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MC4R (melanocortin 4 receptor)

Identity

Other names-
HGNC (Hugo) MC4R
LocusID (NCBI) 4160
Location 18q21.32
Location_base_pair Starts at 58038564 and ends at 58040001 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MC4R   6932
Entrez_Gene (NCBI)MC4R  4160  melanocortin 4 receptor
Cards
GeneCards (Weizmann)MC4R
Ensembl (Hinxton)ENSG00000166603 [Gene_View]  chr18:58038564-58040001 [Contig_View]  MC4R [Vega]
AceView (NCBI)MC4R
Genatlas (Paris)MC4R
SOURCE (Stanford)NM_005912
Genomic and cartography
GoldenPath (UCSC)MC4R  -  18q21.32   chr18:58038564-58040001 -  18q21.32   [Description]    (hg19-Feb_2009)
EnsemblMC4R - 18q21.32 [CytoView]
Mapping of homologs : NCBIMC4R [Mapview]
OMIM155541   601665   
Gene and transcription
Genbank (Entrez)AK314130 BC069172 BC101802 BC111992 DA362673
RefSeq transcript (SRS)NM_005912
RefSeq transcript (Entrez)NM_005912
RefSeq genomic (SRS)AC_000150 NC_000018 NC_018929 NG_016441 NT_025028 NW_001838469 NW_004078095
RefSeq genomic (Entrez)AC_000150 NC_000018 NC_018929 NG_016441 NT_025028 NW_001838469 NW_004078095
Consensus coding sequences : CCDS (NCBI)MC4R
Cluster EST : UnigeneHs.532833 [ SRS ] Hs.532833 [ NCBI ]
CGAP (NCI)Hs.532833
Alternative Splicing : Fast-db (Paris)GSHG0014336
Alternative Splicing GalleryENSG00000166603
Gene ExpressionMC4R [ NCBI-GEO ]   MC4R [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32245 (SRS) P32245 (Uniprot)
NextProtP32245
With graphics : InterProP32245
Splice isoforms : SwissVarP32245(Swissvar)
Domaine pattern : Prosite (SRS)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (SRS)7TM_GPCR_Rhodpsn    GPCR_Rhodpsn_supfam    Mcort_rcpt_4    Melancort_rcpt    Melcrt_ACTH_rcpt   
Domains : Interpro (EBI)7TM_GPCR_Rhodpsn    GPCR_Rhodpsn_supfam    Mcort_rcpt_4    Melancort_rcpt    Melcrt_ACTH_rcpt   
Related proteins : CluSTrP32245
Domain families : Pfam (SRS)7tm_1 (PF00001)   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
DMDM4160
Blocks (Seattle)P32245
PDB (SRS)2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
PDB (PDBSum)2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
PDB (IMB)2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
PDB (RSDB)2IQP    2IQR    2IQS    2IQU    2IQV    2IQW   
Human Protein AtlasENSG00000166603
HPRD01116
IPIIPI00027684   
Protein Interaction databases
DIP (DOE-UCLA)P32245
IntAct (EBI)P32245
FunCoupENSG00000166603
REACTOMEMC4R
Protein Interaction Database4160
BioGRIDMC4R
InParanoidP32245
Interologous Interaction database P32245
IntegromeDBMC4R
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MC4R
SNP (GeneSNP Utah)MC4R
SNP : HGBaseMC4R
Genetic variants : HAPMAPMC4R
Somatic Mutations in Cancer : COSMICMC4R 
CONAN: Copy Number AnalysisMC4R 
Mutations and Diseases : HGMDMC4R
OMIM155541    601665   
GENETests155541    601665   
Disease Genetic AssociationMC4R
Huge Navigator MC4R [HugePedia]  MC4R [HugeCancerGEM]
Genomic VariantsMC4R  MC4R [DGVbeta]
snp3D : Map Gene to Disease4160
General knowledge
Homologs : HomoloGeneMC4R
Homology/Alignments : Family Browser (UCSC)MC4R
Phylogenetic Trees/Animal Genes : TreeFamMC4R
Chemical/Protein Interactions : CTD4160
Chemical/Pharm GKB GenePA30676
Clinical trialMC4R
Cancer Resource (Charite)ENSG00000166603
Ontology : AmiGOdiet induced thermogenesis  melanocortin receptor activity  melanocyte-stimulating hormone receptor activity  protein binding  plasma membrane  energy reserve metabolic process  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  feeding behavior  integral to membrane  peptide hormone binding  insulin secretion  positive regulation of cAMP biosynthetic process  ubiquitin protein ligase binding  response to insulin stimulus  neuropeptide binding  positive regulation of bone resorption  
Ontology : EGO-EBIdiet induced thermogenesis  melanocortin receptor activity  melanocyte-stimulating hormone receptor activity  protein binding  plasma membrane  energy reserve metabolic process  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  feeding behavior  integral to membrane  peptide hormone binding  insulin secretion  positive regulation of cAMP biosynthetic process  ubiquitin protein ligase binding  response to insulin stimulus  neuropeptide binding  positive regulation of bone resorption  
Pathways : KEGGNeuroactive ligand-receptor interaction
Other databases
Probes
Litterature
PubMed253 Pubmed reference(s) in Entrez
PubGeneMC4R
iHOPMC4R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:24:34 CEST 2013
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