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MARK3 (microtubule affinity regulating kinase 3)

Identity

Alias_namesMAP/microtubule affinity-regulating kinase 3
Alias_symbol (synonym)CTAK1
KP78
PAR-1A
Other aliasPAR1A
Par-1a
VIPB
HGNC (Hugo) MARK3
LocusID (NCBI) 4140
Atlas_Id 43352
Location 14q32.32  [Link to chromosome band 14q32]
Location_base_pair Starts at 103385364 and ends at 103503829 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APOPT1 (14q32.33) / MARK3 (14q32.32)CAT (11p13) / MARK3 (14q32.32)IKBKAP (9q31.3) / MARK3 (14q32.32)
LOC253039 () / MARK3 (14q32.32)MARK3 (14q32.32) / BAG5 (14q32.33)MARK3 (14q32.32) / CAT (11p13)
MARK3 (14q32.32) / CBFA2T2 (20q11.21)MARK3 (14q32.32) / ENTPD5 (14q24.3)MARK3 (14q32.32) / FBLN5 (14q32.12)
MARK3 (14q32.32) / MARK3 (14q32.32)MARK3 (14q32.32) / MTMR9 (8p23.1)MARK3 (14q32.32) / RP11-407N17.3 ()
MARK3 (14q32.32) / SLC25A21 (14q13.3)MARK3 (14q32.32) / WARS (14q32.2)RP11-73M18.2 () / MARK3 (14q32.32)
SMARCB1 (22q11.23) / MARK3 (14q32.32)MARK3 14q32.32 / BAG5 14q32.33MARK3 14q32.32 / ENTPD5 14q24.3
MARK3 14q32.32 / FBLN5 14q32.12MARK3 14q32.32 RP11-407N17.3MARK3 14q32.32 / SLC25A21 14q13.3
RP11-73M18.2 MARK3 14q32.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]

Solid Tumors TT_t1414q13q32ID101743 TT_t1414q24q32ID101820 TT_t1414q32q32ID101839 TT_t1414q32q32ID101840 TT_t1422q32q11ID101910


