MATK (megakaryocyte-associated tyrosine kinase)

Identity

Other names	CHK
	CTK
	DKFZp434N1212
	HHYLTK
	HYL
	HYLTK
	Lsk
	MGC1708
	MGC2101
HGNC	MATK
Location	19p13.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	MATK   6906
Entrez_Gene	MATK  4145  megakaryocyte-associated tyrosine kinase
	Cards
GeneCards	MATK
Ensembl	MATK [Search_View]   ENSG00000007264 [Gene_View]
Genatlas	MATK
GeneLynx	MATK
eGenome	MATK
euGene	4145
	Genomic and cartography
GoldenPath	MATK  -  19p13.3   chr19:3728967-3752810 -  19p13.3   [Description]    (hg18-March_2006)
Ensembl	MATK - 19p13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MATK
	Gene and transcription
Genbank	AK055395 [ ENTREZ ]
Genbank	AK225834 [ ENTREZ ]
Genbank	AK315646 [ ENTREZ ]
Genbank	AL137754 [ ENTREZ ]
Genbank	BC000114 [ ENTREZ ]
RefSeq	NM_002378 [ SRS ]    NM_002378 [ ENTREZ ]
RefSeq	NM_139354 [ SRS ]    NM_139354 [ ENTREZ ]
RefSeq	NM_139355 [ SRS ]    NM_139355 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	AC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NT_011255 [ SRS ]    NT_011255 [ ENTREZ ]
RefSeq	NW_001838476 [ SRS ]    NW_001838476 [ ENTREZ ]
RefSeq	NW_927173 [ SRS ]    NW_927173 [ ENTREZ ]
AceView	MATK AceView - NCBI
Unigene	Hs.631845 [ SRS ]    Hs.631845 [ NCBI ]     HS631845 [ spliceNest ]
Fast-db	2281 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P42679 [ SRS]    P42679 [ EXPASY ]     P42679 [ INTERPRO ]     P42679 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Prosite	PS50001 SH2 [ SRS ]    PS50001 SH2 [ Expasy ]
Prosite	PS50002 SH3 [ SRS ]    PS50002 SH3 [ Expasy ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR000980 SH2 [ SRS ]    IPR000980 SH2 [ EBI ]
Interpro	IPR001452 SH3 [ SRS ]    IPR001452 SH3 [ EBI ]
Interpro	IPR015773 Tyr_kinase_megakaryocyte-assoc [ SRS ]    IPR015773 Tyr_kinase_megakaryocyte-assoc [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
CluSTr	P42679
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Pfam	PF00017 SH2 [ SRS ]    PF00017 SH2 [ Sanger ]    pfam00017 [ NCBI-CDD ]
Pfam	PF00018 SH3_1 [ SRS ]    PF00018 SH3_1 [ Sanger ]    pfam00018 [ NCBI-CDD ]
Smart	SM00252 SH2 [EMBL]
Smart	SM00326 SH3 [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P42679 MATK_HUMAN [ Domain structure ]   P42679 MATK_HUMAN  [ sequences sharing at least 1 domain ]
Prodom	PD000001[INRA-Toulouse]
Prodom	P42679 MATK_HUMAN [ Domain structure ]   P42679 MATK_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P42679
PDB	1JWO [ SRS ]    1JWO [ PdbSum ],   1JWO [ IMB ]   1JWO [ RSDB ]
PDB	1X6G [ SRS ]    1X6G [ PdbSum ],   1X6G [ IMB ]   1X6G [ RSDB ]
HPRD	02496
	Protein Interaction databases
DIP	P42679
IntAct	P42679
	Polymorphism : SNP, mutations, diseases
OMIM	600038    [ map ]
GENECLINICS	600038
SNP	MATK [dbSNP-NCBI]
SNP	NM_002378 [SNP-NCI]
SNP	NM_139354 [SNP-NCI]
SNP	NM_139355 [SNP-NCI]
SNP	MATK [GeneSNPs - Utah]  MATK] [HGBASE - SRS]
HAPMAP	MATK [HAPMAP]
COSMIC	MATK [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	MATK
	General knowledge
Family Browser	MATK [UCSC Family Browser]
SOURCE	NM_002378
SOURCE	NM_139354
SOURCE	NM_139355
SMD	Hs.631845
SAGE	Hs.631845
Enzyme	2.7.10.2 [ Enzyme-Expasy ]   2.7.10.2 [ Enzyme-SRS ]   2.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   2.7.10.2 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	protein tyrosine kinase activity [Amigo]  protein tyrosine kinase activity
GO	non-membrane spanning protein tyrosine kinase activity [Amigo]  non-membrane spanning protein tyrosine kinase activity
GO	protein binding [Amigo]  protein binding
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	mesoderm development [Amigo]  mesoderm development
GO	positive regulation of cell proliferation [Amigo]  positive regulation of cell proliferation
GO	transferase activity [Amigo]  transferase activity
KEGG	Regulation of actin cytoskeleton
KEGG	Epithelial cell signaling in Helicobacter pylori infection
PubGene	MATK
TreeFam	MATK
CTD	4145 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MATK Related clones (RZPD - Berlin)
	PubMed
PubMed	35 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:19:36 2008