MAX (MYC associated factor X)

2003-02-01  

Identity

HGNC
LOCATION
14q23.3
LOCUSID
ALIAS
bHLHd4
FUSION GENES

Other Information

Locus ID:

NCBI: 4149
MIM: 154950
HGNC: 6913
Ensembl: ENSG00000125952

Variants:

dbSNP: 4149
ClinVar: 4149
TCGA: ENSG00000125952
COSMIC: MAX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125952ENST00000246163P61244
ENSG00000125952ENST00000284165P61244
ENSG00000125952ENST00000341653P61244
ENSG00000125952ENST00000358402P61244
ENSG00000125952ENST00000358664P61244
ENSG00000125952ENST00000394606P61244
ENSG00000125952ENST00000394606A0A024R682
ENSG00000125952ENST00000553928P61244
ENSG00000125952ENST00000553928A0A024R682
ENSG00000125952ENST00000555419G3V5L1
ENSG00000125952ENST00000555667Q6V3B1
ENSG00000125952ENST00000555932G3V2N4
ENSG00000125952ENST00000556443G3V2R5
ENSG00000125952ENST00000556892G3V570
ENSG00000125952ENST00000556979P61244
ENSG00000125952ENST00000556979A0A024R682
ENSG00000125952ENST00000557277G3V302
ENSG00000125952ENST00000557746G3V563
ENSG00000125952ENST00000618858P61244
ENSG00000125952ENST00000618858A0A024R682
ENSG00000125952ENST00000651648A0A494C130

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Small cell lung cancerKEGGko05222
MAPK signaling pathwayKEGGhsa04010
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125539082003X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors.172
216859152011Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma.138
224529452012MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma.63
243622642014MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1.56
237070732013EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer.52
246577982015Small-molecule inhibitors of the Myc oncoprotein.47
216700792011Inhibition of miR-193a expression by Max and RXRα activates K-Ras and PLAU to mediate distinct aspects of cellular transformation.39
248577472015Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.38
202148782010Differentiation-associated miR-22 represses Max expression and inhibits cell cycle progression.34
283847942017Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention.31

Citation

Dessen P

MAX (MYC associated factor X)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/215/max