| Nomenclature |
|---|
| HGNC (Hugo) | MBL2 6922 |
| LRG (Locus Reference Genomic) | LRG_154 |
| Cards |
|---|
| Entrez_Gene (NCBI) | MBL2 mannose binding lectin 2 |
| Aliases | COLEC1; HSMBPC; MBL; MBL2D; |
| MBP; MBP-C; MBP1; MBPD |
| GeneCards (Weizmann) | MBL2 |
| Ensembl hg19 (Hinxton) | ENSG00000165471 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000165471 [Gene_View] ENSG00000165471 [Sequence] chr10:52765380-52771700 [Contig_View] MBL2 [Vega] |
| ICGC DataPortal | ENSG00000165471 |
| TCGA cBioPortal | MBL2 |
| AceView (NCBI) | MBL2 |
| Genatlas (Paris) | MBL2 |
| SOURCE (Princeton) | MBL2 |
| Genetics Home Reference (NIH) | MBL2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | MBL2 - chr10:52765380-52771700 - 10q21.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | MBL2 - 10q21.1 [Description] (hg19-Feb_2009) |
| GoldenPath | MBL2 - 10q21.1 [CytoView hg19] MBL2 - 10q21.1 [CytoView hg38] |
| ImmunoBase | ENSG00000165471 |
| genome Data Viewer NCBI | MBL2 [Mapview hg19] |
| OMIM | 154545 614372 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF360991 AY826184 BC069338 BC096179 BC096180 |
| RefSeq transcript (Entrez) | NM_000242 NM_001378373 NM_001378374 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | MBL2 |
| Alternative Splicing Gallery | ENSG00000165471 |
| Gene Expression | MBL2 [ NCBI-GEO ] MBL2 [ EBI - ARRAY_EXPRESS ]
MBL2 [ SEEK ] MBL2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MBL2 [ Firebrowse - Broad ] |
| Genevisible | Expression of MBL2 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4153 |
| GTEX Portal (Tissue expression) | MBL2 |
| Human Protein Atlas | ENSG00000165471-MBL2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P11226 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P11226 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P11226 |
| Splice isoforms : SwissVar | P11226 |
| PhosPhoSitePlus | P11226 |
| Domaine pattern : Prosite (Expaxy) | C_TYPE_LECTIN_1 (PS00615) C_TYPE_LECTIN_2 (PS50041) |
| Domains : Interpro (EBI) | C-type_lectin-like C-type_lectin-like/link_sf C-type_lectin_CS Collagen Collectin_CTLD CTDL_fold Mannose-binding_protein_C |
| Domain families : Pfam (Sanger) | Collagen (PF01391) Lectin_C (PF00059) |
| Domain families : Pfam (NCBI) | pfam01391 pfam00059 |
| Domain families : Smart (EMBL) | CLECT (SM00034) |
| Conserved Domain (NCBI) | MBL2 |
| Blocks (Seattle) | MBL2 |
| PDB (RSDB) | 1HUP |
| PDB Europe | 1HUP |
| PDB (PDBSum) | 1HUP |
| PDB (IMB) | 1HUP |
| Structural Biology KnowledgeBase | 1HUP |
| SCOP (Structural Classification of Proteins) | 1HUP |
| CATH (Classification of proteins structures) | 1HUP |
| Superfamily | P11226 |
| Human Protein Atlas [tissue] | ENSG00000165471-MBL2 [tissue] |
| Peptide Atlas | P11226 |
| HPRD | 01107 |
| IPI | IPI00004373 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P11226 |
| IntAct (EBI) | P11226 |
| BioGRID | MBL2 |
| STRING (EMBL) | MBL2 |
| ZODIAC | MBL2 |
| Ontologies - Pathways |
|---|
| QuickGO | P11226 |
| Ontology : AmiGO | complement activation, lectin pathway complement activation, lectin pathway complement activation, lectin pathway signaling receptor binding protein binding mannose binding mannose binding mannose binding extracellular region collagen trimer extracellular space extracellular space acute-phase response complement activation complement activation, classical pathway response to oxidative stress opsonization cell surface defense response to bacterium innate immune response calcium-dependent protein binding negative regulation of viral process positive regulation of phagocytosis defense response to Gram-positive bacterium killing by host of symbiont cells collagen-containing extracellular matrix |
| Ontology : EGO-EBI | complement activation, lectin pathway complement activation, lectin pathway complement activation, lectin pathway signaling receptor binding protein binding mannose binding mannose binding mannose binding extracellular region collagen trimer extracellular space extracellular space acute-phase response complement activation complement activation, classical pathway response to oxidative stress opsonization cell surface defense response to bacterium innate immune response calcium-dependent protein binding negative regulation of viral process positive regulation of phagocytosis defense response to Gram-positive bacterium killing by host of symbiont cells collagen-containing extracellular matrix |
| Pathways : KEGG | Phagosome Complement and coagulation cascades Staphylococcus aureus infection |
| NDEx Network | MBL2 |
| Atlas of Cancer Signalling Network | MBL2 |
| Wikipedia pathways | MBL2 |
| Orthology - Evolution |
|---|
| OrthoDB | 4153 |
| GeneTree (enSembl) | ENSG00000165471 |
| Phylogenetic Trees/Animal Genes : TreeFam | MBL2 |
| HOGENOM | P11226 |
| Homologs : HomoloGene | MBL2 |
| Homology/Alignments : Family Browser (UCSC) | MBL2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | MBL2 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | MBL2 [hg38] |
| dbVar | MBL2 |
| ClinVar | MBL2 |
| Monarch | MBL2 |
| 1000_Genomes | MBL2 |
| Exome Variant Server | MBL2 |
| GNOMAD Browser | ENSG00000165471 |
| Varsome Browser | MBL2 |
| Genomic Variants (DGV) | MBL2 [DGVbeta] |
| DECIPHER | MBL2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | MBL2 |
| Mutations |
|---|
| ICGC Data Portal | MBL2 |
| TCGA Data Portal | MBL2 |
| Broad Tumor Portal | MBL2 |
| OASIS Portal | MBL2 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | MBL2 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | MBL2 |
| Mutations and Diseases : HGMD | MBL2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | **PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database |
| LOVD (Leiden Open Variation Database) | TBsLVD Tuberculosis susceptibility Locus Variation Database |
| BioMuta | search MBL2 |
| DgiDB (Drug Gene Interaction Database) | MBL2 |
| DoCM (Curated mutations) | MBL2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MBL2 (select a term) |
| intoGen | MBL2 |
| Cancer3D | MBL2(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 154545 614372 |
| Orphanet | 23617 |
| DisGeNET | MBL2 |
| Medgen | MBL2 |
| Genetic Testing Registry | MBL2
|
| NextProt | P11226 [Medical] |
| GENETests | MBL2 |
| Target Validation | MBL2 |
| Huge Navigator |
MBL2 [HugePedia] |
| ClinGen | MBL2 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | MBL2 |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA30665 |
| Pharos | P11226 |
| Clinical trial | MBL2 |
| Miscellaneous |
|---|
| canSAR (ICR) | MBL2 (select the gene name) |
| Harmonizome | MBL2 |
| DataMed Index | MBL2 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | MBL2 |
