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MCM4 (minichromosome maintenance complex component 4)

Identity

Other namesCDC21
CDC54
NKCD
NKGCD
P1-CDC21
hCdc21
HGNC (Hugo) MCM4
LocusID (NCBI) 4173
Atlas_Id 41320
Location 8q11.21
Location_base_pair Starts at 48872763 and ends at 48890719 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MCM4   6947
Cards
Entrez_Gene (NCBI)MCM4  4173  minichromosome maintenance complex component 4
GeneCards (Weizmann)MCM4
Ensembl hg19 (Hinxton)ENSG00000104738 [Gene_View]  chr8:48872763-48890719 [Contig_View]  MCM4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000104738 [Gene_View]  chr8:48872763-48890719 [Contig_View]  MCM4 [Vega]
ICGC DataPortalENSG00000104738
TCGA cBioPortalMCM4
AceView (NCBI)MCM4
Genatlas (Paris)MCM4
WikiGenes4173
SOURCE (Princeton)MCM4
Genomic and cartography
GoldenPath hg19 (UCSC)MCM4  -     chr8:48872763-48890719 +  8q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MCM4  -     8q11.21   [Description]    (hg38-Dec_2013)
EnsemblMCM4 - 8q11.21 [CytoView hg19]  MCM4 - 8q11.21 [CytoView hg38]
Mapping of homologs : NCBIMCM4 [Mapview hg19]  MCM4 [Mapview hg38]
OMIM602638   609981   
Gene and transcription
Genbank (Entrez)AK022899 AK296913 AK309812 AM493756 BC031061
RefSeq transcript (Entrez)NM_005914 NM_182746
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_032967 NT_008183 NW_004929339
Consensus coding sequences : CCDS (NCBI)MCM4
Cluster EST : UnigeneHs.460184 [ NCBI ]
CGAP (NCI)Hs.460184
Alternative Splicing : Fast-db (Paris)GSHG0028997
Alternative Splicing GalleryENSG00000104738
Gene ExpressionMCM4 [ NCBI-GEO ]     MCM4 [ SEEK ]   MCM4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33991 (Uniprot)
NextProtP33991  [Medical]  [Publications]
With graphics : InterProP33991
Splice isoforms : SwissVarP33991 (Swissvar)
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)MCM_1 (PS00847)    MCM_2 (PS50051)   
Domains : Interpro (EBI)AAA+_ATPase    MCM_4    MCM_CS    MCM_DNA-dep_ATPase    MCM_N    NA-bd_OB-fold    P-loop_NTPase    Rubredoxin-type_fold   
Related proteins : CluSTrP33991
Domain families : Pfam (Sanger)MCM (PF00493)    MCM_N (PF14551)   
Domain families : Pfam (NCBI)pfam00493    pfam14551   
Domain families : Smart (EMBL)AAA (SM00382)  MCM (SM00350)  
DMDM Disease mutations4173
Blocks (Seattle)P33991
Human Protein AtlasENSG00000104738
Peptide AtlasP33991
HPRD09094
IPIIPI00018349   IPI00795318   IPI01013303   IPI00797037   IPI00985223   IPI00977491   IPI00974419   IPI00979941   IPI00980607   
Protein Interaction databases
DIP (DOE-UCLA)P33991
IntAct (EBI)P33991
FunCoupENSG00000104738
BioGRIDMCM4
IntegromeDBMCM4
STRING (EMBL)MCM4
Ontologies - Pathways
QuickGOP33991
Ontology : AmiGOG1/S transition of mitotic cell cycle  mitotic cell cycle  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  DNA strand elongation involved in DNA replication  membrane  MCM complex  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  mitotic cell cycle  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  DNA strand elongation involved in DNA replication  membrane  MCM complex  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGDNA replication    Cell cycle   
Protein Interaction DatabaseMCM4
DoCM (Curated mutations)MCM4
Wikipedia pathwaysMCM4
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerMCM4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM4
dbVarMCM4
ClinVarMCM4
1000_GenomesMCM4 
Exome Variant ServerMCM4
SNP (GeneSNP Utah)MCM4
SNP : HGBaseMCM4
Genetic variants : HAPMAPMCM4
Genomic Variants (DGV)MCM4 [DGVbeta]
Mutations
ICGC Data PortalMCM4 
TCGA Data PortalMCM4 
Tumor PortalMCM4
Somatic Mutations in Cancer : COSMICMCM4 
LOVD (Leiden Open Variation Database)genes/MCM4
LOVD (Leiden Open Variation Database)genes/MCM4
LOVD (Leiden Open Variation Database)genes/MCM4
LOVD (Leiden Open Variation Database)genes/MCM4
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:48872763-48890719
CONAN: Copy Number AnalysisMCM4 
Mutations and Diseases : HGMDMCM4
OMIM602638    609981   
MedgenMCM4
NextProtP33991 [Medical]
GENETestsMCM4
Disease Genetic AssociationMCM4
Huge Navigator MCM4 [HugePedia]  MCM4 [HugeCancerGEM]
snp3D : Map Gene to Disease4173
DGIdb (Drug Gene Interaction db)MCM4
BioCentury BCIQMCM4
General knowledge
Homologs : HomoloGeneMCM4
Homology/Alignments : Family Browser (UCSC)MCM4
Phylogenetic Trees/Animal Genes : TreeFamMCM4
Chemical/Protein Interactions : CTD4173
Chemical/Pharm GKB GenePA30694
Clinical trialMCM4
Cancer Resource (Charite)ENSG00000104738
Other databases
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
CoreMineMCM4
GoPubMedMCM4
iHOPMCM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 29 18:51:07 CEST 2015

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