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MCF2L (MCF.2 cell line derived transforming sequence like)

Identity

Alias_symbol (synonym)KIAA0362
DBS
OST
ARHGEF14
Other alias
HGNC (Hugo) MCF2L
LocusID (NCBI) 23263
Atlas_Id 41316
Location 13q34  [Link to chromosome band 13q34]
Location_base_pair Starts at 113623535 and ends at 113754053 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LAMP1 (13q34) / MCF2L (13q34)MCF2L (13q34) / STK24 (13q32.2)MCF2L 13q34 / STK24 13q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MCF2L   14576
Cards
Entrez_Gene (NCBI)MCF2L  23263  MCF.2 cell line derived transforming sequence like
AliasesARHGEF14; DBS; OST
GeneCards (Weizmann)MCF2L
Ensembl hg19 (Hinxton)ENSG00000126217 [Gene_View]  chr13:113623535-113754053 [Contig_View]  MCF2L [Vega]
Ensembl hg38 (Hinxton)ENSG00000126217 [Gene_View]  chr13:113623535-113754053 [Contig_View]  MCF2L [Vega]
ICGC DataPortalENSG00000126217
TCGA cBioPortalMCF2L
AceView (NCBI)MCF2L
Genatlas (Paris)MCF2L
WikiGenes23263
SOURCE (Princeton)MCF2L
Genetics Home Reference (NIH)MCF2L
Genomic and cartography
GoldenPath hg19 (UCSC)MCF2L  -     chr13:113623535-113754053 +  13q34   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MCF2L  -     13q34   [Description]    (hg38-Dec_2013)
EnsemblMCF2L - 13q34 [CytoView hg19]  MCF2L - 13q34 [CytoView hg38]
Mapping of homologs : NCBIMCF2L [Mapview hg19]  MCF2L [Mapview hg38]
OMIM609499   
Gene and transcription
Genbank (Entrez)AB002360 AB116074 AB116075 AF086413 AK022184
RefSeq transcript (Entrez)NM_001112732 NM_001320815 NM_001320816 NM_001320817 NM_024979
RefSeq genomic (Entrez)NC_000013 NC_018924 NT_027140 NW_004929390
Consensus coding sequences : CCDS (NCBI)MCF2L
Cluster EST : UnigeneHs.170422 [ NCBI ]
CGAP (NCI)Hs.170422
Alternative Splicing GalleryENSG00000126217
Gene ExpressionMCF2L [ NCBI-GEO ]   MCF2L [ EBI - ARRAY_EXPRESS ]   MCF2L [ SEEK ]   MCF2L [ MEM ]
Gene Expression Viewer (FireBrowse)MCF2L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23263
GTEX Portal (Tissue expression)MCF2L
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15068   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15068  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15068
Splice isoforms : SwissVarO15068
PhosPhoSitePlusO15068
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)    DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)    SH3 (PS50002)   
Domains : Interpro (EBI)CRAL-TRIO_dom    DH-domain    GDS_CDC24_CS    PH_dom-like    PH_domain    SH3_2    SH3_domain    Spectrin/alpha-actinin    Spectrin_repeat   
Domain families : Pfam (Sanger)CRAL_TRIO_2 (PF13716)    PH (PF00169)    RhoGEF (PF00621)    SH3_2 (PF07653)    Spectrin (PF00435)   
Domain families : Pfam (NCBI)pfam13716    pfam00169    pfam00621    pfam07653    pfam00435   
Domain families : Smart (EMBL)PH (SM00233)  RhoGEF (SM00325)  SEC14 (SM00516)  SH3 (SM00326)  SPEC (SM00150)  
Conserved Domain (NCBI)MCF2L
DMDM Disease mutations23263
Blocks (Seattle)MCF2L
SuperfamilyO15068
Human Protein AtlasENSG00000126217
Peptide AtlasO15068
HPRD14371
IPIIPI00477099   IPI00297139   IPI00793824   IPI00902842   IPI00789896   IPI00916224   IPI00924952   IPI00872702   IPI01020773   IPI00644699   IPI00939487   IPI00978315   IPI00976775   IPI01012256   IPI00746757   IPI00926692   IPI00794373   IPI00793973   IPI01019039   IPI00796542   IPI00798115   IPI00894026   IPI00916431   IPI00917864   
Protein Interaction databases
DIP (DOE-UCLA)O15068
IntAct (EBI)O15068
FunCoupENSG00000126217
BioGRIDMCF2L
STRING (EMBL)MCF2L
ZODIACMCF2L
Ontologies - Pathways
QuickGOO15068
Ontology : AmiGOguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  extracellular space  cytoplasm  cytosol  plasma membrane  endomembrane system  extrinsic component of cytoplasmic side of plasma membrane  regulation of Rho protein signal transduction  positive regulation of Rho protein signal transduction  phosphatidylinositol binding  intracellular signal transduction  positive regulation of apoptotic process  positive regulation of GTPase activity  positive regulation of GTPase activity  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  extracellular space  cytoplasm  cytosol  plasma membrane  endomembrane system  extrinsic component of cytoplasmic side of plasma membrane  regulation of Rho protein signal transduction  positive regulation of Rho protein signal transduction  phosphatidylinositol binding  intracellular signal transduction  positive regulation of apoptotic process  positive regulation of GTPase activity  positive regulation of GTPase activity  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
NDEx NetworkMCF2L
Atlas of Cancer Signalling NetworkMCF2L
Wikipedia pathwaysMCF2L
Orthology - Evolution
OrthoDB23263
GeneTree (enSembl)ENSG00000126217
Phylogenetic Trees/Animal Genes : TreeFamMCF2L
HOVERGENO15068
HOGENOMO15068
Homologs : HomoloGeneMCF2L
Homology/Alignments : Family Browser (UCSC)MCF2L
Gene fusions - Rearrangements
Fusion : MitelmanMCF2L/STK24 [13q34/13q32.2]  
Fusion: TCGAMCF2L 13q34 STK24 13q32.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCF2L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCF2L
dbVarMCF2L
ClinVarMCF2L
1000_GenomesMCF2L 
Exome Variant ServerMCF2L
ExAC (Exome Aggregation Consortium)MCF2L (select the gene name)
Genetic variants : HAPMAP23263
Genomic Variants (DGV)MCF2L [DGVbeta]
DECIPHER (Syndromes)13:113623535-113754053  ENSG00000126217
CONAN: Copy Number AnalysisMCF2L 
Mutations
ICGC Data PortalMCF2L 
TCGA Data PortalMCF2L 
Broad Tumor PortalMCF2L
OASIS PortalMCF2L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCF2L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMCF2L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MCF2L
DgiDB (Drug Gene Interaction Database)MCF2L
DoCM (Curated mutations)MCF2L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCF2L (select a term)
intoGenMCF2L
Cancer3DMCF2L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609499   
Orphanet
MedgenMCF2L
Genetic Testing Registry MCF2L
NextProtO15068 [Medical]
TSGene23263
GENETestsMCF2L
Huge Navigator MCF2L [HugePedia]
snp3D : Map Gene to Disease23263
BioCentury BCIQMCF2L
ClinGenMCF2L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23263
Chemical/Pharm GKB GenePA30685
Clinical trialMCF2L
Miscellaneous
canSAR (ICR)MCF2L (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCF2L
EVEXMCF2L
GoPubMedMCF2L
iHOPMCF2L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:08:46 CEST 2017

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