MAS1 (MAS1 proto-oncogene, G protein-coupled receptor)

2003-02-01  

Identity

HGNC
MAS1
LOCATION
6q25.3
LOCUSID
4142
ALIAS
MAS,MGRA

Other Information

Locus ID:

NCBI: 4142
MIM: 165180
HGNC: 6899
Ensembl: ENSG00000130368

Variants:

dbSNP: 4142
ClinVar: 4142
TCGA: ENSG00000130368
COSMIC: MAS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130368ENST00000252660P04201
ENSG00000130368ENST00000252660W8W3P4
ENSG00000130368ENST00000674077W8W3P4

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Renin-angiotensin systemKEGGko04614
Neuroactive ligand-receptor interactionKEGGhsa04080
Renin-angiotensin systemKEGGhsa04614

References

Pubmed IDYearTitleCitations
293515142018The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7).91
234888002013ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis.88
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
194616482009Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis.64
241682602014Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-κB pathway.33
269953002016ACE inhibition, ACE2 and angiotensin-(1-7) axis in kidney and cardiac inflammation and fibrosis.32
166116422006Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.23
186363142008Angiotensin metabolites can stimulate receptors of the Mas-related genes family.23
220030542012Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection.15
220489482012Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma.15

Citation

Dessen P

MAS1 (MAS1 proto-oncogene, G protein-coupled receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41302/mas1