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MBP (myelin basic protein)

Identity

Other alias-
HGNC (Hugo) MBP
LocusID (NCBI) 4155
Atlas_Id 51260
Location 18q23  [Link to chromosome band 18q23]
Location_base_pair Starts at 74690789 and ends at 74729055 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CCDC18 (1p22.1) / MBP (18q23)CDV3 (3q22.1) / MBP (18q23)DDX41 (5q35.3) / MBP (18q23)
EFR3B (2p23.3) / MBP (18q23)FEZ2 (2p22.2) / MBP (18q23)HAPLN2 (1q23.1) / MBP (18q23)
KDM5A (12p13.33) / MBP (18q23)KIAA0907 (1q22) / MBP (18q23)L2HGDH (14q21.3) / MBP (18q23)
LOC100507412 (-) / MBP (18q23)MBP (18q23) / ALMS1 (2p13.1)MBP (18q23) / ARFGEF2 (20q13.13)
MBP (18q23) / ETNK2 (1q32.1)MBP (18q23) / FEZ1 (11q24.2)MBP (18q23) / GNB1 (1p36.33)
MBP (18q23) / MBP (18q23)MBP (18q23) / MPO (17q22)MBP (18q23) / MYO1D (17q11.2)
MBP (18q23) / N4BP2L2 (13q13.1)MBP (18q23) / OSBPL1A (18q11.2)MBP (18q23) / PAXIP1 (7q36.2)
MBP (18q23) / RGS2 (1q31.2)MBP (18q23) / SLC1A3 (5p13.2)MBP (18q23) / SWAP70 (11p15.4)
N4BP2L2 (13q13.1) / MBP (18q23)NAP1L4 (11p15.4) / MBP (18q23)NEAT1 (11q13.1) / MBP (18q23)
PHYKPL (5q35.3) / MBP (18q23)PTPRVP (1q32.1) / MBP (18q23)RASGRF2 (5q14.1) / MBP (18q23)
RGPD5 (2q13) / MBP (18q23)SEC14L5 (16p13.3) / MBP (18q23)SMARCAL1 (2q35) / MBP (18q23)
TMEM107 (17p13.1) / MBP (18q23)VPS13C (15q22.2) / MBP (18q23)WDR43 (2p23.2) / MBP (18q23)
ZFYVE1 (14q24.2) / MBP (18q23)MBP 18q23 / ARFGEF2 20q13.13MBP 18q23 / MYO1D 17q11.2
MBP 18q23 / SLC1A3 5p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MBP   6925
Cards
Entrez_Gene (NCBI)MBP  4155  myelin basic protein
Aliases
GeneCards (Weizmann)MBP
Ensembl hg19 (Hinxton)ENSG00000197971 [Gene_View]  chr18:74690789-74729055 [Contig_View]  MBP [Vega]
Ensembl hg38 (Hinxton)ENSG00000197971 [Gene_View]  chr18:74690789-74729055 [Contig_View]  MBP [Vega]
ICGC DataPortalENSG00000197971
TCGA cBioPortalMBP
AceView (NCBI)MBP
Genatlas (Paris)MBP
WikiGenes4155
SOURCE (Princeton)MBP
Genetics Home Reference (NIH)MBP
Genomic and cartography
GoldenPath hg19 (UCSC)MBP  -     chr18:74690789-74729055 -  18q23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MBP  -     18q23   [Description]    (hg38-Dec_2013)
EnsemblMBP - 18q23 [CytoView hg19]  MBP - 18q23 [CytoView hg38]
Mapping of homologs : NCBIMBP [Mapview hg19]  MBP [Mapview hg38]
OMIM159430   
Gene and transcription
Genbank (Entrez)AB208986 AK074315 AK093588 AK094611 AK095121
RefSeq transcript (Entrez)NM_001025081 NM_001025090 NM_001025092 NM_001025094 NM_001025098 NM_001025100 NM_001025101 NM_002385
RefSeq genomic (Entrez)NC_000018 NC_018929 NT_010966 NW_004929411
Consensus coding sequences : CCDS (NCBI)MBP
Cluster EST : UnigeneHs.551713 [ NCBI ]
CGAP (NCI)Hs.551713
Alternative Splicing GalleryENSG00000197971
Gene ExpressionMBP [ NCBI-GEO ]   MBP [ EBI - ARRAY_EXPRESS ]   MBP [ SEEK ]   MBP [ MEM ]
Gene Expression Viewer (FireBrowse)MBP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4155
GTEX Portal (Tissue expression)MBP
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02686   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02686  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02686
Splice isoforms : SwissVarP02686
PhosPhoSitePlusP02686
Domaine pattern : Prosite (Expaxy)MYELIN_MBP (PS00569)   
Domains : Interpro (EBI)Myelin_BP   
Domain families : Pfam (Sanger)Myelin_MBP (PF01669)   
Domain families : Pfam (NCBI)pfam01669   
Conserved Domain (NCBI)MBP
DMDM Disease mutations4155
Blocks (Seattle)MBP
PDB (SRS)1BX2    1FV1    1HQR    1K2D    1QCL    1YMM    1ZGL   
PDB (PDBSum)1BX2    1FV1    1HQR    1K2D    1QCL    1YMM    1ZGL   
PDB (IMB)1BX2    1FV1    1HQR    1K2D    1QCL    1YMM    1ZGL   
PDB (RSDB)1BX2    1FV1    1HQR    1K2D    1QCL    1YMM    1ZGL   
Structural Biology KnowledgeBase1BX2    1FV1    1HQR    1K2D    1QCL    1YMM    1ZGL   
SCOP (Structural Classification of Proteins)1BX2    1FV1    1HQR    1K2D    1QCL    1YMM    1ZGL   
