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MARK1 (microtubule affinity regulating kinase 1)

Identity

Alias_namesMAP/microtubule affinity-regulating kinase 1
Alias_symbol (synonym)MARK
PAR-1C
Other aliasPar-1c
Par1c
HGNC (Hugo) MARK1
LocusID (NCBI) 4139
Atlas_Id 68815
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at 220528183 and ends at 220664457 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MARK1 (1q41) / PFKP (10p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MARK1   6896
Cards
Entrez_Gene (NCBI)MARK1  4139  microtubule affinity regulating kinase 1
AliasesMARK; Par-1c; Par1c
GeneCards (Weizmann)MARK1
Ensembl hg19 (Hinxton)ENSG00000116141 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116141 [Gene_View]  chr1:220528183-220664457 [Contig_View]  MARK1 [Vega]
ICGC DataPortalENSG00000116141
TCGA cBioPortalMARK1
AceView (NCBI)MARK1
Genatlas (Paris)MARK1
WikiGenes4139
SOURCE (Princeton)MARK1
Genetics Home Reference (NIH)MARK1
Genomic and cartography
GoldenPath hg38 (UCSC)MARK1  -     chr1:220528183-220664457 +  1q41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARK1  -     1q41   [Description]    (hg19-Feb_2009)
EnsemblMARK1 - 1q41 [CytoView hg19]  MARK1 - 1q41 [CytoView hg38]
Mapping of homologs : NCBIMARK1 [Mapview hg19]  MARK1 [Mapview hg38]
OMIM606511   
Gene and transcription
Genbank (Entrez)AB040910 AF154845 AK027493 AK098103 AK295506
RefSeq transcript (Entrez)NM_001286124 NM_001286126 NM_001286128 NM_001286129 NM_018650
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MARK1
Cluster EST : UnigeneHs.497806 [ NCBI ]
CGAP (NCI)Hs.497806
Alternative Splicing GalleryENSG00000116141
Gene ExpressionMARK1 [ NCBI-GEO ]   MARK1 [ EBI - ARRAY_EXPRESS ]   MARK1 [ SEEK ]   MARK1 [ MEM ]
Gene Expression Viewer (FireBrowse)MARK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4139
GTEX Portal (Tissue expression)MARK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P0L2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P0L2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P0L2
Splice isoforms : SwissVarQ9P0L2
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9P0L2
Domaine pattern : Prosite (Expaxy)KA1 (PS50032)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UBA (PS50030)   
Domains : Interpro (EBI)KA1/Ssp2_C    KA1_dom    Kinase-like_dom    MARK/par1    MARK1    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    UBA   
Domain families : Pfam (Sanger)KA1 (PF02149)    Pkinase (PF00069)    UBA (PF00627)   
Domain families : Pfam (NCBI)pfam02149    pfam00069    pfam00627   
Domain families : Smart (EMBL)S_TKc (SM00220)  UBA (SM00165)  
Conserved Domain (NCBI)MARK1
DMDM Disease mutations4139
Blocks (Seattle)MARK1
PDB (SRS)2HAK    3OSE   
PDB (PDBSum)2HAK    3OSE   
PDB (IMB)2HAK    3OSE   
PDB (RSDB)2HAK    3OSE   
Structural Biology KnowledgeBase2HAK    3OSE   
SCOP (Structural Classification of Proteins)2HAK    3OSE   
CATH (Classification of proteins structures)2HAK    3OSE   
SuperfamilyQ9P0L2
Human Protein AtlasENSG00000116141
Peptide AtlasQ9P0L2
HPRD07353
IPIIPI00185037   IPI00555711   IPI00292809   
Protein Interaction databases
DIP (DOE-UCLA)Q9P0L2
IntAct (EBI)Q9P0L2
FunCoupENSG00000116141
BioGRIDMARK1
STRING (EMBL)MARK1
ZODIACMARK1
Ontologies - Pathways
QuickGOQ9P0L2
Ontology : AmiGOmicrotubule cytoskeleton organization  magnesium ion binding  neuron migration  phosphatidylserine binding  protein serine/threonine kinase activity  ATP binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  cytoskeleton  plasma membrane  protein phosphorylation  cytoskeleton organization  microtubule cytoskeleton  Wnt signaling pathway  establishment of cell polarity  intracellular signal transduction  tau-protein kinase activity  phosphatidic acid binding  
Ontology : EGO-EBImicrotubule cytoskeleton organization  magnesium ion binding  neuron migration  phosphatidylserine binding  protein serine/threonine kinase activity  ATP binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  cytoskeleton  plasma membrane  protein phosphorylation  cytoskeleton organization  microtubule cytoskeleton  Wnt signaling pathway  establishment of cell polarity  intracellular signal transduction  tau-protein kinase activity  phosphatidic acid binding  
NDEx NetworkMARK1
Atlas of Cancer Signalling NetworkMARK1
Wikipedia pathwaysMARK1
Orthology - Evolution
OrthoDB4139
GeneTree (enSembl)ENSG00000116141
Phylogenetic Trees/Animal Genes : TreeFamMARK1
HOVERGENQ9P0L2
HOGENOMQ9P0L2
Homologs : HomoloGeneMARK1
Homology/Alignments : Family Browser (UCSC)MARK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARK1
dbVarMARK1
ClinVarMARK1
1000_GenomesMARK1 
Exome Variant ServerMARK1
ExAC (Exome Aggregation Consortium)MARK1 (select the gene name)
Genetic variants : HAPMAP4139
Genomic Variants (DGV)MARK1 [DGVbeta]
DECIPHERMARK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARK1 
Mutations
ICGC Data PortalMARK1 
TCGA Data PortalMARK1 
Broad Tumor PortalMARK1
OASIS PortalMARK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMARK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MARK1
DgiDB (Drug Gene Interaction Database)MARK1
DoCM (Curated mutations)MARK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARK1 (select a term)
intoGenMARK1
Cancer3DMARK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606511   
Orphanet
MedgenMARK1
Genetic Testing Registry MARK1
NextProtQ9P0L2 [Medical]
TSGene4139
GENETestsMARK1
Target ValidationMARK1
Huge Navigator MARK1 [HugePedia]
snp3D : Map Gene to Disease4139
BioCentury BCIQMARK1
ClinGenMARK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4139
Chemical/Pharm GKB GenePA30639
Clinical trialMARK1
Miscellaneous
canSAR (ICR)MARK1 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMARK1
EVEXMARK1
GoPubMedMARK1
iHOPMARK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:26:58 CEST 2017

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