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MAVS (mitochondrial antiviral signaling protein)

Identity

Alias_symbol (synonym)VISA
KIAA1271
IPS-1
Cardif
Other aliasCARDIF
IPS1
HGNC (Hugo) MAVS
LocusID (NCBI) 57506
Atlas_Id 50844
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 3846799 and ends at 3876123 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AP5S1 (20p13) / MAVS (20p13)HDLBP (2q37.3) / MAVS (20p13)MAVS (20p13) / ACBD3 (1q42.12)
MAVS (20p13) / CFI (4q25)PANK2 (20p13) / MAVS (20p13)TRIM56 (7q22.1) / MAVS (20p13)
VAT1 (17q21.31) / MAVS (20p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAVS   29233
Cards
Entrez_Gene (NCBI)MAVS  57506  mitochondrial antiviral signaling protein
AliasesCARDIF; IPS-1; IPS1; VISA
GeneCards (Weizmann)MAVS
Ensembl hg19 (Hinxton)ENSG00000088888 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088888 [Gene_View]  chr20:3846799-3876123 [Contig_View]  MAVS [Vega]
ICGC DataPortalENSG00000088888
TCGA cBioPortalMAVS
AceView (NCBI)MAVS
Genatlas (Paris)MAVS
WikiGenes57506
SOURCE (Princeton)MAVS
Genetics Home Reference (NIH)MAVS
Genomic and cartography
GoldenPath hg38 (UCSC)MAVS  -     chr20:3846799-3876123 +  20p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAVS  -     20p13   [Description]    (hg19-Feb_2009)
EnsemblMAVS - 20p13 [CytoView hg19]  MAVS - 20p13 [CytoView hg38]
Mapping of homologs : NCBIMAVS [Mapview hg19]  MAVS [Mapview hg38]
OMIM609676   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001206491 NM_020746
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAVS
Cluster EST : UnigeneHs.570362 [ NCBI ]
CGAP (NCI)Hs.570362
Alternative Splicing GalleryENSG00000088888
Gene ExpressionMAVS [ NCBI-GEO ]   MAVS [ EBI - ARRAY_EXPRESS ]   MAVS [ SEEK ]   MAVS [ MEM ]
Gene Expression Viewer (FireBrowse)MAVS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57506
GTEX Portal (Tissue expression)MAVS
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z434   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z434  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z434
Splice isoforms : SwissVarQ7Z434
PhosPhoSitePlusQ7Z434
Domains : Interpro (EBI)CARD_dom    Mt_antiviral_sig_pro   
Domain families : Pfam (Sanger)CARD_2 (PF16739)   
Domain families : Pfam (NCBI)pfam16739   
Conserved Domain (NCBI)MAVS
DMDM Disease mutations57506
Blocks (Seattle)MAVS
PDB (SRS)2MS7    2MS8    2VGQ    3J6C    3J6J    3RC5    4P4H    4Z8M    5JEK   
PDB (PDBSum)2MS7    2MS8    2VGQ    3J6C    3J6J    3RC5    4P4H    4Z8M    5JEK   
PDB (IMB)2MS7    2MS8    2VGQ    3J6C    3J6J    3RC5    4P4H    4Z8M    5JEK   
PDB (RSDB)2MS7    2MS8    2VGQ    3J6C    3J6J    3RC5    4P4H    4Z8M    5JEK   
Structural Biology KnowledgeBase2MS7    2MS8    2VGQ    3J6C    3J6J    3RC5    4P4H    4Z8M    5JEK   
SCOP (Structural Classification of Proteins)2MS7    2MS8    2VGQ    3J6C    3J6J    3RC5    4P4H    4Z8M    5JEK   
CATH (Classification of proteins structures)2MS7    2MS8    2VGQ    3J6C    3J6J    3RC5    4P4H    4Z8M    5JEK   
SuperfamilyQ7Z434
Human Protein AtlasENSG00000088888
Peptide AtlasQ7Z434
HPRD13847
IPIIPI00020719   IPI00411576   IPI00411577   IPI00893017   IPI00893406   IPI01012141   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z434
IntAct (EBI)Q7Z434
FunCoupENSG00000088888
BioGRIDMAVS
STRING (EMBL)MAVS
ZODIACMAVS
Ontologies - Pathways
QuickGOQ7Z434
Ontology : AmiGOpositive regulation of protein phosphorylation  activation of innate immune response  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  signal transducer activity  protein binding  mitochondrion  mitochondrial outer membrane  mitochondrial outer membrane  peroxisomal membrane  signal transduction  integral component of membrane  protein deubiquitination  protein kinase binding  mitochondrial membrane  negative regulation of type I interferon production  positive regulation of interferon-alpha production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of protein import into nucleus, translocation  RIG-I signaling pathway  defense response to