MARCHF2 (membrane associated ring-CH-type finger 2)

2014-11-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
HSPC240,MARCH-II,MARCH2,RNF172

Other Information

Locus ID:

NCBI: 51257
MIM: 613332
HGNC: 28038
Ensembl: ENSG00000099785

Variants:

dbSNP: 51257
ClinVar: 51257
TCGA: ENSG00000099785
COSMIC: MARCHF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099785ENST00000215555Q9P0N8
ENSG00000099785ENST00000381035Q9P0N8
ENSG00000099785ENST00000595142M0R1P2
ENSG00000099785ENST00000595213M0R0S4
ENSG00000099785ENST00000601283M0QXU4
ENSG00000099785ENST00000601724M0R138
ENSG00000099785ENST00000602117Q9P0N8

References

Pubmed IDYearTitleCitations
156894992005MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.32
231663512012MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.26
238189892013Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6.21
179805542008DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.11
273088912016MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signaling.8
295736642018MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation.7
306309522019Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection.5
311426152019The E3 ubiquitin ligase MARCH2 regulates ERGIC3-dependent trafficking of secretory proteins.1

Citation

Dessen P

MARCHF2 (membrane associated ring-CH-type finger 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68809/marchf2