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MARS2 (methionyl-tRNA synthetase 2, mitochondrial)

Identity

Alias_symbol (synonym)mtMetRS
SPAX3
Other aliasMetRS
HGNC (Hugo) MARS2
LocusID (NCBI) 92935
Atlas_Id 68818
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 198570028 and ends at 198573114 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MARS2   25133
Cards
Entrez_Gene (NCBI)MARS2  92935  methionyl-tRNA synthetase 2, mitochondrial
AliasesMetRS; mtMetRS
GeneCards (Weizmann)MARS2
Ensembl hg19 (Hinxton)ENSG00000247626 [Gene_View]  chr2:198570028-198573114 [Contig_View]  MARS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000247626 [Gene_View]  chr2:198570028-198573114 [Contig_View]  MARS2 [Vega]
ICGC DataPortalENSG00000247626
TCGA cBioPortalMARS2
AceView (NCBI)MARS2
Genatlas (Paris)MARS2
WikiGenes92935
SOURCE (Princeton)MARS2
Genetics Home Reference (NIH)MARS2
Genomic and cartography
GoldenPath hg19 (UCSC)MARS2  -     chr2:198570028-198573114 +  2q33.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MARS2  -     2q33.1   [Description]    (hg38-Dec_2013)
EnsemblMARS2 - 2q33.1 [CytoView hg19]  MARS2 - 2q33.1 [CytoView hg38]
Mapping of homologs : NCBIMARS2 [Mapview hg19]  MARS2 [Mapview hg38]
OMIM609728   611390   
Gene and transcription
Genbank (Entrez)AB107013 AK098121 AK301252 BC009115 BC026361
RefSeq transcript (Entrez)NM_138395
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_034122 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)MARS2
Cluster EST : UnigeneHs.744330 [ NCBI ]
CGAP (NCI)Hs.744330
Alternative Splicing GalleryENSG00000247626
Gene ExpressionMARS2 [ NCBI-GEO ]   MARS2 [ EBI - ARRAY_EXPRESS ]   MARS2 [ SEEK ]   MARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)MARS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92935
GTEX Portal (Tissue expression)MARS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96GW9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96GW9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96GW9
Splice isoforms : SwissVarQ96GW9
Catalytic activity : Enzyme6.1.1.10 [ Enzyme-Expasy ]   6.1.1.106.1.1.10 [ IntEnz-EBI ]   6.1.1.10 [ BRENDA ]   6.1.1.10 [ KEGG ]   
PhosPhoSitePlusQ96GW9
Domains : Interpro (EBI)Met-tRNA_synth    Methionyl/Leucyl_tRNA_Synth    Rossmann-like_a/b/a_fold    tRNAsynth_1a_anticodon-bd   
Domain families : Pfam (Sanger)tRNA-synt_1g (PF09334)   
Domain families : Pfam (NCBI)pfam09334   
Conserved Domain (NCBI)MARS2
DMDM Disease mutations92935
Blocks (Seattle)MARS2
SuperfamilyQ96GW9
Human Protein AtlasENSG00000247626
Peptide AtlasQ96GW9
HPRD14363
IPIIPI00062839   IPI00911041   
Protein Interaction databases
DIP (DOE-UCLA)Q96GW9
IntAct (EBI)Q96GW9
FunCoupENSG00000247626
BioGRIDMARS2
STRING (EMBL)MARS2
ZODIACMARS2
Ontologies - Pathways
QuickGOQ96GW9
Ontology : AmiGOmethionine-tRNA ligase activity  ATP binding  mitochondrial matrix  mitochondrial matrix  cytosol  tRNA aminoacylation for protein translation  methionyl-tRNA aminoacylation  gene expression  
Ontology : EGO-EBImethionine-tRNA ligase activity  ATP binding  mitochondrial matrix  mitochondrial matrix  cytosol  tRNA aminoacylation for protein translation  methionyl-tRNA aminoacylation  gene expression  
Pathways : KEGGSelenocompound metabolism    Aminoacyl-tRNA biosynthesis   
NDEx NetworkMARS2
Atlas of Cancer Signalling NetworkMARS2
Wikipedia pathwaysMARS2
Orthology - Evolution
OrthoDB92935
GeneTree (enSembl)ENSG00000247626
Phylogenetic Trees/Animal Genes : TreeFamMARS2
HOVERGENQ96GW9
HOGENOMQ96GW9
Homologs : HomoloGeneMARS2
Homology/Alignments : Family Browser (UCSC)MARS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MARS2
dbVarMARS2
ClinVarMARS2
1000_GenomesMARS2 
Exome Variant ServerMARS2
ExAC (Exome Aggregation Consortium)MARS2 (select the gene name)
Genetic variants : HAPMAP92935
Genomic Variants (DGV)MARS2 [DGVbeta]
DECIPHER (Syndromes)2:198570028-198573114  ENSG00000247626
CONAN: Copy Number AnalysisMARS2 
Mutations
ICGC Data PortalMARS2 
TCGA Data PortalMARS2 
Broad Tumor PortalMARS2
OASIS PortalMARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMARS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MARS2
DgiDB (Drug Gene Interaction Database)MARS2
DoCM (Curated mutations)MARS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MARS2 (select a term)
intoGenMARS2
Cancer3DMARS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609728    611390   
Orphanet21501    23553   
MedgenMARS2
Genetic Testing Registry MARS2
NextProtQ96GW9 [Medical]
TSGene92935
GENETestsMARS2
Huge Navigator MARS2 [HugePedia]
snp3D : Map Gene to Disease92935
BioCentury BCIQMARS2
ClinGenMARS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD92935
Chemical/Pharm GKB GenePA134863396
Clinical trialMARS2
Miscellaneous
canSAR (ICR)MARS2 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMARS2
EVEXMARS2
GoPubMedMARS2
iHOPMARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:27:45 CET 2017

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