MARK1 (microtubule affinity regulating kinase 1)

2018-11-01  

Identity

HGNC
MARK1
LOCATION
1q41
LOCUSID
4139
ALIAS
MARK,Par-1c,Par1c
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4139
MIM: 606511
HGNC: 6896
Ensembl: ENSG00000116141

Variants:

dbSNP: 4139
ClinVar: 4139
TCGA: ENSG00000116141
COSMIC: MARK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116141ENST00000366917Q9P0L2
ENSG00000116141ENST00000366918Q9P0L2
ENSG00000116141ENST00000402574B4DIB3
ENSG00000116141ENST00000611084A0A087X0I6

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
243626292014A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.113
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
201583042010A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.52
184927992008Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism.26
184927992008Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism.26
168038892006Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.19
190909972008Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein.12
290764402018MARK1 is a Novel Target for miR-125a-5p: Implications for Cell Migration in Cervical Tumor Cells.10
242431022014Mark/Par-1 marking the polarity of migrating neurons.8
278793742017Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase.7

Citation

Dessen P

MARK1 (microtubule affinity regulating kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57662/mark1