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MAX (MYC associated factor X)

Identity

Other namesbHLHd4
HGNC (Hugo) MAX
LocusID (NCBI) 4149
Location 14q23.3
Location_base_pair Starts at 65550457 and ends at 65569262 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615 11q23ID1030 11q23secondLeukID1131 t1119ELLID1029 t0812q24q22ID2057

External links

Nomenclature
HGNC (Hugo)MAX   6913
Cards
Entrez_Gene (NCBI)MAX  4149  MYC associated factor X
GeneCards (Weizmann)MAX
Ensembl (Hinxton)ENSG00000125952 [Gene_View]  chr14:65550457-65569262 [Contig_View]  MAX [Vega]
ICGC DataPortalENSG00000125952
AceView (NCBI)MAX
Genatlas (Paris)MAX
WikiGenes4149
SOURCE (Princeton)NM_001271068 NM_001271069 NM_002382 NM_145112 NM_145113 NM_145114 NM_145116 NM_197957
Genomic and cartography
GoldenPath (UCSC)MAX  -  14q23.3   chr14:65550457-65569262 -  14q23.3   [Description]    (hg19-Feb_2009)
EnsemblMAX - 14q23.3 [CytoView]
Mapping of homologs : NCBIMAX [Mapview]
OMIM154950   171300   
Gene and transcription
Genbank (Entrez)AI652319 AI655674 AI769390 AI917842 AI954328
RefSeq transcript (Entrez)NM_001271068 NM_001271069 NM_002382 NM_145112 NM_145113 NM_145114 NM_145116 NM_197957
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NG_029830 NT_026437 NW_001838111 NW_004929393
Consensus coding sequences : CCDS (NCBI)MAX
Cluster EST : UnigeneHs.285354 [ NCBI ]
CGAP (NCI)Hs.285354
Alternative Splicing : Fast-db (Paris)GSHG0009428
Alternative Splicing GalleryENSG00000125952
Gene ExpressionMAX [ NCBI-GEO ]     MAX [ SEEK ]   MAX [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61244 (Uniprot)
NextProtP61244  [Medical]
With graphics : InterProP61244
Splice isoforms : SwissVarP61244 (Swissvar)
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom   
Related proteins : CluSTrP61244
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
DMDM Disease mutations4149
Blocks (Seattle)P61244
PDB (SRS)1AN2    1HLO    1NKP    1NLW    1R05   
PDB (PDBSum)1AN2    1HLO    1NKP    1NLW    1R05   
PDB (IMB)1AN2    1HLO    1NKP    1NLW    1R05   
PDB (RSDB)1AN2    1HLO    1NKP    1NLW    1R05   
Human Protein AtlasENSG00000125952
Peptide AtlasP61244
HPRD01113
IPIIPI00018214   IPI00219929   IPI00158128   IPI00910746   IPI01024818   IPI01026513   IPI01026141   IPI00978532   IPI01025079   IPI01024945   IPI01025539   IPI00377126   IPI00157813   IPI00060723   
Protein Interaction databases
DIP (DOE-UCLA)P61244
IntAct (EBI)P61244
FunCoupENSG00000125952
BioGRIDMAX
IntegromeDBMAX
STRING (EMBL)MAX
Ontologies - Pathways
QuickGOP61244
Ontology : AmiGOsequence-specific DNA binding transcription factor activity  transcription cofactor activity  transcription coactivator activity  protein binding  nucleus  nucleolus  cytoplasm  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  protein complex assembly  cellular response to starvation  negative regulation of gene expression  PML body  dendrite  protein complex binding  response to insulin  protein homodimerization activity  sequence-specific DNA binding  protein heterodimerization activity  response to axon injury  neuron apoptotic process  retina development in camera-type eye  MLL1 complex  cellular response to peptide hormone stimulus  
Ontology : EGO-EBIsequence-specific DNA binding transcription factor activity  transcription cofactor activity  transcription coactivator activity  protein binding  nucleus  nucleolus  cytoplasm  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  protein complex assembly  cellular response to starvation  negative regulation of gene expression  PML body  dendrite  protein complex binding  response to insulin  protein homodimerization activity  sequence-specific DNA binding  protein heterodimerization activity  response to axon injury  neuron apoptotic process  retina development in camera-type eye  MLL1 complex  cellular response to peptide hormone stimulus  
Pathways : BIOCARTAp38 MAPK Signaling Pathway [Genes]    Overview of telomerase protein component gene hTert Transcriptional Regulation [Genes]    MAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Pathways in cancer    Transcriptional misregulation in cancer    Small cell lung cancer   
Protein Interaction DatabaseMAX
Wikipedia pathwaysMAX
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAX
SNP (GeneSNP Utah)MAX
SNP : HGBaseMAX
Genetic variants : HAPMAPMAX
1000_GenomesMAX 
ICGC programENSG00000125952 
Cancer Gene: CensusMAX 
CONAN: Copy Number AnalysisMAX 
Somatic Mutations in Cancer : COSMICMAX 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
DECIPHER (Syndromes)14:65550457-65569262
Mutations and Diseases : HGMDMAX
OMIM154950    171300   
MedgenMAX
GENETestsMAX
Disease Genetic AssociationMAX
Huge Navigator MAX [HugePedia]  MAX [HugeCancerGEM]
Genomic VariantsMAX  MAX [DGVbeta]
Exome VariantMAX
dbVarMAX
ClinVarMAX
snp3D : Map Gene to Disease4149
General knowledge
Homologs : HomoloGeneMAX
Homology/Alignments : Family Browser (UCSC)MAX
Phylogenetic Trees/Animal Genes : TreeFamMAX
Chemical/Protein Interactions : CTD4149
Chemical/Pharm GKB GenePA30656
Clinical trialMAX
Cancer Resource (Charite)ENSG00000125952
Other databases
Probes
Litterature
PubMed121 Pubmed reference(s) in Entrez
CoreMineMAX
GoPubMedMAX
iHOPMAX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:39:49 CET 2014

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.