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MAST2 (microtubule associated serine/threonine kinase 2)

Identity

Alias_symbol (synonym)MAST205
KIAA0807
Other aliasMTSSK
HGNC (Hugo) MAST2
LocusID (NCBI) 23139
Atlas_Id 52599
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 45803613 and ends at 46036124 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARID1A (1p36.11) / MAST2 (1p34.1)FOS (14q24.3) / MAST2 (1p34.1)GPBP1L1 (1p34.1) / MAST2 (1p34.1)
HOMER1 (5q14.1) / MAST2 (1p34.1)MAST2 (1p34.1) / AKR1A1 (1p34.1)MAST2 (1p34.1) / C6orf52 (6p24.2)
MAST2 (1p34.1) / CLDN14 (21q22.13)MAST2 (1p34.1) / CSNK1G2 (19p13.3)MAST2 (1p34.1) / MAST2 (1p34.1)
MAST2 (1p34.1) / MMEL1 (1p36.32)MAST2 (1p34.1) / NASP (1p34.1)ARID1A 1p36.11 / MAST2 1p34.1
GPBP1L1 1p34.1 / MAST2 1p34.1HOMER1 5q14.1 / MAST2 1p34.1MAST2 1p34.1 / C6orf52 6p24.2
MAST2 1p34.1 / CLDN14 21q22.13MAST2 1p34.1 / MMEL1 1p36.32MAST2 1p34.1 / NASP 1p34.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAST2   19035
Cards
Entrez_Gene (NCBI)MAST2  23139  microtubule associated serine/threonine kinase 2
AliasesMAST205; MTSSK
GeneCards (Weizmann)MAST2
Ensembl hg19 (Hinxton)ENSG00000086015 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000086015 [Gene_View]  chr1:45803613-46036124 [Contig_View]  MAST2 [Vega]
ICGC DataPortalENSG00000086015
TCGA cBioPortalMAST2
AceView (NCBI)MAST2
Genatlas (Paris)MAST2
WikiGenes23139
SOURCE (Princeton)MAST2
Genetics Home Reference (NIH)MAST2
Genomic and cartography
GoldenPath hg38 (UCSC)MAST2  -     chr1:45803613-46036124 +  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAST2  -     1p34.1   [Description]    (hg19-Feb_2009)
EnsemblMAST2 - 1p34.1 [CytoView hg19]  MAST2 - 1p34.1 [CytoView hg38]
Mapping of homologs : NCBIMAST2 [Mapview hg19]  MAST2 [Mapview hg38]
OMIM612257   
Gene and transcription
Genbank (Entrez)AB018350 AB047005 AK027123 AK055291 AK096519
RefSeq transcript (Entrez)NM_001319245 NM_001324320 NM_001324321 NM_015112
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAST2
Cluster EST : UnigeneHs.319481 [ NCBI ]
CGAP (NCI)Hs.319481
Alternative Splicing GalleryENSG00000086015
Gene ExpressionMAST2 [ NCBI-GEO ]   MAST2 [ EBI - ARRAY_EXPRESS ]   MAST2 [ SEEK ]   MAST2 [ MEM ]
Gene Expression Viewer (FireBrowse)MAST2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23139
GTEX Portal (Tissue expression)MAST2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P0Q8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P0Q8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P0Q8
Splice isoforms : SwissVarQ6P0Q8
PhosPhoSitePlusQ6P0Q8
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PDZ (PS50106)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    MA_Ser/Thr_Kinase_dom    MAST2    MAST_pre-PK_dom    PDZ    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)DUF1908 (PF08926)    PDZ (PF00595)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam08926    pfam00595    pfam00069   
Domain families : Smart (EMBL)PDZ (SM00228)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAST2
DMDM Disease mutations23139
Blocks (Seattle)MAST2
PDB (SRS)2KQF    2KYL   
PDB (PDBSum)2KQF    2KYL   
PDB (IMB)2KQF    2KYL   
PDB (RSDB)2KQF    2KYL   
Structural Biology KnowledgeBase2KQF    2KYL   
SCOP (Structural Classification of Proteins)2KQF    2KYL   
CATH (Classification of proteins structures)2KQF    2KYL   
SuperfamilyQ6P0Q8
Human Protein AtlasENSG00000086015
