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MCM6 (minichromosome maintenance complex component 6)

Identity

Alias (NCBI)MCG40308
Mis5
P105MCM
HGNC (Hugo) MCM6
HGNC Alias symbMis5
HGNC Alias nameMIS5 homolog (S.pombe)
HGNC Previous nameminichromosome maintenance deficient (mis5, S. pombe) 6
 MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
 minichromosome maintenance deficient 6 homolog (S. cerevisiae)
LocusID (NCBI) 4175
Atlas_Id 41322
Location 2q21.3  [Link to chromosome band 2q21]
Location_base_pair Starts at 135839626 and ends at 135876443 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MCM6 (2q21.3) / DARS (2q21.3)MCM6 (2q21.3) / NBAS (2p24.3)MCM6 (2q21.3) / ZRANB3 (2q21.3)
MCM6 2q21.3 / DARS 2q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MCM6   6949
Cards
Entrez_Gene (NCBI)MCM6    minichromosome maintenance complex component 6
AliasesMCG40308; Mis5; P105MCM
GeneCards (Weizmann)MCM6
Ensembl hg19 (Hinxton)ENSG00000076003 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000076003 [Gene_View]  ENSG00000076003 [Sequence]  chr2:135839626-135876443 [Contig_View]  MCM6 [Vega]
ICGC DataPortalENSG00000076003
TCGA cBioPortalMCM6
AceView (NCBI)MCM6
Genatlas (Paris)MCM6
SOURCE (Princeton)MCM6
Genetics Home Reference (NIH)MCM6
Genomic and cartography
GoldenPath hg38 (UCSC)MCM6  -     chr2:135839626-135876443 -  2q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCM6  -     2q21.3   [Description]    (hg19-Feb_2009)
GoldenPathMCM6 - 2q21.3 [CytoView hg19]  MCM6 - 2q21.3 [CytoView hg38]
ImmunoBaseENSG00000076003
Genome Data Viewer NCBIMCM6 [Mapview hg19]  
OMIM223100   601806   
Gene and transcription
Genbank (Entrez)AA577398 AK299236 AK303455 AK312575 AU124893
RefSeq transcript (Entrez)NM_005915
Consensus coding sequences : CCDS (NCBI)MCM6
Gene ExpressionMCM6 [ NCBI-GEO ]   MCM6 [ EBI - ARRAY_EXPRESS ]   MCM6 [ SEEK ]   MCM6 [ MEM ]
Gene Expression Viewer (FireBrowse)MCM6 [ Firebrowse - Broad ]
GenevisibleExpression of MCM6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4175
GTEX Portal (Tissue expression)MCM6
Human Protein AtlasENSG00000076003-MCM6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14566   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14566  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14566
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ14566
Domaine pattern : Prosite (Expaxy)MCM_1 (PS00847)    MCM_2 (PS50051)   
Domains : Interpro (EBI)MCM    MCM6    Mcm6_C    MCM_CS    MCM_dom    MCM_lid    MCM_N    MCM_OB    NA-bd_OB-fold    P-loop_NTPase   
Domain families : Pfam (Sanger)MCM (PF00493)    MCM6_C (PF18263)    MCM_lid (PF17855)    MCM_N (PF14551)    MCM_OB (PF17207)   
Domain families : Pfam (NCBI)pfam00493    pfam18263    pfam17855    pfam14551    pfam17207   
Domain families : Smart (EMBL)MCM (SM00350)  
Conserved Domain (NCBI)MCM6
PDB (RSDB)2KLQ    2LE8    6XTX    6XTY   
PDB Europe2KLQ    2LE8    6XTX    6XTY   
PDB (PDBSum)2KLQ    2LE8    6XTX    6XTY   
PDB (IMB)2KLQ    2LE8    6XTX    6XTY   
Structural Biology KnowledgeBase2KLQ    2LE8    6XTX    6XTY   
SCOP (Structural Classification of Proteins)2KLQ    2LE8    6XTX    6XTY   
CATH (Classification of proteins structures)2KLQ    2LE8    6XTX    6XTY   
SuperfamilyQ14566
AlphaFold pdb e-kbQ14566   
Human Protein Atlas [tissue]ENSG00000076003-MCM6 [tissue]
HPRD03485
Protein Interaction databases
DIP (DOE-UCLA)Q14566
IntAct (EBI)Q14566
BioGRIDMCM6
STRING (EMBL)MCM6
ZODIACMCM6
Ontologies - Pathways
QuickGOQ14566
Ontology : AmiGOdouble-strand break repair via break-induced replication  chromosome, telomeric region  DNA helicase activity  DNA replication origin binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication  pre-replicative complex assembly involved in nuclear cell cycle DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  hydrolase activity  pre-replicative complex assembly  MCM complex  MCM complex  identical protein binding  CMG complex  mitotic DNA replication  single-stranded 3'-5' DNA helicase activity  
Ontology : EGO-EBIdouble-strand break repair via break-induced replication  chromosome, telomeric region  DNA helicase activity  DNA replication origin binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication  pre-replicative complex assembly involved in nuclear cell cycle DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  hydrolase activity  pre-replicative complex assembly  MCM complex  MCM complex  identical protein binding  CMG complex  mitotic DNA replication  single-stranded 3'-5' DNA helicase activity  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGDNA replication    Cell cycle   
NDEx NetworkMCM6
Atlas of Cancer Signalling NetworkMCM6
Wikipedia pathwaysMCM6
Orthology - Evolution
OrthoDB4175
GeneTree (enSembl)ENSG00000076003
Phylogenetic Trees/Animal Genes : TreeFamMCM6
Homologs : HomoloGeneMCM6
Homology/Alignments : Family Browser (UCSC)MCM6
Gene fusions - Rearrangements
Fusion : MitelmanMCM6/DARS [2q21.3/2q21.3]  
Fusion : QuiverMCM6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCM6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM6
dbVarMCM6
ClinVarMCM6
MonarchMCM6
1000_GenomesMCM6 
Exome Variant ServerMCM6
GNOMAD BrowserENSG00000076003
Varsome BrowserMCM6
ACMGMCM6 variants
VarityQ14566
Genomic Variants (DGV)MCM6 [DGVbeta]
DECIPHERMCM6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCM6 
Mutations
ICGC Data PortalMCM6 
TCGA Data PortalMCM6 
Broad Tumor PortalMCM6
OASIS PortalMCM6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMCM6
Mutations and Diseases : HGMDMCM6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMCM6
DgiDB (Drug Gene Interaction Database)MCM6
DoCM (Curated mutations)MCM6
CIViC (Clinical Interpretations of Variants in Cancer)MCM6
Cancer3DMCM6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM223100    601806   
Orphanet
DisGeNETMCM6
MedgenMCM6
Genetic Testing Registry MCM6
NextProtQ14566 [Medical]
GENETestsMCM6
Target ValidationMCM6
Huge Navigator MCM6 [HugePedia]
ClinGenMCM6
Clinical trials, drugs, therapy
MyCancerGenomeMCM6
Protein Interactions : CTDMCM6
Pharm GKB GenePA30696
PharosQ14566
Clinical trialMCM6
Miscellaneous
canSAR (ICR)MCM6
HarmonizomeMCM6
DataMed IndexMCM6
Probes
Litterature
PubMed196 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMCM6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:18:05 CEST 2021

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