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MARK2 (microtubule affinity regulating kinase 2)

Identity

Alias_namesEMK1
ELKL motif kinase
MAP/microtubule affinity-regulating kinase 2
Alias_symbol (synonym)PAR-1
Par1b
PAR-1B
Other aliasEMK-1
Par-1b
HGNC (Hugo) MARK2
LocusID (NCBI) 2011
Atlas_Id 41300
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 63888515 and ends at 63911020 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MARK2 (11q13.1) / ALDOC (17q11.2)MARK2 (11q13.1) / BPIFA2 (20q11.21)MARK2 (11q13.1) / DLAT (11q23.1)
MARK2 (11q13.1) / FAM168A (11q13.4)MARK2 (11q13.1) / MARK2 (11q13.1)cytochrome_b () / MARK2 (11q13.1)
MARK2 11q13.1 / BPIFA2 20q11.21MARK2 11q13.1 / DLAT 11q23.1MARK2 11q13.1 / FAM168A 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  MARK2/FAM168A (11q13)
t(11;11)(q13;q23) MARK2/DLAT
t(11;20)(q13;q11) MARK2/BPIFA2


External links

Nomenclature
HGNC (Hugo)MARK2   3332
Cards
Entrez_Gene (NCBI)MARK2  2011  microtubule affinity regulating kinase 2
AliasesEMK-1; EMK1; PAR-1; Par-1b; 
Par1b
GeneCards (Weizmann)MARK2
Ensembl hg19 (Hinxton)ENSG00000072518 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072518 [Gene_View]  ENSG00000072518 [Sequence]  chr11:63888515-63911020 [Contig_View]  MARK2 [Vega]
ICGC DataPortalENSG00000072518
TCGA cBioPortalMARK2
AceView (NCBI)MARK2
Genatlas (Paris)MARK2
WikiGenes2011
SOURCE (Princeton)MARK2
Genetics Home Reference (NIH)MARK2
Genomic and cartography
GoldenPath hg38 (UCSC)MARK2  -     chr11:63888515-63911020 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARK2  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblMARK2 - 11q13.1 [CytoView hg19]  MARK2 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIMARK2 [Mapview hg19]  MARK2 [Mapview hg38]
OMIM600526   
Gene and transcription
Genbank (Entrez)AB188493 AB271694 AF387638 AI524222 AK225766
RefSeq transcript (Entrez)NM_001039469 NM_001163296 NM_001163297 NM_004954 NM_017490
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MARK2
Cluster EST : UnigeneHs.567261 [ NCBI ]
CGAP (NCI)Hs.567261
Alternative Splicing GalleryENSG00000072518
Gene ExpressionMARK2 [ NCBI-GEO ]   MARK2 [ EBI - ARRAY_EXPRESS ]   MARK2 [ SEEK ]   MARK2 [ MEM ]
Gene Expression Viewer (FireBrowse)MARK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2011
GTEX Portal (Tissue expression)MARK2
Human Protein AtlasENSG00000072518-MARK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7KZI7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7KZI7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7KZI7
Splice isoforms : SwissVarQ7KZI7
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ7KZI7
Domaine pattern : Prosite (Expaxy)KA1 (PS50032)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UBA (PS50030)   
Domains : Interpro (EBI)KA1/Ssp2_C    KA1_dom    Kinase-like_dom_sf    MARK/par1    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    UBA   
Domain families : Pfam (Sanger)KA1 (PF02149)    Pkinase (PF00069)    UBA (PF00627)   
Domain families : Pfam (NCBI)pfam02149    pfam00069    pfam00627   
Domain families : Smart (EMBL)S_TKc (SM00220)  UBA (SM00165)  
Conserved Domain (NCBI)MARK2
DMDM Disease mutations2011
Blocks (Seattle)MARK2
PDB (RSDB)3IEC    5EAK    5KZ7    5KZ8   
PDB Europe3IEC    5EAK    5KZ7    5KZ8   
PDB (PDBSum)3IEC    5EAK    5KZ7    5KZ8   
PDB (IMB)3IEC    5EAK    5KZ7    5KZ8   
Structural Biology KnowledgeBase3IEC    5EAK    5KZ7    5KZ8   
SCOP (Structural Classification of Proteins)3IEC    5EAK    5KZ7    5KZ8   
CATH (Classification of proteins structures)3IEC    5EAK    5KZ7    5KZ8   
SuperfamilyQ7KZI7
Human Protein Atlas [tissue]ENSG00000072518-MARK2 [tissue]
Peptide AtlasQ7KZI7
HPRD02753
IPIIPI00555838   IPI00555760   IPI00556468   IPI00555696   IPI00939910   IPI00877119   IPI00556593   IPI00718858   IPI00556171   IPI00556650   IPI00335766   IPI00290158   IPI00556187   IPI00556620   IPI01012573   IPI00902451   IPI00967656   IPI00719748   IPI01009849   IPI00719075   IPI00943799   IPI01013568   IPI01011537   
Protein Interaction databases
DIP (DOE-UCLA)Q7KZI7
IntAct (EBI)Q7KZI7
FunCoupENSG00000072518
BioGRIDMARK2
STRING (EMBL)MARK2
ZODIACMARK2
Ontologies - Pathways
QuickGOQ7KZI7