Peptide AtlasQ6P0Q8
HPRD11294
IPIIPI00514071   IPI00480046   IPI00815635   IPI00902972   IPI00902764   IPI00983969   IPI00641573   
Protein Interaction databases
DIP (DOE-UCLA)Q6P0Q8
IntAct (EBI)Q6P0Q8
FunCoupENSG00000086015
BioGRIDMAST2
STRING (EMBL)MAST2
ZODIACMAST2
Ontologies - Pathways
QuickGOQ6P0Q8
Ontology : AmiGOmagnesium ion binding  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  plasma membrane  protein phosphorylation  cytoskeleton organization  microtubule binding  microtubule cytoskeleton  peptidyl-serine phosphorylation  phosphatase binding  intracellular signal transduction  regulation of interleukin-12 biosynthetic process  spermatid differentiation  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  plasma membrane  protein phosphorylation  cytoskeleton organization  microtubule binding  microtubule cytoskeleton  peptidyl-serine phosphorylation  phosphatase binding  intracellular signal transduction  regulation of interleukin-12 biosynthetic process  spermatid differentiation  
NDEx NetworkMAST2
Atlas of Cancer Signalling NetworkMAST2
Wikipedia pathwaysMAST2
Orthology - Evolution
OrthoDB23139
GeneTree (enSembl)ENSG00000086015
Phylogenetic Trees/Animal Genes : TreeFamMAST2
HOVERGENQ6P0Q8
HOGENOMQ6P0Q8
Homologs : HomoloGeneMAST2
Homology/Alignments : Family Browser (UCSC)MAST2
Gene fusions - Rearrangements
Fusion : MitelmanARID1A/MAST2 [1p36.11/1p34.1]  [t(1;1)(p34;p36)]  
Fusion : MitelmanHOMER1/MAST2 [5q14.1/1p34.1]  [t(1;5)(p34;q14)]  
Fusion : MitelmanMAST2/C6orf52 [1p34.1/6p24.2]  [t(1;6)(p34;p24)]  
Fusion : MitelmanMAST2/CLDN14 [1p34.1/21q22.13]  [t(1;21)(p34;q22)]  
Fusion : MitelmanMAST2/MMEL1 [1p34.1/1p36.32]  [t(1;1)(p34;p36)]  
Fusion : MitelmanMAST2/NASP [1p34.1/1p34.1]  [t(1;1)(p34;p34)]  
Fusion: TCGAHOMER1 5q14.1 MAST2 1p34.1 LGG
Fusion: TCGAMAST2 1p34.1 C6orf52 6p24.2 BRCA
Fusion: TCGAMAST2 1p34.1 CLDN14 21q22.13 OV
Fusion: TCGAMAST2 1p34.1 MMEL1 1p36.32 BRCA
Fusion: TCGAMAST2 1p34.1 NASP 1p34.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAST2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAST2
dbVarMAST2
ClinVarMAST2
1000_GenomesMAST2 
Exome Variant ServerMAST2
ExAC (Exome Aggregation Consortium)MAST2 (select the gene name)
Genetic variants : HAPMAP23139
Genomic Variants (DGV)MAST2 [DGVbeta]
DECIPHERMAST2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAST2 
Mutations
ICGC Data PortalMAST2 
TCGA Data PortalMAST2 
Broad Tumor PortalMAST2
OASIS PortalMAST2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMAST2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAST2
DgiDB (Drug Gene Interaction Database)MAST2
DoCM (Curated mutations)MAST2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAST2 (select a term)
intoGenMAST2
Cancer3DMAST2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612257   
Orphanet
MedgenMAST2
Genetic Testing Registry MAST2
NextProtQ6P0Q8 [Medical]
TSGene23139
GENETestsMAST2
Target ValidationMAST2
Huge Navigator MAST2 [HugePedia]
snp3D : Map Gene to Disease23139
BioCentury BCIQMAST2
ClinGenMAST2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23139
Chemical/Pharm GKB GenePA134954073
Clinical trialMAST2
Miscellaneous
canSAR (ICR)MAST2 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAST2
EVEXMAST2
GoPubMedMAST2
iHOPMAST2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:58:48 CEST 2017

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