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MAT1A (methionine adenosyltransferase 1A)

Identity

Alias_namesmethionine adenosyltransferase I
Alias_symbol (synonym)MAT
SAMS
MATA1
SAMS1
Other alias
HGNC (Hugo) MAT1A
LocusID (NCBI) 4143
Atlas_Id 52635
Location 10q22.3  [Link to chromosome band 10q22]
Location_base_pair Starts at 80271820 and ends at 80289678 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
STK39 (2q24.3) / MAT1A (10q23.1)STK39 2q24.3 / MAT1A 10q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;10)(q24;q23) STK39/MAT1A


External links

Nomenclature
HGNC (Hugo)MAT1A   6903
Cards
Entrez_Gene (NCBI)MAT1A  4143  methionine adenosyltransferase 1A
AliasesMAT; MATA1; SAMS; SAMS1
GeneCards (Weizmann)MAT1A
Ensembl hg19 (Hinxton)ENSG00000151224 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151224 [Gene_View]  ENSG00000151224 [Sequence]  chr10:80271820-80289678 [Contig_View]  MAT1A [Vega]
ICGC DataPortalENSG00000151224
TCGA cBioPortalMAT1A
AceView (NCBI)MAT1A
Genatlas (Paris)MAT1A
WikiGenes4143
SOURCE (Princeton)MAT1A
Genetics Home Reference (NIH)MAT1A
Genomic and cartography
GoldenPath hg38 (UCSC)MAT1A  -     chr10:80271820-80289678 -  10q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAT1A  -     10q22.3   [Description]    (hg19-Feb_2009)
EnsemblMAT1A - 10q22.3 [CytoView hg19]  MAT1A - 10q22.3 [CytoView hg38]
Mapping of homologs : NCBIMAT1A [Mapview hg19]  MAT1A [Mapview hg38]
OMIM250850   610550   
Gene and transcription
Genbank (Entrez)AK026931 AK290820 BC018359 BM738684 BX496326
RefSeq transcript (Entrez)NM_000429
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAT1A
Cluster EST : UnigeneHs.282670 [ NCBI ]
CGAP (NCI)Hs.282670
Alternative Splicing GalleryENSG00000151224
Gene ExpressionMAT1A [ NCBI-GEO ]   MAT1A [ EBI - ARRAY_EXPRESS ]   MAT1A [ SEEK ]   MAT1A [ MEM ]
Gene Expression Viewer (FireBrowse)MAT1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4143
GTEX Portal (Tissue expression)MAT1A
Human Protein AtlasENSG00000151224-MAT1A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00266   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00266  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00266
Splice isoforms : SwissVarQ00266
PhosPhoSitePlusQ00266
Domaine pattern : Prosite (Expaxy)ADOMET_SYNTHASE_1 (PS00376)    ADOMET_SYNTHASE_2 (PS00377)   
Domains : Interpro (EBI)ADOMET_SYNTHASE_CS    S-AdoMet_synt_C    S-AdoMet_synt_central    S-AdoMet_synt_N    S-AdoMet_synthetase    S-AdoMet_synthetase_sfam   
Domain families : Pfam (Sanger)S-AdoMet_synt_C (PF02773)    S-AdoMet_synt_M (PF02772)    S-AdoMet_synt_N (PF00438)   
Domain families : Pfam (NCBI)pfam02773    pfam02772    pfam00438   
Conserved Domain (NCBI)MAT1A
DMDM Disease mutations4143
Blocks (Seattle)MAT1A
PDB (SRS)2OBV   
PDB (PDBSum)2OBV   
PDB (IMB)2OBV   
PDB (RSDB)2OBV   
Structural Biology KnowledgeBase2OBV   
SCOP (Structural Classification of Proteins)2OBV   
CATH (Classification of proteins structures)2OBV   
SuperfamilyQ00266
Human Protein Atlas [tissue]ENSG00000151224-MAT1A [tissue]
Peptide AtlasQ00266
HPRD02013
IPIIPI00021772   IPI00513876   
Protein Interaction databases
DIP (DOE-UCLA)Q00266
IntAct (EBI)Q00266
FunCoupENSG00000151224
BioGRIDMAT1A
STRING (EMBL)MAT1A
ZODIACMAT1A
Ontologies - Pathways
QuickGOQ00266
Ontology : AmiGOsulfur amino acid metabolic process  selenium compound metabolic process  methionine adenosyltransferase activity  methionine adenosyltransferase activity  methionine adenosyltransferase activity  ATP binding  cytosol  cytosol  S-adenosylmethionine biosynthetic process  S-adenosylmethionine biosynthetic process  one-carbon metabolic process  methionine catabolic process  methylation  identical protein binding  metal ion binding  protein homotetramerization  selenomethionine adenosyltransferase activity  
Ontology : EGO-EBIsulfur amino acid metabolic process  selenium compound metabolic process  methionine adenosyltransferase activity  methionine adenosyltransferase activity  methionine adenosyltransferase activity  ATP binding  cytosol  cytosol  S-adenosylmethionine biosynthetic process  S-adenosylmethionine biosynthetic process  one-carbon metabolic process  methionine catabolic process  methylation  identical protein binding  metal ion binding  protein homotetramerization  selenomethionine adenosyltransferase activity  
Pathways : KEGGCysteine and methionine metabolism   
NDEx NetworkMAT1A
Atlas of Cancer Signalling NetworkMAT1A
Wikipedia pathwaysMAT1A
Orthology - Evolution
OrthoDB4143
GeneTree (enSembl)ENSG00000151224
Phylogenetic Trees/Animal Genes : TreeFamMAT1A
HOVERGENQ00266
HOGENOMQ00266
Homologs : HomoloGeneMAT1A
Homology/Alignments : Family Browser (UCSC)MAT1A
Gene fusions - Rearrangements
Fusion : MitelmanSTK39/MAT1A [2q24.3/10q23.1]  [t(2;10)(q24;q23)]  
Fusion PortalSTK39 2q24.3 MAT1A 10q23.1 BRCA
Fusion : QuiverMAT1A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAT1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAT1A
dbVarMAT1A
ClinVarMAT1A
1000_GenomesMAT1A 
Exome Variant ServerMAT1A
ExAC (Exome Aggregation Consortium)ENSG00000151224
GNOMAD BrowserENSG00000151224
Varsome BrowserMAT1A
Genetic variants : HAPMAP4143
Genomic Variants (DGV)MAT1A [DGVbeta]
DECIPHERMAT1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAT1A 
Mutations
ICGC Data PortalMAT1A 
TCGA Data PortalMAT1A 
Broad Tumor PortalMAT1A
OASIS PortalMAT1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAT1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAT1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAT1A
DgiDB (Drug Gene Interaction Database)MAT1A
DoCM (Curated mutations)MAT1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAT1A (select a term)
intoGenMAT1A
Cancer3DMAT1A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM250850    610550   
Orphanet17780   
DisGeNETMAT1A
MedgenMAT1A
Genetic Testing Registry MAT1A
NextProtQ00266 [Medical]
TSGene4143
GENETestsMAT1A
Target ValidationMAT1A
Huge Navigator MAT1A [HugePedia]
snp3D : Map Gene to Disease4143
BioCentury BCIQMAT1A
ClinGenMAT1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4143
Chemical/Pharm GKB GenePA30646
Clinical trialMAT1A
Miscellaneous
canSAR (ICR)MAT1A (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAT1A
EVEXMAT1A
GoPubMedMAT1A
iHOPMAT1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:19:07 CET 2018

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