| Nomenclature |
|---|
| HGNC (Hugo) | MBL2 6922 |
| Cards |
|---|
| Entrez_Gene (NCBI) | MBL2 4153 mannose-binding lectin (protein C) 2, soluble |
| GeneCards (Weizmann) | MBL2 |
| Ensembl hg19 (Hinxton) | ENSG00000165471 [Gene_View] chr10:54525140-54531460 [Contig_View] MBL2 [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000165471 [Gene_View] chr10:54525140-54531460 [Contig_View] MBL2 [Vega] |
| ICGC DataPortal | ENSG00000165471 |
| cBioPortal | MBL2 |
| AceView (NCBI) | MBL2 |
| Genatlas (Paris) | MBL2 |
| WikiGenes | 4153 |
| SOURCE (Princeton) | MBL2 |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | MBL2 - chr10:54525140-54531460 - 10q21.1 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | MBL2 - 10q21.1 [Description] (hg38-Dec_2013) |
| Ensembl | MBL2 - 10q21.1 [CytoView hg19] MBL2 - 10q21.1 [CytoView hg38] |
| Mapping of homologs : NCBI | MBL2 [Mapview hg19] MBL2 [Mapview hg38] |
| OMIM | 154545 614372 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF360991 AY826184 BC069338 BC096179 BC096180 |
| RefSeq transcript (Entrez) | NM_000242 |
| RefSeq genomic (Entrez) | AC_000142 NC_000010 NC_018921 NG_008196 NT_030059 NW_001837985 NW_004929376 |
| Consensus coding sequences : CCDS (NCBI) | MBL2 |
| Cluster EST : Unigene | Hs.499674 [ NCBI ] |
| CGAP (NCI) | Hs.499674 |
| Alternative Splicing : Fast-db (Paris) | GSHG0004086 |
| Alternative Splicing Gallery | ENSG00000165471 |
| Gene Expression | MBL2 [ NCBI-GEO ] MBL2 [ SEEK ] MBL2 [ MEM ] |
| SOURCE (Princeton) | Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P11226 (Uniprot) |
| NextProt | P11226 [Medical] |
| With graphics : InterPro | P11226 |
| Splice isoforms : SwissVar | P11226 (Swissvar) |
| Domaine pattern : Prosite (Expaxy) | C_TYPE_LECTIN_1 (PS00615) C_TYPE_LECTIN_2 (PS50041) |
| Domains : Interpro (EBI) | C-type_lectin C-type_lectin-like C-type_lectin_CS C-type_lectin_fold Collagen |
| Related proteins : CluSTr | P11226 |
| Domain families : Pfam (Sanger) | Collagen (PF01391) Lectin_C (PF00059) |
| Domain families : Pfam (NCBI) | pfam01391 pfam00059 |
| Domain families : Smart (EMBL) | CLECT (SM00034) |
| DMDM Disease mutations | 4153 |
| Blocks (Seattle) | P11226 |
| PDB (SRS) | 1HUP |
| PDB (PDBSum) | 1HUP |
| PDB (IMB) | 1HUP |
| PDB (RSDB) | 1HUP |
| Human Protein Atlas | ENSG00000165471 |
| Peptide Atlas | P11226 |
| HPRD | 01107 |
| IPI | IPI00004373 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P11226 |
| IntAct (EBI) | P11226 |
| FunCoup | ENSG00000165471 |
| BioGRID | MBL2 |
| IntegromeDB | MBL2 |
| STRING (EMBL) | MBL2 |
| Ontologies - Pathways |
|---|
| QuickGO | P11226 |
| Ontology : AmiGO | complement activation, lectin pathway complement activation, lectin pathway complement activation, lectin pathway receptor binding protein binding mannose binding mannose binding mannose binding extracellular region collagen trimer extracellular space acute-phase response complement activation complement activation, classical pathway response to oxidative stress opsonization cell surface defense response to bacterium negative regulation of growth of symbiont in host innate immune response innate immune response calcium-dependent protein binding negative regulation of viral process positive regulation of phagocytosis defense response to Gram-positive bacterium killing by host of symbiont cells |
| Ontology : EGO-EBI | complement activation, lectin pathway complement activation, lectin pathway complement activation, lectin pathway receptor binding protein binding mannose binding mannose binding mannose binding extracellular region collagen trimer extracellular space acute-phase response complement activation complement activation, classical pathway response to oxidative stress opsonization cell surface defense response to bacterium negative regulation of growth of symbiont in host innate immune response innate immune response calcium-dependent protein binding negative regulation of viral process positive regulation of phagocytosis defense response to Gram-positive bacterium killing by host of symbiont cells |
| Pathways : BIOCARTA | Lectin Induced Complement Pathway [Genes] Complement Pathway [Genes] |
| Pathways : KEGG | Phagosome Complement and coagulation cascades Staphylococcus aureus infection |
| Protein Interaction Database | MBL2 |
| DoCM (Curated mutations) | MBL2 |
| Wikipedia pathways | MBL2 |
| Gene fusion - rearrangements |
|---|
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | MBL2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MBL2 |
| dbVar | MBL2 |
| ClinVar | MBL2 |
| 1000_Genomes | MBL2 |
| Exome Variant Server | MBL2 |
| SNP (GeneSNP Utah) | MBL2 |
| SNP : HGBase | MBL2 |
| Genetic variants : HAPMAP | MBL2 |
| Genomic Variants | MBL2 MBL2 [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | ENSG00000165471 |
| Somatic Mutations in Cancer : COSMIC | MBL2 |
| CONAN: Copy Number Analysis | MBL2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | **PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database |
| LOVD (Leiden Open Variation Database) | TBsLVD Tuberculosis susceptibility Locus Variation Database |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 10:54525140-54531460 |
| Mutations and Diseases : HGMD | MBL2 |
| OMIM | 154545 614372 |
| Medgen | MBL2 |
| NextProt | P11226 [Medical] |
| GENETests | MBL2 |
| Disease Genetic Association | MBL2 |
| Huge Navigator |
MBL2 [HugePedia] MBL2 [HugeCancerGEM] |
| snp3D : Map Gene to Disease | 4153 |
| DGIdb (Drug Gene Interaction db) | MBL2 |
| General knowledge |
|---|
| Homologs : HomoloGene | MBL2 |
| Homology/Alignments : Family Browser (UCSC) | MBL2 |
| Phylogenetic Trees/Animal Genes : TreeFam | MBL2 |
| Chemical/Protein Interactions : CTD | 4153 |
| Chemical/Pharm GKB Gene | PA30665 |
| Clinical trial | MBL2 |
| Cancer Resource (Charite) | ENSG00000165471 |
| Other databases |
|---|
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| CoreMine | MBL2 |
| GoPubMed | MBL2 |
| iHOP | MBL2 |
