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MAT2A (methionine adenosyltransferase 2A)

Identity

Alias_namesmethionine adenosyltransferase II
Alias_symbol (synonym)SAMS2
MATA2
MATII
Other alias
HGNC (Hugo) MAT2A
LocusID (NCBI) 4144
Atlas_Id 43637
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 85538978 and ends at 85545280 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTSL4 (1q21.3) / MAT2A (2p11.2)MAT2A (2p11.2) / CNOT7 (8p22)MAT2A (2p11.2) / CNTN2 (1q32.1)
MAT2A (2p11.2) / CYP19A1 (15q21.2)MAT2A (2p11.2) / GSS (20q11.22)MAT2A (2p11.2) / UBE2O (17q25.1)
PARP15 (3q21.1) / MAT2A (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAT2A   6904
Cards
Entrez_Gene (NCBI)MAT2A  4144  methionine adenosyltransferase 2A
AliasesMATA2; MATII; SAMS2
GeneCards (Weizmann)MAT2A
Ensembl hg19 (Hinxton)ENSG00000168906 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168906 [Gene_View]  ENSG00000168906 [Sequence]  chr2:85538978-85545280 [Contig_View]  MAT2A [Vega]
ICGC DataPortalENSG00000168906
TCGA cBioPortalMAT2A
AceView (NCBI)MAT2A
Genatlas (Paris)MAT2A
WikiGenes4144
SOURCE (Princeton)MAT2A
Genetics Home Reference (NIH)MAT2A
Genomic and cartography
GoldenPath hg38 (UCSC)MAT2A  -     chr2:85538978-85545280 +  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAT2A  -     2p11.2   [Description]    (hg19-Feb_2009)
EnsemblMAT2A - 2p11.2 [CytoView hg19]  MAT2A - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBIMAT2A [Mapview hg19]  MAT2A [Mapview hg38]
OMIM601468   
Gene and transcription
Genbank (Entrez)AK291126 AK293841 AK294208 AK297758 AK297797
RefSeq transcript (Entrez)NM_005911
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAT2A
Cluster EST : UnigeneHs.516157 [ NCBI ]
CGAP (NCI)Hs.516157
Alternative Splicing GalleryENSG00000168906
Gene ExpressionMAT2A [ NCBI-GEO ]   MAT2A [ EBI - ARRAY_EXPRESS ]   MAT2A [ SEEK ]   MAT2A [ MEM ]
Gene Expression Viewer (FireBrowse)MAT2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4144
GTEX Portal (Tissue expression)MAT2A
Human Protein AtlasENSG00000168906-MAT2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31153   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31153  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31153
Splice isoforms : SwissVarP31153
PhosPhoSitePlusP31153
Domaine pattern : Prosite (Expaxy)ADOMET_SYNTHASE_1 (PS00376)    ADOMET_SYNTHASE_2 (PS00377)   
Domains : Interpro (EBI)ADOMET_SYNTHASE_CS    S-AdoMet_synt_C    S-AdoMet_synt_central    S-AdoMet_synt_N    S-AdoMet_synthetase    S-AdoMet_synthetase_sfam   
Domain families : Pfam (Sanger)S-AdoMet_synt_C (PF02773)    S-AdoMet_synt_M (PF02772)    S-AdoMet_synt_N (PF00438)   
Domain families : Pfam (NCBI)pfam02773    pfam02772    pfam00438   
Conserved Domain (NCBI)MAT2A
DMDM Disease mutations4144
Blocks (Seattle)MAT2A
PDB (SRS)2P02    4KTT    4KTV    4NDN    5A19    5A1G    5A1I   
PDB (PDBSum)2P02    4KTT    4KTV    4NDN    5A19    5A1G    5A1I   
PDB (IMB)2P02    4KTT    4KTV    4NDN    5A19    5A1G    5A1I   
PDB (RSDB)2P02    4KTT    4KTV    4NDN    5A19    5A1G    5A1I   
Structural Biology KnowledgeBase2P02    4KTT    4KTV    4NDN    5A19    5A1G    5A1I   
SCOP (Structural Classification of Proteins)2P02    4KTT    4KTV    4NDN    5A19    5A1G    5A1I   