CATH (Classification of proteins structures)1BX2    1FV1    1HQR    1K2D    1QCL    1YMM    1ZGL   
SuperfamilyP02686
Human Protein AtlasENSG00000197971
Peptide AtlasP02686
HPRD01158
IPIIPI00021907   IPI00216474   IPI00216475   IPI00607642   IPI00216477   IPI00216478   IPI00718832   IPI00446097   IPI00793055   IPI00791623   IPI00789377   IPI00792445   IPI00976672   IPI00985241   IPI00983524   IPI00977875   IPI00984669   IPI00979365   IPI00974225   IPI00979936   IPI00977253   IPI00984132   IPI00984610   IPI01010143   
Protein Interaction databases
DIP (DOE-UCLA)P02686
IntAct (EBI)P02686
FunCoupENSG00000197971
BioGRIDMBP
STRING (EMBL)MBP
ZODIACMBP
Ontologies - Pathways
QuickGOP02686
Ontology : AmiGOprotease binding  protein binding  nucleus  plasma membrane  immune response  synaptic transmission  central nervous system development  aging  axon ensheathment  response to toxic substance  structural constituent of myelin sheath  substantia nigra development  response to progesterone  internode region of axon  response to tumor necrosis factor  myelination  neuronal cell body  compact myelin  response to mercury ion  negative regulation of axonogenesis  membrane organization  response to fatty acid  cell periphery  
Ontology : EGO-EBIprotease binding  protein binding  nucleus  plasma membrane  immune response  synaptic transmission  central nervous system development  aging  axon ensheathment  response to toxic substance  structural constituent of myelin sheath  substantia nigra development  response to progesterone  internode region of axon  response to tumor necrosis factor  myelination  neuronal cell body  compact myelin  response to mercury ion  negative regulation of axonogenesis  membrane organization  response to fatty acid  cell periphery  
NDEx NetworkMBP
Atlas of Cancer Signalling NetworkMBP
Wikipedia pathwaysMBP
Orthology - Evolution
OrthoDB4155
GeneTree (enSembl)ENSG00000197971
Phylogenetic Trees/Animal Genes : TreeFamMBP
HOVERGENP02686
HOGENOMP02686
Homologs : HomoloGeneMBP
Homology/Alignments : Family Browser (UCSC)MBP
Gene fusions - Rearrangements
Fusion : MitelmanMBP/ARFGEF2 [18q23/20q13.13]  
Fusion : MitelmanMBP/MYO1D [18q23/17q11.2]  [t(17;18)(q11;q23)]  
Fusion : MitelmanMBP/SLC1A3 [18q23/5p13.2]  [t(5;18)(p13;q23)]  
Fusion: TCGAMBP 18q23 ARFGEF2 20q13.13 LGG
Fusion: TCGAMBP 18q23 MYO1D 17q11.2 LGG
Fusion: TCGAMBP 18q23 SLC1A3 5p13.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMBP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MBP
dbVarMBP
ClinVarMBP
1000_GenomesMBP 
Exome Variant ServerMBP
ExAC (Exome Aggregation Consortium)MBP (select the gene name)
Genetic variants : HAPMAP4155
Genomic Variants (DGV)MBP [DGVbeta]
DECIPHER (Syndromes)18:74690789-74729055  ENSG00000197971
CONAN: Copy Number AnalysisMBP 
Mutations
ICGC Data PortalMBP 
TCGA Data PortalMBP 
Broad Tumor PortalMBP
OASIS PortalMBP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMBP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMBP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MBP
DgiDB (Drug Gene Interaction Database)MBP
DoCM (Curated mutations)MBP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MBP (select a term)
intoGenMBP
Cancer3DMBP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM159430   
Orphanet
MedgenMBP
Genetic Testing Registry MBP
NextProtP02686 [Medical]
TSGene4155
GENETestsMBP
Huge Navigator MBP [HugePedia]
snp3D : Map Gene to Disease4155
BioCentury BCIQMBP
ClinGenMBP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4155
Chemical/Pharm GKB GenePA30667
Clinical trialMBP
Miscellaneous
canSAR (ICR)MBP (select the gene name)
Probes
Litterature
PubMed192 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMBP
EVEXMBP
GoPubMedMBP
iHOPMBP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:14:42 CET 2017

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