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MARCH8 (membrane associated ring-CH-type finger 8)

Identity

Alias_namesMIR
c-mir, cellular modulator of immune recognition
membrane-associated ring finger (C3HC4) 8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
Alias_symbol (synonym)c-MIR
CMIR
MARCH-VIII
RNF178
Other alias
HGNC (Hugo) MARCH8
LocusID (NCBI) 220972
Atlas_Id 54089
Location 10q11.21  [Link to chromosome band 10q11]
Location_base_pair Starts at 45950033 and ends at 46030842 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MARCH8 (10q11.21) / DEFB119 (20q11.21)MARCH8 (10q11.21) / MSMB (10q11.23)MARCH8 (10q11.21) / PRKG1 (10q11.23)
MARCH8 10q11.21 / DEFB119 20q11.21MARCH8 10q11.21 / MSMB 10q11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Adenocarcinoma
Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)MARCH8   23356
Cards
Entrez_Gene (NCBI)MARCH8  220972  membrane associated ring-CH-type finger 8
AliasesCMIR; MARCH-VIII; MIR; RNF178; 
c-MIR
GeneCards (Weizmann)MARCH8
Ensembl hg19 (Hinxton)ENSG00000165406 [Gene_View]  chr10:45950033-46030842 [Contig_View]  MARCH8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000165406 [Gene_View]  chr10:45950033-46030842 [Contig_View]  MARCH8 [Vega]
ICGC DataPortalENSG00000165406
TCGA cBioPortalMARCH8
AceView (NCBI)MARCH8
Genatlas (Paris)MARCH8
WikiGenes220972
SOURCE (Princeton)MARCH8
Genetics Home Reference (NIH)MARCH8
Genomic and cartography
GoldenPath hg19 (UCSC)MARCH8  -     chr10:45950033-46030842 -  10q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MARCH8  -     10q11.21   [Description]    (hg38-Dec_2013)
EnsemblMARCH8 - 10q11.21 [CytoView hg19]  MARCH8 - 10q11.21 [CytoView hg38]
Mapping of homologs : NCBIMARCH8 [Mapview hg19]  MARCH8 [Mapview hg38]
OMIM613335   
Gene and transcription
Genbank (Entrez)AA418494 AK023636 AK025472 AK057289 AK125414
RefSeq transcript (Entrez)NM_001002265 NM_001002266 NM_001282866 NM_145021
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_003315935 NW_004929371
Consensus coding sequences : CCDS (NCBI)MARCH8
Cluster EST : UnigeneHs.499489 [ NCBI ]
CGAP (NCI)Hs.499489
Alternative Splicing GalleryENSG00000165406
Gene ExpressionMARCH8 [ NCBI-GEO ]   MARCH8 [ EBI - ARRAY_EXPRESS ]   MARCH8 [ SEEK ]   MARCH8 [ MEM ]
Gene Expression Viewer (FireBrowse)MARCH8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)220972
GTEX Portal (Tissue expression)MARCH8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5T0T0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5T0T0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5T0T0
Splice isoforms : SwissVarQ5T0T0
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ5T0T0
Domaine pattern : Prosite (Expaxy)ZF_RING_CH (PS51292)   
Domains : Interpro (EBI)Znf_RING-CH    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)RINGv (PF12906)   
Domain families : Pfam (NCBI)pfam12906   
Domain families : Smart (EMBL)RINGv (SM00744)  
Conserved Domain (NCBI)MARCH8
DMDM Disease mutations220972
Blocks (Seattle)MARCH8
PDB (SRS)2D8S   
PDB (PDBSum)2D8S   
PDB (IMB)2D8S   
PDB (RSDB)2D8S   
Structural Biology KnowledgeBase2D8S   
SCOP (Structural Classification of Proteins)2D8S   
CATH (Classification of proteins structures)2D8S   
SuperfamilyQ5T0T0
Human Protein AtlasENSG00000165406
Peptide AtlasQ5T0T0
HPRD17466
