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MCM4 (minichromosome maintenance complex component 4)

Identity

Other namesCDC21
CDC54
NKCD
NKGCD
P1-CDC21
hCdc21
HGNC (Hugo) MCM4
LocusID (NCBI) 4173
Location 8q11.21
Location_base_pair Starts at 48872763 and ends at 48890719 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MCM4   6947
Cards
Entrez_Gene (NCBI)MCM4  4173  minichromosome maintenance complex component 4
GeneCards (Weizmann)MCM4
Ensembl (Hinxton)ENSG00000104738 [Gene_View]  chr8:48872763-48890719 [Contig_View]  MCM4 [Vega]
ICGC DataPortalENSG00000104738
cBioPortalMCM4
AceView (NCBI)MCM4
Genatlas (Paris)MCM4
WikiGenes4173
SOURCE (Princeton)NM_005914 NM_182746
Genomic and cartography
GoldenPath (UCSC)MCM4  -  8q11.21   chr8:48872763-48890719 +  8q11.21   [Description]    (hg19-Feb_2009)
EnsemblMCM4 - 8q11.21 [CytoView]
Mapping of homologs : NCBIMCM4 [Mapview]
OMIM602638   609981   
Gene and transcription
Genbank (Entrez)AK022899 AK296913 AK309812 AM493756 BC031061
RefSeq transcript (Entrez)NM_005914 NM_182746
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_032967 NT_008183 NW_001839132 NW_004929339
Consensus coding sequences : CCDS (NCBI)MCM4
Cluster EST : UnigeneHs.460184 [ NCBI ]
CGAP (NCI)Hs.460184
Alternative Splicing : Fast-db (Paris)GSHG0028997
Alternative Splicing GalleryENSG00000104738
Gene ExpressionMCM4 [ NCBI-GEO ]     MCM4 [ SEEK ]   MCM4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33991 (Uniprot)
NextProtP33991  [Medical]
With graphics : InterProP33991
Splice isoforms : SwissVarP33991 (Swissvar)
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)MCM_1 (PS00847)    MCM_2 (PS50051)   
Domains : Interpro (EBI)AAA+_ATPase [organisation]   MCM_4 [organisation]   MCM_CS [organisation]   MCM_DNA-dep_ATPase [organisation]   MCM_N [organisation]   NA-bd_OB-fold [organisation]   P-loop_NTPase [organisation]   Rubredoxin-type_fold [organisation]  
Related proteins : CluSTrP33991
Domain families : Pfam (Sanger)MCM (PF00493)    MCM_N (PF14551)   
Domain families : Pfam (NCBI)pfam00493    pfam14551   
Domain families : Smart (EMBL)AAA (SM00382)  MCM (SM00350)  
DMDM Disease mutations4173
Blocks (Seattle)P33991
Human Protein AtlasENSG00000104738 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP33991
HPRD09094
IPIIPI00018349   IPI00795318   IPI01013303   IPI00797037   IPI00985223   IPI00977491   IPI00974419   IPI00979941   IPI00980607   
Protein Interaction databases
DIP (DOE-UCLA)P33991
IntAct (EBI)P33991
FunCoupENSG00000104738
BioGRIDMCM4
InParanoidP33991
Interologous Interaction database P33991
IntegromeDBMCM4
STRING (EMBL)MCM4
Ontologies - Pathways
Ontology : AmiGOG1/S transition of mitotic cell cycle  mitotic cell cycle  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  DNA replication  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  DNA strand elongation involved in DNA replication  membrane  MCM complex  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  mitotic cell cycle  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  DNA replication  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  DNA strand elongation involved in DNA replication  membrane  MCM complex  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGDNA replication    Cell cycle   
Protein Interaction DatabaseMCM4
Wikipedia pathwaysMCM4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MCM4
snp3D : Map Gene to Disease4173
SNP (GeneSNP Utah)MCM4
SNP : HGBaseMCM4
Genetic variants : HAPMAPMCM4
Exome VariantMCM4
1000_GenomesMCM4 
ICGC programENSG00000104738 
Somatic Mutations in Cancer : COSMICMCM4 
CONAN: Copy Number AnalysisMCM4 
Mutations and Diseases : HGMDMCM4
Mutations and Diseases : intOGenMCM4
Genomic VariantsMCM4  MCM4 [DGVbeta]
dbVarMCM4
ClinVarMCM4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM602638    609981   
MedgenMCM4
GENETestsMCM4
Disease Genetic AssociationMCM4
Huge Navigator MCM4 [HugePedia]  MCM4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMCM4
Homology/Alignments : Family Browser (UCSC)MCM4
Phylogenetic Trees/Animal Genes : TreeFamMCM4
Chemical/Protein Interactions : CTD4173
Chemical/Pharm GKB GenePA30694
Clinical trialMCM4
Cancer Resource (Charite)ENSG00000104738
Other databases
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
CoreMineMCM4
iHOPMCM4
OncoSearchMCM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 19:02:15 CEST 2014

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