Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MARK2 (microtubule affinity regulating kinase 2)

Identity

Alias (NCBI)EMK-1
EMK1
PAR-1
Par-1b
Par1b
HGNC (Hugo) MARK2
HGNC Alias symbPAR-1
Par1b
PAR-1B
HGNC Alias nameELKL motif kinase 1
 serine/threonine kinase
 protein-serine/threonine kinase
 Ser/Thr protein kinase PAR-1B
HGNC Previous nameEMK1
HGNC Previous nameELKL motif kinase
 MAP/microtubule affinity-regulating kinase 2
LocusID (NCBI) 2011
Atlas_Id 41300
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 63888537 and ends at 63911020 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MARK2 (11q13.1) / ALDOC (17q11.2)MARK2 (11q13.1) / BPIFA2 (20q11.21)MARK2 (11q13.1) / DLAT (11q23.1)
MARK2 (11q13.1) / FAM168A (11q13.4)MARK2 (11q13.1) / MARK2 (11q13.1)cytochrome_b () / MARK2 (11q13.1)
MARK2 11q13.1 / BPIFA2 20q11.21MARK2 11q13.1 / DLAT 11q23.1MARK2 11q13.1 / FAM168A 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)MARK2   3332
Cards
Entrez_Gene (NCBI)MARK2    microtubule affinity regulating kinase 2
AliasesEMK-1; EMK1; PAR-1; Par-1b; 
Par1b
GeneCards (Weizmann)MARK2
Ensembl hg19 (Hinxton)ENSG00000072518 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072518 [Gene_View]  ENSG00000072518 [Sequence]  chr11:63888537-63911020 [Contig_View]  MARK2 [Vega]
ICGC DataPortalENSG00000072518
TCGA cBioPortalMARK2
AceView (NCBI)MARK2
Genatlas (Paris)MARK2
SOURCE (Princeton)MARK2
Genetics Home Reference (NIH)MARK2
Genomic and cartography
GoldenPath hg38 (UCSC)MARK2  -     chr11:63888537-63911020 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARK2  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathMARK2 - 11q13.1 [CytoView hg19]  MARK2 - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000072518
genome Data Viewer NCBIMARK2 [Mapview hg19]  
OMIM600526   
Gene and transcription
Genbank (Entrez)AB188493 AB271694 AF387638 AI524222 AK225766
RefSeq transcript (Entrez)NM_001039469 NM_001163296 NM_001163297 NM_004954 NM_017490
Consensus coding sequences : CCDS (NCBI)MARK2
Alternative Splicing GalleryENSG00000072518
Gene ExpressionMARK2 [ NCBI-GEO ]   MARK2 [ EBI - ARRAY_EXPRESS ]   MARK2 [ SEEK ]   MARK2 [ MEM ]
Gene Expression Viewer (FireBrowse)MARK2 [ Firebrowse - Broad ]
GenevisibleExpression of MARK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2011
GTEX Portal (Tissue expression)MARK2
Human Protein AtlasENSG00000072518-MARK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7KZI7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7KZI7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7KZI7
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ7KZI7
Domaine pattern : Prosite (Expaxy)KA1 (PS50032)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UBA (PS50030)   
Domains : Interpro (EBI)KA1/Ssp2_C    KA1_dom    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    UBA   
Domain families : Pfam (Sanger)KA1 (PF02149)    Pkinase (PF00069)    UBA (PF00627)   
Domain families : Pfam (NCBI)pfam02149    pfam00069    pfam00627   
Domain families : Smart (EMBL)S_TKc (SM00220)  UBA (SM00165)  
Conserved Domain (NCBI)MARK2
PDB (RSDB)3IEC    5EAK    5KZ7    5KZ8   
PDB Europe3IEC    5EAK    5KZ7    5KZ8   
PDB (PDBSum)3IEC    5EAK    5KZ7    5KZ8   
PDB (IMB)3IEC    5EAK    5KZ7    5KZ8   
Structural Biology KnowledgeBase3IEC    5EAK    5KZ7    5KZ8   
SCOP (Structural Classification of Proteins)3IEC    5EAK    5KZ7    5KZ8   
CATH (Classification of proteins structures)3IEC    5EAK    5KZ7    5KZ8   
SuperfamilyQ7KZI7
AlphaFold pdb e-kbQ7KZI7   
Human Protein Atlas [tissue]ENSG00000072518-MARK2 [tissue]
HPRD02753
Protein Interaction databases
DIP (DOE-UCLA)Q7KZI7
IntAct (EBI)Q7KZI7
BioGRIDMARK2
STRING (EMBL)MARK2
ZODIACMARK2
Ontologies - Pathways
QuickGOQ7KZI7
