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MCM6 (minichromosome maintenance complex component 6)

Identity

Other namesMCG40308
Mis5
P105MCM
HGNC (Hugo) MCM6
LocusID (NCBI) 4175
Atlas_Id 41322
Location 2q21.3  [Link to chromosome band 2q21]
Location_base_pair Starts at 136597196 and ends at 136634047 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MCM6 (2q21.3) / DARS (2q21.3)MCM6 (2q21.3) / NBAS (2p24.3)MCM6 (2q21.3) / ZRANB3 (2q21.3)
MCM6 2q21.3 / DARS 2q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MCM6   6949
Cards
Entrez_Gene (NCBI)MCM6  4175  minichromosome maintenance complex component 6
AliasesMCG40308; Mis5; P105MCM
GeneCards (Weizmann)MCM6
Ensembl hg19 (Hinxton)ENSG00000076003 [Gene_View]  chr2:136597196-136634047 [Contig_View]  MCM6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000076003 [Gene_View]  chr2:136597196-136634047 [Contig_View]  MCM6 [Vega]
ICGC DataPortalENSG00000076003
TCGA cBioPortalMCM6
AceView (NCBI)MCM6
Genatlas (Paris)MCM6
WikiGenes4175
SOURCE (Princeton)MCM6
Genomic and cartography
GoldenPath hg19 (UCSC)MCM6  -     chr2:136597196-136634047 -  2q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MCM6  -     2q21.3   [Description]    (hg38-Dec_2013)
EnsemblMCM6 - 2q21.3 [CytoView hg19]  MCM6 - 2q21.3 [CytoView hg38]
Mapping of homologs : NCBIMCM6 [Mapview hg19]  MCM6 [Mapview hg38]
OMIM223100   601806   
Gene and transcription
Genbank (Entrez)AA577398 AK299236 AK303455 AK312575 AU124893
RefSeq transcript (Entrez)NM_005915
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_008958 NT_005403 NW_004929304
Consensus coding sequences : CCDS (NCBI)MCM6
Cluster EST : UnigeneHs.444118 [ NCBI ]
CGAP (NCI)Hs.444118
Alternative Splicing GalleryENSG00000076003
Gene ExpressionMCM6 [ NCBI-GEO ]   MCM6 [ EBI - ARRAY_EXPRESS ]   MCM6 [ SEEK ]   MCM6 [ MEM ]
Gene Expression Viewer (FireBrowse)MCM6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4175
GTEX Portal (Tissue expression)MCM6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14566 (Uniprot)
NextProtQ14566  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14566
Splice isoforms : SwissVarQ14566 (Swissvar)
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
PhosPhoSitePlusQ14566
Domaine pattern : Prosite (Expaxy)MCM_1 (PS00847)    MCM_2 (PS50051)   
Domains : Interpro (EBI)MCM    MCM6    MCM_CS    MCM_dom    MCM_N    NA-bd_OB-fold    P-loop_NTPase    Rubredoxin-type_fold   
Domain families : Pfam (Sanger)MCM (PF00493)    MCM_N (PF14551)   
Domain families : Pfam (NCBI)pfam00493    pfam14551   
Domain families : Smart (EMBL)MCM (SM00350)  
DMDM Disease mutations4175
Blocks (Seattle)MCM6
PDB (SRS)2KLQ    2LE8   
PDB (PDBSum)2KLQ    2LE8   
PDB (IMB)2KLQ    2LE8   
PDB (RSDB)2KLQ    2LE8   
Structural Biology KnowledgeBase2KLQ    2LE8   
SCOP (Structural Classification of Proteins)2KLQ    2LE8   
CATH (Classification of proteins structures)2KLQ    2LE8   
SuperfamilyQ14566
Human Protein AtlasENSG00000076003
Peptide AtlasQ14566
HPRD03485
IPIIPI00031517   IPI00908729   
Protein Interaction databases
DIP (DOE-UCLA)Q14566
IntAct (EBI)Q14566
FunCoupENSG00000076003
BioGRIDMCM6
STRING (EMBL)MCM6
ZODIACMCM6
Ontologies - Pathways
QuickGOQ14566
Ontology : AmiGOG1/S transition of mitotic cell cycle  nuclear chromosome, telomeric region  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  MCM complex  identical protein binding  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  nuclear chromosome, telomeric region  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  MCM complex  identical protein binding  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGDNA replication    Cell cycle   
NDEx Network
Atlas of Cancer Signalling NetworkMCM6
Wikipedia pathwaysMCM6
Orthology - Evolution
OrthoDB4175
GeneTree (enSembl)ENSG00000076003
Phylogenetic Trees/Animal Genes : TreeFamMCM6
Homologs : HomoloGeneMCM6
Homology/Alignments : Family Browser (UCSC)MCM6
Gene fusions - Rearrangements
Fusion: TCGAMCM6 2q21.3 DARS 2q21.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerMCM6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM6
dbVarMCM6
ClinVarMCM6
1000_GenomesMCM6 
Exome Variant ServerMCM6
ExAC (Exome Aggregation Consortium)MCM6 (select the gene name)
Genetic variants : HAPMAP4175
Genomic Variants (DGV)MCM6 [DGVbeta]
Mutations
ICGC Data PortalMCM6 
TCGA Data PortalMCM6 
Broad Tumor PortalMCM6
OASIS PortalMCM6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM6 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MCM6
DgiDB (Drug Gene Interaction Database)MCM6
DoCM (Curated mutations)MCM6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCM6 (select a term)
intoGenMCM6
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:136597196-136634047  ENSG00000076003
CONAN: Copy Number AnalysisMCM6 
Mutations and Diseases : HGMDMCM6
OMIM223100    601806   
MedgenMCM6
Genetic Testing Registry MCM6
NextProtQ14566 [Medical]
TSGene4175
GENETestsMCM6
Huge Navigator MCM6 [HugePedia]
snp3D : Map Gene to Disease4175
BioCentury BCIQMCM6
ClinGenMCM6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4175
Chemical/Pharm GKB GenePA30696
Clinical trialMCM6
Miscellaneous
canSAR (ICR)MCM6 (select the gene name)
Probes
Litterature
PubMed108 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCM6
EVEXMCM6
GoPubMedMCM6
iHOPMCM6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:05:33 CEST 2016

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