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MCL1 (MCL1 apoptosis regulator, BCL2 family member)

Identity

Alias (NCBI)BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
HGNC (Hugo) MCL1
HGNC Alias symbBCL2L3
Mcl-1
HGNC Previous namemyeloid cell leukemia sequence 1 (BCL2-related)
 myeloid cell leukemia 1
 MCL1, BCL2 family apoptosis regulator
LocusID (NCBI) 4170
Atlas_Id 41317
Location 1q21.2  [Link to chromosome band 1q21]
Location_base_pair Starts at 150574551 and ends at 150579738 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCL4 (17q12) / MCL1 (1q21.3)MCL1 (1q21.3) / APLNR (11q12.1)MCL1 (1q21.3) / AR (Xq12)
MCL1 (1q21.3) / CTSS (1q21.3)MCL1 (1q21.3) / GARS (7p14.3)MCL1 (1q21.3) / MCL1 (1q21.3)
MCL1 (1q21.3) / SERPINA1 (14q32.13)PPP1R12B (1q32.1) / MCL1 (1q21.3)SLC25A1 (22q11.21) / MCL1 (1q21.3)
ZZZ3 (1p31.1) / MCL1 (1q21.3)MCL1 1q21.3 / AR Xq12MCL1 1q21.3 / CTSS 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  Burkitt's lymphoma (BL)
Multiple Myeloma
t(2;18)(p11;q21)IGK/BCL2 and IGK/KDSR
t(4;11)(q21;q23) KMT2A/AFF1
t(14;19)(q32;q13) IGH/Various Partners

External links

Nomenclature
HGNC (Hugo)MCL1   6943
Cards
Entrez_Gene (NCBI)MCL1    MCL1 apoptosis regulator, BCL2 family member
AliasesBCL2L3; EAT; MCL1-ES; MCL1L; 
MCL1S; Mcl-1; TM; bcl2-L-3; mcl1/EAT
GeneCards (Weizmann)MCL1
Ensembl hg19 (Hinxton)ENSG00000143384 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143384 [Gene_View]  ENSG00000143384 [Sequence]  chr1:150574551-150579738 [Contig_View]  MCL1 [Vega]
ICGC DataPortalENSG00000143384
TCGA cBioPortalMCL1
AceView (NCBI)MCL1
Genatlas (Paris)MCL1
SOURCE (Princeton)MCL1
Genetics Home Reference (NIH)MCL1
Genomic and cartography
GoldenPath hg38 (UCSC)MCL1  -     chr1:150574551-150579738 -  1q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCL1  -     1q21.2   [Description]    (hg19-Feb_2009)
GoldenPathMCL1 - 1q21.2 [CytoView hg19]  MCL1 - 1q21.2 [CytoView hg38]
ImmunoBaseENSG00000143384
genome Data Viewer NCBIMCL1 [Mapview hg19]  
OMIM159552   
Gene and transcription
Genbank (Entrez)AA453505 AF118124 AF118276 AF118277 AF118278
RefSeq transcript (Entrez)NM_001197320 NM_021960 NM_182763
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MCL1
Alternative Splicing GalleryENSG00000143384
Gene ExpressionMCL1 [ NCBI-GEO ]   MCL1 [ EBI - ARRAY_EXPRESS ]   MCL1 [ SEEK ]   MCL1 [ MEM ]
Gene Expression Viewer (FireBrowse)MCL1 [ Firebrowse - Broad ]
GenevisibleExpression of MCL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4170
GTEX Portal (Tissue expression)MCL1
Human Protein AtlasENSG00000143384-MCL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MCL1
Blocks (Seattle)MCL1
Human Protein Atlas [tissue]ENSG00000143384-MCL1 [tissue]
HPRD08870
IPIIPI00030356   IPI00221306   IPI00943348   IPI00953631   
Protein Interaction databases
BioGRIDMCL1
STRING (EMBL)MCL1
ZODIACMCL1
Ontologies - Pathways
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMCL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:31:15 CET 2021
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