CATH (Classification of proteins structures)2P02    4KTT    4KTV    4NDN    5A19    5A1G    5A1I   
SuperfamilyP31153
Human Protein Atlas [tissue]ENSG00000168906-MAT2A [tissue]
Peptide AtlasP31153
HPRD03275
IPIIPI00010157   IPI00909877   IPI00909932   IPI00916229   
Protein Interaction databases
DIP (DOE-UCLA)P31153
IntAct (EBI)P31153
FunCoupENSG00000168906
BioGRIDMAT2A
STRING (EMBL)MAT2A
ZODIACMAT2A
Ontologies - Pathways
QuickGOP31153
Ontology : AmiGOmethionine adenosyltransferase activity  protein binding  ATP binding  cytosol  cytosol  S-adenosylmethionine biosynthetic process  S-adenosylmethionine biosynthetic process  one-carbon metabolic process  methylation  protein hexamerization  identical protein binding  metal ion binding  methionine adenosyltransferase complex  protein heterooligomerization  cellular response to leukemia inhibitory factor  
Ontology : EGO-EBImethionine adenosyltransferase activity  protein binding  ATP binding  cytosol  cytosol  S-adenosylmethionine biosynthetic process  S-adenosylmethionine biosynthetic process  one-carbon metabolic process  methylation  protein hexamerization  identical protein binding  metal ion binding  methionine adenosyltransferase complex  protein heterooligomerization  cellular response to leukemia inhibitory factor  
Pathways : KEGGSelenoamino acid metabolism    Methionine metabolism   
NDEx NetworkMAT2A
Atlas of Cancer Signalling NetworkMAT2A
Wikipedia pathwaysMAT2A
Orthology - Evolution
OrthoDB4144
GeneTree (enSembl)ENSG00000168906
Phylogenetic Trees/Animal Genes : TreeFamMAT2A
HOVERGENP31153
HOGENOMP31153
Homologs : HomoloGeneMAT2A
Homology/Alignments : Family Browser (UCSC)MAT2A
Gene fusions - Rearrangements
Fusion : QuiverMAT2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAT2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAT2A
dbVarMAT2A
ClinVarMAT2A
1000_GenomesMAT2A 
Exome Variant ServerMAT2A
ExAC (Exome Aggregation Consortium)ENSG00000168906
GNOMAD BrowserENSG00000168906
Genetic variants : HAPMAP4144
Genomic Variants (DGV)MAT2A [DGVbeta]
DECIPHERMAT2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAT2A 
Mutations
ICGC Data PortalMAT2A 
TCGA Data PortalMAT2A 
Broad Tumor PortalMAT2A
OASIS PortalMAT2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAT2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAT2A
intOGen PortalMAT2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAT2A
DgiDB (Drug Gene Interaction Database)MAT2A
DoCM (Curated mutations)MAT2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAT2A (select a term)
intoGenMAT2A
Cancer3DMAT2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601468   
Orphanet
DisGeNETMAT2A
MedgenMAT2A
Genetic Testing Registry MAT2A
NextProtP31153 [Medical]
TSGene4144
GENETestsMAT2A
Target ValidationMAT2A
Huge Navigator MAT2A [HugePedia]
snp3D : Map Gene to Disease4144
BioCentury BCIQMAT2A
ClinGenMAT2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4144
Chemical/Pharm GKB GenePA30647
Clinical trialMAT2A
Miscellaneous
canSAR (ICR)MAT2A (select the gene name)
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAT2A
EVEXMAT2A
GoPubMedMAT2A
iHOPMAT2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:35:08 CEST 2018

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