Ontology : AmiGOmicrotubule cytoskeleton organization  magnesium ion binding  autophagy of mitochondrion  neuron migration  RNA binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytoplasm  mitochondrion  actin filament  plasma membrane  protein phosphorylation  protein phosphorylation  protein phosphorylation  lipid binding  positive regulation of neuron projection development  membrane  Wnt signaling pathway  lateral plasma membrane  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  establishment of cell polarity  establishment of cell polarity  protein kinase activator activity  dendrite  activation of protein kinase activity  intracellular signal transduction  intracellular signal transduction  establishment or maintenance of epithelial cell apical/basal polarity  cadherin binding  protein autophosphorylation  tau protein binding  tau protein binding  tau-protein kinase activity  tau-protein kinase activity  tau-protein kinase activity  tau-protein kinase activity  regulation of axonogenesis  regulation of cytoskeleton organization  mitochondrion localization  axon development  regulation of microtubule cytoskeleton organization  establishment or maintenance of cell polarity regulating cell shape  microtubule bundle  protein serine kinase activity  protein threonine kinase activity  regulation of microtubule binding  
Ontology : EGO-EBImicrotubule cytoskeleton organization  magnesium ion binding  autophagy of mitochondrion  neuron migration  RNA binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytoplasm  mitochondrion  actin filament  plasma membrane  protein phosphorylation  protein phosphorylation  protein phosphorylation  lipid binding  positive regulation of neuron projection development  membrane  Wnt signaling pathway  lateral plasma membrane  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  establishment of cell polarity  establishment of cell polarity  protein kinase activator activity  dendrite  activation of protein kinase activity  intracellular signal transduction  intracellular signal transduction  establishment or maintenance of epithelial cell apical/basal polarity  cadherin binding  protein autophosphorylation  tau protein binding  tau protein binding  tau-protein kinase activity  tau-protein kinase activity  tau-protein kinase activity  tau-protein kinase activity  regulation of axonogenesis  regulation of cytoskeleton organization  mitochondrion localization  axon development  regulation of microtubule cytoskeleton organization  establishment or maintenance of cell polarity regulating cell shape  microtubule bundle  protein serine kinase activity  protein threonine kinase activity  regulation of microtubule binding  
NDEx NetworkMARK2
Atlas of Cancer Signalling NetworkMARK2
Wikipedia pathwaysMARK2
Orthology - Evolution
OrthoDB2011
GeneTree (enSembl)ENSG00000072518
Phylogenetic Trees/Animal Genes : TreeFamMARK2
Homologs : HomoloGeneMARK2
Homology/Alignments : Family Browser (UCSC)MARK2
Gene fusions - Rearrangements
Fusion : MitelmanMARK2/BPIFA2 [11q13.1/20q11.21]  
Fusion : MitelmanMARK2/DLAT [11q13.1/11q23.1]  
Fusion : MitelmanMARK2/FAM168A [11q13.1/11q13.4]  
Fusion PortalMARK2 11q13.1 BPIFA2 20q11.21 HNSC
Fusion PortalMARK2 11q13.1 DLAT 11q23.1 LUAD
Fusion PortalMARK2 11q13.1 FAM168A 11q13.4 BRCA
Fusion Cancer (Beijing)cytochrome_b [MARK2]  -  11q13.1 [FUSC004329]
Fusion : QuiverMARK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARK2
dbVarMARK2
ClinVarMARK2
MonarchMARK2
1000_GenomesMARK2 
Exome Variant ServerMARK2
GNOMAD BrowserENSG00000072518
Varsome BrowserMARK2
Genomic Variants (DGV)MARK2 [DGVbeta]
DECIPHERMARK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARK2 
Mutations
ICGC Data PortalMARK2 
TCGA Data PortalMARK2 
Broad Tumor PortalMARK2
OASIS PortalMARK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMARK2
Mutations and Diseases : HGMDMARK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch MARK2
DgiDB (Drug Gene Interaction Database)MARK2
DoCM (Curated mutations)MARK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARK2 (select a term)
Cancer3DMARK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600526   
Orphanet
DisGeNETMARK2
MedgenMARK2
Genetic Testing Registry MARK2
NextProtQ7KZI7 [Medical]
GENETestsMARK2
Target ValidationMARK2
Huge Navigator MARK2 [HugePedia]
ClinGenMARK2
Clinical trials, drugs, therapy
MyCancerGenomeMARK2
Protein Interactions : CTDMARK2
Pharm GKB GenePA35047
PharosQ7KZI7
Clinical trialMARK2
Miscellaneous
canSAR (ICR)MARK2
HarmonizomeMARK2
DataMed IndexMARK2
Probes
Litterature
PubMed134 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMARK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Sep 15 22:22:52 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.