| Nomenclature |
|---|
| HGNC (Hugo) | MBL2 6922 |
| LRG (Locus Reference Genomic) | LRG_154 |
| Cards |
|---|
| Entrez_Gene (NCBI) | MBL2 4153 mannose binding lectin 2 |
| Aliases | COLEC1; HSMBPC; MBL; MBL2D; |
| MBP; MBP-C; MBP1; MBPD |
| GeneCards (Weizmann) | MBL2 |
| Ensembl hg19 (Hinxton) | ENSG00000165471 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000165471 [Gene_View] ENSG00000165471 [Sequence] chr10:52765380-52771700 [Contig_View] MBL2 [Vega] |
| ICGC DataPortal | ENSG00000165471 |
| TCGA cBioPortal | MBL2 |
| AceView (NCBI) | MBL2 |
| Genatlas (Paris) | MBL2 |
| WikiGenes | 4153 |
| SOURCE (Princeton) | MBL2 |
| Genetics Home Reference (NIH) | MBL2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | MBL2 - chr10:52765380-52771700 - 10q21.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | MBL2 - 10q21.1 [Description] (hg19-Feb_2009) |
MBL2 - 10q21.1 [CytoView hg19] MBL2 - 10q21.1 [CytoView hg38] |
| Mapping of homologs : NCBI | MBL2 [Mapview hg19] MBL2 [Mapview hg38] |
| OMIM | 154545 614372 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF360991 AY826184 BC069338 BC096179 BC096180 |
| RefSeq transcript (Entrez) | NM_000242 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | MBL2 |
| Cluster EST : Unigene | Hs.499674 [ NCBI ] |
| CGAP (NCI) | Hs.499674 |
| Alternative Splicing Gallery | ENSG00000165471 |
| Gene Expression | MBL2 [ NCBI-GEO ] MBL2 [ EBI - ARRAY_EXPRESS ]
MBL2 [ SEEK ] MBL2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MBL2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4153 |
| GTEX Portal (Tissue expression) | MBL2 |
| Human Protein Atlas | ENSG00000165471-MBL2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P11226 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P11226 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P11226 |
| Splice isoforms : SwissVar | P11226 |
| PhosPhoSitePlus | P11226 |
| Domaine pattern : Prosite (Expaxy) | C_TYPE_LECTIN_1 (PS00615) C_TYPE_LECTIN_2 (PS50041) |
| Domains : Interpro (EBI) | C-type_lectin-like C-type_lectin-like/link_sf C-type_lectin_CS Collagen Collectin_CTLD CTDL_fold Mannose-binding_protein |
| Domain families : Pfam (Sanger) | Collagen (PF01391) Lectin_C (PF00059) |
| Domain families : Pfam (NCBI) | pfam01391 pfam00059 |
| Domain families : Smart (EMBL) | CLECT (SM00034) |
| Conserved Domain (NCBI) | MBL2 |
| DMDM Disease mutations | 4153 |
| Blocks (Seattle) | MBL2 |
| PDB (RSDB) | 1HUP |
| PDB Europe | 1HUP |
| PDB (PDBSum) | 1HUP |
| PDB (IMB) | 1HUP |
| Structural Biology KnowledgeBase | 1HUP |
| SCOP (Structural Classification of Proteins) | 1HUP |
| CATH (Classification of proteins structures) | 1HUP |
| Superfamily | P11226 |
| Human Protein Atlas [tissue] | ENSG00000165471-MBL2 [tissue] |
| Peptide Atlas | P11226 |
| HPRD | 01107 |
| IPI | IPI00004373 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P11226 |
| IntAct (EBI) | P11226 |
| FunCoup | ENSG00000165471 |
| BioGRID | MBL2 |
| STRING (EMBL) | MBL2 |
| ZODIAC | MBL2 |
| Ontologies - Pathways |
|---|
| QuickGO | P11226 |
| Ontology : AmiGO | complement activation, lectin pathway complement activation, lectin pathway complement activation, lectin pathway complement activation, lectin pathway growth plate cartilage chondrocyte morphogenesis serine-type endopeptidase activity signaling receptor binding calcium ion binding protein binding mannose binding mannose binding mannose binding mannose binding extracellular region collagen trimer extracellular space extracellular space proteolysis acute-phase response complement activation complement activation, classical pathway response to oxidative stress opsonization cell surface extracellular matrix defense response to bacterium negative regulation of growth of symbiont in host innate immune response calcium-dependent protein binding negative regulation of viral process positive regulation of phagocytosis defense response to Gram-positive bacterium killing by host of symbiont cells |
