| Nomenclature |
|---|
| HGNC (Hugo) | MBL2 6922 |
| Cards |
|---|
| Entrez_Gene (NCBI) | MBL2 4153 mannose binding lectin 2 |
| Aliases | COLEC1; HSMBPC; MBL; MBL2D; |
| MBP; MBP-C; MBP1; MBPD |
| GeneCards (Weizmann) | MBL2 |
| Ensembl hg19 (Hinxton) | ENSG00000165471 [Gene_View] chr10:54525140-54531460 [Contig_View] MBL2 [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000165471 [Gene_View] chr10:54525140-54531460 [Contig_View] MBL2 [Vega] |
| ICGC DataPortal | ENSG00000165471 |
| TCGA cBioPortal | MBL2 |
| AceView (NCBI) | MBL2 |
| Genatlas (Paris) | MBL2 |
| WikiGenes | 4153 |
| SOURCE (Princeton) | MBL2 |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | MBL2 - chr10:54525140-54531460 - 10q21.1 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | MBL2 - 10q21.1 [Description] (hg38-Dec_2013) |
| Ensembl | MBL2 - 10q21.1 [CytoView hg19] MBL2 - 10q21.1 [CytoView hg38] |
| Mapping of homologs : NCBI | MBL2 [Mapview hg19] MBL2 [Mapview hg38] |
| OMIM | 154545 614372 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF360991 AY826184 BC069338 BC096179 BC096180 |
| RefSeq transcript (Entrez) | NM_000242 |
| RefSeq genomic (Entrez) | NC_000010 NC_018921 NG_008196 NT_030059 NW_004929376 |
| Consensus coding sequences : CCDS (NCBI) | MBL2 |
| Cluster EST : Unigene | Hs.499674 [ NCBI ] |
| CGAP (NCI) | Hs.499674 |
| Alternative Splicing Gallery | ENSG00000165471 |
| Gene Expression | MBL2 [ NCBI-GEO ] MBL2 [ EBI - ARRAY_EXPRESS ]
MBL2 [ SEEK ] MBL2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MBL2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4153 |
| GTEX Portal (Tissue expression) | MBL2 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P11226 (Uniprot) |
| NextProt | P11226 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P11226 |
| Splice isoforms : SwissVar | P11226 (Swissvar) |
| PhosPhoSitePlus | P11226 |
| Domaine pattern : Prosite (Expaxy) | C_TYPE_LECTIN_1 (PS00615) C_TYPE_LECTIN_2 (PS50041) |
| Domains : Interpro (EBI) | C-type_lectin C-type_lectin-like C-type_lectin_CS C-type_lectin_fold Collagen |
| Domain families : Pfam (Sanger) | Collagen (PF01391) Lectin_C (PF00059) |
| Domain families : Pfam (NCBI) | pfam01391 pfam00059 |
| Domain families : Smart (EMBL) | CLECT (SM00034) |
| DMDM Disease mutations | 4153 |
| Blocks (Seattle) | MBL2 |
| PDB (SRS) | 1HUP |
| PDB (PDBSum) | 1HUP |
| PDB (IMB) | 1HUP |
| PDB (RSDB) | 1HUP |
| Structural Biology KnowledgeBase | 1HUP |
| SCOP (Structural Classification of Proteins) | 1HUP |
| CATH (Classification of proteins structures) | 1HUP |
| Superfamily | P11226 |
| Human Protein Atlas | ENSG00000165471 |
| Peptide Atlas | P11226 |
| HPRD | 01107 |
| IPI | IPI00004373 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P11226 |
| IntAct (EBI) | P11226 |
| FunCoup | ENSG00000165471 |
| BioGRID | MBL2 |
| STRING (EMBL) | MBL2 |
| ZODIAC | MBL2 |
| Ontologies - Pathways |
|---|
| QuickGO | P11226 |
| Ontology : AmiGO | complement activation, lectin pathway complement activation, lectin pathway complement activation, lectin pathway serine-type endopeptidase activity receptor binding calcium ion binding protein binding mannose binding mannose binding mannose binding extracellular region collagen trimer extracellular space proteolysis acute-phase response complement activation complement activation, classical pathway response to oxidative stress opsonization cell surface defense response to bacterium negative regulation of growth of symbiont in host innate immune response calcium-dependent protein binding negative regulation of viral process positive regulation of phagocytosis defense response to Gram-positive bacterium killing by host of symbiont cells |
| Ontology : EGO-EBI | complement activation, lectin pathway complement activation, lectin pathway complement activation, lectin pathway serine-type endopeptidase activity receptor binding calcium ion binding protein binding mannose binding mannose binding mannose binding extracellular region collagen trimer extracellular space proteolysis acute-phase response complement activation complement activation, classical pathway response to oxidative stress opsonization cell surface defense response to bacterium negative regulation of growth of symbiont in host innate immune response calcium-dependent protein binding negative regulation of viral process positive regulation of phagocytosis defense response to Gram-positive bacterium killing by host of symbiont cells |
| Pathways : BIOCARTA | Lectin Induced Complement Pathway [Genes] Complement Pathway [Genes] |
| Pathways : KEGG | Phagosome Complement and coagulation cascades Staphylococcus aureus infection |
| NDEx Network | MBL2 |
| Atlas of Cancer Signalling Network | MBL2 |
| Wikipedia pathways | MBL2 |
| Orthology - Evolution |
|---|
| OrthoDB | 4153 |
| GeneTree (enSembl) | ENSG00000165471 |
| Phylogenetic Trees/Animal Genes : TreeFam | MBL2 |
| Homologs : HomoloGene | MBL2 |
| Homology/Alignments : Family Browser (UCSC) | MBL2 |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | MBL2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MBL2 |
| dbVar | MBL2 |
| ClinVar | MBL2 |
| 1000_Genomes | MBL2 |
| Exome Variant Server | MBL2 |
| ExAC (Exome Aggregation Consortium) | MBL2 (select the gene name) |
| Genetic variants : HAPMAP | 4153 |
| Genomic Variants (DGV) | MBL2 [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | MBL2 |
| TCGA Data Portal | MBL2 |
| Broad Tumor Portal | MBL2 |
| OASIS Portal | MBL2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | MBL2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | **PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database |
| LOVD (Leiden Open Variation Database) | TBsLVD Tuberculosis susceptibility Locus Variation Database |
| BioMuta | search MBL2 |
| DgiDB (Drug Gene Interaction Database) | MBL2 |
| DoCM (Curated mutations) | MBL2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MBL2 (select a term) |
| intoGen | MBL2 |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 10:54525140-54531460 ENSG00000165471 |
| CONAN: Copy Number Analysis | MBL2 |
| Mutations and Diseases : HGMD | MBL2 |
| OMIM | 154545 614372 |
| Medgen | MBL2 |
| Genetic Testing Registry | MBL2
|
| NextProt | P11226 [Medical] |
| TSGene | 4153 |
| GENETests | MBL2 |
| Huge Navigator |
MBL2 [HugePedia] |
| snp3D : Map Gene to Disease | 4153 |
| BioCentury BCIQ | MBL2 |
| ClinGen | MBL2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 4153 |
| Chemical/Pharm GKB Gene | PA30665 |
| Clinical trial | MBL2 |
| Miscellaneous |
|---|
| canSAR (ICR) | MBL2 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | MBL2 |
| EVEX | MBL2 |
| GoPubMed | MBL2 |
| iHOP | MBL2 |
