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MARS (methionyl-tRNA synthetase)

Identity

Alias_symbol (synonym)MetRS
SPG70
CMT2U
Other aliasILFS2
ILLD
METRS
MRS
MTRNS
HGNC (Hugo) MARS
LocusID (NCBI) 4141
Atlas_Id 68817
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 57487953 and ends at 57516655 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP9 (12q13.3) / MARS (12q13.3)EWSR1 (22q12.2) / MARS (12q13.3)FBRSL1 (12q24.33) / MARS (12q13.3)
FUS (16p11.2) / MARS (12q13.3)MARS (12q13.3) / AVIL (12q14.1)MARS (12q13.3) / EIF3L (22q13.1)
MARS (12q13.3) / MARS (12q13.3)MARS (12q13.3) / NOP2 (12p13.31)MON2 (12q14.1) / MARS (12q13.3)
YEATS4 (12q15) / MARS (12q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MARS   6898
Cards
Entrez_Gene (NCBI)MARS  4141  methionyl-tRNA synthetase
AliasesCMT2U; ILFS2; ILLD; METRS; 
MRS; MTRNS; SPG70
GeneCards (Weizmann)MARS
Ensembl hg19 (Hinxton)ENSG00000166986 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166986 [Gene_View]  chr12:57487953-57516655 [Contig_View]  MARS [Vega]
ICGC DataPortalENSG00000166986
TCGA cBioPortalMARS
AceView (NCBI)MARS
Genatlas (Paris)MARS
WikiGenes4141
SOURCE (Princeton)MARS
Genetics Home Reference (NIH)MARS
Genomic and cartography
GoldenPath hg38 (UCSC)MARS  -     chr12:57487953-57516655 +  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MARS  -     12q13.3   [Description]    (hg19-Feb_2009)
EnsemblMARS - 12q13.3 [CytoView hg19]  MARS - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBIMARS [Mapview hg19]  MARS [Mapview hg38]
OMIM156560   615486   616280   
Gene and transcription
Genbank (Entrez)AK092986 AK122956 AK222767 AK290857 AK293945
RefSeq transcript (Entrez)NM_004990
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MARS
Cluster EST : UnigeneHs.632707 [ NCBI ]
CGAP (NCI)Hs.632707
Alternative Splicing GalleryENSG00000166986
Gene ExpressionMARS [ NCBI-GEO ]   MARS [ EBI - ARRAY_EXPRESS ]   MARS [ SEEK ]   MARS [ MEM ]
Gene Expression Viewer (FireBrowse)MARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4141
GTEX Portal (Tissue expression)MARS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56192   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56192  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56192
Splice isoforms : SwissVarP56192
Catalytic activity : Enzyme6.1.1.10 [ Enzyme-Expasy ]   6.1.1.106.1.1.10 [ IntEnz-EBI ]   6.1.1.10 [ BRENDA ]   6.1.1.10 [ KEGG ]   
PhosPhoSitePlusP56192
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)    GST_CTER (PS50405)    WHEP_TRS_1 (PS00762)    WHEP_TRS_2 (PS51185)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    Glutathione-S-Trfase_C-like    GST_C    Met-tRNA_ligase_1    Met-tRNA_synth    Methionyl/Leucyl_tRNA_Synth    MetRS_core    MetRS_Zn    Rossmann-like_a/b/a_fold    S15_NS1_RNA-bd    tRNAsynth_Ia_anticodon-bd    WHEP-TRS_dom   
Domain families : Pfam (Sanger)GST_C (PF00043)    tRNA-synt_1g (PF09334)    WHEP-TRS (PF00458)   
Domain families : Pfam (NCBI)pfam00043    pfam09334    pfam00458   
Domain families : Smart (EMBL)WHEP-TRS (SM00991)  
Conserved Domain (NCBI)MARS
DMDM Disease mutations4141
Blocks (Seattle)MARS
PDB (SRS)2DJV    4BL7    4BVX    4BVY   
PDB (PDBSum)2DJV    4BL7    4BVX    4BVY   
PDB (IMB)2DJV    4BL7    4BVX    4BVY   
PDB (RSDB)2DJV    4BL7    4BVX    4BVY   
Structural Biology KnowledgeBase2DJV    4BL7    4BVX    4BVY   
SCOP (Structural Classification of Proteins)2DJV    4BL7    4BVX    4BVY   
CATH (Classification of proteins structures)2DJV    4BL7    4BVX    4BVY   
