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MAST2 (microtubule associated serine/threonine kinase 2)

Identity

Alias (NCBI)MAST205
MTSSK
HGNC (Hugo) MAST2
HGNC Alias symbMAST205
KIAA0807
LocusID (NCBI) 23139
Atlas_Id 52599
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 45803612 and ends at 46036122 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARID1A (1p36.11) / MAST2 (1p34.1)FOS (14q24.3) / MAST2 (1p34.1)GPBP1L1 (1p34.1) / MAST2 (1p34.1)
HOMER1 (5q14.1) / MAST2 (1p34.1)MAST2 (1p34.1) / AKR1A1 (1p34.1)MAST2 (1p34.1) / C6orf52 (6p24.2)
MAST2 (1p34.1) / CLDN14 (21q22.13)MAST2 (1p34.1) / CSNK1G2 (19p13.3)MAST2 (1p34.1) / MAST2 (1p34.1)
MAST2 (1p34.1) / MMEL1 (1p36.32)MAST2 (1p34.1) / NASP (1p34.1)GPBP1L1 1p34.1 / MAST2 1p34.1
HOMER1 5q14.1 / MAST2 1p34.1MAST2 1p34.1 / C6orf52 6p24.2MAST2 1p34.1 / CLDN14 21q22.13
MAST2 1p34.1 / MMEL1 1p36.32MAST2 1p34.1 / NASP 1p34.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MAST2   19035
Cards
Entrez_Gene (NCBI)MAST2    microtubule associated serine/threonine kinase 2
AliasesMAST205; MTSSK
GeneCards (Weizmann)MAST2
Ensembl hg19 (Hinxton)ENSG00000086015 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000086015 [Gene_View]  ENSG00000086015 [Sequence]  chr1:45803612-46036122 [Contig_View]  MAST2 [Vega]
ICGC DataPortalENSG00000086015
TCGA cBioPortalMAST2
AceView (NCBI)MAST2
Genatlas (Paris)MAST2
SOURCE (Princeton)MAST2
Genetics Home Reference (NIH)MAST2
Genomic and cartography
GoldenPath hg38 (UCSC)MAST2  -     chr1:45803612-46036122 +  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAST2  -     1p34.1   [Description]    (hg19-Feb_2009)
GoldenPathMAST2 - 1p34.1 [CytoView hg19]  MAST2 - 1p34.1 [CytoView hg38]
ImmunoBaseENSG00000086015
Genome Data Viewer NCBIMAST2 [Mapview hg19]  
OMIM612257   
Gene and transcription
Genbank (Entrez)AB018350 AB047005 AK027123 AK055291 AK096519
RefSeq transcript (Entrez)NM_001319245 NM_001324320 NM_001324321 NM_015112
Consensus coding sequences : CCDS (NCBI)MAST2
Gene ExpressionMAST2 [ NCBI-GEO ]   MAST2 [ EBI - ARRAY_EXPRESS ]   MAST2 [ SEEK ]   MAST2 [ MEM ]
Gene Expression Viewer (FireBrowse)MAST2 [ Firebrowse - Broad ]
GenevisibleExpression of MAST2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23139
GTEX Portal (Tissue expression)MAST2
Human Protein AtlasENSG00000086015-MAST2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P0Q8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P0Q8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P0Q8
PhosPhoSitePlusQ6P0Q8
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PDZ (PS50106)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom_sf    MA_Ser/Thr_Kinase_dom    MAST    MAST2    MAST_pre-PK_dom_sf    PDZ    PDZ_6    PDZ_sf    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)DUF1908 (PF08926)    PDZ_6 (PF17820)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam08926    pfam17820    pfam00069   
Domain families : Smart (EMBL)PDZ (SM00228)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAST2
PDB (RSDB)2KQF    2KYL   
PDB Europe2KQF    2KYL   
PDB (PDBSum)2KQF    2KYL   
PDB (IMB)2KQF    2KYL   
Structural Biology KnowledgeBase2KQF    2KYL   
SCOP (Structural Classification of Proteins)2KQF    2KYL   
CATH (Classification of proteins structures)2KQF    2KYL   
SuperfamilyQ6P0Q8
AlphaFold pdb e-kbQ6P0Q8   
Human Protein Atlas [tissue]ENSG00000086015-MAST2 [tissue]
HPRD11294
Protein Interaction databases
DIP (DOE-UCLA)Q6P0Q8
IntAct (EBI)Q6P0Q8
BioGRIDMAST2
STRING (EMBL)MAST2
ZODIACMAST2
Ontologies - Pathways
QuickGOQ6P0Q8
Ontology : AmiGOmagnesium ion binding  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  plasma membrane  protein phosphorylation  cytoskeleton organization  microtubule binding  microtubule cytoskeleton  peptidyl-serine phosphorylation  phosphatase binding  regulation of interleukin-12 production  intracellular signal transduction  spermatid differentiation  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  plasma membrane  protein phosphorylation  cytoskeleton organization  microtubule binding  microtubule cytoskeleton  peptidyl-serine phosphorylation  phosphatase binding  regulation of interleukin-12 production  intracellular signal transduction  spermatid differentiation  protein serine kinase activity  protein threonine kinase activity  
NDEx NetworkMAST2
Atlas of Cancer Signalling NetworkMAST2
Wikipedia pathwaysMAST2
Orthology - Evolution
OrthoDB23139
GeneTree (enSembl)ENSG00000086015
Phylogenetic Trees/Animal Genes : TreeFamMAST2
Homologs : HomoloGeneMAST2
Homology/Alignments : Family Browser (UCSC)MAST2
Gene fusions - Rearrangements
Fusion : MitelmanARID1A/MAST2 [1p36.11/1p34.1]  
Fusion : MitelmanHOMER1/MAST2 [5q14.1/1p34.1]  
Fusion : MitelmanMAST2/C6orf52 [1p34.1/6p24.2]  
Fusion : MitelmanMAST2/CLDN14 [1p34.1/21q22.13]  
Fusion : MitelmanMAST2/MMEL1 [1p34.1/1p36.32]  
Fusion : MitelmanMAST2/NASP [1p34.1/1p34.1]  
Fusion : QuiverMAST2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAST2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAST2
dbVarMAST2
ClinVarMAST2
MonarchMAST2
1000_GenomesMAST2 
Exome Variant ServerMAST2
GNOMAD BrowserENSG00000086015
Varsome BrowserMAST2
ACMGMAST2 variants
VarityQ6P0Q8
Genomic Variants (DGV)MAST2 [DGVbeta]
DECIPHERMAST2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAST2 
Mutations
ICGC Data PortalMAST2 
TCGA Data PortalMAST2 
Broad Tumor PortalMAST2
OASIS PortalMAST2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAST2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAST2
Mutations and Diseases : HGMDMAST2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAST2
DgiDB (Drug Gene Interaction Database)MAST2
DoCM (Curated mutations)MAST2
CIViC (Clinical Interpretations of Variants in Cancer)MAST2
Cancer3DMAST2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612257   
Orphanet
DisGeNETMAST2
MedgenMAST2
Genetic Testing Registry MAST2
NextProtQ6P0Q8 [Medical]
GENETestsMAST2
Target ValidationMAST2
Huge Navigator MAST2 [HugePedia]
ClinGenMAST2
Clinical trials, drugs, therapy
MyCancerGenomeMAST2
Protein Interactions : CTDMAST2
Pharm GKB GenePA134954073
PharosQ6P0Q8
Clinical trialMAST2
Miscellaneous
canSAR (ICR)MAST2
HarmonizomeMAST2
DataMed IndexMAST2
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAST2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:17:55 CEST 2021

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