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MBL2 (mannose-binding lectin (protein C) 2, soluble)

Identity

Other namesCOLEC1
HSMBPC
MBL
MBL2D
MBP
MBP-C
MBP1
MBPD
HGNC (Hugo) MBL2
LocusID (NCBI) 4153
Location 10q21.1
Location_base_pair Starts at 54525140 and ends at 54531460 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MBL2   6922
Cards
Entrez_Gene (NCBI)MBL2  4153  mannose-binding lectin (protein C) 2, soluble
GeneCards (Weizmann)MBL2
Ensembl (Hinxton)ENSG00000165471 [Gene_View]  chr10:54525140-54531460 [Contig_View]  MBL2 [Vega]
ICGC DataPortalENSG00000165471
AceView (NCBI)MBL2
Genatlas (Paris)MBL2
WikiGenes4153
SOURCE (Princeton)NM_000242
Genomic and cartography
GoldenPath (UCSC)MBL2  -  10q21.1   chr10:54525140-54531460 -  10q21.1   [Description]    (hg19-Feb_2009)
EnsemblMBL2 - 10q21.1 [CytoView]
Mapping of homologs : NCBIMBL2 [Mapview]
OMIM154545   614372   
Gene and transcription
Genbank (Entrez)AF360991 AY826184 BC069338 BC096179 BC096180
RefSeq transcript (Entrez)NM_000242
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_008196 NT_030059 NW_001837985 NW_004929376
Consensus coding sequences : CCDS (NCBI)MBL2
Cluster EST : UnigeneHs.499674 [ NCBI ]
CGAP (NCI)Hs.499674
Alternative Splicing : Fast-db (Paris)GSHG0004086
Alternative Splicing GalleryENSG00000165471
Gene ExpressionMBL2 [ NCBI-GEO ]     MBL2 [ SEEK ]   MBL2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11226 (Uniprot)
NextProtP11226  [Medical]
With graphics : InterProP11226
Splice isoforms : SwissVarP11226 (Swissvar)
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_1 (PS00615)    C_TYPE_LECTIN_2 (PS50041)   
Domains : Interpro (EBI)C-type_lectin    C-type_lectin-like    C-type_lectin_CS    C-type_lectin_fold    Collagen   
Related proteins : CluSTrP11226
Domain families : Pfam (Sanger)Collagen (PF01391)    Lectin_C (PF00059)   
Domain families : Pfam (NCBI)pfam01391    pfam00059   
Domain families : Smart (EMBL)CLECT (SM00034)  
DMDM Disease mutations4153
Blocks (Seattle)P11226
PDB (SRS)1HUP   
PDB (PDBSum)1HUP   
PDB (IMB)1HUP   
PDB (RSDB)1HUP   
Human Protein AtlasENSG00000165471
Peptide AtlasP11226
HPRD01107
IPIIPI00004373   
Protein Interaction databases
DIP (DOE-UCLA)P11226
IntAct (EBI)P11226
FunCoupENSG00000165471
BioGRIDMBL2
IntegromeDBMBL2
STRING (EMBL)MBL2
Ontologies - Pathways
QuickGOP11226
Ontology : AmiGOcomplement activation, lectin pathway  complement activation, lectin pathway  complement activation, lectin pathway  receptor binding  protein binding  mannose binding  mannose binding  mannose binding  extracellular region  collagen trimer  extracellular space  acute-phase response  complement activation  complement activation, classical pathway  response to oxidative stress  opsonization  cell surface  defense response to bacterium  negative regulation of growth of symbiont in host  innate immune response  innate immune response  calcium-dependent protein binding  negative regulation of viral process  positive regulation of phagocytosis  defense response to Gram-positive bacterium  killing by host of symbiont cells  
Ontology : EGO-EBIcomplement activation, lectin pathway  complement activation, lectin pathway  complement activation, lectin pathway  receptor binding  protein binding  mannose binding  mannose binding  mannose binding  extracellular region  collagen trimer  extracellular space  acute-phase response  complement activation  complement activation, classical pathway  response to oxidative stress  opsonization  cell surface  defense response to bacterium  negative regulation of growth of symbiont in host  innate immune response  innate immune response  calcium-dependent protein binding  negative regulation of viral process  positive regulation of phagocytosis  defense response to Gram-positive bacterium  killing by host of symbiont cells  
Pathways : BIOCARTALectin Induced Complement Pathway [Genes]    Complement Pathway [Genes]   
Pathways : KEGGPhagosome    Complement and coagulation cascades    Staphylococcus aureus infection   
Protein Interaction DatabaseMBL2
Wikipedia pathwaysMBL2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MBL2
SNP (GeneSNP Utah)MBL2
SNP : HGBaseMBL2
Genetic variants : HAPMAPMBL2
1000_GenomesMBL2 
ICGC programENSG00000165471 
CONAN: Copy Number AnalysisMBL2 
Somatic Mutations in Cancer : COSMICMBL2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
DECIPHER (Syndromes)10:54525140-54531460
Mutations and Diseases : HGMDMBL2
OMIM154545    614372   
MedgenMBL2
GENETestsMBL2
Disease Genetic AssociationMBL2
Huge Navigator MBL2 [HugePedia]  MBL2 [HugeCancerGEM]
Genomic VariantsMBL2  MBL2 [DGVbeta]
Exome VariantMBL2
dbVarMBL2
ClinVarMBL2
snp3D : Map Gene to Disease4153
General knowledge
Homologs : HomoloGeneMBL2
Homology/Alignments : Family Browser (UCSC)MBL2
Phylogenetic Trees/Animal Genes : TreeFamMBL2
Chemical/Protein Interactions : CTD4153
Chemical/Pharm GKB GenePA30665
Clinical trialMBL2
Cancer Resource (Charite)ENSG00000165471
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineMBL2
GoPubMedMBL2
iHOPMBL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:39:52 CET 2014

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