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MCM2 (minichromosome maintenance complex component 2)

Identity

Alias_namesCCNL1
CDCL1
minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin)
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)
Alias_symbol (synonym)D3S3194
KIAA0030
BM28
cdc19
Other aliasDFNA70
MITOTIN
HGNC (Hugo) MCM2
LocusID (NCBI) 4171
Atlas_Id 41318
Location 3q21.3  [Link to chromosome band 3q21]
Location_base_pair Starts at 127598357 and ends at 127622435 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GTF3A (13q12.2) / MCM2 (3q21.3)MCM2 (3q21.3) / MCM2 (3q21.3)MCM2 (3q21.3) / TBC1D5 (3p24.3)
MCM2 (3q21.3) / TFEB (6p21.1)TFEB (6p21.1) / MCM2 (3q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and neck: Retinoblastoma


External links

Nomenclature
HGNC (Hugo)MCM2   6944
Cards
Entrez_Gene (NCBI)MCM2  4171  minichromosome maintenance complex component 2
AliasesBM28; CCNL1; CDCL1; D3S3194; 
DFNA70; MITOTIN; cdc19
GeneCards (Weizmann)MCM2
Ensembl hg19 (Hinxton)ENSG00000073111 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073111 [Gene_View]  chr3:127598357-127622435 [Contig_View]  MCM2 [Vega]
ICGC DataPortalENSG00000073111
TCGA cBioPortalMCM2
AceView (NCBI)MCM2
Genatlas (Paris)MCM2
WikiGenes4171
SOURCE (Princeton)MCM2
Genetics Home Reference (NIH)MCM2
Genomic and cartography
GoldenPath hg38 (UCSC)MCM2  -     chr3:127598357-127622435 +  3q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCM2  -     3q21.3   [Description]    (hg19-Feb_2009)
EnsemblMCM2 - 3q21.3 [CytoView hg19]  MCM2 - 3q21.3 [CytoView hg38]
Mapping of homologs : NCBIMCM2 [Mapview hg19]  MCM2 [Mapview hg38]
OMIM116945   616968   
Gene and transcription
Genbank (Entrez)AK128291 AK299934 AK304204 AK309335 BC000300
RefSeq transcript (Entrez)NM_004526
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MCM2
Cluster EST : UnigeneHs.477481 [ NCBI ]
CGAP (NCI)Hs.477481
Alternative Splicing GalleryENSG00000073111
Gene ExpressionMCM2 [ NCBI-GEO ]   MCM2 [ EBI - ARRAY_EXPRESS ]   MCM2 [ SEEK ]   MCM2 [ MEM ]
Gene Expression Viewer (FireBrowse)MCM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4171
GTEX Portal (Tissue expression)MCM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49736   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49736  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49736
Splice isoforms : SwissVarP49736
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
PhosPhoSitePlusP49736
Domaine pattern : Prosite (Expaxy)MCM_1 (PS00847)    MCM_2 (PS50051)   
Domains : Interpro (EBI)MCM    MCM2    MCM_CS    MCM_dom    MCM_N    MCM_OB    NA-bd_OB-fold    P-loop_NTPase   
Domain families : Pfam (Sanger)MCM (PF00493)    MCM2_N (PF12619)    MCM_N (PF14551)    MCM_OB (PF17207)   
Domain families : Pfam (NCBI)pfam00493    pfam12619    pfam14551    pfam17207   
Domain families : Smart (EMBL)MCM (SM00350)  
Conserved Domain (NCBI)MCM2
DMDM Disease mutations4171
Blocks (Seattle)MCM2
PDB (SRS)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4   
PDB (PDBSum)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4   
PDB (IMB)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4   
PDB (RSDB)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4   
Structural Biology KnowledgeBase4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4   
SCOP (Structural Classification of Proteins)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4   
CATH (Classification of proteins structures)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4   
SuperfamilyP49736
Human Protein AtlasENSG00000073111
Peptide AtlasP49736
HPRD00303
IPIIPI00184330   IPI00922181   IPI01013402   IPI00791616   IPI00945525   IPI00946193   IPI00946031   
Protein Interaction databases
DIP (DOE-UCLA)P49736
IntAct (EBI)P49736
FunCoupENSG00000073111
BioGRIDMCM2
STRING (EMBL)MCM2
ZODIACMCM2
Ontologies - Pathways
QuickGOP49736
Ontology : AmiGOG1/S transition of mitotic cell cycle  nuclear chromosome, telomeric region  chromatin  DNA binding  DNA helicase activity  DNA replication origin binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nuclear origin of replication recognition complex  cytoplasm  cytosol  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  nucleosome assembly  apoptotic process  microtubule cytoskeleton  enzyme binding  histone binding  MCM complex  metal ion binding  cellular response to interleukin-4  cochlea development  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  nuclear chromosome, telomeric region  chromatin  DNA binding  DNA helicase activity  DNA replication origin binding  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nuclear origin of replication recognition complex  cytoplasm  cytosol  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  nucleosome assembly  apoptotic process  microtubule cytoskeleton  enzyme binding  histone binding  MCM complex  metal ion binding  cellular response to interleukin-4  cochlea development  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGDNA replication    Cell cycle   
NDEx NetworkMCM2
Atlas of Cancer Signalling NetworkMCM2
Wikipedia pathwaysMCM2
Orthology - Evolution
OrthoDB4171
GeneTree (enSembl)ENSG00000073111
Phylogenetic Trees/Animal Genes : TreeFamMCM2
HOVERGENP49736
HOGENOMP49736
Homologs : HomoloGeneMCM2
Homology/Alignments : Family Browser (UCSC)MCM2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM2
dbVarMCM2
ClinVarMCM2
1000_GenomesMCM2 
Exome Variant ServerMCM2
ExAC (Exome Aggregation Consortium)MCM2 (select the gene name)
Genetic variants : HAPMAP4171
Genomic Variants (DGV)MCM2 [DGVbeta]
DECIPHERMCM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCM2 
Mutations
ICGC Data PortalMCM2 
TCGA Data PortalMCM2 
Broad Tumor PortalMCM2
OASIS PortalMCM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMCM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MCM2
DgiDB (Drug Gene Interaction Database)MCM2
DoCM (Curated mutations)MCM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCM2 (select a term)
intoGenMCM2
Cancer3DMCM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM116945    616968   
Orphanet12046   
MedgenMCM2
Genetic Testing Registry MCM2
NextProtP49736 [Medical]
TSGene4171
GENETestsMCM2
Target ValidationMCM2
Huge Navigator MCM2 [HugePedia]
snp3D : Map Gene to Disease4171
BioCentury BCIQMCM2
ClinGenMCM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4171
Chemical/Pharm GKB GenePA164742061
Clinical trialMCM2
Miscellaneous
canSAR (ICR)MCM2 (select the gene name)
Probes
Litterature
PubMed191 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCM2
EVEXMCM2
GoPubMedMCM2
iHOPMCM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:42:33 CEST 2017

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