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MBOAT2 (membrane bound O-acyltransferase domain containing 2)

Identity

Alias_namesOACT2
O-acyltransferase (membrane bound) domain containing 2
Alias_symbol (synonym)FLJ14415
FLJ90298
Other aliasLPAAT
LPCAT4
LPEAT
LPLAT 2
HGNC (Hugo) MBOAT2
LocusID (NCBI) 129642
Atlas_Id 53023
Location 2p25.1  [Link to chromosome band 2p25]
Location_base_pair Starts at 8996701 and ends at 9143876 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FABP2 (4q26) / MBOAT2 (2p25.1)IDH1 (2q34) / MBOAT2 (2p25.1)MBOAT2 (2p25.1) / ARHGAP25 (2p13.3)
MBOAT2 (2p25.1) / BRAT1 (7p22.3)MBOAT2 (2p25.1) / PRKCE (2p21)PRKCE (2p21) / MBOAT2 (2p25.1)
MBOAT2 2p25.1 / PRKCE 2p21MBOAT2 2p25.1 / ARHGAP25 2p13.3MBOAT2 2p25.1 / BRAT1 7p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MBOAT2   25193
Cards
Entrez_Gene (NCBI)MBOAT2  129642  membrane bound O-acyltransferase domain containing 2
AliasesLPAAT; LPCAT4; LPEAT; LPLAT; 
OACT2
GeneCards (Weizmann)MBOAT2
Ensembl hg19 (Hinxton)ENSG00000143797 [Gene_View]  chr2:8996701-9143876 [Contig_View]  MBOAT2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000143797 [Gene_View]  chr2:8996701-9143876 [Contig_View]  MBOAT2 [Vega]
ICGC DataPortalENSG00000143797
TCGA cBioPortalMBOAT2
AceView (NCBI)MBOAT2
Genatlas (Paris)MBOAT2
WikiGenes129642
SOURCE (Princeton)MBOAT2
Genetics Home Reference (NIH)MBOAT2
Genomic and cartography
GoldenPath hg19 (UCSC)MBOAT2  -     chr2:8996701-9143876 -  2p25.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MBOAT2  -     2p25.1   [Description]    (hg38-Dec_2013)
EnsemblMBOAT2 - 2p25.1 [CytoView hg19]  MBOAT2 - 2p25.1 [CytoView hg38]
Mapping of homologs : NCBIMBOAT2 [Mapview hg19]  MBOAT2 [Mapview hg38]
OMIM611949   
Gene and transcription
Genbank (Entrez)AB305044 AF052107 AK027321 AK074779 AK295907
RefSeq transcript (Entrez)NM_001321265 NM_001321266 NM_001321267 NM_138799
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005334 NW_004929298
Consensus coding sequences : CCDS (NCBI)MBOAT2
Cluster EST : UnigeneHs.593538 [ NCBI ]
CGAP (NCI)Hs.593538
Alternative Splicing GalleryENSG00000143797
Gene ExpressionMBOAT2 [ NCBI-GEO ]   MBOAT2 [ EBI - ARRAY_EXPRESS ]   MBOAT2 [ SEEK ]   MBOAT2 [ MEM ]
Gene Expression Viewer (FireBrowse)MBOAT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)129642
GTEX Portal (Tissue expression)MBOAT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZWT7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZWT7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZWT7
Splice isoforms : SwissVarQ6ZWT7
Catalytic activity : Enzyme2.3.1.- [ Enzyme-Expasy ]   2.3.1.-2.3.1.- [ IntEnz-EBI ]   2.3.1.- [ BRENDA ]   2.3.1.- [ KEGG ]   
PhosPhoSitePlusQ6ZWT7
Domains : Interpro (EBI)MBOAT_fam   
Domain families : Pfam (Sanger)MBOAT (PF03062)   
Domain families : Pfam (NCBI)pfam03062   
Conserved Domain (NCBI)MBOAT2
DMDM Disease mutations129642
Blocks (Seattle)MBOAT2
SuperfamilyQ6ZWT7
Human Protein AtlasENSG00000143797
Peptide AtlasQ6ZWT7
HPRD11410
IPIIPI00419221   IPI00945255   IPI00945097   IPI00945380   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZWT7
IntAct (EBI)Q6ZWT7
FunCoupENSG00000143797
BioGRIDMBOAT2
STRING (EMBL)MBOAT2
ZODIACMBOAT2
Ontologies - Pathways
QuickGOQ6ZWT7
Ontology : AmiGO1-acylglycerol-3-phosphate O-acyltransferase activity  endoplasmic reticulum membrane  phospholipid biosynthetic process  integral component of membrane  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  2-acylglycerol-3-phosphate O-acyltransferase activity  
Ontology : EGO-EBI1-acylglycerol-3-phosphate O-acyltransferase activity  endoplasmic reticulum membrane  phospholipid biosynthetic process  integral component of membrane  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  2-acylglycerol-3-phosphate O-acyltransferase activity  
Pathways : KEGGGlycerolipid metabolism    Glycerophospholipid metabolism   
NDEx NetworkMBOAT2
Atlas of Cancer Signalling NetworkMBOAT2
Wikipedia pathwaysMBOAT2
Orthology - Evolution
OrthoDB129642
GeneTree (enSembl)ENSG00000143797
Phylogenetic Trees/Animal Genes : TreeFamMBOAT2
HOVERGENQ6ZWT7
HOGENOMQ6ZWT7
Homologs : HomoloGeneMBOAT2
Homology/Alignments : Family Browser (UCSC)MBOAT2
Gene fusions - Rearrangements
Fusion : MitelmanMBOAT2/ARHGAP25 [2p25.1/2p13.3]  
Fusion : MitelmanMBOAT2/BRAT1 [2p25.1/7p22.3]  [t(2;7)(p25;p22)]  
Fusion : MitelmanMBOAT2/PRKCE [2p25.1/2p21]  [t(2;2)(p21;p25)]  
Fusion: TCGAMBOAT2 2p25.1 ARHGAP25 2p13.3 BRCA
Fusion: TCGAMBOAT2 2p25.1 BRAT1 7p22.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMBOAT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MBOAT2
dbVarMBOAT2
ClinVarMBOAT2
1000_GenomesMBOAT2 
Exome Variant ServerMBOAT2
ExAC (Exome Aggregation Consortium)MBOAT2 (select the gene name)
Genetic variants : HAPMAP129642
Genomic Variants (DGV)MBOAT2 [DGVbeta]
DECIPHER (Syndromes)2:8996701-9143876  ENSG00000143797
CONAN: Copy Number AnalysisMBOAT2 
Mutations
ICGC Data PortalMBOAT2 
TCGA Data PortalMBOAT2 
Broad Tumor PortalMBOAT2
OASIS PortalMBOAT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMBOAT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMBOAT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MBOAT2
DgiDB (Drug Gene Interaction Database)MBOAT2
DoCM (Curated mutations)MBOAT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MBOAT2 (select a term)
intoGenMBOAT2
Cancer3DMBOAT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611949   
Orphanet
MedgenMBOAT2
Genetic Testing Registry MBOAT2
NextProtQ6ZWT7 [Medical]
TSGene129642
GENETestsMBOAT2
Huge Navigator MBOAT2 [HugePedia]
snp3D : Map Gene to Disease129642
BioCentury BCIQMBOAT2
ClinGenMBOAT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD129642
Chemical/Pharm GKB GenePA134987740
Clinical trialMBOAT2
Miscellaneous
canSAR (ICR)MBOAT2 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMBOAT2
EVEXMBOAT2
GoPubMedMBOAT2
iHOPMBOAT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:08:44 CEST 2017

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