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MCM4 (minichromosome maintenance complex component 4)

Identity

Alias (NCBI)CDC21
CDC54
IMD54
NKCD
NKGCD
P1-CDC21
hCdc21
HGNC (Hugo) MCM4
HGNC Alias symbCDC54
hCdc21
P1-Cdc21
MGC33310
HGNC Alias nameDNA replication licensing factor MCM4
HGNC Previous nameCDC21
HGNC Previous nameMCM4 minichromosome maintenance deficient 4 (S. cerevisiae)
LocusID (NCBI) 4173
Atlas_Id 41320
Location 8q11.21  [Link to chromosome band 8q11]
Location_base_pair Starts at 47960941 and ends at 47978159 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MCM4 (8q11.21) / AP2M1 (3q27.1)MCM4 (8q11.21) / PRKDC (8q11.21)MEF2BNB-MEF2B (19p13.11) / MCM4 (8q11.21)
TPGS2 (18q12.2) / MCM4 (8q11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MCM4   6947
Cards
Entrez_Gene (NCBI)MCM4    minichromosome maintenance complex component 4
AliasesCDC21; CDC54; IMD54; NKCD; 
NKGCD; P1-CDC21; hCdc21
GeneCards (Weizmann)MCM4
Ensembl hg19 (Hinxton)ENSG00000104738 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104738 [Gene_View]  ENSG00000104738 [Sequence]  chr8:47960941-47978159 [Contig_View]  MCM4 [Vega]
ICGC DataPortalENSG00000104738
TCGA cBioPortalMCM4
AceView (NCBI)MCM4
Genatlas (Paris)MCM4
SOURCE (Princeton)MCM4
Genetics Home Reference (NIH)MCM4
Genomic and cartography
GoldenPath hg38 (UCSC)MCM4  -     chr8:47960941-47978159 +  8q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCM4  -     8q11.21   [Description]    (hg19-Feb_2009)
GoldenPathMCM4 - 8q11.21 [CytoView hg19]  MCM4 - 8q11.21 [CytoView hg38]
ImmunoBaseENSG00000104738
Genome Data Viewer NCBIMCM4 [Mapview hg19]  
OMIM602638   609981   
Gene and transcription
Genbank (Entrez)AK022899 AK296913 AK309812 AM493756 BC031061
RefSeq transcript (Entrez)NM_005914 NM_182746
Consensus coding sequences : CCDS (NCBI)MCM4
Gene ExpressionMCM4 [ NCBI-GEO ]   MCM4 [ EBI - ARRAY_EXPRESS ]   MCM4 [ SEEK ]   MCM4 [ MEM ]
Gene Expression Viewer (FireBrowse)MCM4 [ Firebrowse - Broad ]
GenevisibleExpression of MCM4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4173
GTEX Portal (Tissue expression)MCM4
Human Protein AtlasENSG00000104738-MCM4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33991   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33991  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33991
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP33991
Domaine pattern : Prosite (Expaxy)MCM_1 (PS00847)    MCM_2 (PS50051)   
Domains : Interpro (EBI)MCM    MCM_4    MCM_CS    MCM_dom    MCM_lid    MCM_N    MCM_OB    NA-bd_OB-fold    P-loop_NTPase   
Domain families : Pfam (Sanger)MCM (PF00493)    MCM_lid (PF17855)    MCM_N (PF14551)    MCM_OB (PF17207)   
Domain families : Pfam (NCBI)pfam00493    pfam17855    pfam14551    pfam17207   
Domain families : Smart (EMBL)MCM (SM00350)  
Conserved Domain (NCBI)MCM4
PDB (RSDB)6XTX    6XTY   
PDB Europe6XTX    6XTY   
PDB (PDBSum)6XTX    6XTY   
PDB (IMB)6XTX    6XTY   
Structural Biology KnowledgeBase6XTX    6XTY   
SCOP (Structural Classification of Proteins)6XTX    6XTY   
CATH (Classification of proteins structures)6XTX    6XTY   
SuperfamilyP33991
AlphaFold pdb e-kbP33991   
Human Protein Atlas [tissue]ENSG00000104738-MCM4 [tissue]
HPRD09094
Protein Interaction databases
DIP (DOE-UCLA)P33991
IntAct (EBI)P33991
BioGRIDMCM4
STRING (EMBL)MCM4
ZODIACMCM4
Ontologies - Pathways
QuickGOP33991
Ontology : AmiGOdouble-strand break repair via break-induced replication  chromosome, telomeric region  DNA helicase activity  DNA replication origin binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication  pre-replicative complex assembly involved in nuclear cell cycle DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  DNA strand elongation involved in DNA replication  membrane  hydrolase activity  pre-replicative complex assembly  MCM complex  MCM complex  CMG complex  mitotic DNA replication initiation  
Ontology : EGO-EBIdouble-strand break repair via break-induced replication  chromosome, telomeric region  DNA helicase activity  DNA replication origin binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication  pre-replicative complex assembly involved in nuclear cell cycle DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  DNA strand elongation involved in DNA replication  membrane  hydrolase activity  pre-replicative complex assembly  MCM complex  MCM complex  CMG complex  mitotic DNA replication initiation  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGDNA replication    Cell cycle   
NDEx NetworkMCM4
Atlas of Cancer Signalling NetworkMCM4
Wikipedia pathwaysMCM4
Orthology - Evolution
OrthoDB4173
GeneTree (enSembl)ENSG00000104738
Phylogenetic Trees/Animal Genes : TreeFamMCM4
Homologs : HomoloGeneMCM4
Homology/Alignments : Family Browser (UCSC)MCM4
Gene fusions - Rearrangements
Fusion : QuiverMCM4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCM4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM4
dbVarMCM4
ClinVarMCM4
MonarchMCM4
1000_GenomesMCM4 
Exome Variant ServerMCM4
GNOMAD BrowserENSG00000104738
Varsome BrowserMCM4
ACMGMCM4 variants
VarityP33991
Genomic Variants (DGV)MCM4 [DGVbeta]
DECIPHERMCM4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCM4 
Mutations
ICGC Data PortalMCM4 
TCGA Data PortalMCM4 
Broad Tumor PortalMCM4
OASIS PortalMCM4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMCM4
Mutations and Diseases : HGMDMCM4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMCM4
DgiDB (Drug Gene Interaction Database)MCM4
DoCM (Curated mutations)MCM4
CIViC (Clinical Interpretations of Variants in Cancer)MCM4
Cancer3DMCM4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602638    609981   
Orphanet11081   
DisGeNETMCM4
MedgenMCM4
Genetic Testing Registry MCM4
NextProtP33991 [Medical]
GENETestsMCM4
Target ValidationMCM4
Huge Navigator MCM4 [HugePedia]
ClinGenMCM4
Clinical trials, drugs, therapy
MyCancerGenomeMCM4
Protein Interactions : CTDMCM4
Pharm GKB GenePA30694
PharosP33991
Clinical trialMCM4
Miscellaneous
canSAR (ICR)MCM4
HarmonizomeMCM4
DataMed IndexMCM4
Probes
Litterature
PubMed183 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMCM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:18:05 CEST 2021

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