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MCCC2 (methylcrotonyl-CoA carboxylase subunit 2)

Identity

Alias (NCBI)MCCB
MCCCbeta
HGNC (Hugo) MCCC2
HGNC Alias symbMCCB
HGNC Alias namemethylcrotonoyl-CoA carboxylase beta
HGNC Previous namemethylcrotonoyl-Coenzyme A carboxylase 2 (beta)
LocusID (NCBI) 64087
Atlas_Id 68840
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 71587340 and ends at 71658706 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNPO1 (5q13.2)::MCCC2 (5q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MCCC2   6937
Cards
Entrez_Gene (NCBI)MCCC2    methylcrotonyl-CoA carboxylase subunit 2
AliasesMCCB; MCCCbeta
GeneCards (Weizmann)MCCC2
Ensembl hg19 (Hinxton)ENSG00000131844 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131844 [Gene_View]  ENSG00000131844 [Sequence]  chr5:71587340-71658706 [Contig_View]  MCCC2 [Vega]
ICGC DataPortalENSG00000131844
TCGA cBioPortalMCCC2
AceView (NCBI)MCCC2
Genatlas (Paris)MCCC2
SOURCE (Princeton)MCCC2
Genetics Home Reference (NIH)MCCC2
Genomic and cartography
GoldenPath hg38 (UCSC)MCCC2  -     chr5:71587340-71658706 +  5q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCCC2  -     5q13.2   [Description]    (hg19-Feb_2009)
GoldenPathMCCC2 - 5q13.2 [CytoView hg19]  MCCC2 - 5q13.2 [CytoView hg38]
ImmunoBaseENSG00000131844
Genome Data Viewer NCBIMCCC2 [Mapview hg19]  
OMIM210210   609014   
Gene and transcription
Genbank (Entrez)AB050049 AF261884 AF301000 AF310971 AK025591
RefSeq transcript (Entrez)NM_001363147 NM_022132
Consensus coding sequences : CCDS (NCBI)MCCC2
Gene ExpressionMCCC2 [ NCBI-GEO ]   MCCC2 [ EBI - ARRAY_EXPRESS ]   MCCC2 [ SEEK ]   MCCC2 [ MEM ]
Gene Expression Viewer (FireBrowse)MCCC2 [ Firebrowse - Broad ]
GenevisibleExpression of MCCC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64087
GTEX Portal (Tissue expression)MCCC2
Human Protein AtlasENSG00000131844-MCCC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCC0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCC0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCC0
PhosPhoSitePlusQ9HCC0
Domaine pattern : Prosite (Expaxy)COA_CT_CTER (PS50989)    COA_CT_NTER (PS50980)   
Domains : Interpro (EBI)AcCoA_carboxyl    ClpP/crotonase-like_dom_sf    COA_CT_C    COA_CT_N   
Domain families : Pfam (Sanger)Carboxyl_trans (PF01039)   
Domain families : Pfam (NCBI)pfam01039   
Conserved Domain (NCBI)MCCC2
SuperfamilyQ9HCC0
AlphaFold pdb e-kbQ9HCC0   
Human Protein Atlas [tissue]ENSG00000131844-MCCC2 [tissue]
HPRD01952
Protein Interaction databases
DIP (DOE-UCLA)Q9HCC0
IntAct (EBI)Q9HCC0
BioGRIDMCCC2
STRING (EMBL)MCCC2
ZODIACMCCC2
Ontologies - Pathways
QuickGOQ9HCC0
Ontology : AmiGO3-methylcrotonyl-CoA carboxylase complex, mitochondrial  3-methylcrotonyl-CoA carboxylase complex, mitochondrial  methylcrotonoyl-CoA carboxylase activity  methylcrotonoyl-CoA carboxylase activity  methylcrotonoyl-CoA carboxylase activity  protein binding  ATP binding  mitochondrion  mitochondrion  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  leucine catabolic process  leucine catabolic process  leucine catabolic process  biotin metabolic process  branched-chain amino acid catabolic process  coenzyme A metabolic process  methylcrotonoyl-CoA carboxylase complex  methylcrotonoyl-CoA carboxylase complex  
Ontology : EGO-EBI3-methylcrotonyl-CoA carboxylase complex, mitochondrial  3-methylcrotonyl-CoA carboxylase complex, mitochondrial  methylcrotonoyl-CoA carboxylase activity  methylcrotonoyl-CoA carboxylase activity  methylcrotonoyl-CoA carboxylase activity  protein binding  ATP binding  mitochondrion  mitochondrion  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  leucine catabolic process  leucine catabolic process  leucine catabolic process  biotin metabolic process  branched-chain amino acid catabolic process  coenzyme A metabolic process  methylcrotonoyl-CoA carboxylase complex  methylcrotonoyl-CoA carboxylase complex  
Pathways : KEGGValine, leucine and isoleucine degradation   
NDEx NetworkMCCC2
Atlas of Cancer Signalling NetworkMCCC2
Wikipedia pathwaysMCCC2
Orthology - Evolution
OrthoDB64087
GeneTree (enSembl)ENSG00000131844
Phylogenetic Trees/Animal Genes : TreeFamMCCC2
Homologs : HomoloGeneMCCC2
Homology/Alignments : Family Browser (UCSC)MCCC2
Gene fusions - Rearrangements
Fusion : QuiverMCCC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCCC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCCC2
dbVarMCCC2
ClinVarMCCC2
MonarchMCCC2
1000_GenomesMCCC2 
Exome Variant ServerMCCC2
GNOMAD BrowserENSG00000131844
Varsome BrowserMCCC2
ACMGMCCC2 variants
VarityQ9HCC0
Genomic Variants (DGV)MCCC2 [DGVbeta]
DECIPHERMCCC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCCC2 
Mutations
ICGC Data PortalMCCC2 
TCGA Data PortalMCCC2 
Broad Tumor PortalMCCC2
OASIS PortalMCCC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCCC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMCCC2
Mutations and Diseases : HGMDMCCC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMCCC2
DgiDB (Drug Gene Interaction Database)MCCC2
DoCM (Curated mutations)MCCC2
CIViC (Clinical Interpretations of Variants in Cancer)MCCC2
Cancer3DMCCC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM210210    609014   
Orphanet3297   
DisGeNETMCCC2
MedgenMCCC2
Genetic Testing Registry MCCC2
NextProtQ9HCC0 [Medical]
GENETestsMCCC2
Target ValidationMCCC2
Huge Navigator MCCC2 [HugePedia]
ClinGenMCCC2
Clinical trials, drugs, therapy
MyCancerGenomeMCCC2
Protein Interactions : CTDMCCC2
Pharm GKB GenePA30681
PharosQ9HCC0
Clinical trialMCCC2
Miscellaneous
canSAR (ICR)MCCC2
HarmonizomeMCCC2
ARCHS4MCCC2
DataMed IndexMCCC2
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMCCC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 19:10:13 CET 2022

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