Ontology : AmiGOmicrotubule cytoskeleton organization  magnesium ion binding  autophagy of mitochondrion  neuron migration  RNA binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytoplasm  mitochondrion  actin filament  plasma membrane  protein phosphorylation  protein phosphorylation  protein phosphorylation  lipid binding  positive regulation of neuron projection development  membrane  Wnt signaling pathway  lateral plasma membrane  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  establishment of cell polarity  establishment of cell polarity  protein kinase activator activity  dendrite  activation of protein kinase activity  intracellular signal transduction  intracellular signal transduction  establishment or maintenance of epithelial cell apical/basal polarity  cadherin binding  protein autophosphorylation  tau protein binding  tau protein binding  tau-protein kinase activity  tau-protein kinase activity  tau-protein kinase activity  tau-protein kinase activity  regulation of axonogenesis  regulation of cytoskeleton organization  mitochondrion localization  axon development  regulation of microtubule cytoskeleton organization  establishment or maintenance of cell polarity regulating cell shape  microtubule bundle  regulation of microtubule binding  
Ontology : EGO-EBImicrotubule cytoskeleton organization  magnesium ion binding  autophagy of mitochondrion  neuron migration  RNA binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytoplasm  mitochondrion  actin filament  plasma membrane  protein phosphorylation  protein phosphorylation  protein phosphorylation  lipid binding  positive regulation of neuron projection development  membrane  Wnt signaling pathway  lateral plasma membrane  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  establishment of cell polarity  establishment of cell polarity  protein kinase activator activity  dendrite  activation of protein kinase activity  intracellular signal transduction  intracellular signal transduction  establishment or maintenance of epithelial cell apical/basal polarity  cadherin binding  protein autophosphorylation  tau protein binding  tau protein binding  tau-protein kinase activity  tau-protein kinase activity  tau-protein kinase activity  tau-protein kinase activity  regulation of axonogenesis  regulation of cytoskeleton organization  mitochondrion localization  axon development  regulation of microtubule cytoskeleton organization  establishment or maintenance of cell polarity regulating cell shape  microtubule bundle  regulation of microtubule binding  
NDEx NetworkMARK2
Atlas of Cancer Signalling NetworkMARK2
Wikipedia pathwaysMARK2
Orthology - Evolution
OrthoDB2011
GeneTree (enSembl)ENSG00000072518
Phylogenetic Trees/Animal Genes : TreeFamMARK2
HOGENOMQ7KZI7
Homologs : HomoloGeneMARK2
Homology/Alignments : Family Browser (UCSC)MARK2
Gene fusions - Rearrangements
Fusion : MitelmanMARK2/BPIFA2 [11q13.1/20q11.21]  
Fusion : MitelmanMARK2/DLAT [11q13.1/11q23.1]  [t(11;11)(q13;q23)]  
Fusion : MitelmanMARK2/FAM168A [11q13.1/11q13.4]  [t(11;11)(q13;q13)]  
Fusion PortalMARK2 11q13.1 BPIFA2 20q11.21 HNSC
Fusion PortalMARK2 11q13.1 DLAT 11q23.1 LUAD
Fusion PortalMARK2 11q13.1 FAM168A 11q13.4 BRCA
Fusion Cancer (Beijing)cytochrome_b [MARK2]  -  11q13.1 [FUSC004329]
Fusion : QuiverMARK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARK2
dbVarMARK2
ClinVarMARK2
1000_GenomesMARK2 
Exome Variant ServerMARK2
ExAC (Exome Aggregation Consortium)ENSG00000072518
GNOMAD BrowserENSG00000072518
Varsome BrowserMARK2
Genetic variants : HAPMAP2011
Genomic Variants (DGV)MARK2 [DGVbeta]
DECIPHERMARK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARK2 
Mutations
ICGC Data PortalMARK2 
TCGA Data PortalMARK2 
Broad Tumor PortalMARK2
OASIS PortalMARK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMARK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MARK2
DgiDB (Drug Gene Interaction Database)MARK2
DoCM (Curated mutations)MARK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARK2 (select a term)
intoGenMARK2
Cancer3DMARK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600526   
Orphanet
DisGeNETMARK2
MedgenMARK2
Genetic Testing Registry MARK2
NextProtQ7KZI7 [Medical]
TSGene2011
GENETestsMARK2
Target ValidationMARK2
Huge Navigator MARK2 [HugePedia]
snp3D : Map Gene to Disease2011
BioCentury BCIQMARK2
ClinGenMARK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2011
Chemical/Pharm GKB GenePA35047
Clinical trialMARK2
Miscellaneous
canSAR (ICR)MARK2 (select the gene name)
DataMed IndexMARK2
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMARK2
EVEXMARK2
GoPubMedMARK2
iHOPMARK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:22:23 CET 2019

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