MCL1 (MCL1, BCL2 family apoptosis regulator)

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MCL1 (MCL1, BCL2 family apoptosis regulator)

Identity

Alias_names	myeloid cell leukemia sequence 1 (BCL2-related)
	myeloid cell leukemia 1
Alias_symbol (synonym)	BCL2L3
	Mcl-1
Other alias	EAT
	MCL1-ES
	MCL1L
	MCL1S
	TM
	bcl2-L-3
	mcl1/EAT
HGNC (Hugo)	MCL1
LocusID (NCBI)	4170
Atlas_Id	41317
Location	1q21.2 [Link to chromosome band 1q21]
Location_base_pair	Starts at 150574551 and ends at 150579738 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

CCL4 (17q12) / MCL1 (1q21.3)	MCL1 (1q21.3) / APLNR (11q12.1)	MCL1 (1q21.3) / AR (Xq12)
MCL1 (1q21.3) / CTSS (1q21.3)	MCL1 (1q21.3) / GARS (7p14.3)	MCL1 (1q21.3) / MCL1 (1q21.3)
MCL1 (1q21.3) / SERPINA1 (14q32.13)	PPP1R12B (1q32.1) / MCL1 (1q21.3)	SLC25A1 (22q11.21) / MCL1 (1q21.3)
ZZZ3 (1p31.1) / MCL1 (1q21.3)	MCL1 1q21.3 / AR Xq12	MCL1 1q21.3 / CTSS 1q21.3

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]

Burkitt's lymphoma (BL)
Multiple Myeloma
t(2;18)(p11;q21)IGK/BCL2 and IGK/KDSR
t(4;11)(q21;q23) KMT2A/AFF1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]

