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MCHR2 (melanin concentrating hormone receptor 2)

Identity

Alias_namesGPR145
G protein-coupled receptor 145
melanin-concentrating hormone receptor 2
Alias_symbol (synonym)SLT
MCH2
MCH2R
Other aliasGPRv17
MCH-2R
MCH-R2
MCHR-2
HGNC (Hugo) MCHR2
LocusID (NCBI) 84539
Atlas_Id 56492
Location 6q16.2  [Link to chromosome band 6q16]
Location_base_pair Starts at 99919910 and ends at 99994238 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RPS6KA2 (6q27) / MCHR2 (6q16.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q16;q27) RPS6KA2/MCHR2


External links

Nomenclature
HGNC (Hugo)MCHR2   20867
Cards
Entrez_Gene (NCBI)MCHR2  84539  melanin concentrating hormone receptor 2
AliasesGPR145; GPRv17; MCH-2R; MCH-R2; 
MCH2; MCH2R; MCHR-2; SLT
GeneCards (Weizmann)MCHR2
Ensembl hg19 (Hinxton)ENSG00000152034 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152034 [Gene_View]  ENSG00000152034 [Sequence]  chr6:99919910-99994238 [Contig_View]  MCHR2 [Vega]
ICGC DataPortalENSG00000152034
TCGA cBioPortalMCHR2
AceView (NCBI)MCHR2
Genatlas (Paris)MCHR2
WikiGenes84539
SOURCE (Princeton)MCHR2
Genetics Home Reference (NIH)MCHR2
Genomic and cartography
GoldenPath hg38 (UCSC)MCHR2  -     chr6:99919910-99994238 -  6q16.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCHR2  -     6q16.2   [Description]    (hg19-Feb_2009)
EnsemblMCHR2 - 6q16.2 [CytoView hg19]  MCHR2 - 6q16.2 [CytoView hg38]
Mapping of homologs : NCBIMCHR2 [Mapview hg19]  MCHR2 [Mapview hg38]
OMIM606111   
Gene and transcription
Genbank (Entrez)AB058849 AB060151 AF347063 AF399937 AK123634
RefSeq transcript (Entrez)NM_001040179 NM_032503
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MCHR2
Cluster EST : UnigeneHs.591342 [ NCBI ]
CGAP (NCI)Hs.591342
Alternative Splicing GalleryENSG00000152034
Gene ExpressionMCHR2 [ NCBI-GEO ]   MCHR2 [ EBI - ARRAY_EXPRESS ]   MCHR2 [ SEEK ]   MCHR2 [ MEM ]
Gene Expression Viewer (FireBrowse)MCHR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84539
GTEX Portal (Tissue expression)MCHR2
Human Protein AtlasENSG00000152034-MCHR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969V1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969V1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969V1
Splice isoforms : SwissVarQ969V1
PhosPhoSitePlusQ969V1
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    MCH2_receptor    MCH_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)MCHR2
DMDM Disease mutations84539
Blocks (Seattle)MCHR2
SuperfamilyQ969V1
Human Protein Atlas [tissue]ENSG00000152034-MCHR2 [tissue]
Peptide AtlasQ969V1
HPRD12088
IPIIPI00299952   
Protein Interaction databases
DIP (DOE-UCLA)Q969V1
IntAct (EBI)Q969V1
FunCoupENSG00000152034
BioGRIDMCHR2
STRING (EMBL)MCHR2
ZODIACMCHR2
Ontologies - Pathways
QuickGOQ969V1
Ontology : AmiGOplasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  G protein-coupled peptide receptor activity  
Ontology : EGO-EBIplasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  G protein-coupled peptide receptor activity  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkMCHR2
Atlas of Cancer Signalling NetworkMCHR2
Wikipedia pathwaysMCHR2
Orthology - Evolution
OrthoDB84539
GeneTree (enSembl)ENSG00000152034
Phylogenetic Trees/Animal Genes : TreeFamMCHR2
HOVERGENQ969V1
HOGENOMQ969V1
Homologs : HomoloGeneMCHR2
Homology/Alignments : Family Browser (UCSC)MCHR2
Gene fusions - Rearrangements
Fusion : QuiverMCHR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCHR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCHR2
dbVarMCHR2
ClinVarMCHR2
1000_GenomesMCHR2 
Exome Variant ServerMCHR2
ExAC (Exome Aggregation Consortium)ENSG00000152034
GNOMAD BrowserENSG00000152034
Varsome BrowserMCHR2
Genetic variants : HAPMAP84539
Genomic Variants (DGV)MCHR2 [DGVbeta]
DECIPHERMCHR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCHR2 
Mutations
ICGC Data PortalMCHR2 
TCGA Data PortalMCHR2 
Broad Tumor PortalMCHR2
OASIS PortalMCHR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCHR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMCHR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MCHR2
DgiDB (Drug Gene Interaction Database)MCHR2
DoCM (Curated mutations)MCHR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCHR2 (select a term)
intoGenMCHR2
Cancer3DMCHR2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606111   
Orphanet
DisGeNETMCHR2
MedgenMCHR2
Genetic Testing Registry MCHR2
NextProtQ969V1 [Medical]
TSGene84539
GENETestsMCHR2
Target ValidationMCHR2
Huge Navigator MCHR2 [HugePedia]
snp3D : Map Gene to Disease84539
BioCentury BCIQMCHR2
ClinGenMCHR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84539
Chemical/Pharm GKB GenePA134950856
Clinical trialMCHR2
Miscellaneous
canSAR (ICR)MCHR2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCHR2
EVEXMCHR2
GoPubMedMCHR2
iHOPMCHR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:19:18 CET 2018

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