Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAST1 (microtubule associated serine/threonine kinase 1)

Identity

Alias_symbol (synonym)SAST
KIAA0973
Other aliasMCCCHCM
HGNC (Hugo) MAST1
LocusID (NCBI) 22983
Atlas_Id 43353
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12838445 and ends at 12874952 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FRMD8 (11q13.1) / MAST1 (19p13.2)HOOK2 (19p13.2) / MAST1 (19p13.2)NFIX (19p13.2) / MAST1 (19p13.2)
TADA2A (17q12) / MAST1 (19p13.2)ZNF700 (19p13.2) / MAST1 (19p13.2)ZNF700 19p13.2 / MAST1 19p13.13
FRMD8 11q13.1 / MAST1 19p13.2HOOK2 19p13.2 / MAST1 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(11;19)(q13;p13) FRMD8/MAST1
HOOK2/MAST1 (19p13)
NFIX/MAST1 (19p13)
ZNF700/MAST1 (19p13)

External links

Nomenclature
HGNC (Hugo)MAST1   19034
Cards
Entrez_Gene (NCBI)MAST1  22983  microtubule associated serine/threonine kinase 1
AliasesMCCCHCM; SAST
GeneCards (Weizmann)MAST1
Ensembl hg19 (Hinxton)ENSG00000105613 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105613 [Gene_View]  ENSG00000105613 [Sequence]  chr19:12838445-12874952 [Contig_View]  MAST1 [Vega]
ICGC DataPortalENSG00000105613
TCGA cBioPortalMAST1
AceView (NCBI)MAST1
Genatlas (Paris)MAST1
WikiGenes22983
SOURCE (Princeton)MAST1
Genetics Home Reference (NIH)MAST1
Genomic and cartography
GoldenPath hg38 (UCSC)MAST1  -     chr19:12838445-12874952 +  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAST1  -     19p13.13   [Description]    (hg19-Feb_2009)
GoldenPathMAST1 - 19p13.13 [CytoView hg19]  MAST1 - 19p13.13 [CytoView hg38]
ImmunoBaseENSG00000105613
Mapping of homologs : NCBIMAST1 [Mapview hg19]  MAST1 [Mapview hg38]
OMIM612256   618273   
Gene and transcription
Genbank (Entrez)AB023190 AK297553 BC017485 BC026709 BC027985
RefSeq transcript (Entrez)NM_014975
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAST1
Cluster EST : UnigeneHs.227489 [ NCBI ]
CGAP (NCI)Hs.227489
Alternative Splicing GalleryENSG00000105613
Gene ExpressionMAST1 [ NCBI-GEO ]   MAST1 [ EBI - ARRAY_EXPRESS ]   MAST1 [ SEEK ]   MAST1 [ MEM ]
Gene Expression Viewer (FireBrowse)MAST1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22983
GTEX Portal (Tissue expression)MAST1
Human Protein AtlasENSG00000105613-MAST1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2H9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2H9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2H9
Splice isoforms : SwissVarQ9Y2H9
PhosPhoSitePlusQ9Y2H9
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PDZ (PS50106)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom_sf    MA_Ser/Thr_Kinase_dom    MAST    MAST1    MAST_pre-PK_dom_sf    PDZ    PDZ_sf    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)DUF1908 (PF08926)    PDZ (PF00595)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam08926    pfam00595    pfam00069   
Domain families : Smart (EMBL)PDZ (SM00228)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAST1
DMDM Disease mutations22983
Blocks (Seattle)MAST1
PDB (RSDB)2M9X    3PS4   
PDB Europe2M9X    3PS4   
PDB (PDBSum)2M9X    3PS4   
PDB (IMB)2M9X    3PS4   
Structural Biology KnowledgeBase2M9X    3PS4   
SCOP (Structural Classification of Proteins)2M9X    3PS4   
CATH (Classification of proteins structures)2M9X    3PS4   
SuperfamilyQ9Y2H9
Human Protein Atlas [tissue]ENSG00000105613-MAST1 [tissue]
Peptide AtlasQ9Y2H9
HPRD17469
IPIIPI00027883   IPI01012341   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2H9
IntAct (EBI)Q9Y2H9
FunCoupENSG00000105613
BioGRIDMAST1
STRING (EMBL)MAST1
ZODIACMAST1
Ontologies - Pathways
QuickGOQ9Y2H9
Ontology : AmiGOmagnesium ion binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoskeleton  plasma membrane  protein phosphorylation  cytoskeleton organization  cytoskeleton organization  brain development  microtubule binding  peptidyl-serine phosphorylation  intracellular signal transduction  intracellular signal transduction  neuron projection  neuronal cell body  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoskeleton  plasma membrane  protein phosphorylation  cytoskeleton organization  cytoskeleton organization  brain development  microtubule binding  peptidyl-serine phosphorylation  intracellular signal transduction  intracellular signal transduction  neuron projection  neuronal cell body  
NDEx NetworkMAST1
Atlas of Cancer Signalling NetworkMAST1
Wikipedia pathwaysMAST1
Orthology - Evolution
OrthoDB22983
GeneTree (enSembl)ENSG00000105613
Phylogenetic Trees/Animal Genes : TreeFamMAST1
HOGENOMQ9Y2H9
Homologs : HomoloGeneMAST1
Homology/Alignments : Family Browser (UCSC)MAST1
Gene fusions - Rearrangements
Fusion : MitelmanFRMD8/MAST1 [11q13.1/19p13.2]  [t(11;19)(q13;p13)]  
Fusion : MitelmanHOOK2/MAST1 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanNFIX/MAST1 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanZNF700/MAST1 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion PortalFRMD8 11q13.1 MAST1 19p13.2 BRCA
Fusion PortalHOOK2 19p13.2 MAST1 19p13.2 OV
Fusion : QuiverMAST1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAST1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAST1
dbVarMAST1
ClinVarMAST1
1000_GenomesMAST1 
Exome Variant ServerMAST1
ExAC (Exome Aggregation Consortium)ENSG00000105613
GNOMAD BrowserENSG00000105613
Varsome BrowserMAST1
Genetic variants : HAPMAP22983
Genomic Variants (DGV)MAST1 [DGVbeta]
DECIPHERMAST1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAST1 
Mutations
ICGC Data PortalMAST1 
TCGA Data PortalMAST1 
Broad Tumor PortalMAST1
OASIS PortalMAST1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAST1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAST1
Mutations and Diseases : HGMDMAST1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAST1
DgiDB (Drug Gene Interaction Database)MAST1
DoCM (Curated mutations)MAST1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAST1 (select a term)
intoGenMAST1
Cancer3DMAST1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612256    618273   
Orphanet
DisGeNETMAST1
MedgenMAST1
Genetic Testing Registry MAST1
NextProtQ9Y2H9 [Medical]
TSGene22983
GENETestsMAST1
Target ValidationMAST1
Huge Navigator MAST1 [HugePedia]
snp3D : Map Gene to Disease22983
BioCentury BCIQMAST1
ClinGenMAST1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22983
Chemical/Pharm GKB GenePA134946727
Clinical trialMAST1
Miscellaneous
canSAR (ICR)MAST1 (select the gene name)
DataMed IndexMAST1
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAST1
EVEXMAST1
GoPubMedMAST1
iHOPMAST1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:52:47 CET 2019
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