Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MC4R (melanocortin 4 receptor)

Identity

Other alias-
HGNC (Hugo) MC4R
LocusID (NCBI) 4160
Atlas_Id 50231
Location 18q21.32  [Link to chromosome band 18q21]
Location_base_pair Starts at 58038564 and ends at 58040001 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MC4R   6932
Cards
Entrez_Gene (NCBI)MC4R  4160  melanocortin 4 receptor
Aliases
GeneCards (Weizmann)MC4R
Ensembl hg19 (Hinxton)ENSG00000166603 [Gene_View]  chr18:58038564-58040001 [Contig_View]  MC4R [Vega]
Ensembl hg38 (Hinxton)ENSG00000166603 [Gene_View]  chr18:58038564-58040001 [Contig_View]  MC4R [Vega]
ICGC DataPortalENSG00000166603
TCGA cBioPortalMC4R
AceView (NCBI)MC4R
Genatlas (Paris)MC4R
WikiGenes4160
SOURCE (Princeton)MC4R
Genetics Home Reference (NIH)MC4R
Genomic and cartography
GoldenPath hg19 (UCSC)MC4R  -     chr18:58038564-58040001 -  18q21.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MC4R  -     18q21.32   [Description]    (hg38-Dec_2013)
EnsemblMC4R - 18q21.32 [CytoView hg19]  MC4R - 18q21.32 [CytoView hg38]
Mapping of homologs : NCBIMC4R [Mapview hg19]  MC4R [Mapview hg38]
OMIM155541   601665   
Gene and transcription
Genbank (Entrez)AK314130 BC069172 BC101802 BC111992 DA362673
RefSeq transcript (Entrez)NM_005912
RefSeq genomic (Entrez)NC_000018 NC_018929 NG_016441 NT_010966 NW_004929411
Consensus coding sequences : CCDS (NCBI)MC4R
Cluster EST : UnigeneHs.532833 [ NCBI ]
CGAP (NCI)Hs.532833
Alternative Splicing GalleryENSG00000166603
Gene ExpressionMC4R [ NCBI-GEO ]   MC4R [ EBI - ARRAY_EXPRESS ]   MC4R [ SEEK ]   MC4R [ MEM ]
Gene Expression Viewer (FireBrowse)MC4R [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4160
GTEX Portal (Tissue expression)MC4R
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32245   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32245  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32245
Splice isoforms : SwissVarP32245
PhosPhoSitePlusP32245
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Mcort_rcpt_4    Melancort_rcpt    Melcrt_ACTH_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)MC4R
DMDM Disease mutations4160
Blocks (Seattle)MC4R
PDB (SRS)2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
PDB (PDBSum)2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
PDB (IMB)2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
PDB (RSDB)2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
Structural Biology KnowledgeBase2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
SCOP (Structural Classification of Proteins)2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
CATH (Classification of proteins structures)2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
SuperfamilyP32245
Human Protein AtlasENSG00000166603
Peptide AtlasP32245
HPRD01116
IPIIPI00027684   
Protein Interaction databases
DIP (DOE-UCLA)P32245
IntAct (EBI)P32245
FunCoupENSG00000166603
BioGRIDMC4R
STRING (EMBL)MC4R
ZODIACMC4R
Ontologies - Pathways
QuickGOP32245
Ontology : AmiGOdiet induced thermogenesis  melanocortin receptor activity  melanocyte-stimulating hormone receptor activity  melanocyte-stimulating hormone receptor activity  protein binding  nucleus  plasma membrane  energy reserve metabolic process  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  feeding behavior  integral component of membrane  peptide hormone binding  insulin secretion  positive regulation of cAMP biosynthetic process  ubiquitin protein ligase binding  response to insulin  neuropeptide binding  positive regulation of bone resorption  negative regulation of feeding behavior  regulation of grooming behavior  
Ontology : EGO-EBIdiet induced thermogenesis  melanocortin receptor activity  melanocyte-stimulating hormone receptor activity  melanocyte-stimulating hormone receptor activity  protein binding  nucleus  plasma membrane  energy reserve metabolic process  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  feeding behavior  integral component of membrane  peptide hormone binding  insulin secretion  positive regulation of cAMP biosynthetic process  ubiquitin protein ligase binding  response to insulin  neuropeptide binding  positive regulation of bone resorption  negative regulation of feeding behavior  regulation of grooming behavior  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkMC4R
Atlas of Cancer Signalling NetworkMC4R
Wikipedia pathwaysMC4R
Orthology - Evolution
OrthoDB4160
GeneTree (enSembl)ENSG00000166603
Phylogenetic Trees/Animal Genes : TreeFamMC4R
HOVERGENP32245
HOGENOMP32245
Homologs : HomoloGeneMC4R
Homology/Alignments : Family Browser (UCSC)MC4R
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMC4R [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MC4R
dbVarMC4R
ClinVarMC4R
1000_GenomesMC4R 
Exome Variant ServerMC4R
ExAC (Exome Aggregation Consortium)MC4R (select the gene name)
Genetic variants : HAPMAP4160
Genomic Variants (DGV)MC4R [DGVbeta]
DECIPHER (Syndromes)18:58038564-58040001  ENSG00000166603
CONAN: Copy Number AnalysisMC4R 
Mutations
ICGC Data PortalMC4R 
TCGA Data PortalMC4R 
Broad Tumor PortalMC4R
OASIS PortalMC4R [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMC4R  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMC4R
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MC4R
DgiDB (Drug Gene Interaction Database)MC4R
DoCM (Curated mutations)MC4R (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MC4R (select a term)
intoGenMC4R
Cancer3DMC4R(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM155541    601665   
Orphanet11022   
MedgenMC4R
Genetic Testing Registry MC4R
NextProtP32245 [Medical]
TSGene4160
GENETestsMC4R
Huge Navigator MC4R [HugePedia]
snp3D : Map Gene to Disease4160
BioCentury BCIQMC4R
ClinGenMC4R
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4160
Chemical/Pharm GKB GenePA30676
Clinical trialMC4R
Miscellaneous
canSAR (ICR)MC4R (select the gene name)
Probes
Litterature
PubMed336 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMC4R
EVEXMC4R
GoPubMedMC4R
iHOPMC4R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:08:45 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.