MCL1/CTSS (1q21)
t(X;1)(q12;q21) MCL1/AR

External links

	Nomenclature
HGNC (Hugo)	MCL1 6943
	Cards
Entrez_Gene (NCBI)	MCL1 4170 MCL1, BCL2 family apoptosis regulator
Aliases	BCL2L3; EAT; MCL1-ES; MCL1L;
	MCL1S; Mcl-1; TM; bcl2-L-3; mcl1/EAT
GeneCards (Weizmann)	MCL1
Ensembl hg19 (Hinxton)	ENSG00000143384 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000143384 [Gene_View] ENSG00000143384 [Sequence] chr1:150574551-150579738 [Contig_View] MCL1 [Vega]
ICGC DataPortal	ENSG00000143384
TCGA cBioPortal	MCL1
AceView (NCBI)	MCL1
Genatlas (Paris)	MCL1
WikiGenes	4170
SOURCE (Princeton)	MCL1
Genetics Home Reference (NIH)	MCL1
	Genomic and cartography
GoldenPath hg38 (UCSC)	MCL1 - chr1:150574551-150579738 - 1q21.2 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	MCL1 - 1q21.2 [Description] (hg19-Feb_2009)
Ensembl	MCL1 - 1q21.2 [CytoView hg19] MCL1 - 1q21.2 [CytoView hg38]
Mapping of homologs : NCBI	MCL1 [Mapview hg19] MCL1 [Mapview hg38]
OMIM	159552
	Gene and transcription
Genbank (Entrez)	AA453505 AF118124 AF118276 AF118277 AF118278
RefSeq transcript (Entrez)	NM_001197320 NM_021960 NM_182763
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	MCL1
Cluster EST : Unigene	Hs.632486 [ NCBI ]
CGAP (NCI)	Hs.632486
Alternative Splicing Gallery	ENSG00000143384
Gene Expression	MCL1 [ NCBI-GEO ] MCL1 [ EBI - ARRAY_EXPRESS ] MCL1 [ SEEK ] MCL1 [ MEM ]
Gene Expression Viewer (FireBrowse)	MCL1 [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevestigator	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	4170
GTEX Portal (Tissue expression)	MCL1
Human Protein Atlas	ENSG00000143384-MCL1 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	Q07820 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	Q07820 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	Q07820
Splice isoforms : SwissVar	Q07820
PhosPhoSitePlus	Q07820
Domaine pattern : Prosite (Expaxy)	BCL2_FAMILY (PS50062) BH1 (PS01080) BH2 (PS01258) BH3 (PS01259)
Domains : Interpro (EBI)	Apop_reg_Mc1 Bcl2-like Bcl2_BH1_motif_CS Bcl2_BH2_motif_CS Bcl2_BH3_motif_CS Blc2-like_sf Blc2_fam
Domain families : Pfam (Sanger)	Bcl-2 (PF00452)
Domain families : Pfam (NCBI)	pfam00452
Conserved Domain (NCBI)	MCL1
DMDM Disease mutations	4170
Blocks (Seattle)	MCL1
PDB (SRS)	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8
PDB (PDBSum)	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8
PDB (IMB)	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8
PDB (RSDB)	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8
Structural Biology KnowledgeBase	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8
SCOP (Structural Classification of Proteins)	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8
CATH (Classification of proteins structures)	2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8
Superfamily	Q07820
Human Protein Atlas [tissue]	ENSG00000143384-MCL1 [tissue]
Peptide Atlas	Q07820
HPRD	08870
IPI	IPI00030356 IPI00221306 IPI00943348 IPI00953631
	Protein Interaction databases
DIP (DOE-UCLA)	Q07820
IntAct (EBI)	Q07820
FunCoup	ENSG00000143384
BioGRID	MCL1
STRING (EMBL)	MCL1
ZODIAC	MCL1
	Ontologies - Pathways
QuickGO	Q07820
Ontology : AmiGO	cell fate determination protein binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane mitochondrial outer membrane mitochondrial matrix cytosol cytosol multicellular organism development protein transmembrane transporter activity intrinsic apoptotic signaling pathway in response to DNA damage apoptotic mitochondrial changes negative regulation of autophagy membrane membrane integral component of membrane cytokine-mediated signaling pathway cellular homeostasis response to cytokine protein homodimerization activity negative regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity protein heterodimerization activity BH3 domain binding protein transmembrane transport Bcl-2 family protein complex extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of anoikis regulation of response to DNA damage stimulus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway
Ontology : EGO-EBI	cell fate determination protein binding nucleus nucleoplasm cytoplasm mitochondrion mitochondrial outer membrane mitochondrial outer membrane mitochondrial matrix cytosol cytosol multicellular organism development protein transmembrane transporter activity intrinsic apoptotic signaling pathway in response to DNA damage apoptotic mitochondrial changes negative regulation of autophagy membrane membrane integral component of membrane cytokine-mediated signaling pathway cellular homeostasis response to cytokine protein homodimerization activity negative regulation of apoptotic process negative regulation of apoptotic process protein heterodimerization activity protein heterodimerization activity BH3 domain binding protein transmembrane transport Bcl-2 family protein complex extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of anoikis regulation of response to DNA damage stimulus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway
Pathways : KEGG	PI3K-Akt signaling pathway MicroRNAs in cancer
NDEx Network	MCL1
Atlas of Cancer Signalling Network	MCL1
Wikipedia pathways	MCL1
	Orthology - Evolution
OrthoDB	4170
GeneTree (enSembl)	ENSG00000143384
Phylogenetic Trees/Animal Genes : TreeFam	MCL1
HOVERGEN	Q07820
HOGENOM	Q07820
Homologs : HomoloGene	MCL1
Homology/Alignments : Family Browser (UCSC)	MCL1
	Gene fusions - Rearrangements
Fusion : Mitelman	MCL1/AR [1q21.3/Xq12]
Fusion : Mitelman	MCL1/CTSS [1q21.3/1q21.3] [t(1;1)(q21;q21)]
Fusion Portal	MCL1 1q21.3 AR Xq12 PRAD
Fusion Portal	MCL1 1q21.3 CTSS 1q21.3 OV
Fusion : Quiver	MCL1
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	MCL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	MCL1
dbVar	MCL1
ClinVar	MCL1
1000_Genomes	MCL1
Exome Variant Server	MCL1
ExAC (Exome Aggregation Consortium)	ENSG00000143384
GNOMAD Browser	ENSG00000143384
Varsome Browser	MCL1
Genetic variants : HAPMAP	4170
Genomic Variants (DGV)	MCL1 [DGVbeta]
DECIPHER	MCL1 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	MCL1
	Mutations
ICGC Data Portal	MCL1
TCGA Data Portal	MCL1
Broad Tumor Portal	MCL1
OASIS Portal	MCL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	MCL1 [overview] [genome browser] [tissue] [distribution]
Mutations and Diseases : HGMD	MCL1
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search MCL1
DgiDB (Drug Gene Interaction Database)	MCL1
DoCM (Curated mutations)	MCL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	MCL1 (select a term)
intoGen	MCL1
Cancer3D	MCL1(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	159552
Orphanet
DisGeNET	MCL1
Medgen	MCL1
Genetic Testing Registry	MCL1
NextProt	Q07820 [Medical]
TSGene	4170
GENETests	MCL1
Target Validation	MCL1
Huge Navigator	MCL1 [HugePedia]
snp3D : Map Gene to Disease	4170
BioCentury BCIQ	MCL1
ClinGen	MCL1
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	4170
Chemical/Pharm GKB Gene	PA30688
Clinical trial	MCL1
	Miscellaneous
canSAR (ICR)	MCL1 (select the gene name)
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	MCL1
EVEX	MCL1
GoPubMed	MCL1
iHOP	MCL1

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Aug 27 11:34:36 CEST 2018

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

MCL1 (MCL1, BCL2 family apoptosis regulator)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute