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MCM2 (minichromosome maintenance complex component 2)

Identity

Alias (NCBI)BM28
CCNL1
CDCL1
D3S3194
DFNA70
MITOTIN
cdc19
HGNC (Hugo) MCM2
HGNC Alias symbD3S3194
KIAA0030
BM28
cdc19
DFNA70
HGNC Alias namemitotin
HGNC Previous nameCCNL1
 CDCL1
HGNC Previous nameminichromosome maintenance deficient (S. cerevisiae) 2 (mitotin)
 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)
LocusID (NCBI) 4171
Atlas_Id 41318
Location 3q21.3  [Link to chromosome band 3q21]
Location_base_pair Starts at 127598411 and ends at 127622435 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GTF3A (13q12.2)::MCM2 (3q21.3)MCM2 (3q21.3)::MCM2 (3q21.3)MCM2 (3q21.3)::TBC1D5 (3p24.3)
MCM2 (3q21.3)::TFEB (6p21.1)TFEB (6p21.1)::MCM2 (3q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MCM2   6944
Cards
Entrez_Gene (NCBI)MCM2    minichromosome maintenance complex component 2
AliasesBM28; CCNL1; CDCL1; D3S3194; 
DFNA70; MITOTIN; cdc19
GeneCards (Weizmann)MCM2
Ensembl hg19 (Hinxton)ENSG00000073111 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073111 [Gene_View]  ENSG00000073111 [Sequence]  chr3:127598411-127622435 [Contig_View]  MCM2 [Vega]
ICGC DataPortalENSG00000073111
TCGA cBioPortalMCM2
AceView (NCBI)MCM2
Genatlas (Paris)MCM2
SOURCE (Princeton)MCM2
Genetics Home Reference (NIH)MCM2
Genomic and cartography
GoldenPath hg38 (UCSC)MCM2  -     chr3:127598411-127622435 +  3q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCM2  -     3q21.3   [Description]    (hg19-Feb_2009)
GoldenPathMCM2 - 3q21.3 [CytoView hg19]  MCM2 - 3q21.3 [CytoView hg38]
ImmunoBaseENSG00000073111
Genome Data Viewer NCBIMCM2 [Mapview hg19]  
OMIM116945   616968   
Gene and transcription
Genbank (Entrez)AK128291 AK299934 AK304204 AK309335 BC000300
RefSeq transcript (Entrez)NM_004526
Consensus coding sequences : CCDS (NCBI)MCM2
Gene ExpressionMCM2 [ NCBI-GEO ]   MCM2 [ EBI - ARRAY_EXPRESS ]   MCM2 [ SEEK ]   MCM2 [ MEM ]
Gene Expression Viewer (FireBrowse)MCM2 [ Firebrowse - Broad ]
GenevisibleExpression of MCM2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4171
GTEX Portal (Tissue expression)MCM2
Human Protein AtlasENSG00000073111-MCM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49736   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49736  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49736
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP49736
Domaine pattern : Prosite (Expaxy)MCM_1 (PS00847)    MCM_2 (PS50051)   
Domains : Interpro (EBI)MCM    MCM2    MCM_CS    MCM_dom    MCM_lid    MCM_N    MCM_OB    NA-bd_OB-fold    P-loop_NTPase   
Domain families : Pfam (Sanger)MCM (PF00493)    MCM2_N (PF12619)    MCM_lid (PF17855)    MCM_N (PF14551)    MCM_OB (PF17207)   
Domain families : Pfam (NCBI)pfam00493    pfam12619    pfam17855    pfam14551    pfam17207   
Domain families : Smart (EMBL)MCM (SM00350)  
Conserved Domain (NCBI)MCM2
PDB (RSDB)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4    6XTX    6XTY    6YA7   
PDB Europe4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4    6XTX    6XTY    6YA7   
PDB (PDBSum)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4    6XTX    6XTY    6YA7   
PDB (IMB)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4    6XTX    6XTY    6YA7   
Structural Biology KnowledgeBase4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4    6XTX    6XTY    6YA7   
SCOP (Structural Classification of Proteins)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4    6XTX    6XTY    6YA7   
CATH (Classification of proteins structures)4UUZ    5BNV    5BNX    5BO0    5C3I    5JA4    6XTX    6XTY    6YA7   
