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MCM6 (minichromosome maintenance complex component 6)

Identity

Other namesMCG40308
Mis5
P105MCM
HGNC (Hugo) MCM6
LocusID (NCBI) 4175
Location 2q21.3
Location_base_pair Starts at 136597196 and ends at 136634047 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MCM6   6949
Cards
Entrez_Gene (NCBI)MCM6  4175  minichromosome maintenance complex component 6
GeneCards (Weizmann)MCM6
Ensembl hg19 (Hinxton)ENSG00000076003 [Gene_View]  chr2:136597196-136634047 [Contig_View]  MCM6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000076003 [Gene_View]  chr2:136597196-136634047 [Contig_View]  MCM6 [Vega]
ICGC DataPortalENSG00000076003
cBioPortalMCM6
AceView (NCBI)MCM6
Genatlas (Paris)MCM6
WikiGenes4175
SOURCE (Princeton)MCM6
Genomic and cartography
GoldenPath hg19 (UCSC)MCM6  -     chr2:136597196-136634047 -  2q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MCM6  -     2q21.3   [Description]    (hg38-Dec_2013)
EnsemblMCM6 - 2q21.3 [CytoView hg19]  MCM6 - 2q21.3 [CytoView hg38]
Mapping of homologs : NCBIMCM6 [Mapview hg19]  MCM6 [Mapview hg38]
OMIM223100   601806   
Gene and transcription
Genbank (Entrez)AA577398 AK299236 AK303455 AK312575 AU124893
RefSeq transcript (Entrez)NM_005915
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_008958 NT_005403 NW_001838859 NW_004929304
Consensus coding sequences : CCDS (NCBI)MCM6
Cluster EST : UnigeneHs.444118 [ NCBI ]
CGAP (NCI)Hs.444118
Alternative Splicing : Fast-db (Paris)GSHG0018032
Alternative Splicing GalleryENSG00000076003
Gene ExpressionMCM6 [ NCBI-GEO ]     MCM6 [ SEEK ]   MCM6 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14566 (Uniprot)
NextProtQ14566  [Medical]
With graphics : InterProQ14566
Splice isoforms : SwissVarQ14566 (Swissvar)
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)MCM_1 (PS00847)    MCM_2 (PS50051)   
Domains : Interpro (EBI)MCM6    MCM_CS    MCM_DNA-dep_ATPase    MCM_N    NA-bd_OB-fold    P-loop_NTPase    Rubredoxin-type_fold   
Related proteins : CluSTrQ14566
Domain families : Pfam (Sanger)MCM (PF00493)    MCM_N (PF14551)   
Domain families : Pfam (NCBI)pfam00493    pfam14551   
Domain families : Smart (EMBL)MCM (SM00350)  
DMDM Disease mutations4175
Blocks (Seattle)Q14566
PDB (SRS)2KLQ    2LE8   
PDB (PDBSum)2KLQ    2LE8   
PDB (IMB)2KLQ    2LE8   
PDB (RSDB)2KLQ    2LE8   
Human Protein AtlasENSG00000076003
Peptide AtlasQ14566
HPRD03485
IPIIPI00031517   IPI00908729   
Protein Interaction databases
DIP (DOE-UCLA)Q14566
IntAct (EBI)Q14566
FunCoupENSG00000076003
BioGRIDMCM6
IntegromeDBMCM6
STRING (EMBL)MCM6
Ontologies - Pathways
QuickGOQ14566
Ontology : AmiGOG1/S transition of mitotic cell cycle  mitotic cell cycle  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  DNA replication  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  DNA strand elongation involved in DNA replication  MCM complex  identical protein binding  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  mitotic cell cycle  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  DNA replication  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  DNA strand elongation involved in DNA replication  MCM complex  identical protein binding  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGDNA replication    Cell cycle   
Protein Interaction DatabaseMCM6
DoCM (Curated mutations)MCM6
Wikipedia pathwaysMCM6
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMCM6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM6
dbVarMCM6
ClinVarMCM6
1000_GenomesMCM6 
Exome Variant ServerMCM6
SNP (GeneSNP Utah)MCM6
SNP : HGBaseMCM6
Genetic variants : HAPMAPMCM6
Genomic VariantsMCM6  MCM6 [DGVbeta]
Mutations
ICGC Data PortalENSG00000076003 
Somatic Mutations in Cancer : COSMICMCM6 
CONAN: Copy Number AnalysisMCM6 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:136597196-136634047
Mutations and Diseases : HGMDMCM6
OMIM223100    601806   
MedgenMCM6
NextProtQ14566 [Medical]
GENETestsMCM6
Disease Genetic AssociationMCM6
Huge Navigator MCM6 [HugePedia]  MCM6 [HugeCancerGEM]
snp3D : Map Gene to Disease4175
DGIdb (Drug Gene Interaction db)MCM6
General knowledge
Homologs : HomoloGeneMCM6
Homology/Alignments : Family Browser (UCSC)MCM6
Phylogenetic Trees/Animal Genes : TreeFamMCM6
Chemical/Protein Interactions : CTD4175
Chemical/Pharm GKB GenePA30696
Clinical trialMCM6
Cancer Resource (Charite)ENSG00000076003
Other databases
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
CoreMineMCM6
GoPubMedMCM6
iHOPMCM6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 23:36:54 CET 2014

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