Identity
HGNC
LOCATION
1q21.2
LOCUSID
ALIAS
BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S,Mcl-1,TM,bcl2-L-3,mcl1/EAT
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4170
MIM: 159552
HGNC: 6943
Ensembl: ENSG00000143384
Variants:
dbSNP: 4170
ClinVar: 4170
TCGA: ENSG00000143384
COSMIC: MCL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000143384 | ENST00000307940 | Q07820 |
| ENSG00000143384 | ENST00000369026 | Q07820 |
| ENSG00000143384 | ENST00000620947 | A0A087WT64 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37676378 | 2024 | Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization. | 0 |
| 38256213 | 2024 | Mcl-1 Protein and Viral Infections: A Narrative Review. | 0 |
| 38661028 | 2024 | TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1. | 0 |
| 37676378 | 2024 | Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization. | 0 |
| 38256213 | 2024 | Mcl-1 Protein and Viral Infections: A Narrative Review. | 0 |
| 38661028 | 2024 | TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1. | 0 |
| 36226498 | 2023 | Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation. | 6 |
| 36260529 | 2023 | N6-methyladenosine modification in trophoblasts promotes circSETD2 expression, inhibits miR-181a-5p, and elevates MCL1 transcription to reduce apoptosis of trophoblasts. | 4 |
| 36346691 | 2023 | Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies. | 6 |
| 36918717 | 2023 | Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer. | 6 |
| 37142223 | 2023 | Polypyrimidine tract binding protein 1 (PTBP1) contains a novel regulatory sequence, the rBH3, that binds the prosurvival protein MCL1. | 2 |
| 37160897 | 2023 | SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication. | 9 |
| 37349598 | 2023 | MCL1 regulates AML cells metabolism via direct interaction with HK2. Metabolic signature at onset predicts overall survival in AMLs' patients. | 4 |
| 37467344 | 2023 | Myeloid cell leukemia-1 as a candidate prognostic biomarker in cancers: a systematic review and meta-analysis. | 1 |
| 38055341 | 2023 | FBXW7 affects autophagy through MCL1 in oral squamous cell carcinoma. | 1 |
Citation
Dessen P
MCL1 (MCL1 apoptosis regulator, BCL2 family member)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41317/mcl1