SuperfamilyP49736
AlphaFold pdb e-kbP49736   
Human Protein Atlas [tissue]ENSG00000073111-MCM2 [tissue]
HPRD00303
Protein Interaction databases
DIP (DOE-UCLA)P49736
IntAct (EBI)P49736
BioGRIDMCM2
STRING (EMBL)MCM2
ZODIACMCM2
Ontologies - Pathways
QuickGOP49736
Ontology : AmiGOdouble-strand break repair via break-induced replication  chromosome, telomeric region  chromatin  DNA binding  DNA replication origin binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nuclear origin of replication recognition complex  nucleolus  cytoplasm  DNA replication  DNA unwinding involved in DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  nucleosome assembly  apoptotic process  ATP hydrolysis activity  single-stranded DNA helicase activity  enzyme binding  histone binding  MCM complex  MCM complex  MCM complex  3'-5' DNA helicase activity  metal ion binding  CMG complex  CMG complex  cellular response to interleukin-4  cochlea development  mitotic DNA replication initiation  negative regulation of DNA helicase activity  
Ontology : EGO-EBIdouble-strand break repair via break-induced replication  chromosome, telomeric region  chromatin  DNA binding  DNA replication origin binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nuclear origin of replication recognition complex  nucleolus  cytoplasm  DNA replication  DNA unwinding involved in DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  nucleosome assembly  apoptotic process  ATP hydrolysis activity  single-stranded DNA helicase activity  enzyme binding  histone binding  MCM complex  MCM complex  MCM complex  3'-5' DNA helicase activity  metal ion binding  CMG complex  CMG complex  cellular response to interleukin-4  cochlea development  mitotic DNA replication initiation  negative regulation of DNA helicase activity  
Pathways : BIOCARTABIOCARTA_MCMPATHWAY   
Pathways : KEGGKEGG_DNA_REPLICATION    KEGG_CELL_CYCLE   
NDEx NetworkMCM2
Atlas of Cancer Signalling NetworkMCM2
Wikipedia pathwaysMCM2
Orthology - Evolution
OrthoDB4171
GeneTree (enSembl)ENSG00000073111
Phylogenetic Trees/Animal Genes : TreeFamMCM2
Homologs : HomoloGeneMCM2
Homology/Alignments : Family Browser (UCSC)MCM2
Gene fusions - Rearrangements
Fusion : QuiverMCM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM2
dbVarMCM2
ClinVarMCM2
MonarchMCM2
1000_GenomesMCM2 
Exome Variant ServerMCM2
GNOMAD BrowserENSG00000073111
Varsome BrowserMCM2
ACMGMCM2 variants
VarityP49736
Genomic Variants (DGV)MCM2 [DGVbeta]
DECIPHERMCM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCM2 
Mutations
ICGC Data PortalMCM2 
TCGA Data PortalMCM2 
Broad Tumor PortalMCM2
OASIS PortalMCM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMCM2
Mutations and Diseases : HGMDMCM2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMCM2
DgiDB (Drug Gene Interaction Database)MCM2
DoCM (Curated mutations)MCM2
CIViC (Clinical Interpretations of Variants in Cancer)MCM2
Cancer3DMCM2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM116945    616968   
Orphanet12046   
DisGeNETMCM2
MedgenMCM2
Genetic Testing Registry MCM2
NextProtP49736 [Medical]
GENETestsMCM2
Target ValidationMCM2
Huge Navigator MCM2 [HugePedia]
ClinGenMCM2
Clinical trials, drugs, therapy
MyCancerGenomeMCM2
Protein Interactions : CTDMCM2
Pharm GKB GenePA164742061
PharosP49736
Clinical trialMCM2
Miscellaneous
canSAR (ICR)MCM2
HarmonizomeMCM2
ARCHS4MCM2
DataMed IndexMCM2
Probes
Litterature
PubMed293 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMCM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:43:35 CET 2022

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