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MCM3AP (minichromosome maintenance complex component 3 associated protein)

Identity

Alias_namesminichromosome maintenance deficient (S. cerevisiae) 3-associated protein
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein
Alias_symbol (synonym)Map80
KIAA0572
GANP
SAC3
Other aliasMAP80
HGNC (Hugo) MCM3AP
LocusID (NCBI) 8888
Atlas_Id 43358
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 46235125 and ends at 46285394 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LOC100507373 (19p13.12) / MCM3AP (21q22.3)PTPRG (3p14.2) / MCM3AP (21q22.3)RNF138 (18q12.1) / MCM3AP (21q22.3)
PTPRG 3p14.2 / MCM3AP 21q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MCM3AP   6946
Cards
Entrez_Gene (NCBI)MCM3AP  8888  minichromosome maintenance complex component 3 associated protein
AliasesGANP; MAP80; SAC3
GeneCards (Weizmann)MCM3AP
Ensembl hg19 (Hinxton)ENSG00000160294 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160294 [Gene_View]  chr21:46235125-46285394 [Contig_View]  MCM3AP [Vega]
ICGC DataPortalENSG00000160294
TCGA cBioPortalMCM3AP
AceView (NCBI)MCM3AP
Genatlas (Paris)MCM3AP
WikiGenes8888
SOURCE (Princeton)MCM3AP
Genetics Home Reference (NIH)MCM3AP
Genomic and cartography
GoldenPath hg38 (UCSC)MCM3AP  -     chr21:46235125-46285394 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCM3AP  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblMCM3AP - 21q22.3 [CytoView hg19]  MCM3AP - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIMCM3AP [Mapview hg19]  MCM3AP [Mapview hg38]
OMIM603294   
Gene and transcription
Genbank (Entrez)AA659734 AB005543 AB011144 AJ010089 AK022303
RefSeq transcript (Entrez)NM_003906
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MCM3AP
Cluster EST : UnigeneHs.592438 [ NCBI ]
CGAP (NCI)Hs.592438
Alternative Splicing GalleryENSG00000160294
Gene ExpressionMCM3AP [ NCBI-GEO ]   MCM3AP [ EBI - ARRAY_EXPRESS ]   MCM3AP [ SEEK ]   MCM3AP [ MEM ]
Gene Expression Viewer (FireBrowse)MCM3AP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8888
GTEX Portal (Tissue expression)MCM3AP
Human Protein AtlasENSG00000160294-MCM3AP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60318   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60318  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60318
Splice isoforms : SwissVarO60318
Catalytic activity : Enzyme2.3.1.- [ Enzyme-Expasy ]   2.3.1.-2.3.1.- [ IntEnz-EBI ]   2.3.1.- [ BRENDA ]   2.3.1.- [ KEGG ]   
PhosPhoSitePlusO60318
Domains : Interpro (EBI)GANP_CID_dom    MCM3AP_GANP    MCM3AP_RRM    NupH_GANP    RRM_dom    SAC3/GANP/THP3   
Domain families : Pfam (Sanger)CID_GANP (PF16766)    MCM3AP_GANP (PF16769)    NupH_GANP (PF16768)    SAC3_GANP (PF03399)   
Domain families : Pfam (NCBI)pfam16766    pfam16769    pfam16768    pfam03399   
Conserved Domain (NCBI)MCM3AP
DMDM Disease mutations8888
Blocks (Seattle)MCM3AP
PDB (SRS)4DHX   
PDB (PDBSum)4DHX   
PDB (IMB)4DHX   
PDB (RSDB)4DHX   
Structural Biology KnowledgeBase4DHX   
SCOP (Structural Classification of Proteins)4DHX   
CATH (Classification of proteins structures)4DHX   
SuperfamilyO60318
Human Protein Atlas [tissue]ENSG00000160294-MCM3AP [tissue]
Peptide AtlasO60318
HPRD04483
IPIIPI00028954   IPI01009859   IPI00798207   
Protein Interaction databases
DIP (DOE-UCLA)O60318
IntAct (EBI)O60318
FunCoupENSG00000160294
BioGRIDMCM3AP
STRING (EMBL)MCM3AP
ZODIACMCM3AP
Ontologies - Pathways
QuickGOO60318
Ontology : AmiGOimmune system process  DNA binding  nucleus  nuclear pore  nucleoplasm  cytosol  protein import into nucleus  transferase activity, transferring acyl groups  nuclear membrane  mRNA transport  
Ontology : EGO-EBIimmune system process  DNA binding  nucleus  nuclear pore  nucleoplasm  cytosol  protein import into nucleus  transferase activity, transferring acyl groups  nuclear membrane  mRNA transport  
NDEx NetworkMCM3AP
Atlas of Cancer Signalling NetworkMCM3AP
Wikipedia pathwaysMCM3AP
Orthology - Evolution
OrthoDB8888
GeneTree (enSembl)ENSG00000160294
Phylogenetic Trees/Animal Genes : TreeFamMCM3AP
HOVERGENO60318
HOGENOMO60318
Homologs : HomoloGeneMCM3AP
Homology/Alignments : Family Browser (UCSC)MCM3AP
Gene fusions - Rearrangements
Fusion : MitelmanPTPRG/MCM3AP [3p14.2/21q22.3]  [t(3;21)(p14;q22)]  
Fusion: TCGA_MDACCPTPRG 3p14.2 MCM3AP 21q22.3 LUSC
Tumor Fusion PortalMCM3AP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCM3AP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM3AP
dbVarMCM3AP
ClinVarMCM3AP
1000_GenomesMCM3AP 
Exome Variant ServerMCM3AP
ExAC (Exome Aggregation Consortium)ENSG00000160294
GNOMAD BrowserENSG00000160294
Genetic variants : HAPMAP8888
Genomic Variants (DGV)MCM3AP [DGVbeta]
DECIPHERMCM3AP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCM3AP 
Mutations
ICGC Data PortalMCM3AP 
TCGA Data PortalMCM3AP 
Broad Tumor PortalMCM3AP
OASIS PortalMCM3AP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM3AP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMCM3AP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MCM3AP
DgiDB (Drug Gene Interaction Database)MCM3AP
DoCM (Curated mutations)MCM3AP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCM3AP (select a term)
intoGenMCM3AP
Cancer3DMCM3AP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603294   
Orphanet
DisGeNETMCM3AP
MedgenMCM3AP
Genetic Testing Registry MCM3AP
NextProtO60318 [Medical]
TSGene8888
GENETestsMCM3AP
Target ValidationMCM3AP
Huge Navigator MCM3AP [HugePedia]
snp3D : Map Gene to Disease8888
BioCentury BCIQMCM3AP
ClinGenMCM3AP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8888
Chemical/Pharm GKB GenePA30692
Clinical trialMCM3AP
Miscellaneous
canSAR (ICR)MCM3AP (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCM3AP
EVEXMCM3AP
GoPubMedMCM3AP
iHOPMCM3AP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Nov 20 20:45:27 CET 2017

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