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MARCHF5 (membrane associated ring-CH-type finger 5)

Identity

Alias (NCBI)MARCH-V
MARCH5
MITOL
RNF153
HGNC (Hugo) MARCHF5
HGNC Alias symbFLJ20445
MARCH-V
MITOL
HGNC Alias namemitochondrial ubiquitin ligase
HGNC Previous nameRNF153
 MARCH5
HGNC Previous namering finger protein 153
 membrane-associated ring finger (C3HC4) 5
LocusID (NCBI) 54708
Atlas_Id 58113
Location 10q23.32  [Link to chromosome band 10q23]
Location_base_pair Starts at 92291167 and ends at 92353964 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)MARCHF5   26025
Cards
Entrez_Gene (NCBI)MARCHF5    membrane associated ring-CH-type finger 5
AliasesMARCH-V; MARCH5; MITOL; RNF153
GeneCards (Weizmann)MARCHF5
Ensembl hg19 (Hinxton)ENSG00000198060 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198060 [Gene_View]  ENSG00000198060 [Sequence]  chr10:92291167-92353964 [Contig_View]  MARCHF5 [Vega]
ICGC DataPortalENSG00000198060
TCGA cBioPortalMARCHF5
AceView (NCBI)MARCHF5
Genatlas (Paris)MARCHF5
SOURCE (Princeton)MARCHF5
Genetics Home Reference (NIH)MARCHF5
Genomic and cartography
GoldenPath hg38 (UCSC)MARCHF5  -     chr10:92291167-92353964 +  10q23.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARCHF5  -     10q23.32   [Description]    (hg19-Feb_2009)
GoldenPathMARCHF5 - 10q23.32 [CytoView hg19]  MARCHF5 - 10q23.32 [CytoView hg38]
ImmunoBaseENSG00000198060
Genome Data Viewer NCBIMARCHF5 [Mapview hg19]  
OMIM610637   
Gene and transcription
Genbank (Entrez)AB191202 AK000452 AK294799 AK309175 BC015480
RefSeq transcript (Entrez)NM_017824
Consensus coding sequences : CCDS (NCBI)MARCHF5
Gene ExpressionMARCHF5 [ NCBI-GEO ]   MARCHF5 [ EBI - ARRAY_EXPRESS ]   MARCHF5 [ SEEK ]   MARCHF5 [ MEM ]
Gene Expression Viewer (FireBrowse)MARCHF5 [ Firebrowse - Broad ]
GenevisibleExpression of MARCHF5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54708
GTEX Portal (Tissue expression)MARCHF5
Human Protein AtlasENSG00000198060-MARCHF5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NX47   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NX47  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NX47
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NX47
Domaine pattern : Prosite (Expaxy)ZF_RING_CH (PS51292)   
Domains : Interpro (EBI)Znf_RING-CH    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)RINGv (PF12906)   
Domain families : Pfam (NCBI)pfam12906   
Domain families : Smart (EMBL)RINGv (SM00744)  
Conserved Domain (NCBI)MARCHF5
SuperfamilyQ9NX47
AlphaFold pdb e-kbQ9NX47   
Human Protein Atlas [tissue]ENSG00000198060-MARCHF5 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9NX47
IntAct (EBI)Q9NX47
BioGRIDMARCHF5
STRING (EMBL)MARCHF5
ZODIACMARCHF5
Ontologies - Pathways
QuickGOQ9NX47
Ontology : AmiGOprotein polyubiquitination  protein binding  mitochondrion  mitochondrial outer membrane  endoplasmic reticulum  endoplasmic reticulum membrane  zinc ion binding  membrane  integral component of membrane  GTPase binding  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  protein localization to mitochondrion  regulation of mitochondrial fission  positive regulation of mitochondrial fission  negative regulation of cell aging  
Ontology : EGO-EBIprotein polyubiquitination  protein binding  mitochondrion  mitochondrial outer membrane  endoplasmic reticulum  endoplasmic reticulum membrane  zinc ion binding  membrane  integral component of membrane  GTPase binding  protein autoubiquitination  ubiquitin protein ligase activity  ubiquitin protein ligase activity  protein localization to mitochondrion  regulation of mitochondrial fission  positive regulation of mitochondrial fission  negative regulation of cell aging  
NDEx NetworkMARCHF5
Atlas of Cancer Signalling NetworkMARCHF5
Wikipedia pathwaysMARCHF5
Orthology - Evolution
OrthoDB54708
GeneTree (enSembl)ENSG00000198060
Phylogenetic Trees/Animal Genes : TreeFamMARCHF5
Homologs : HomoloGeneMARCHF5
Homology/Alignments : Family Browser (UCSC)MARCHF5
Gene fusions - Rearrangements
Fusion : QuiverMARCHF5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARCHF5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARCHF5
dbVarMARCHF5
ClinVarMARCHF5
MonarchMARCHF5
1000_GenomesMARCHF5 
Exome Variant ServerMARCHF5
GNOMAD BrowserENSG00000198060
Varsome BrowserMARCHF5
ACMGMARCHF5 variants
VarityQ9NX47
Genomic Variants (DGV)MARCHF5 [DGVbeta]
DECIPHERMARCHF5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARCHF5 
Mutations
ICGC Data PortalMARCHF5 
TCGA Data PortalMARCHF5 
Broad Tumor PortalMARCHF5
OASIS PortalMARCHF5 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMARCHF5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMARCHF5
DgiDB (Drug Gene Interaction Database)MARCHF5
DoCM (Curated mutations)MARCHF5
CIViC (Clinical Interpretations of Variants in Cancer)MARCHF5
Cancer3DMARCHF5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610637   
Orphanet
DisGeNETMARCHF5
MedgenMARCHF5
Genetic Testing Registry MARCHF5
NextProtQ9NX47 [Medical]
GENETestsMARCHF5
Target ValidationMARCHF5
Huge Navigator MARCHF5 [HugePedia]
ClinGenMARCHF5
Clinical trials, drugs, therapy
MyCancerGenomeMARCHF5
Protein Interactions : CTDMARCHF5
PharosQ9NX47
Clinical trialMARCHF5
Miscellaneous
canSAR (ICR)MARCHF5
HarmonizomeMARCHF5
DataMed IndexMARCHF5
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMARCHF5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:51 CEST 2021

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