SuperfamilyP56192
Human Protein AtlasENSG00000166986
Peptide AtlasP56192
HPRD08864
IPIIPI00008240   IPI00185398   IPI01015558   IPI01021036   IPI00976594   IPI01018640   IPI01022954   IPI01022995   IPI01022809   IPI01020886   IPI01020714   IPI01021195   IPI01021517   IPI01021332   IPI01021858   IPI01021686   IPI01022183   
Protein Interaction databases
DIP (DOE-UCLA)P56192
IntAct (EBI)P56192
FunCoupENSG00000166986
BioGRIDMARS
STRING (EMBL)MARS
ZODIACMARS
Ontologies - Pathways
QuickGOP56192
Ontology : AmiGOtRNA binding  methionine-tRNA ligase activity  ATP binding  nucleolus  cytoplasm  cytosol  cytosol  cytosol  tRNA aminoacylation for protein translation  tRNA aminoacylation for protein translation  methionyl-tRNA aminoacylation  cellular response to starvation  rRNA transcription  membrane  aminoacyl-tRNA synthetase multienzyme complex  cellular response to insulin stimulus  cellular response to platelet-derived growth factor stimulus  extracellular exosome  cellular response to epidermal growth factor stimulus  positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter  
Ontology : EGO-EBItRNA binding  methionine-tRNA ligase activity  ATP binding  nucleolus  cytoplasm  cytosol  cytosol  cytosol  tRNA aminoacylation for protein translation  tRNA aminoacylation for protein translation  methionyl-tRNA aminoacylation  cellular response to starvation  rRNA transcription  membrane  aminoacyl-tRNA synthetase multienzyme complex  cellular response to insulin stimulus  cellular response to platelet-derived growth factor stimulus  extracellular exosome  cellular response to epidermal growth factor stimulus  positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter  
Pathways : KEGGSelenocompound metabolism    Aminoacyl-tRNA biosynthesis   
NDEx NetworkMARS
Atlas of Cancer Signalling NetworkMARS
Wikipedia pathwaysMARS
Orthology - Evolution
OrthoDB4141
GeneTree (enSembl)ENSG00000166986
Phylogenetic Trees/Animal Genes : TreeFamMARS
HOVERGENP56192
HOGENOMP56192
Homologs : HomoloGeneMARS
Homology/Alignments : Family Browser (UCSC)MARS
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARS
dbVarMARS
ClinVarMARS
1000_GenomesMARS 
Exome Variant ServerMARS
ExAC (Exome Aggregation Consortium)MARS (select the gene name)
Genetic variants : HAPMAP4141
Genomic Variants (DGV)MARS [DGVbeta]
DECIPHERMARS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMARS 
Mutations
ICGC Data PortalMARS 
TCGA Data PortalMARS 
Broad Tumor PortalMARS
OASIS PortalMARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMARS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MARS
DgiDB (Drug Gene Interaction Database)MARS
DoCM (Curated mutations)MARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARS (select a term)
intoGenMARS
Cancer3DMARS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM156560    615486    616280   
Orphanet22838    22697    23408   
MedgenMARS
Genetic Testing Registry MARS
NextProtP56192 [Medical]
TSGene4141
GENETestsMARS
Target ValidationMARS
Huge Navigator MARS [HugePedia]
snp3D : Map Gene to Disease4141
BioCentury BCIQMARS
ClinGenMARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4141
Chemical/Pharm GKB GenePA30642
Clinical trialMARS
Miscellaneous
canSAR (ICR)MARS (select the gene name)
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMARS
EVEXMARS
GoPubMedMARS
iHOPMARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:26:58 CEST 2017

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