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MAST4 (microtubule associated serine/threonine kinase family member 4)

Identity

Alias_symbol (synonym)KIAA0303
Other alias-
HGNC (Hugo) MAST4
LocusID (NCBI) 375449
Atlas_Id 43355
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 66596348 and ends at 67169595 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IFT80 (3q25.33) / MAST4 (5q12.3)MAST4 (5q12.3) / ABR (17p13.3)MAST4 (5q12.3) / COL12A1 (6q13)
MAST4 (5q12.3) / MAST4 (5q12.3)MAST4 (5q12.3) / MRPS27 (5q13.2)MAST4 (5q12.3) / NLN (5q12.3)
NDUFAF2 (5q12.1) / MAST4 (5q12.3)MAST4 5q12.3 / MRPS27 5q13.2MAST4 5q12.3 / NLN 5q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)MAST4   19037
Cards
Entrez_Gene (NCBI)MAST4  375449  microtubule associated serine/threonine kinase family member 4
Aliases
GeneCards (Weizmann)MAST4
Ensembl hg19 (Hinxton)ENSG00000069020 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069020 [Gene_View]  chr5:66596348-67169595 [Contig_View]  MAST4 [Vega]
ICGC DataPortalENSG00000069020
TCGA cBioPortalMAST4
AceView (NCBI)MAST4
Genatlas (Paris)MAST4
WikiGenes375449
SOURCE (Princeton)MAST4
Genetics Home Reference (NIH)MAST4
Genomic and cartography
GoldenPath hg38 (UCSC)MAST4  -     chr5:66596348-67169595 +  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAST4  -     5q12.3   [Description]    (hg19-Feb_2009)
EnsemblMAST4 - 5q12.3 [CytoView hg19]  MAST4 - 5q12.3 [CytoView hg38]
Mapping of homologs : NCBIMAST4 [Mapview hg19]  MAST4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB002301 AK057601 AK131421 AK296707 AK299538
RefSeq transcript (Entrez)NM_001164664 NM_001290226 NM_001290227 NM_001290228 NM_001297651 NM_015183 NM_198828
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAST4
Cluster EST : UnigeneHs.732793 [ NCBI ]
CGAP (NCI)Hs.732793
Alternative Splicing GalleryENSG00000069020
Gene ExpressionMAST4 [ NCBI-GEO ]   MAST4 [ EBI - ARRAY_EXPRESS ]   MAST4 [ SEEK ]   MAST4 [ MEM ]
Gene Expression Viewer (FireBrowse)MAST4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)375449
GTEX Portal (Tissue expression)MAST4
Human Protein AtlasENSG00000069020-MAST4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15021   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15021  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15021
Splice isoforms : SwissVarO15021
PhosPhoSitePlusO15021
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PDZ (PS50106)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    MA_Ser/Thr_Kinase_dom    MAST_pre-PK_dom    PDZ    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)DUF1908 (PF08926)    PDZ (PF00595)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam08926    pfam00595    pfam00069   
Domain families : Smart (EMBL)PDZ (SM00228)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAST4
DMDM Disease mutations375449
Blocks (Seattle)MAST4
PDB (SRS)2W7R   
PDB (PDBSum)2W7R   
PDB (IMB)2W7R   
PDB (RSDB)2W7R   
Structural Biology KnowledgeBase2W7R   
SCOP (Structural Classification of Proteins)2W7R   
CATH (Classification of proteins structures)2W7R   
SuperfamilyO15021
Human Protein Atlas [tissue]ENSG00000069020-MAST4 [tissue]
Peptide AtlasO15021
HPRD14195
IPIIPI00894093   IPI00788168   IPI00827896   IPI00893655   IPI00914890   IPI00940467   IPI01025074   IPI00894030   IPI00893784   IPI00847251   IPI00893237   IPI00892921   IPI00892699   IPI00892570   IPI00894446   IPI00894331   IPI00894194   IPI00967781   
Protein Interaction databases
DIP (DOE-UCLA)O15021
IntAct (EBI)O15021
FunCoupENSG00000069020
BioGRIDMAST4
STRING (EMBL)MAST4
ZODIACMAST4
Ontologies - Pathways
QuickGOO15021
Ontology : AmiGOmagnesium ion binding  protein serine/threonine kinase activity  ATP binding  intracellular  cytoplasm  cytoskeleton organization  peptidyl-serine phosphorylation  intracellular signal transduction  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine kinase activity  ATP binding  intracellular  cytoplasm  cytoskeleton organization  peptidyl-serine phosphorylation  intracellular signal transduction  
NDEx NetworkMAST4
Atlas of Cancer Signalling NetworkMAST4
Wikipedia pathwaysMAST4
Orthology - Evolution
OrthoDB375449
GeneTree (enSembl)ENSG00000069020
Phylogenetic Trees/Animal Genes : TreeFamMAST4
HOVERGENO15021
HOGENOMO15021
Homologs : HomoloGeneMAST4
Homology/Alignments : Family Browser (UCSC)MAST4
Gene fusions - Rearrangements
Fusion : MitelmanERBB2IP/MAST4 [5q12.3/5q12.3]  [t(5;5)(q12;q12)]  
Fusion : MitelmanMAST4/MRPS27 [5q12.3/5q13.2]  [t(5;5)(q12;q13)]  
Fusion : MitelmanMAST4/NLN [5q12.3/5q12.3]  [t(5;5)(q12;q12)]  
Fusion : MitelmanNDUFAF2/MAST4 [5q12.1/5q12.3]  [t(5;5)(q12;q12)]  
Fusion: TCGA_MDACCMAST4 5q12.3 MRPS27 5q13.2 LUAD
Fusion: TCGA_MDACCMAST4 5q12.3 NLN 5q12.3 BRCA
Tumor Fusion PortalMAST4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAST4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAST4
dbVarMAST4
ClinVarMAST4
1000_GenomesMAST4 
Exome Variant ServerMAST4
ExAC (Exome Aggregation Consortium)ENSG00000069020
GNOMAD BrowserENSG00000069020
Genetic variants : HAPMAP375449
Genomic Variants (DGV)MAST4 [DGVbeta]
DECIPHERMAST4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAST4 
Mutations
ICGC Data PortalMAST4 
TCGA Data PortalMAST4 
Broad Tumor PortalMAST4
OASIS PortalMAST4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMAST4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAST4
DgiDB (Drug Gene Interaction Database)MAST4
DoCM (Curated mutations)MAST4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAST4 (select a term)
intoGenMAST4
Cancer3DMAST4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETMAST4
MedgenMAST4
Genetic Testing Registry MAST4
NextProtO15021 [Medical]
TSGene375449
GENETestsMAST4
Target ValidationMAST4
Huge Navigator MAST4 [HugePedia]
snp3D : Map Gene to Disease375449
BioCentury BCIQMAST4
ClinGenMAST4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD375449
Chemical/Pharm GKB GenePA134920494
Clinical trialMAST4
Miscellaneous
canSAR (ICR)MAST4 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAST4
EVEXMAST4
GoPubMedMAST4
iHOPMAST4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:21:46 CET 2017

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