bacterium  positive regulation of transcription factor import into nucleus  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of viral genome replication  innate immune response  innate immune response  positive regulation of transcription from RNA polymerase II promoter  CARD domain binding  positive regulation of sequence-specific DNA binding transcription factor activity  defense response to virus  positive regulation of type I interferon-mediated signaling pathway  cellular response to exogenous dsRNA  positive regulation of chemokine (C-C motif) ligand 5 production  positive regulation of IP-10 production  regulation of peroxisome organization  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  activation of innate immune response  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  signal transducer activity  protein binding  mitochondrion  mitochondrial outer membrane  mitochondrial outer membrane  peroxisomal membrane  signal transduction  integral component of membrane  protein deubiquitination  protein kinase binding  mitochondrial membrane  negative regulation of type I interferon production  positive regulation of interferon-alpha production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  positive regulation of protein import into nucleus, translocation  RIG-I signaling pathway  defense response to bacterium  positive regulation of transcription factor import into nucleus  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of viral genome replication  innate immune response  innate immune response  positive regulation of transcription from RNA polymerase II promoter  CARD domain binding  positive regulation of sequence-specific DNA binding transcription factor activity  defense response to virus  positive regulation of type I interferon-mediated signaling pathway  cellular response to exogenous dsRNA  positive regulation of chemokine (C-C motif) ligand 5 production  positive regulation of IP-10 production  regulation of peroxisome organization  
Pathways : KEGGRIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection   
NDEx NetworkMAVS
Atlas of Cancer Signalling NetworkMAVS
Wikipedia pathwaysMAVS
Orthology - Evolution
OrthoDB57506
GeneTree (enSembl)ENSG00000088888
Phylogenetic Trees/Animal Genes : TreeFamMAVS
HOVERGENQ7Z434
HOGENOMQ7Z434
Homologs : HomoloGeneMAVS
Homology/Alignments : Family Browser (UCSC)MAVS
Gene fusions - Rearrangements
Fusion Cancer (Beijing)MAVS [20p13]  -  CFI [4q25]  [FUSC001956]  [FUSC001956]  [FUSC001956]  [FUSC001956]  [FUSC001956]  [FUSC001956]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAVS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAVS
dbVarMAVS
ClinVarMAVS
1000_GenomesMAVS 
Exome Variant ServerMAVS
ExAC (Exome Aggregation Consortium)MAVS (select the gene name)
Genetic variants : HAPMAP57506
Genomic Variants (DGV)MAVS [DGVbeta]
DECIPHERMAVS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAVS 
Mutations
ICGC Data PortalMAVS 
TCGA Data PortalMAVS 
Broad Tumor PortalMAVS
OASIS PortalMAVS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAVS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAVS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAVS
DgiDB (Drug Gene Interaction Database)MAVS
DoCM (Curated mutations)MAVS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAVS (select a term)
intoGenMAVS
Cancer3DMAVS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609676   
Orphanet
MedgenMAVS
Genetic Testing Registry MAVS
NextProtQ7Z434 [Medical]
TSGene57506
GENETestsMAVS
Target ValidationMAVS
Huge Navigator MAVS [HugePedia]
snp3D : Map Gene to Disease57506
BioCentury BCIQMAVS
ClinGenMAVS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57506
Chemical/Pharm GKB GenePA164722208
Clinical trialMAVS
Miscellaneous
canSAR (ICR)MAVS (select the gene name)
Probes
Litterature
PubMed184 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAVS
EVEXMAVS
GoPubMedMAVS
iHOPMAVS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:17:24 CEST 2017

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