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MARCHF6 (membrane associated ring-CH-type finger 6)

Identity

Alias (NCBI)DOA10
FAME3
MARCH-VI
MARCH6
RNF176
TEB4
HGNC (Hugo) MARCHF6
HGNC Alias symbTEB4
MARCH-VI
RNF176
HGNC Previous name7-Mar
HGNC Previous namemembrane-associated ring finger (C3HC4) 6
 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
LocusID (NCBI) 10299
Atlas_Id 54088
Location 5p15.2  [Link to chromosome band 5p15]
Location_base_pair Starts at 10353695 and ends at 10440388 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)MARCHF6   30550
Cards
Entrez_Gene (NCBI)MARCHF6    membrane associated ring-CH-type finger 6
AliasesDOA10; FAME3; MARCH-VI; MARCH6; 
RNF176; TEB4
GeneCards (Weizmann)MARCHF6
Ensembl hg19 (Hinxton)ENSG00000145495 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145495 [Gene_View]  ENSG00000145495 [Sequence]  chr5:10353695-10440388 [Contig_View]  MARCHF6 [Vega]
ICGC DataPortalENSG00000145495
TCGA cBioPortalMARCHF6
AceView (NCBI)MARCHF6
Genatlas (Paris)MARCHF6
SOURCE (Princeton)MARCHF6
Genetics Home Reference (NIH)MARCHF6
Genomic and cartography
GoldenPath hg38 (UCSC)MARCHF6  -     chr5:10353695-10440388 +  5p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARCHF6  -     5p15.2   [Description]    (hg19-Feb_2009)
GoldenPathMARCHF6 - 5p15.2 [CytoView hg19]  MARCHF6 - 5p15.2 [CytoView hg38]
ImmunoBaseENSG00000145495
Genome Data Viewer NCBIMARCHF6 [Mapview hg19]  
OMIM613297   613608   
Gene and transcription
Genbank (Entrez)AB011169 AF009301 AF056433 AK000970 AK056198
RefSeq transcript (Entrez)NM_001270660 NM_001270661 NM_005885
Consensus coding sequences : CCDS (NCBI)MARCHF6
Gene ExpressionMARCHF6 [ NCBI-GEO ]   MARCHF6 [ EBI - ARRAY_EXPRESS ]   MARCHF6 [ SEEK ]   MARCHF6 [ MEM ]
Gene Expression Viewer (FireBrowse)MARCHF6 [ Firebrowse - Broad ]
GenevisibleExpression of MARCHF6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10299
GTEX Portal (Tissue expression)MARCHF6
Human Protein AtlasENSG00000145495-MARCHF6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60337   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60337  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60337
PhosPhoSitePlusO60337
Domaine pattern : Prosite (Expaxy)ZF_RING_CH (PS51292)   
Domains : Interpro (EBI)Znf_RING-CH    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)RINGv (PF12906)   
Domain families : Pfam (NCBI)pfam12906   
Domain families : Smart (EMBL)RINGv (SM00744)  
Conserved Domain (NCBI)MARCHF6
SuperfamilyO60337
AlphaFold pdb e-kbO60337   
Human Protein Atlas [tissue]ENSG00000145495-MARCHF6 [tissue]
HPRD11095
Protein Interaction databases
DIP (DOE-UCLA)O60337
IntAct (EBI)O60337
BioGRIDMARCHF6
STRING (EMBL)MARCHF6
ZODIACMARCHF6
Ontologies - Pathways
QuickGOO60337
Ontology : AmiGOER ubiquitin ligase complex  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  zinc ion binding  proteasomal protein catabolic process  membrane  integral component of membrane  protein ubiquitination  enzyme binding  integral component of endoplasmic reticulum membrane  integral component of endoplasmic reticulum membrane  ubiquitin-dependent ERAD pathway  ubiquitin conjugating enzyme binding  ERAD pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  endoplasmic reticulum quality control compartment  ubiquitin protein ligase activity  ubiquitin protein ligase activity  protein K48-linked ubiquitination  endoplasmic reticulum mannose trimming  ubiquitin-specific protease binding  
Ontology : EGO-EBIER ubiquitin ligase complex  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  zinc ion binding  proteasomal protein catabolic process  membrane  integral component of membrane  protein ubiquitination  enzyme binding  integral component of endoplasmic reticulum membrane  integral component of endoplasmic reticulum membrane  ubiquitin-dependent ERAD pathway  ubiquitin conjugating enzyme binding  ERAD pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  endoplasmic reticulum quality control compartment  ubiquitin protein ligase activity  ubiquitin protein ligase activity  protein K48-linked ubiquitination  endoplasmic reticulum mannose trimming  ubiquitin-specific protease binding  
NDEx NetworkMARCHF6
Atlas of Cancer Signalling NetworkMARCHF6
Wikipedia pathwaysMARCHF6
Orthology - Evolution
OrthoDB10299
GeneTree (enSembl)ENSG00000145495
Phylogenetic Trees/Animal Genes : TreeFamMARCHF6
Homologs : HomoloGeneMARCHF6
Homology/Alignments : Family Browser (UCSC)MARCHF6
Gene fusions - Rearrangements
Fusion : MitelmanMARCH6/IRX4 [5p15.2/5p15.33]  
Fusion : QuiverMARCHF6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARCHF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARCHF6
dbVarMARCHF6
ClinVarMARCHF6
MonarchMARCHF6
1000_GenomesMARCHF6 
Exome Variant ServerMARCHF6
GNOMAD BrowserENSG00000145495
Varsome BrowserMARCHF6
ACMGMARCHF6 variants
VarityO60337
Genomic Variants (DGV)MARCHF6 [DGVbeta]
DECIPHERMARCHF6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARCHF6 
Mutations
ICGC Data PortalMARCHF6 
TCGA Data PortalMARCHF6 
Broad Tumor PortalMARCHF6
OASIS PortalMARCHF6 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMARCHF6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMARCHF6
DgiDB (Drug Gene Interaction Database)MARCHF6
DoCM (Curated mutations)MARCHF6
CIViC (Clinical Interpretations of Variants in Cancer)MARCHF6
Cancer3DMARCHF6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613297    613608   
Orphanet
DisGeNETMARCHF6
MedgenMARCHF6
Genetic Testing Registry MARCHF6
NextProtO60337 [Medical]
GENETestsMARCHF6
Target ValidationMARCHF6
Huge Navigator MARCHF6 [HugePedia]
ClinGenMARCHF6
Clinical trials, drugs, therapy
MyCancerGenomeMARCHF6
Protein Interactions : CTDMARCHF6
PharosO60337
Clinical trialMARCHF6
Miscellaneous
canSAR (ICR)MARCHF6
HarmonizomeMARCHF6
DataMed IndexMARCHF6
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMARCHF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:51 CEST 2021

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