MAST1 (microtubule associated serine/threonine kinase 1)

2006-10-01  

Identity

HGNC
MAST1
LOCATION
19p13.13
LOCUSID
22983
ALIAS
MCCCHCM,SAST
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22983
MIM: 612256
HGNC: 19034
Ensembl: ENSG00000105613

Variants:

dbSNP: 22983
ClinVar: 22983
TCGA: ENSG00000105613
COSMIC: MAST1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105613ENST00000251472Q9Y2H9
ENSG00000105613ENST00000588379K7EJZ9
ENSG00000105613ENST00000590204K7EJI7
ENSG00000105613ENST00000591495K7EME4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221017662011Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.142
104041831999Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases.39
126146772003Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions.3
304496572018Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.2
314490532019Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation.1

Citation

Dessen P

MAST1 (microtubule associated serine/threonine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43353/mast1