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MBD3 (methyl-CpG binding domain protein 3)

Identity

Other names-
HGNC (Hugo) MBD3
LocusID (NCBI) 53615
Location 19p13.3
Location_base_pair Starts at 1576670 and ends at 1592760 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MBD3   6918
Cards
Entrez_Gene (NCBI)MBD3  53615  methyl-CpG binding domain protein 3
GeneCards (Weizmann)MBD3
Ensembl (Hinxton)ENSG00000071655 [Gene_View]  chr19:1576670-1592760 [Contig_View]  MBD3 [Vega]
ICGC DataPortalENSG00000071655
cBioPortalMBD3
AceView (NCBI)MBD3
Genatlas (Paris)MBD3
WikiGenes53615
SOURCE (Princeton)NM_001281453 NM_001281454 NM_003926
Genomic and cartography
GoldenPath (UCSC)MBD3  -  19p13.3   chr19:1576670-1592760 -  19p13.3   [Description]    (hg19-Feb_2009)
EnsemblMBD3 - 19p13.3 [CytoView]
Mapping of homologs : NCBIMBD3 [Mapview]
OMIM603573   
Gene and transcription
Genbank (Entrez)AA576859 AF072247 AK001474 AK021532 AK092508
RefSeq transcript (Entrez)NM_001281453 NM_001281454 NM_003926
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_029897 NT_011295 NW_001838476 NW_004929412
Consensus coding sequences : CCDS (NCBI)MBD3
Cluster EST : UnigeneHs.595754 [ NCBI ]
CGAP (NCI)Hs.595754
Alternative Splicing : Fast-db (Paris)GSHG0015321
Alternative Splicing GalleryENSG00000071655
Gene ExpressionMBD3 [ NCBI-GEO ]     MBD3 [ SEEK ]   MBD3 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95983 (Uniprot)
NextProtO95983  [Medical]
With graphics : InterProO95983
Splice isoforms : SwissVarO95983 (Swissvar)
Domaine pattern : Prosite (Expaxy)MBD (PS50982)   
Domains : Interpro (EBI)DNA-bd_dom [organisation]   MeCpG-bd_2/3_C_dom [organisation]   Methyl_CpG_DNA-bd [organisation]  
Related proteins : CluSTrO95983
Domain families : Pfam (Sanger)MBD (PF01429)    MBD_C (PF14048)   
Domain families : Pfam (NCBI)pfam01429    pfam14048   
Domain families : Smart (EMBL)MBD (SM00391)  
DMDM Disease mutations53615
Blocks (Seattle)O95983
PDB (SRS)2MB7   
PDB (PDBSum)2MB7   
PDB (IMB)2MB7   
PDB (RSDB)2MB7   
Human Protein AtlasENSG00000071655 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO95983
HPRD04653
IPIIPI00439194   IPI00439195   IPI00382954   
Protein Interaction databases
DIP (DOE-UCLA)O95983
IntAct (EBI)O95983
FunCoupENSG00000071655
BioGRIDMBD3
InParanoidO95983
Interologous Interaction database O95983
IntegromeDBMBD3
STRING (EMBL)MBD3
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  heterochromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  in utero embryonic development  DNA binding  protein binding  cytoplasm  methylation-dependent chromatin silencing  transcription, DNA-templated  methyl-CpG binding  tissue development  histone acetylation  NuRD complex  nucleosomal DNA binding  ATP-dependent chromatin remodeling  protein complex  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  heterochromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  in utero embryonic development  DNA binding  protein binding  cytoplasm  methylation-dependent chromatin silencing  transcription, DNA-templated  methyl-CpG binding  tissue development  histone acetylation  NuRD complex  nucleosomal DNA binding  ATP-dependent chromatin remodeling  protein complex  
Pathways : BIOCARTADownregulated of MTA-3 in ER-negative Breast Tumors [Genes]   
Protein Interaction DatabaseMBD3
Wikipedia pathwaysMBD3
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MBD3
snp3D : Map Gene to Disease53615
SNP (GeneSNP Utah)MBD3
SNP : HGBaseMBD3
Genetic variants : HAPMAPMBD3
Exome VariantMBD3
1000_GenomesMBD3 
ICGC programENSG00000071655 
Somatic Mutations in Cancer : COSMICMBD3 
CONAN: Copy Number AnalysisMBD3 
Mutations and Diseases : HGMDMBD3
Genomic VariantsMBD3  MBD3 [DGVbeta]
dbVarMBD3
ClinVarMBD3
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM603573   
MedgenMBD3
GENETestsMBD3
Disease Genetic AssociationMBD3
Huge Navigator MBD3 [HugePedia]  MBD3 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMBD3
Homology/Alignments : Family Browser (UCSC)MBD3
Phylogenetic Trees/Animal Genes : TreeFamMBD3
Chemical/Protein Interactions : CTD53615
Chemical/Pharm GKB GenePA30661
Clinical trialMBD3
Cancer Resource (Charite)ENSG00000071655
Other databases
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
CoreMineMBD3
iHOPMBD3
OncoSearchMBD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:38:36 CEST 2014

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