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MC3R (melanocortin 3 receptor)

Identity

Alias_symbol (synonym)MC3
Other aliasBMIQ9
MC3-R
OB20
OQTL
HGNC (Hugo) MC3R
LocusID (NCBI) 4159
Atlas_Id 68836
Location 20q13.2  [Link to chromosome band 20q13]
Location_base_pair Starts at 54823788 and ends at 54824871 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MC3R   6931
Cards
Entrez_Gene (NCBI)MC3R  4159  melanocortin 3 receptor
AliasesBMIQ9; MC3; MC3-R; OB20; 
OQTL
GeneCards (Weizmann)MC3R
Ensembl hg19 (Hinxton)ENSG00000124089 [Gene_View]  chr20:54823788-54824871 [Contig_View]  MC3R [Vega]
Ensembl hg38 (Hinxton)ENSG00000124089 [Gene_View]  chr20:54823788-54824871 [Contig_View]  MC3R [Vega]
ICGC DataPortalENSG00000124089
TCGA cBioPortalMC3R
AceView (NCBI)MC3R
Genatlas (Paris)MC3R
WikiGenes4159
SOURCE (Princeton)MC3R
Genetics Home Reference (NIH)MC3R
Genomic and cartography
GoldenPath hg19 (UCSC)MC3R  -     chr20:54823788-54824871 +  20q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MC3R  -     20q13.2   [Description]    (hg38-Dec_2013)
EnsemblMC3R - 20q13.2 [CytoView hg19]  MC3R - 20q13.2 [CytoView hg38]
Mapping of homologs : NCBIMC3R [Mapview hg19]  MC3R [Mapview hg38]
OMIM155540   602025   607948   
Gene and transcription
Genbank (Entrez)AY227893 BC069105 BC069591 BC069599 BC096702
RefSeq transcript (Entrez)NM_019888
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_012200 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)MC3R
Cluster EST : UnigeneHs.248018 [ NCBI ]
CGAP (NCI)Hs.248018
Alternative Splicing GalleryENSG00000124089
Gene ExpressionMC3R [ NCBI-GEO ]   MC3R [ EBI - ARRAY_EXPRESS ]   MC3R [ SEEK ]   MC3R [ MEM ]
Gene Expression Viewer (FireBrowse)MC3R [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4159
GTEX Portal (Tissue expression)MC3R
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41968   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41968  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41968
Splice isoforms : SwissVarP41968
PhosPhoSitePlusP41968
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Mcort_3_rcpt    Melancort_rcpt    Melcrt_ACTH_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)MC3R
DMDM Disease mutations4159
Blocks (Seattle)MC3R
SuperfamilyP41968
Human Protein AtlasENSG00000124089
Peptide AtlasP41968
HPRD01115
IPIIPI00018253   
Protein Interaction databases
DIP (DOE-UCLA)P41968
IntAct (EBI)P41968
FunCoupENSG00000124089
BioGRIDMC3R
STRING (EMBL)MC3R
ZODIACMC3R
Ontologies - Pathways
QuickGOP41968
Ontology : AmiGOregulation of heart rate  melanocortin receptor activity  melanocyte-stimulating hormone receptor activity  protein binding  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  regulation of blood pressure  peptide hormone binding  positive regulation of cAMP biosynthetic process  circadian regulation of gene expression  homoiothermy  neuropeptide binding  sodium ion homeostasis  
Ontology : EGO-EBIregulation of heart rate  melanocortin receptor activity  melanocyte-stimulating hormone receptor activity  protein binding  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  regulation of blood pressure  peptide hormone binding  positive regulation of cAMP biosynthetic process  circadian regulation of gene expression  homoiothermy  neuropeptide binding  sodium ion homeostasis  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkMC3R
Atlas of Cancer Signalling NetworkMC3R
Wikipedia pathwaysMC3R
Orthology - Evolution
OrthoDB4159
GeneTree (enSembl)ENSG00000124089
Phylogenetic Trees/Animal Genes : TreeFamMC3R
HOVERGENP41968
HOGENOMP41968
Homologs : HomoloGeneMC3R
Homology/Alignments : Family Browser (UCSC)MC3R
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMC3R [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MC3R
dbVarMC3R
ClinVarMC3R
1000_GenomesMC3R 
Exome Variant ServerMC3R
ExAC (Exome Aggregation Consortium)MC3R (select the gene name)
Genetic variants : HAPMAP4159
Genomic Variants (DGV)MC3R [DGVbeta]
DECIPHER (Syndromes)20:54823788-54824871  ENSG00000124089
CONAN: Copy Number AnalysisMC3R 
Mutations
ICGC Data PortalMC3R 
TCGA Data PortalMC3R 
Broad Tumor PortalMC3R
OASIS PortalMC3R [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMC3R  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMC3R
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch MC3R
DgiDB (Drug Gene Interaction Database)MC3R
DoCM (Curated mutations)MC3R (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MC3R (select a term)
intoGenMC3R
Cancer3DMC3R(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM155540    602025    607948   
Orphanet18812   
MedgenMC3R
Genetic Testing Registry MC3R
NextProtP41968 [Medical]
TSGene4159
GENETestsMC3R
Huge Navigator MC3R [HugePedia]
snp3D : Map Gene to Disease4159
BioCentury BCIQMC3R
ClinGenMC3R
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4159
Chemical/Pharm GKB GenePA30675
Clinical trialMC3R
Miscellaneous
canSAR (ICR)MC3R (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMC3R
EVEXMC3R
GoPubMedMC3R
iHOPMC3R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:27:49 CET 2017

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