IPIIPI00152297   IPI00552856   IPI00639884   
Protein Interaction databases
DIP (DOE-UCLA)Q5T0T0
IntAct (EBI)Q5T0T0
FunCoupENSG00000165406
BioGRIDMARCH8
STRING (EMBL)MARCH8
ZODIACMARCH8
Ontologies - Pathways
QuickGOQ5T0T0
Ontology : AmiGOprotein polyubiquitination  adaptive immune response  antigen processing and presentation of peptide antigen via MHC class II  ubiquitin-protein transferase activity  lysosome  lysosomal membrane  endosome  zinc ion binding  integral component of membrane  ligase activity  cytoplasmic vesicle membrane  early endosome membrane  MHC class II protein binding  negative regulation of MHC class II biosynthetic process  ubiquitin protein ligase activity  
Ontology : EGO-EBIprotein polyubiquitination  adaptive immune response  antigen processing and presentation of peptide antigen via MHC class II  ubiquitin-protein transferase activity  lysosome  lysosomal membrane  endosome  zinc ion binding  integral component of membrane  ligase activity  cytoplasmic vesicle membrane  early endosome membrane  MHC class II protein binding  negative regulation of MHC class II biosynthetic process  ubiquitin protein ligase activity  
NDEx NetworkMARCH8
Atlas of Cancer Signalling NetworkMARCH8
Wikipedia pathwaysMARCH8
Orthology - Evolution
OrthoDB220972
GeneTree (enSembl)ENSG00000165406
Phylogenetic Trees/Animal Genes : TreeFamMARCH8
HOVERGENQ5T0T0
HOGENOMQ5T0T0
Homologs : HomoloGeneMARCH8
Homology/Alignments : Family Browser (UCSC)MARCH8
Gene fusions - Rearrangements
Fusion : MitelmanMARCH8/DEFB119 [10q11.21/20q11.21]  
Fusion : MitelmanMARCH8/MSMB [10q11.21/10q11.23]  [t(10;10)(q11;q11)]  
Fusion : MitelmanMARCH8/PRKG1 [10q11.21/10q11.23]  [t(10;10)(q11;q11)]  
Fusion: TCGAMARCH8 10q11.21 DEFB119 20q11.21 LGG
Fusion: TCGAMARCH8 10q11.21 MSMB 10q11.23 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARCH8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARCH8
dbVarMARCH8
ClinVarMARCH8
1000_GenomesMARCH8 
Exome Variant ServerMARCH8
ExAC (Exome Aggregation Consortium)MARCH8 (select the gene name)
Genetic variants : HAPMAP220972
Genomic Variants (DGV)MARCH8 [DGVbeta]
DECIPHER (Syndromes)10:45950033-46030842  ENSG00000165406
CONAN: Copy Number AnalysisMARCH8 
Mutations
ICGC Data PortalMARCH8 
TCGA Data PortalMARCH8 
Broad Tumor PortalMARCH8
OASIS PortalMARCH8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARCH8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMARCH8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MARCH8
DgiDB (Drug Gene Interaction Database)MARCH8
DoCM (Curated mutations)MARCH8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARCH8 (select a term)
intoGenMARCH8
Cancer3DMARCH8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613335   
Orphanet
MedgenMARCH8
Genetic Testing Registry MARCH8
NextProtQ5T0T0 [Medical]
TSGene220972
GENETestsMARCH8
Huge Navigator MARCH8 [HugePedia]
snp3D : Map Gene to Disease220972
BioCentury BCIQMARCH8
ClinGenMARCH8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD220972
Chemical/Pharm GKB GenePA134880669
Clinical trialMARCH8
Miscellaneous
canSAR (ICR)MARCH8 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMARCH8
EVEXMARCH8
GoPubMedMARCH8
iHOPMARCH8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:14:33 CET 2017

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