MARCHF1 (membrane associated ring-CH-type finger 1)

2017-04-01  

Identity

HGNC
LOCATION
4q32.2
LOCUSID
ALIAS
MARCH-I,MARCH1,RNF171

Other Information

Locus ID:

NCBI: 55016
MIM: 613331
HGNC: 26077
Ensembl: ENSG00000145416

Variants:

dbSNP: 55016
ClinVar: 55016
TCGA: ENSG00000145416
COSMIC: MARCHF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145416ENST00000274056Q8TCQ1
ENSG00000145416ENST00000339875Q8TCQ1
ENSG00000145416ENST00000503008Q8TCQ1
ENSG00000145416ENST00000507270D6REN1
ENSG00000145416ENST00000510786B7Z739
ENSG00000145416ENST00000514618D6RGC4

References

Pubmed IDYearTitleCitations
183051732008MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.98
183894772008Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
217575422011MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.43
275777452016MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels.17
225089292012Autoregulation of MARCH1 expression by dimerization and autoubiquitination.15
276334802016Silencing MARCH1 suppresses proliferation, migration and invasion of ovarian cancer SKOV3 cells via downregulation of NF-κB and Wnt/β-catenin pathways.11
232647392013Identification of a novel motif that affects the conformation and activity of the MARCH1 E3 ubiquitin ligase.5
306309522019Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection.5
294147872018Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I.4

Citation

Dessen P

MARCHF1 (membrane associated ring-CH-type finger 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56895/marchf1