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MAT2B (methionine adenosyltransferase 2B)

Identity

Alias_namesmember 1
Alias_symbol (synonym)MATIIbeta
SDR23E1
Other aliasMAT-II
Nbla02999
TGR
HGNC (Hugo) MAT2B
LocusID (NCBI) 27430
Atlas_Id 50028
Location 5q34  [Link to chromosome band 5q34]
Location_base_pair Starts at 163505528 and ends at 163519353 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MAT2B (5q34) / HMMR (5q34)S100A13 (1q21.3) / MAT2B (5q34)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAT2B   6905
Cards
Entrez_Gene (NCBI)MAT2B  27430  methionine adenosyltransferase 2B
AliasesMAT-II; MATIIbeta; Nbla02999; SDR23E1; 
TGR
GeneCards (Weizmann)MAT2B
Ensembl hg19 (Hinxton)ENSG00000038274 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000038274 [Gene_View]  chr5:163505528-163519353 [Contig_View]  MAT2B [Vega]
ICGC DataPortalENSG00000038274
TCGA cBioPortalMAT2B
AceView (NCBI)MAT2B
Genatlas (Paris)MAT2B
WikiGenes27430
SOURCE (Princeton)MAT2B
Genetics Home Reference (NIH)MAT2B
Genomic and cartography
GoldenPath hg38 (UCSC)MAT2B  -     chr5:163505528-163519353 +  5q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAT2B  -     5q34   [Description]    (hg19-Feb_2009)
EnsemblMAT2B - 5q34 [CytoView hg19]  MAT2B - 5q34 [CytoView hg38]
Mapping of homologs : NCBIMAT2B [Mapview hg19]  MAT2B [Mapview hg38]
OMIM605527   
Gene and transcription
Genbank (Entrez)AB073390 AF113225 AF182814 AJ243721 AK096178
RefSeq transcript (Entrez)NM_013283 NM_182796
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAT2B
Cluster EST : UnigeneHs.54642 [ NCBI ]
CGAP (NCI)Hs.54642
Alternative Splicing GalleryENSG00000038274
Gene ExpressionMAT2B [ NCBI-GEO ]   MAT2B [ EBI - ARRAY_EXPRESS ]   MAT2B [ SEEK ]   MAT2B [ MEM ]
Gene Expression Viewer (FireBrowse)MAT2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27430
GTEX Portal (Tissue expression)MAT2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZL9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZL9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZL9
Splice isoforms : SwissVarQ9NZL9
PhosPhoSitePlusQ9NZL9
Domains : Interpro (EBI)dTDP_dehydrorham_reduct    NAD(P)-bd_dom    RmlD-like-bd   
Domain families : Pfam (Sanger)RmlD_sub_bind (PF04321)   
Domain families : Pfam (NCBI)pfam04321   
Conserved Domain (NCBI)MAT2B
DMDM Disease mutations27430
Blocks (Seattle)MAT2B
PDB (SRS)2YDX    2YDY    4KTT    4KTV    4NDN   
PDB (PDBSum)2YDX    2YDY    4KTT    4KTV    4NDN   
PDB (IMB)2YDX    2YDY    4KTT    4KTV    4NDN   
PDB (RSDB)2YDX    2YDY    4KTT    4KTV    4NDN   
Structural Biology KnowledgeBase2YDX    2YDY    4KTT    4KTV    4NDN   
SCOP (Structural Classification of Proteins)2YDX    2YDY    4KTT    4KTV    4NDN   
CATH (Classification of proteins structures)2YDX    2YDY    4KTT    4KTV    4NDN   
SuperfamilyQ9NZL9
Human Protein AtlasENSG00000038274
Peptide AtlasQ9NZL9
HPRD05701
IPIIPI00002324   IPI00181717   IPI00845294   IPI00845510   IPI00845444   IPI00921893   IPI00981635   IPI00973068   IPI00974257   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZL9
IntAct (EBI)Q9NZL9
FunCoupENSG00000038274
BioGRIDMAT2B
STRING (EMBL)MAT2B
ZODIACMAT2B
Ontologies - Pathways
QuickGOQ9NZL9
Ontology : AmiGOprotein binding  intracellular  nucleus  mitochondrion  cytosol  S-adenosylmethionine biosynthetic process  S-adenosylmethionine biosynthetic process  one-carbon metabolic process  enzyme binding  methylation  methionine adenosyltransferase complex  methionine adenosyltransferase regulator activity  regulation of catalytic activity  extracellular exosome  
Ontology : EGO-EBIprotein binding  intracellular  nucleus  mitochondrion  cytosol  S-adenosylmethionine biosynthetic process  S-adenosylmethionine biosynthetic process  one-carbon metabolic process  enzyme binding  methylation  methionine adenosyltransferase complex  methionine adenosyltransferase regulator activity  regulation of catalytic activity  extracellular exosome  
Pathways : KEGGCysteine and methionine metabolism   
NDEx NetworkMAT2B
Atlas of Cancer Signalling NetworkMAT2B
Wikipedia pathwaysMAT2B
Orthology - Evolution
OrthoDB27430
GeneTree (enSembl)ENSG00000038274
Phylogenetic Trees/Animal Genes : TreeFamMAT2B
HOVERGENQ9NZL9
HOGENOMQ9NZL9
Homologs : HomoloGeneMAT2B
Homology/Alignments : Family Browser (UCSC)MAT2B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAT2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAT2B
dbVarMAT2B
ClinVarMAT2B
1000_GenomesMAT2B 
Exome Variant ServerMAT2B
ExAC (Exome Aggregation Consortium)MAT2B (select the gene name)
Genetic variants : HAPMAP27430
Genomic Variants (DGV)MAT2B [DGVbeta]
DECIPHERMAT2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAT2B 
Mutations
ICGC Data PortalMAT2B 
TCGA Data PortalMAT2B 
Broad Tumor PortalMAT2B
OASIS PortalMAT2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAT2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAT2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MAT2B
DgiDB (Drug Gene Interaction Database)MAT2B
DoCM (Curated mutations)MAT2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAT2B (select a term)
intoGenMAT2B
Cancer3DMAT2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605527   
Orphanet
MedgenMAT2B
Genetic Testing Registry MAT2B
NextProtQ9NZL9 [Medical]
TSGene27430
GENETestsMAT2B
Target ValidationMAT2B
Huge Navigator MAT2B [HugePedia]
snp3D : Map Gene to Disease27430
BioCentury BCIQMAT2B
ClinGenMAT2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27430
Chemical/Pharm GKB GenePA30648
Clinical trialMAT2B
Miscellaneous
canSAR (ICR)MAT2B (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAT2B
EVEXMAT2B
GoPubMedMAT2B
iHOPMAT2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:42:25 CEST 2017

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