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MCL1 (MCL1 apoptosis regulator, BCL2 family member)

Identity

Alias (NCBI)BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
HGNC (Hugo) MCL1
HGNC Alias symbBCL2L3
Mcl-1
HGNC Previous namemyeloid cell leukemia sequence 1 (BCL2-related)
 myeloid cell leukemia 1
 MCL1, BCL2 family apoptosis regulator
LocusID (NCBI) 4170
Atlas_Id 41317
Location 1q21.2  [Link to chromosome band 1q21]
Location_base_pair Starts at 150574551 and ends at 150579738 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCL4 (17q12) / MCL1 (1q21.3)MCL1 (1q21.3) / APLNR (11q12.1)MCL1 (1q21.3) / AR (Xq12)
MCL1 (1q21.3) / CTSS (1q21.3)MCL1 (1q21.3) / GARS (7p14.3)MCL1 (1q21.3) / MCL1 (1q21.3)
MCL1 (1q21.3) / SERPINA1 (14q32.13)PPP1R12B (1q32.1) / MCL1 (1q21.3)SLC25A1 (22q11.21) / MCL1 (1q21.3)
ZZZ3 (1p31.1) / MCL1 (1q21.3)MCL1 1q21.3 / AR Xq12MCL1 1q21.3 / CTSS 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  Burkitt's lymphoma (BL)
Multiple Myeloma
t(2;18)(p11;q21)IGK/BCL2 and IGK/KDSR
t(4;11)(q21;q23) KMT2A/AFF1
t(14;19)(q32;q13) IGH/Various Partners

External links

Nomenclature
HGNC (Hugo)MCL1   6943
Cards
Entrez_Gene (NCBI)MCL1    MCL1 apoptosis regulator, BCL2 family member
AliasesBCL2L3; EAT; MCL1-ES; MCL1L; 
MCL1S; Mcl-1; TM; bcl2-L-3; mcl1/EAT
GeneCards (Weizmann)MCL1
Ensembl hg19 (Hinxton)ENSG00000143384 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143384 [Gene_View]  ENSG00000143384 [Sequence]  chr1:150574551-150579738 [Contig_View]  MCL1 [Vega]
ICGC DataPortalENSG00000143384
TCGA cBioPortalMCL1
AceView (NCBI)MCL1
Genatlas (Paris)MCL1
SOURCE (Princeton)MCL1
Genetics Home Reference (NIH)MCL1
Genomic and cartography
GoldenPath hg38 (UCSC)MCL1  -     chr1:150574551-150579738 -  1q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCL1  -     1q21.2   [Description]    (hg19-Feb_2009)
GoldenPathMCL1 - 1q21.2 [CytoView hg19]  MCL1 - 1q21.2 [CytoView hg38]
ImmunoBaseENSG00000143384
Genome Data Viewer NCBIMCL1 [Mapview hg19]  
OMIM159552   
Gene and transcription
Genbank (Entrez)AA453505 AF118124 AF118276 AF118277 AF118278
RefSeq transcript (Entrez)NM_001197320 NM_021960 NM_182763
Consensus coding sequences : CCDS (NCBI)MCL1
Gene ExpressionMCL1 [ NCBI-GEO ]   MCL1 [ EBI - ARRAY_EXPRESS ]   MCL1 [ SEEK ]   MCL1 [ MEM ]
Gene Expression Viewer (FireBrowse)MCL1 [ Firebrowse - Broad ]
GenevisibleExpression of MCL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4170
GTEX Portal (Tissue expression)MCL1
Human Protein AtlasENSG00000143384-MCL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MCL1
Human Protein Atlas [tissue]ENSG00000143384-MCL1 [tissue]
HPRD08870
Protein Interaction databases
BioGRIDMCL1
STRING (EMBL)MCL1
ZODIACMCL1
Ontologies - Pathways
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMCL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:18:04 CEST 2021
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