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MATK (megakaryocyte-associated tyrosine kinase)

Identity

Alias_symbol (synonym)HYLTK
CTK
HYL
Lsk
CHK
HHYLTK
DKFZp434N1212
MGC1708
MGC2101
Other alias
HGNC (Hugo) MATK
LocusID (NCBI) 4145
Atlas_Id 41305
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 3777967 and ends at 3801810 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PIP5K1C (19p13.3) / MATK (19p13.3)PIP5K1C 19p13.3 / MATK 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MATK   6906
Cards
Entrez_Gene (NCBI)MATK  4145  megakaryocyte-associated tyrosine kinase
AliasesCHK; CTK; HHYLTK; HYL; 
HYLTK; Lsk
GeneCards (Weizmann)MATK
Ensembl hg19 (Hinxton)ENSG00000007264 [Gene_View]  chr19:3777967-3801810 [Contig_View]  MATK [Vega]
Ensembl hg38 (Hinxton)ENSG00000007264 [Gene_View]  chr19:3777967-3801810 [Contig_View]  MATK [Vega]
ICGC DataPortalENSG00000007264
TCGA cBioPortalMATK
AceView (NCBI)MATK
Genatlas (Paris)MATK
WikiGenes4145
SOURCE (Princeton)MATK
Genetics Home Reference (NIH)MATK
Genomic and cartography
GoldenPath hg19 (UCSC)MATK  -     chr19:3777967-3801810 -  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MATK  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblMATK - 19p13.3 [CytoView hg19]  MATK - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIMATK [Mapview hg19]  MATK [Mapview hg38]
OMIM600038   
Gene and transcription
Genbank (Entrez)AB593100 AK055395 AK225834 AK315646 AL137754
RefSeq transcript (Entrez)NM_002378 NM_139354 NM_139355
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)MATK
Cluster EST : UnigeneHs.631845 [ NCBI ]
CGAP (NCI)Hs.631845
Alternative Splicing GalleryENSG00000007264
Gene ExpressionMATK [ NCBI-GEO ]   MATK [ EBI - ARRAY_EXPRESS ]   MATK [ SEEK ]   MATK [ MEM ]
Gene Expression Viewer (FireBrowse)MATK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4145
GTEX Portal (Tissue expression)MATK
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42679   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42679  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42679
Splice isoforms : SwissVarP42679
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
PhosPhoSitePlusP42679
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)MATK
DMDM Disease mutations4145
Blocks (Seattle)MATK
PDB (SRS)1JWO    1X6G    3US4   
PDB (PDBSum)1JWO    1X6G    3US4   
PDB (IMB)1JWO    1X6G    3US4   
PDB (RSDB)1JWO    1X6G    3US4   
Structural Biology KnowledgeBase1JWO    1X6G    3US4   
SCOP (Structural Classification of Proteins)1JWO    1X6G    3US4   
CATH (Classification of proteins structures)1JWO    1X6G    3US4   
SuperfamilyP42679
Human Protein AtlasENSG00000007264
Peptide AtlasP42679
HPRD02496
IPIIPI00000868   IPI00477563   IPI00160403   
Protein Interaction databases
DIP (DOE-UCLA)P42679
IntAct (EBI)P42679
FunCoupENSG00000007264
BioGRIDMATK
STRING (EMBL)MATK
ZODIACMATK
Ontologies - Pathways
QuickGOP42679
Ontology : AmiGOprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  cytosol  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  mesoderm development  cell proliferation  positive regulation of cell proliferation  cell migration  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  peptidyl-tyrosine autophosphorylation  ERBB2 signaling pathway  innate immune response  
Ontology : EGO-EBIprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  cytosol  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  mesoderm development  cell proliferation  positive regulation of cell proliferation  cell migration  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  peptidyl-tyrosine autophosphorylation  ERBB2 signaling pathway  innate immune response  
Pathways : KEGGNeurotrophin signaling pathway   
NDEx NetworkMATK
Atlas of Cancer Signalling NetworkMATK
Wikipedia pathwaysMATK
Orthology - Evolution
OrthoDB4145
GeneTree (enSembl)ENSG00000007264
Phylogenetic Trees/Animal Genes : TreeFamMATK
HOVERGENP42679
HOGENOMP42679
Homologs : HomoloGeneMATK
Homology/Alignments : Family Browser (UCSC)MATK
Gene fusions - Rearrangements
Fusion : MitelmanPIP5K1C/MATK [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGAPIP5K1C 19p13.3 MATK 19p13.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMATK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MATK
dbVarMATK
ClinVarMATK
1000_GenomesMATK 
Exome Variant ServerMATK
ExAC (Exome Aggregation Consortium)MATK (select the gene name)
Genetic variants : HAPMAP4145
Genomic Variants (DGV)MATK [DGVbeta]
DECIPHER (Syndromes)19:3777967-3801810  ENSG00000007264
CONAN: Copy Number AnalysisMATK 
Mutations
ICGC Data PortalMATK 
TCGA Data PortalMATK 
Broad Tumor PortalMATK
OASIS PortalMATK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMATK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMATK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MATK
DgiDB (Drug Gene Interaction Database)MATK
DoCM (Curated mutations)MATK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MATK (select a term)
intoGenMATK
Cancer3DMATK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600038   
Orphanet
MedgenMATK
Genetic Testing Registry MATK
NextProtP42679 [Medical]
TSGene4145
GENETestsMATK
Huge Navigator MATK [HugePedia]
snp3D : Map Gene to Disease4145
BioCentury BCIQMATK
ClinGenMATK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4145
Chemical/Pharm GKB GenePA30649
Clinical trialMATK
Miscellaneous
canSAR (ICR)MATK (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMATK
EVEXMATK
GoPubMedMATK
iHOPMATK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:08:40 CEST 2017

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