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MBD3 (methyl-CpG binding domain protein 3)

Identity

Alias (NCBI)-
HGNC (Hugo) MBD3
LocusID (NCBI) 53615
Atlas_Id 41310
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 1573596 and ends at 1592865 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IPO4 (14q12)::MBD3 (19p13.3)MALAT1 (11q13.1)::MBD3 (19p13.3)ULK2 (17p11.2)::MBD3 (19p13.3)
ULK2 17p11.2::MBD3 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MBD3   6918
Cards
Entrez_Gene (NCBI)MBD3    methyl-CpG binding domain protein 3
Aliases
GeneCards (Weizmann)MBD3
Ensembl hg19 (Hinxton)ENSG00000071655 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000071655 [Gene_View]  ENSG00000071655 [Sequence]  chr19:1573596-1592865 [Contig_View]  MBD3 [Vega]
ICGC DataPortalENSG00000071655
TCGA cBioPortalMBD3
AceView (NCBI)MBD3
Genatlas (Paris)MBD3
SOURCE (Princeton)MBD3
Genetics Home Reference (NIH)MBD3
Genomic and cartography
GoldenPath hg38 (UCSC)MBD3  -     chr19:1573596-1592865 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MBD3  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathMBD3 - 19p13.3 [CytoView hg19]  MBD3 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000071655
Genome Data Viewer NCBIMBD3 [Mapview hg19]  
OMIM603573   
Gene and transcription
Genbank (Entrez)AA576859 AF072247 AK001474 AK021532 AK092508
RefSeq transcript (Entrez)NM_001281453 NM_001281454 NM_003926
Consensus coding sequences : CCDS (NCBI)MBD3
Gene ExpressionMBD3 [ NCBI-GEO ]   MBD3 [ EBI - ARRAY_EXPRESS ]   MBD3 [ SEEK ]   MBD3 [ MEM ]
Gene Expression Viewer (FireBrowse)MBD3 [ Firebrowse - Broad ]
GenevisibleExpression of MBD3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53615
GTEX Portal (Tissue expression)MBD3
Human Protein AtlasENSG00000071655-MBD3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95983   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95983  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95983
PhosPhoSitePlusO95983
Domaine pattern : Prosite (Expaxy)MBD (PS50982)   
Domains : Interpro (EBI)DNA-bd_dom_sf    MBD2/MBD3_p55-bd    MBD3    MeCpG-bd_2/3_C_dom    Methyl_CpG_DNA-bd   
Domain families : Pfam (Sanger)MBD (PF01429)    MBD_C (PF14048)    MBDa (PF16564)   
Domain families : Pfam (NCBI)pfam01429    pfam14048    pfam16564   
Domain families : Smart (EMBL)MBD (SM00391)  
Conserved Domain (NCBI)MBD3
PDB (RSDB)2MB7    6CC8    6CCG    6CEU    6CEV   
PDB Europe2MB7    6CC8    6CCG    6CEU    6CEV   
PDB (PDBSum)2MB7    6CC8    6CCG    6CEU    6CEV   
PDB (IMB)2MB7    6CC8    6CCG    6CEU    6CEV   
Structural Biology KnowledgeBase2MB7    6CC8    6CCG    6CEU    6CEV   
SCOP (Structural Classification of Proteins)2MB7    6CC8    6CCG    6CEU    6CEV   
CATH (Classification of proteins structures)2MB7    6CC8    6CCG    6CEU    6CEV   
SuperfamilyO95983
AlphaFold pdb e-kbO95983   
Human Protein Atlas [tissue]ENSG00000071655-MBD3 [tissue]
HPRD04653
Protein Interaction databases
DIP (DOE-UCLA)O95983
IntAct (EBI)O95983
BioGRIDMBD3
STRING (EMBL)MBD3
ZODIACMBD3
Ontologies - Pathways
QuickGOO95983
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  heterochromatin  in utero embryonic development  DNA binding  protein binding  nucleoplasm  cytoplasm  chromatin remodeling  chromatin remodeling  DNA methylation-dependent heterochromatin assembly  brain development  heart development  aging  methyl-CpG binding  tissue development  histone acetylation  histone deacetylation  NuRD complex  nucleosomal DNA binding  response to nutrient levels  response to estradiol  protein-containing complex  regulation of DNA methylation  embryonic organ development  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  heterochromatin  in utero embryonic development  DNA binding  protein binding  nucleoplasm  cytoplasm  chromatin remodeling  chromatin remodeling  DNA methylation-dependent heterochromatin assembly  brain development  heart development  aging  methyl-CpG binding  tissue development  histone acetylation  histone deacetylation  NuRD complex  nucleosomal DNA binding  response to nutrient levels  response to estradiol  protein-containing complex  regulation of DNA methylation  embryonic organ development  
Pathways : BIOCARTABIOCARTA_MTA3PATHWAY   
NDEx NetworkMBD3
Atlas of Cancer Signalling NetworkMBD3
Wikipedia pathwaysMBD3
Orthology - Evolution
OrthoDB53615
GeneTree (enSembl)ENSG00000071655
Phylogenetic Trees/Animal Genes : TreeFamMBD3
Homologs : HomoloGeneMBD3
Homology/Alignments : Family Browser (UCSC)MBD3
Gene fusions - Rearrangements
Fusion : MitelmanULK2::MBD3 [17p11.2/19p13.3]  
Fusion : QuiverMBD3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMBD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MBD3
dbVarMBD3
ClinVarMBD3
MonarchMBD3
1000_GenomesMBD3 
Exome Variant ServerMBD3
GNOMAD BrowserENSG00000071655
Varsome BrowserMBD3
ACMGMBD3 variants
VarityO95983
Genomic Variants (DGV)MBD3 [DGVbeta]
DECIPHERMBD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMBD3 
Mutations
ICGC Data PortalMBD3 
TCGA Data PortalMBD3 
Broad Tumor PortalMBD3
OASIS PortalMBD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMBD3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMBD3
Mutations and Diseases : HGMDMBD3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMBD3
DgiDB (Drug Gene Interaction Database)MBD3
DoCM (Curated mutations)MBD3
CIViC (Clinical Interpretations of Variants in Cancer)MBD3
Cancer3DMBD3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603573   
Orphanet
DisGeNETMBD3
MedgenMBD3
Genetic Testing Registry MBD3
NextProtO95983 [Medical]
GENETestsMBD3
Target ValidationMBD3
Huge Navigator MBD3 [HugePedia]
ClinGenMBD3
Clinical trials, drugs, therapy
MyCancerGenomeMBD3
Protein Interactions : CTDMBD3
Pharm GKB GenePA30661
PharosO95983
Clinical trialMBD3
Miscellaneous
canSAR (ICR)MBD3
HarmonizomeMBD3
ARCHS4MBD3
DataMed IndexMBD3
Probes
Litterature
PubMed130 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMBD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:43:28 CET 2022

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