| Ontology : EGO-EBI | complement activation, lectin pathway complement activation, lectin pathway complement activation, lectin pathway complement activation, lectin pathway growth plate cartilage chondrocyte morphogenesis serine-type endopeptidase activity signaling receptor binding calcium ion binding protein binding mannose binding mannose binding mannose binding mannose binding extracellular region collagen trimer extracellular space extracellular space proteolysis acute-phase response complement activation complement activation, classical pathway response to oxidative stress opsonization cell surface extracellular matrix defense response to bacterium negative regulation of growth of symbiont in host innate immune response calcium-dependent protein binding negative regulation of viral process positive regulation of phagocytosis defense response to Gram-positive bacterium killing by host of symbiont cells |
| Pathways : KEGG | Phagosome Complement and coagulation cascades Staphylococcus aureus infection |
| NDEx Network | MBL2 |
| Atlas of Cancer Signalling Network | MBL2 |
| Wikipedia pathways | MBL2 |
| Orthology - Evolution |
|---|
| OrthoDB | 4153 |
| GeneTree (enSembl) | ENSG00000165471 |
| Phylogenetic Trees/Animal Genes : TreeFam | MBL2 |
| HOGENOM | P11226 |
| Homologs : HomoloGene | MBL2 |
| Homology/Alignments : Family Browser (UCSC) | MBL2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | MBL2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | MBL2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MBL2 |
| dbVar | MBL2 |
| ClinVar | MBL2 |
| 1000_Genomes | MBL2 |
| Exome Variant Server | MBL2 |
| ExAC (Exome Aggregation Consortium) | ENSG00000165471 |
| GNOMAD Browser | ENSG00000165471 |
| Varsome Browser | MBL2 |
| Genetic variants : HAPMAP | 4153 |
| Genomic Variants (DGV) | MBL2 [DGVbeta] |
| DECIPHER | MBL2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | MBL2 |
| Mutations |
|---|
| ICGC Data Portal | MBL2 |
| TCGA Data Portal | MBL2 |
| Broad Tumor Portal | MBL2 |
| OASIS Portal | MBL2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | MBL2 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | MBL2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | **PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database |
| LOVD (Leiden Open Variation Database) | TBsLVD Tuberculosis susceptibility Locus Variation Database |
| BioMuta | search MBL2 |
| DgiDB (Drug Gene Interaction Database) | MBL2 |
| DoCM (Curated mutations) | MBL2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MBL2 (select a term) |
| intoGen | MBL2 |
| Cancer3D | MBL2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 154545 614372 |
| Orphanet | 23617 |
| DisGeNET | MBL2 |
| Medgen | MBL2 |
| Genetic Testing Registry | MBL2
|
| NextProt | P11226 [Medical] |
| TSGene | 4153 |
| GENETests | MBL2 |
| Target Validation | MBL2 |
| Huge Navigator |
MBL2 [HugePedia] |
| snp3D : Map Gene to Disease | 4153 |
| BioCentury BCIQ | MBL2 |
| ClinGen | MBL2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 4153 |
| Chemical/Pharm GKB Gene | PA30665 |
| Clinical trial | MBL2 |
| Miscellaneous |
|---|
| canSAR (ICR) | MBL2 (select the gene name) |
| DataMed Index | MBL2 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | MBL2 |
| EVEX | MBL2 |
| GoPubMed | MBL2 |
| iHOP | MBL2 |
