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MCM7 (minichromosome maintenance complex component 7)

Identity

Alias_namesregulatory subunit 104
MCM2
Alias_symbol (synonym)CDC47
PPP1R104
Other aliasP1.1-MCM3
P1CDC47
P85MCM
PNAS146
HGNC (Hugo) MCM7
LocusID (NCBI) 4176
Atlas_Id 41323
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 100092728 and ends at 100101940 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
JCHAIN (4q13.3) / MCM7 (7q22.1)MCM7 (7q22.1) / AGAP3 (7q36.1)MCM7 (7q22.1) / BAIAP2L1 (7q21.3)
MCM7 (7q22.1) / FCF1 (14q24.3)MCM7 (7q22.1) / MCM7 (7q22.1)MCM7 (7q22.1) / TCEAL4 (Xq22.2)
SBDSP1 (7q11.23) / MCM7 (7q22.1)SCARA3 (8p21.1) / MCM7 (7q22.1)SNX29 (16p13.13) / MCM7 (7q22.1)
ZNF3 (7q22.1) / MCM7 (7q22.1)ZNF3 7q22.1 / MCM7 7q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MCM7   6950
Cards
Entrez_Gene (NCBI)MCM7  4176  minichromosome maintenance complex component 7
AliasesCDC47; MCM2; P1.1-MCM3; P1CDC47; 
P85MCM; PNAS146; PPP1R104
GeneCards (Weizmann)MCM7
Ensembl hg19 (Hinxton)ENSG00000166508 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166508 [Gene_View]  chr7:100092728-100101940 [Contig_View]  MCM7 [Vega]
ICGC DataPortalENSG00000166508
TCGA cBioPortalMCM7
AceView (NCBI)MCM7
Genatlas (Paris)MCM7
WikiGenes4176
SOURCE (Princeton)MCM7
Genetics Home Reference (NIH)MCM7
Genomic and cartography
GoldenPath hg38 (UCSC)MCM7  -     chr7:100092728-100101940 -  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCM7  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblMCM7 - 7q22.1 [CytoView hg19]  MCM7 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIMCM7 [Mapview hg19]  MCM7 [Mapview hg38]
OMIM600592   
Gene and transcription
Genbank (Entrez)AF279900 AI083651 AK055379 AK096959 AK226175
RefSeq transcript (Entrez)NM_001278595 NM_005916 NM_182776
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MCM7
Cluster EST : UnigeneHs.438720 [ NCBI ]
CGAP (NCI)Hs.438720
Alternative Splicing GalleryENSG00000166508
Gene ExpressionMCM7 [ NCBI-GEO ]   MCM7 [ EBI - ARRAY_EXPRESS ]   MCM7 [ SEEK ]   MCM7 [ MEM ]
Gene Expression Viewer (FireBrowse)MCM7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4176
GTEX Portal (Tissue expression)MCM7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33993   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33993  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33993
Splice isoforms : SwissVarP33993
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
PhosPhoSitePlusP33993
Domaine pattern : Prosite (Expaxy)MCM_1 (PS00847)    MCM_2 (PS50051)   
Domains : Interpro (EBI)AAA+_ATPase    MCM    MCM7    MCM_CS    MCM_dom    MCM_N    MCM_OB    NA-bd_OB-fold    P-loop_NTPase   
Domain families : Pfam (Sanger)MCM (PF00493)    MCM_N (PF14551)    MCM_OB (PF17207)   
Domain families : Pfam (NCBI)pfam00493    pfam14551    pfam17207   
Domain families : Smart (EMBL)AAA (SM00382)  MCM (SM00350)  
Conserved Domain (NCBI)MCM7
DMDM Disease mutations4176
Blocks (Seattle)MCM7
SuperfamilyP33993
Human Protein AtlasENSG00000166508
Peptide AtlasP33993
HPRD01154
IPIIPI00299904   IPI00219740   IPI00925989   IPI01009615   IPI00387004   IPI00376143   IPI01014793   
Protein Interaction databases
DIP (DOE-UCLA)P33993
IntAct (EBI)P33993
FunCoupENSG00000166508
BioGRIDMCM7
STRING (EMBL)MCM7
ZODIACMCM7
Ontologies - Pathways
QuickGOP33993
Ontology : AmiGOG1/S transition of mitotic cell cycle  nuclear chromosome, telomeric region  chromatin  DNA binding  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  cytosol  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  cellular response to DNA damage stimulus  cell proliferation  membrane  regulation of phosphorylation  response to drug  MCM complex  MCM complex  cellular response to epidermal growth factor stimulus  cellular response to xenobiotic stimulus  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  nuclear chromosome, telomeric region  chromatin  DNA binding  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  cytosol  DNA replication  DNA unwinding involved in DNA replication  DNA replication initiation  cellular response to DNA damage stimulus  cell proliferation  membrane  regulation of phosphorylation  response to drug  MCM complex  MCM complex  cellular response to epidermal growth factor stimulus  cellular response to xenobiotic stimulus  
Pathways : BIOCARTACDK Regulation of DNA Replication [Genes]   
Pathways : KEGGDNA replication    Cell cycle   
NDEx NetworkMCM7
Atlas of Cancer Signalling NetworkMCM7
Wikipedia pathwaysMCM7
Orthology - Evolution
OrthoDB4176
GeneTree (enSembl)ENSG00000166508
Phylogenetic Trees/Animal Genes : TreeFamMCM7
HOVERGENP33993
HOGENOMP33993
Homologs : HomoloGeneMCM7
Homology/Alignments : Family Browser (UCSC)MCM7
Gene fusions - Rearrangements
Fusion : MitelmanZNF3/MCM7 [7q22.1/7q22.1]  [t(7;7)(q22;q22)]  
Fusion: TCGAZNF3 7q22.1 MCM7 7q22.1 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCM7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM7
dbVarMCM7
ClinVarMCM7
1000_GenomesMCM7 
Exome Variant ServerMCM7
ExAC (Exome Aggregation Consortium)MCM7 (select the gene name)
Genetic variants : HAPMAP4176
Genomic Variants (DGV)MCM7 [DGVbeta]
DECIPHERMCM7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCM7 
Mutations
ICGC Data PortalMCM7 
TCGA Data PortalMCM7 
Broad Tumor PortalMCM7
OASIS PortalMCM7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMCM7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MCM7
DgiDB (Drug Gene Interaction Database)MCM7
DoCM (Curated mutations)MCM7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCM7 (select a term)
intoGenMCM7
Cancer3DMCM7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600592   
Orphanet
MedgenMCM7
Genetic Testing Registry MCM7
NextProtP33993 [Medical]
TSGene4176
GENETestsMCM7
Target ValidationMCM7
Huge Navigator MCM7 [HugePedia]
snp3D : Map Gene to Disease4176
BioCentury BCIQMCM7
ClinGenMCM7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4176
Chemical/Pharm GKB GenePA30697
Clinical trialMCM7
Miscellaneous
canSAR (ICR)MCM7 (select the gene name)
Probes
Litterature
PubMed185 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCM7
EVEXMCM7
GoPubMedMCM7
iHOPMCM7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:42:34 CEST 2017

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