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MCF2 (MCF.2 cell line derived transforming sequence)

Identity

Alias_symbol (synonym)DBL
ARHGEF21
Other alias
HGNC (Hugo) MCF2
LocusID (NCBI) 4168
Atlas_Id 41315
Location Xq27.1  [Link to chromosome band Xq27]
Location_base_pair Starts at 138663930 and ends at 138790381 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DHX57 (2p22.1) / MCF2 (Xq27.1)DIXDC1 (11q23.1) / MCF2 (Xq27.1)MCF2 (Xq27.1) / MYB (6q23.3)
TMOD3 (15q21.2) / MCF2 (Xq27.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MCF2   6940
Cards
Entrez_Gene (NCBI)MCF2  4168  MCF.2 cell line derived transforming sequence
AliasesARHGEF21; DBL
GeneCards (Weizmann)MCF2
Ensembl hg19 (Hinxton)ENSG00000101977 [Gene_View]  chrX:138663930-138790381 [Contig_View]  MCF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000101977 [Gene_View]  chrX:138663930-138790381 [Contig_View]  MCF2 [Vega]
ICGC DataPortalENSG00000101977
TCGA cBioPortalMCF2
AceView (NCBI)MCF2
Genatlas (Paris)MCF2
WikiGenes4168
SOURCE (Princeton)MCF2
Genetics Home Reference (NIH)MCF2
Genomic and cartography
GoldenPath hg19 (UCSC)MCF2  -     chrX:138663930-138790381 -  Xq27.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MCF2  -     Xq27.1   [Description]    (hg38-Dec_2013)
EnsemblMCF2 - Xq27.1 [CytoView hg19]  MCF2 - Xq27.1 [CytoView hg38]
Mapping of homologs : NCBIMCF2 [Mapview hg19]  MCF2 [Mapview hg38]
OMIM311030   
Gene and transcription
Genbank (Entrez)AB085901 AB085902 AK296488 AK296529 AK302957
RefSeq transcript (Entrez)NM_001099855 NM_001171876 NM_001171877 NM_001171878 NM_001171879 NM_005369
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_016439 NT_011786 NW_004929446
Consensus coding sequences : CCDS (NCBI)MCF2
Cluster EST : UnigeneHs.387262 [ NCBI ]
CGAP (NCI)Hs.387262
Alternative Splicing GalleryENSG00000101977
Gene ExpressionMCF2 [ NCBI-GEO ]   MCF2 [ EBI - ARRAY_EXPRESS ]   MCF2 [ SEEK ]   MCF2 [ MEM ]
Gene Expression Viewer (FireBrowse)MCF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4168
GTEX Portal (Tissue expression)MCF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10911   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10911  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10911
Splice isoforms : SwissVarP10911
PhosPhoSitePlusP10911
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)    DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)CRAL-TRIO_dom    DH-domain    GDS_CDC24_CS    PH_dom-like    PH_domain    Spectrin/alpha-actinin   
Domain families : Pfam (Sanger)CRAL_TRIO_2 (PF13716)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam13716    pfam00169    pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RhoGEF (SM00325)  SPEC (SM00150)  
Conserved Domain (NCBI)MCF2
DMDM Disease mutations4168
Blocks (Seattle)MCF2
SuperfamilyP10911
Human Protein AtlasENSG00000101977
Peptide AtlasP10911
HPRD02406
IPIIPI00339309   IPI00339310   IPI00641162   IPI00339312   IPI00339311   IPI00955487   IPI01012375   IPI00641636   IPI00981456   
Protein Interaction databases
DIP (DOE-UCLA)P10911
IntAct (EBI)P10911
FunCoupENSG00000101977
BioGRIDMCF2
STRING (EMBL)MCF2
ZODIACMCF2
Ontologies - Pathways
QuickGOP10911
Ontology : AmiGOguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  cytosol  cytoskeleton  membrane  dendrite development  regulation of Rho protein signal transduction  intracellular signal transduction  positive regulation of apoptotic process  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  extracellular exosome  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  cytosol  cytoskeleton  membrane  dendrite development  regulation of Rho protein signal transduction  intracellular signal transduction  positive regulation of apoptotic process  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  extracellular exosome  
NDEx NetworkMCF2
Atlas of Cancer Signalling NetworkMCF2
Wikipedia pathwaysMCF2
Orthology - Evolution
OrthoDB4168
GeneTree (enSembl)ENSG00000101977
Phylogenetic Trees/Animal Genes : TreeFamMCF2
HOVERGENP10911
HOGENOMP10911
Homologs : HomoloGeneMCF2
Homology/Alignments : Family Browser (UCSC)MCF2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCF2
dbVarMCF2
ClinVarMCF2
1000_GenomesMCF2 
Exome Variant ServerMCF2
ExAC (Exome Aggregation Consortium)MCF2 (select the gene name)
Genetic variants : HAPMAP4168
Genomic Variants (DGV)MCF2 [DGVbeta]
DECIPHER (Syndromes)X:138663930-138790381  ENSG00000101977
CONAN: Copy Number AnalysisMCF2 
Mutations
ICGC Data PortalMCF2 
TCGA Data PortalMCF2 
Broad Tumor PortalMCF2
OASIS PortalMCF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMCF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch MCF2
DgiDB (Drug Gene Interaction Database)MCF2
DoCM (Curated mutations)MCF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCF2 (select a term)
intoGenMCF2
Cancer3DMCF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM311030   
Orphanet
MedgenMCF2
Genetic Testing Registry MCF2
NextProtP10911 [Medical]
TSGene4168
GENETestsMCF2
Huge Navigator MCF2 [HugePedia]
snp3D : Map Gene to Disease4168
BioCentury BCIQMCF2
ClinGenMCF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4168
Chemical/Pharm GKB GenePA30684
Clinical trialMCF2
Miscellaneous
canSAR (ICR)MCF2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCF2
EVEXMCF2
GoPubMedMCF2
iHOPMCF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:08:45 CEST 2017

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