6p21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)MARCH6   30550
Cards
Entrez_Gene (NCBI)MARCH6  10299  membrane associated ring-CH-type finger 6
AliasesDOA10; MARCH-VI; RNF176; TEB4
GeneCards (Weizmann)MARCH6
Ensembl hg19 (Hinxton)ENSG00000145495 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145495 [Gene_View]  chr5:10353639-10440388 [Contig_View]  MARCH6 [Vega]
ICGC DataPortalENSG00000145495
TCGA cBioPortalMARCH6
AceView (NCBI)MARCH6
Genatlas (Paris)MARCH6
WikiGenes10299
SOURCE (Princeton)MARCH6
Genetics Home Reference (NIH)MARCH6
Genomic and cartography
GoldenPath hg38 (UCSC)MARCH6  -     chr5:10353639-10440388 +  5p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARCH6  -     5p15.2   [Description]    (hg19-Feb_2009)
EnsemblMARCH6 - 5p15.2 [CytoView hg19]  MARCH6 - 5p15.2 [CytoView hg38]
Mapping of homologs : NCBIMARCH6 [Mapview hg19]  MARCH6 [Mapview hg38]
OMIM613297   
Gene and transcription
Genbank (Entrez)AB011169 AF009301 AF056433 AK000970 AK056198
RefSeq transcript (Entrez)NM_001270660 NM_001270661 NM_005885
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MARCH6
Cluster EST : UnigeneHs.432862 [ NCBI ]
CGAP (NCI)Hs.432862
Alternative Splicing GalleryENSG00000145495
Gene ExpressionMARCH6 [ NCBI-GEO ]   MARCH6 [ EBI - ARRAY_EXPRESS ]   MARCH6 [ SEEK ]   MARCH6 [ MEM ]
Gene Expression Viewer (FireBrowse)MARCH6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10299
GTEX Portal (Tissue expression)MARCH6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60337   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60337  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60337
Splice isoforms : SwissVarO60337
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusO60337
Domaine pattern : Prosite (Expaxy)ZF_RING_CH (PS51292)   
Domains : Interpro (EBI)Znf_RING-CH    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)RINGv (PF12906)   
Domain families : Pfam (NCBI)pfam12906   
Domain families : Smart (EMBL)RINGv (SM00744)  
Conserved Domain (NCBI)MARCH6
DMDM Disease mutations10299
Blocks (Seattle)MARCH6
SuperfamilyO60337
Human Protein AtlasENSG00000145495
Peptide AtlasO60337
HPRD11095
IPIIPI00105518   IPI00903053   IPI00967347   IPI00827985   IPI00966794   IPI00964161   
Protein Interaction databases
DIP (DOE-UCLA)O60337
IntAct (EBI)O60337
FunCoupENSG00000145495
BioGRIDMARCH6
STRING (EMBL)MARCH6
ZODIACMARCH6
Ontologies - Pathways
QuickGOO60337
Ontology : AmiGOER ubiquitin ligase complex  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  endoplasmic reticulum  endoplasmic reticulum membrane  zinc ion binding  proteasomal protein catabolic process  membrane  integral component of membrane  enzyme binding  integral component of endoplasmic reticulum membrane  ubiquitin-dependent ERAD pathway  ubiquitin conjugating enzyme binding  ERAD pathway  endoplasmic reticulum quality control compartment  protein K48-linked ubiquitination  ubiquitin protein ligase activity involved in ERAD pathway  endoplasmic reticulum mannose trimming  ubiquitin-specific protease binding  
Ontology : EGO-EBIER ubiquitin ligase complex  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  endoplasmic reticulum  endoplasmic reticulum membrane  zinc ion binding  proteasomal protein catabolic process  membrane  integral component of membrane  enzyme binding  integral component of endoplasmic reticulum membrane  ubiquitin-dependent ERAD pathway  ubiquitin conjugating enzyme binding  ERAD pathway  endoplasmic reticulum quality control compartment  protein K48-linked ubiquitination  ubiquitin protein ligase activity involved in ERAD pathway  endoplasmic reticulum mannose trimming  ubiquitin-specific protease binding  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkMARCH6
Atlas of Cancer Signalling NetworkMARCH6
Wikipedia pathwaysMARCH6
Orthology - Evolution
OrthoDB10299
GeneTree (enSembl)ENSG00000145495
Phylogenetic Trees/Animal Genes : TreeFamMARCH6
HOVERGENO60337
HOGENOMO60337
Homologs : HomoloGeneMARCH6
Homology/Alignments : Family Browser (UCSC)MARCH6
Gene fusions - Rearrangements
Fusion : MitelmanMARCH6/IRX4 [5p15.2/5p15.33]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARCH6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARCH6
dbVarMARCH6
ClinVarMARCH6
1000_GenomesMARCH6 
Exome Variant ServerMARCH6
ExAC (Exome Aggregation Consortium)MARCH6 (select the gene name)
Genetic variants : HAPMAP10299
Genomic Variants (DGV)MARCH6 [DGVbeta]
DECIPHERMARCH6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARCH6 
Mutations
ICGC Data PortalMARCH6 
TCGA Data PortalMARCH6 
Broad Tumor PortalMARCH6
OASIS PortalMARCH6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARCH6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMARCH6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MARCH6
DgiDB (Drug Gene Interaction Database)MARCH6
DoCM (Curated mutations)MARCH6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARCH6 (select a term)
intoGenMARCH6
Cancer3DMARCH6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613297   
Orphanet
MedgenMARCH6
Genetic Testing Registry MARCH6
NextProtO60337 [Medical]
TSGene10299
GENETestsMARCH6
Target ValidationMARCH6
Huge Navigator MARCH6 [HugePedia]
snp3D : Map Gene to Disease10299
BioCentury BCIQMARCH6
ClinGenMARCH6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10299
Chemical/Pharm GKB GenePA134869368
Clinical trialMARCH6
Miscellaneous
canSAR (ICR)MARCH6 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMARCH6
EVEXMARCH6
GoPubMedMARCH6
iHOPMARCH6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:17:17 CEST 2017

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