External links

Nomenclature
HGNC (Hugo)MARK3   6897
Cards
Entrez_Gene (NCBI)MARK3  4140  microtubule affinity regulating kinase 3
AliasesCTAK1; KP78; PAR1A; Par-1a; 
VIPB
GeneCards (Weizmann)MARK3
Ensembl hg19 (Hinxton)ENSG00000075413 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075413 [Gene_View]  ENSG00000075413 [Sequence]  chr14:103385364-103503829 [Contig_View]  MARK3 [Vega]
ICGC DataPortalENSG00000075413
TCGA cBioPortalMARK3
AceView (NCBI)MARK3
Genatlas (Paris)MARK3
WikiGenes4140
SOURCE (Princeton)MARK3
Genetics Home Reference (NIH)MARK3
Genomic and cartography
GoldenPath hg38 (UCSC)MARK3  -     chr14:103385364-103503829 +  14q32.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARK3  -     14q32.32   [Description]    (hg19-Feb_2009)
GoldenPathMARK3 - 14q32.32 [CytoView hg19]  MARK3 - 14q32.32 [CytoView hg38]
ImmunoBaseENSG00000075413
Mapping of homologs : NCBIMARK3 [Mapview hg19]  MARK3 [Mapview hg38]
OMIM602678   618283   
Gene and transcription
Genbank (Entrez)AB209542 AF170723 AF387637 AF465413 AK055814
RefSeq transcript (Entrez)NM_001128918 NM_001128919 NM_001128920 NM_001128921 NM_002376
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MARK3
Cluster EST : UnigeneHs.35828 [ NCBI ]
CGAP (NCI)Hs.35828
Alternative Splicing GalleryENSG00000075413
Gene ExpressionMARK3 [ NCBI-GEO ]   MARK3 [ EBI - ARRAY_EXPRESS ]   MARK3 [ SEEK ]   MARK3 [ MEM ]
Gene Expression Viewer (FireBrowse)MARK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4140
GTEX Portal (Tissue expression)MARK3
Human Protein AtlasENSG00000075413-MARK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27448   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27448  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27448
Splice isoforms : SwissVarP27448
PhosPhoSitePlusP27448
Domaine pattern : Prosite (Expaxy)KA1 (PS50032)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UBA (PS50030)   
Domains : Interpro (EBI)KA1/Ssp2_C    KA1_dom    Kinase-like_dom_sf    MARK/par1    MARK3    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    UBA   
Domain families : Pfam (Sanger)KA1 (PF02149)    Pkinase (PF00069)    UBA (PF00627)   
Domain families : Pfam (NCBI)pfam02149    pfam00069    pfam00627   
Domain families : Smart (EMBL)S_TKc (SM00220)  UBA (SM00165)  
Conserved Domain (NCBI)MARK3
DMDM Disease mutations4140
Blocks (Seattle)MARK3
PDB (RSDB)2QNJ    3FE3   
PDB Europe2QNJ    3FE3   
PDB (PDBSum)2QNJ    3FE3   
PDB (IMB)2QNJ    3FE3   
Structural Biology KnowledgeBase2QNJ    3FE3   
SCOP (Structural Classification of Proteins)2QNJ    3FE3   
CATH (Classification of proteins structures)2QNJ    3FE3   
SuperfamilyP27448
Human Protein Atlas [tissue]ENSG00000075413-MARK3 [tissue]
Peptide AtlasP27448
HPRD04058
IPIIPI00220505   IPI00220506   IPI00220507   IPI00220508   IPI00220509   IPI01025908   IPI00917102   IPI01026028   IPI00183118   IPI00827718   
Protein Interaction databases
DIP (DOE-UCLA)P27448
IntAct (EBI)P27448
FunCoupENSG00000075413
BioGRIDMARK3
STRING (EMBL)MARK3
ZODIACMARK3
Ontologies - Pathways
QuickGOP27448
Ontology : AmiGOMAPK cascade  microtubule cytoskeleton organization  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  protein phosphorylation  peptidyl-serine phosphorylation  dendrite  positive regulation of protein binding  negative regulation of hippo signaling  intracellular signal transduction  peptidyl-serine autophosphorylation  tau protein binding  tau-protein kinase activity  tau-protein kinase activity  tau-protein kinase activity  extracellular exosome  
Ontology : EGO-EBIMAPK cascade  microtubule cytoskeleton organization  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  protein phosphorylation  peptidyl-serine phosphorylation  dendrite  positive regulation of protein binding  negative regulation of hippo signaling  intracellular signal transduction  peptidyl-serine autophosphorylation  tau protein binding  tau-protein kinase activity  tau-protein kinase activity  tau-protein kinase activity  extracellular exosome  
NDEx NetworkMARK3
Atlas of Cancer Signalling NetworkMARK3
Wikipedia pathwaysMARK3
Orthology - Evolution
OrthoDB4140
GeneTree (enSembl)ENSG00000075413
Phylogenetic Trees/Animal Genes : TreeFamMARK3
HOGENOMP27448
Homologs : HomoloGeneMARK3
Homology/Alignments : Family Browser (UCSC)MARK3
Gene fusions - Rearrangements
Fusion : MitelmanMARK3/BAG5 [14q32.32/14q32.33]  
Fusion : MitelmanMARK3/ENTPD5 [14q32.32/14q24.3]  [t(14;14)(q24;q32)]  
Fusion : MitelmanMARK3/FBLN5 [14q32.32/14q32.12]  [t(14;14)(q32;q32)]  
Fusion : MitelmanMARK3/SLC25A21 [14q32.32/14q13.3]  [t(14;14)(q13;q32)]  
Fusion : MitelmanSMARCB1/MARK3 [22q11.23/14q32.32]  [t(14;22)(q32;q11)]  
Fusion PortalMARK3 14q32.32 BAG5 14q32.33 BRCA
Fusion PortalMARK3 14q32.32 ENTPD5 14q24.3 LUSC
Fusion PortalMARK3 14q32.32 FBLN5 14q32.12 LUSC
Fusion PortalMARK3 14q32.32 RP11-407N17.3 BRCA
Fusion PortalMARK3 14q32.32 SLC25A21 14q13.3 BRCA
Fusion PortalRP11-73M18.2 MARK3 14q32.32 BRCA LUAD
Fusion : QuiverMARK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARK3
dbVarMARK3
ClinVarMARK3
1000_GenomesMARK3 
Exome Variant ServerMARK3
ExAC (Exome Aggregation Consortium)ENSG00000075413
GNOMAD BrowserENSG00000075413
Varsome BrowserMARK3
Genetic variants : HAPMAP4140
Genomic Variants (DGV)MARK3 [DGVbeta]
DECIPHERMARK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARK3 
Mutations
ICGC Data PortalMARK3 
TCGA Data PortalMARK3 
Broad Tumor PortalMARK3
OASIS PortalMARK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARK3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMARK3
Mutations and Diseases : HGMDMARK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MARK3
DgiDB (Drug Gene Interaction Database)MARK3
DoCM (Curated mutations)MARK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARK3 (select a term)
intoGenMARK3
Cancer3DMARK3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602678    618283   
Orphanet
DisGeNETMARK3
MedgenMARK3
Genetic Testing Registry MARK3
NextProtP27448 [Medical]
TSGene4140
GENETestsMARK3
Target ValidationMARK3
Huge Navigator MARK3 [HugePedia]
snp3D : Map Gene to Disease4140
BioCentury BCIQMARK3
ClinGenMARK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4140
Chemical/Pharm GKB GenePA30640
Clinical trialMARK3
Miscellaneous
canSAR (ICR)MARK3 (select the gene name)
DataMed IndexMARK3
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMARK3
EVEXMARK3
GoPubMedMARK3
iHOPMARK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:16:21 CEST 2019

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