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MAX (MYC associated factor X)

Identity

Other namesbHLHd4
HGNC (Hugo) MAX
LocusID (NCBI) 4149
Atlas_Id 215
Location 14q23.3
Location_base_pair Starts at 65550457 and ends at 65569262 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DNAJC15 (13q14.11) / MAX (14q23.3)EXTL2 (1p21.2) / MAX (14q23.3)MAX (14q23.3) / FGR (1p36.11)
MAX (14q23.3) / RUNX2 (6p21.1)MAX (14q23.3) / TEX10 (9q31.1)RUNX2 (6p21.1) / MAX (14q23.3)
MAX 14q23.3 / RUNX2 6p21.1MAX 14q23.3 / TEX10 9q31.1RUNX2 6p21.1 / MAX 14q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(2;8)(p15;q24) BCL11A/MYC
t(3;8)(q27;q24) BCL6/MYC
t(7;8)(p12;q24) /MYC
t(8;9)(q24;p13) ?/MYC
t(8;12)(q24;q22) BTG1/MYC

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and Neck: Paraganglioma: an overview
Kidney: Clear cell sarcoma with t(10;17)(q22;p13) YWHAE/NUTM2E

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hereditary paraganglioma (PGL)

External links

Nomenclature
HGNC (Hugo)MAX   6913
Cards
Entrez_Gene (NCBI)MAX  4149  MYC associated factor X
GeneCards (Weizmann)MAX
Ensembl hg19 (Hinxton)ENSG00000125952 [Gene_View]  chr14:65550457-65569262 [Contig_View]  MAX [Vega]
Ensembl hg38 (Hinxton)ENSG00000125952 [Gene_View]  chr14:65550457-65569262 [Contig_View]  MAX [Vega]
ICGC DataPortalENSG00000125952
TCGA cBioPortalMAX
AceView (NCBI)MAX
Genatlas (Paris)MAX
WikiGenes4149
SOURCE (Princeton)MAX
Genomic and cartography
GoldenPath hg19 (UCSC)MAX  -     chr14:65550457-65569262 -  14q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAX  -     14q23.3   [Description]    (hg38-Dec_2013)
EnsemblMAX - 14q23.3 [CytoView hg19]  MAX - 14q23.3 [CytoView hg38]
Mapping of homologs : NCBIMAX [Mapview hg19]  MAX [Mapview hg38]
OMIM154950   171300   
Gene and transcription
Genbank (Entrez)AI652319 AI655674 AI769390 AI917842 AI954328
RefSeq transcript (Entrez)NM_001271068 NM_001271069 NM_001320415 NM_002382 NM_145112 NM_145113 NM_145114 NM_145116 NM_197957
RefSeq genomic (Entrez)NC_000014 NC_018925 NG_029830 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)MAX
Cluster EST : UnigeneHs.285354 [ NCBI ]
CGAP (NCI)Hs.285354
Alternative Splicing : Fast-db (Paris)GSHG0009428
Alternative Splicing GalleryENSG00000125952
Gene ExpressionMAX [ NCBI-GEO ]   MAX [ EBI - ARRAY_EXPRESS ]   MAX [ SEEK ]   MAX [ MEM ]
Gene Expression Viewer (FireBrowse)MAX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4149
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61244 (Uniprot)
NextProtP61244  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61244
Splice isoforms : SwissVarP61244 (Swissvar)
PhosPhoSitePlusP61244
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
DMDM Disease mutations4149
Blocks (Seattle)MAX
PDB (SRS)1AN2    1HLO    1NKP    1NLW    1R05   
PDB (PDBSum)1AN2    1HLO    1NKP    1NLW    1R05   
PDB (IMB)1AN2    1HLO    1NKP    1NLW    1R05   
PDB (RSDB)1AN2    1HLO    1NKP    1NLW    1R05   
Structural Biology KnowledgeBase1AN2    1HLO    1NKP    1NLW    1R05   
SCOP (Structural Classification of Proteins)1AN2    1HLO    1NKP    1NLW    1R05   
CATH (Classification of proteins structures)1AN2    1HLO    1NKP    1NLW    1R05   
SuperfamilyP61244
Human Protein AtlasENSG00000125952
Peptide AtlasP61244
HPRD01113
IPIIPI00018214   IPI00219929   IPI00158128   IPI00910746   IPI01024818   IPI01026513   IPI01026141   IPI00978532   IPI01025079   IPI01024945   IPI01025539   IPI00377126   IPI00157813   IPI00060723   
Protein Interaction databases
DIP (DOE-UCLA)P61244
IntAct (EBI)P61244
FunCoupENSG00000125952
BioGRIDMAX
STRING (EMBL)MAX
ZODIACMAX
