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MARCHF8 (membrane associated ring-CH-type finger 8)

Identity

Alias (NCBI)CMIR
MARCH-VIII
MARCH8
MIR
RNF178
c-MIR
HGNC (Hugo) MARCHF8
HGNC Alias symbc-MIR
CMIR
MARCH-VIII
RNF178
HGNC Previous nameMIR
 MARCH8
HGNC Previous namec-mir, cellular modulator of immune recognition
 membrane-associated ring finger (C3HC4) 8
 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
LocusID (NCBI) 220972
Atlas_Id 58101
Location 10q11.21  [Link to chromosome band 10q11]
Location_base_pair Starts at 45454585 and ends at 45594906 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)MARCHF8   23356
Cards
Entrez_Gene (NCBI)MARCHF8    membrane associated ring-CH-type finger 8
AliasesCMIR; MARCH-VIII; MARCH8; MIR; 
RNF178; c-MIR
GeneCards (Weizmann)MARCHF8
Ensembl hg19 (Hinxton)ENSG00000165406 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165406 [Gene_View]  ENSG00000165406 [Sequence]  chr10:45454585-45594906 [Contig_View]  MARCHF8 [Vega]
ICGC DataPortalENSG00000165406
TCGA cBioPortalMARCHF8
AceView (NCBI)MARCHF8
Genatlas (Paris)MARCHF8
SOURCE (Princeton)MARCHF8
Genetics Home Reference (NIH)MARCHF8
Genomic and cartography
GoldenPath hg38 (UCSC)MARCHF8  -     chr10:45454585-45594906 -  10q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARCHF8  -     10q11.21   [Description]    (hg19-Feb_2009)
GoldenPathMARCHF8 - 10q11.21 [CytoView hg19]  MARCHF8 - 10q11.21 [CytoView hg38]
ImmunoBaseENSG00000165406
Genome Data Viewer NCBIMARCHF8 [Mapview hg19]  
OMIM613335   
Gene and transcription
Genbank (Entrez)AA418494 AK023636 AK025472 AK057289 AK125414
RefSeq transcript (Entrez)NM_001002265 NM_001002266 NM_001282866 NM_145021
Consensus coding sequences : CCDS (NCBI)MARCHF8
Gene ExpressionMARCHF8 [ NCBI-GEO ]   MARCHF8 [ EBI - ARRAY_EXPRESS ]   MARCHF8 [ SEEK ]   MARCHF8 [ MEM ]
Gene Expression Viewer (FireBrowse)MARCHF8 [ Firebrowse - Broad ]
GenevisibleExpression of MARCHF8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)220972
GTEX Portal (Tissue expression)MARCHF8
Human Protein AtlasENSG00000165406-MARCHF8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5T0T0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5T0T0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5T0T0
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ5T0T0
Domaine pattern : Prosite (Expaxy)ZF_RING_CH (PS51292)   
Domains : Interpro (EBI)Znf_RING-CH    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)RINGv (PF12906)   
Domain families : Pfam (NCBI)pfam12906   
Domain families : Smart (EMBL)RINGv (SM00744)  
Conserved Domain (NCBI)MARCHF8
PDB (RSDB)2D8S   
PDB Europe2D8S   
PDB (PDBSum)2D8S   
PDB (IMB)2D8S   
Structural Biology KnowledgeBase2D8S   
SCOP (Structural Classification of Proteins)2D8S   
CATH (Classification of proteins structures)2D8S   
SuperfamilyQ5T0T0
AlphaFold pdb e-kbQ5T0T0   
Human Protein Atlas [tissue]ENSG00000165406-MARCHF8 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q5T0T0
IntAct (EBI)Q5T0T0
BioGRIDMARCHF8
STRING (EMBL)MARCHF8
ZODIACMARCHF8
Ontologies - Pathways
QuickGOQ5T0T0
Ontology : AmiGOprotein polyubiquitination  protein polyubiquitination  adaptive immune response  antigen processing and presentation of peptide antigen via MHC class II  ubiquitin-protein transferase activity  protein binding  cytoplasm  lysosome  lysosome  lysosomal membrane  endosome  immune response  zinc ion binding  integral component of membrane  cytoplasmic vesicle membrane  early endosome membrane  late endosome membrane  MHC protein binding  ubiquitin protein ligase activity  
Ontology : EGO-EBIprotein polyubiquitination  protein polyubiquitination  adaptive immune response  antigen processing and presentation of peptide antigen via MHC class II  ubiquitin-protein transferase activity  protein binding  cytoplasm  lysosome  lysosome  lysosomal membrane  endosome  immune response  zinc ion binding  integral component of membrane  cytoplasmic vesicle membrane  early endosome membrane  late endosome membrane  MHC protein binding  ubiquitin protein ligase activity  
NDEx NetworkMARCHF8
Atlas of Cancer Signalling NetworkMARCHF8
Wikipedia pathwaysMARCHF8
Orthology - Evolution
OrthoDB220972
GeneTree (enSembl)ENSG00000165406
Phylogenetic Trees/Animal Genes : TreeFamMARCHF8
Homologs : HomoloGeneMARCHF8
Homology/Alignments : Family Browser (UCSC)MARCHF8
Gene fusions - Rearrangements
Fusion : QuiverMARCHF8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARCHF8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARCHF8
dbVarMARCHF8
ClinVarMARCHF8
MonarchMARCHF8
1000_GenomesMARCHF8 
Exome Variant ServerMARCHF8
GNOMAD BrowserENSG00000165406
Varsome BrowserMARCHF8
ACMGMARCHF8 variants
VarityQ5T0T0
Genomic Variants (DGV)MARCHF8 [DGVbeta]
DECIPHERMARCHF8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARCHF8 
Mutations
ICGC Data PortalMARCHF8 
TCGA Data PortalMARCHF8 
Broad Tumor PortalMARCHF8
OASIS PortalMARCHF8 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMARCHF8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMARCHF8
DgiDB (Drug Gene Interaction Database)MARCHF8
DoCM (Curated mutations)MARCHF8
CIViC (Clinical Interpretations of Variants in Cancer)MARCHF8
Cancer3DMARCHF8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613335   
Orphanet
DisGeNETMARCHF8
MedgenMARCHF8
Genetic Testing Registry MARCHF8
NextProtQ5T0T0 [Medical]
GENETestsMARCHF8
Target ValidationMARCHF8
Huge Navigator MARCHF8 [HugePedia]
ClinGenMARCHF8
Clinical trials, drugs, therapy
MyCancerGenomeMARCHF8
Protein Interactions : CTDMARCHF8
PharosQ5T0T0
Clinical trialMARCHF8
Miscellaneous
canSAR (ICR)MARCHF8
HarmonizomeMARCHF8
DataMed IndexMARCHF8
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMARCHF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:51 CEST 2021

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