Ontologies - Pathways
QuickGOP61244
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter sequence-specific  transcription factor activity, sequence-specific DNA binding  transcription cofactor activity  transcription coactivator activity  protein binding  nucleus  nucleoplasm  cytoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  protein complex assembly  cellular response to starvation  negative regulation of gene expression  PML body  dendrite  protein complex binding  response to insulin  protein homodimerization activity  protein heterodimerization activity  response to axon injury  neuron apoptotic process  retina development in camera-type eye  MLL1 complex  cellular response to peptide hormone stimulus  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter sequence-specific  transcription factor activity, sequence-specific DNA binding  transcription cofactor activity  transcription coactivator activity  protein binding  nucleus  nucleoplasm  cytoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  protein complex assembly  cellular response to starvation  negative regulation of gene expression  PML body  dendrite  protein complex binding  response to insulin  protein homodimerization activity  protein heterodimerization activity  response to axon injury  neuron apoptotic process  retina development in camera-type eye  MLL1 complex  cellular response to peptide hormone stimulus  
Pathways : BIOCARTAp38 MAPK Signaling Pathway [Genes]    Overview of telomerase protein component gene hTert Transcriptional Regulation [Genes]    MAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Pathways in cancer    Transcriptional misregulation in cancer    Small cell lung cancer   
NDEx Network
Atlas of Cancer Signalling NetworkMAX
Wikipedia pathwaysMAX
Orthology - Evolution
OrthoDB4149
GeneTree (enSembl)ENSG00000125952
Phylogenetic Trees/Animal Genes : TreeFamMAX
Homologs : HomoloGeneMAX
Homology/Alignments : Family Browser (UCSC)MAX
Gene fusions - Rearrangements
Fusion: TCGAMAX 14q23.3 RUNX2 6p21.1 HNSC
Fusion: TCGAMAX 14q23.3 TEX10 9q31.1 LUAD
Fusion: TCGARUNX2 6p21.1 MAX 14q23.3 HNSC
Polymorphisms : SNP, variants
NCBI Variation ViewerMAX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAX
dbVarMAX
ClinVarMAX
1000_GenomesMAX 
Exome Variant ServerMAX
ExAC (Exome Aggregation Consortium)MAX (select the gene name)
SNP (GeneSNP Utah)MAX
SNP : HGBaseMAX
Genetic variants : HAPMAPMAX
Genomic Variants (DGV)MAX [DGVbeta]
Mutations
ICGC Data PortalMAX 
TCGA Data PortalMAX 
Broad Tumor PortalMAX
OASIS PortalMAX [ Somatic mutations - Copy number]
Cancer Gene: CensusMAX 
Somatic Mutations in Cancer : COSMICMAX 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch MAX
DgiDB (Drug Gene Interaction Database)MAX
DoCM (Curated mutations)MAX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAX (select a term)
intoGenMAX
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:65550457-65569262
CONAN: Copy Number AnalysisMAX 
Mutations and Diseases : HGMDMAX
OMIM154950    171300   
MedgenMAX
Genetic Testing Registry MAX
NextProtP61244 [Medical]
TSGene4149
GENETestsMAX
Huge Navigator MAX [HugePedia]  MAX [HugeCancerGEM]
snp3D : Map Gene to Disease4149
BioCentury BCIQMAX
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4149
Chemical/Pharm GKB GenePA30656
Clinical trialMAX
Miscellaneous
canSAR (ICR)MAX (select the gene name)
Probes
Litterature
PubMed147 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAX
GoPubMedMAX
iHOPMAX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:52:40 CEST 2016

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