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MCM8 (minichromosome maintenance 8 homologous recombination repair factor)

Identity

Alias_namesC20orf154
chromosome 20 open reading frame 154
minichromosome maintenance complex component 8
Alias_symbol (synonym)MGC4816
MGC12866
MGC119522
MGC119523
dJ967N21.5
REC
Other aliasPOF10
HGNC (Hugo) MCM8
LocusID (NCBI) 84515
Atlas_Id 43359
Location 20p12.3  [Link to chromosome band 20p12]
Location_base_pair Starts at 5950652 and ends at 5995206 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FERMT1 (20p12.3) / MCM8 (20p12.3)IGF2 (11p15.5) / MCM8 (20p12.3)LRRN4 (20p12.3) / MCM8 (20p12.3)
MCM8 (20p12.3) / MCM8 (20p12.3)FERMT1 20p12.3 / MCM8 20p12.3IGF2 11p15.5 / MCM8 20p12.3
LRRN4 20p12.3 / MCM8 20p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MCM8   16147
Cards
Entrez_Gene (NCBI)MCM8  84515  minichromosome maintenance 8 homologous recombination repair factor
AliasesC20orf154; POF10; dJ967N21.5
GeneCards (Weizmann)MCM8
Ensembl hg19 (Hinxton)ENSG00000125885 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125885 [Gene_View]  chr20:5950652-5995206 [Contig_View]  MCM8 [Vega]
ICGC DataPortalENSG00000125885
TCGA cBioPortalMCM8
AceView (NCBI)MCM8
Genatlas (Paris)MCM8
WikiGenes84515
SOURCE (Princeton)MCM8
Genetics Home Reference (NIH)MCM8
Genomic and cartography
GoldenPath hg38 (UCSC)MCM8  -     chr20:5950652-5995206 +  20p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCM8  -     20p12.3   [Description]    (hg19-Feb_2009)
EnsemblMCM8 - 20p12.3 [CytoView hg19]  MCM8 - 20p12.3 [CytoView hg38]
Mapping of homologs : NCBIMCM8 [Mapview hg19]  MCM8 [Mapview hg38]
OMIM608187   612885   
Gene and transcription
Genbank (Entrez)AI200387 AJ439063 AK022738 AK027644 AK297806
RefSeq transcript (Entrez)NM_001281520 NM_001281521 NM_001281522 NM_032485 NM_182802
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MCM8
Cluster EST : UnigeneHs.656543 [ NCBI ]
CGAP (NCI)Hs.656543
Alternative Splicing GalleryENSG00000125885
Gene ExpressionMCM8 [ NCBI-GEO ]   MCM8 [ EBI - ARRAY_EXPRESS ]   MCM8 [ SEEK ]   MCM8 [ MEM ]
Gene Expression Viewer (FireBrowse)MCM8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84515
GTEX Portal (Tissue expression)MCM8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJA3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJA3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJA3
Splice isoforms : SwissVarQ9UJA3
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
PhosPhoSitePlusQ9UJA3
Domaine pattern : Prosite (Expaxy)MCM_2 (PS50051)   
Domains : Interpro (EBI)AAA+_ATPase    MCM    MCM_dom    MCM_OB    NA-bd_OB-fold    P-loop_NTPase    Rubredoxin-type_fold   
Domain families : Pfam (Sanger)MCM (PF00493)    MCM_OB (PF17207)   
Domain families : Pfam (NCBI)pfam00493    pfam17207   
Domain families : Smart (EMBL)AAA (SM00382)  MCM (SM00350)  
Conserved Domain (NCBI)MCM8
DMDM Disease mutations84515
Blocks (Seattle)MCM8
SuperfamilyQ9UJA3
Human Protein AtlasENSG00000125885
Peptide AtlasQ9UJA3
HPRD12186
IPIIPI00032496   IPI00645911   IPI00337550   IPI00642305   IPI01012037   IPI00441969   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJA3
IntAct (EBI)Q9UJA3
FunCoupENSG00000125885
BioGRIDMCM8
STRING (EMBL)MCM8
ZODIACMCM8
Ontologies - Pathways
QuickGOQ9UJA3
Ontology : AmiGOG1/S transition of mitotic cell cycle  double-strand break repair via homologous recombination  DNA binding  helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  DNA replication  cellular response to DNA damage stimulus  female gamete generation  male gamete generation  MCM8-MCM9 complex  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  double-strand break repair via homologous recombination  DNA binding  helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  DNA replication  cellular response to DNA damage stimulus  female gamete generation  male gamete generation  MCM8-MCM9 complex  
NDEx NetworkMCM8
Atlas of Cancer Signalling NetworkMCM8
Wikipedia pathwaysMCM8
Orthology - Evolution
OrthoDB84515
GeneTree (enSembl)ENSG00000125885
Phylogenetic Trees/Animal Genes : TreeFamMCM8
HOVERGENQ9UJA3
HOGENOMQ9UJA3
Homologs : HomoloGeneMCM8
Homology/Alignments : Family Browser (UCSC)MCM8
Gene fusions - Rearrangements
Fusion : MitelmanFERMT1/MCM8 [20p12.3/20p12.3]  [t(20;20)(p12;p12)]  
Fusion : MitelmanIGF2/MCM8 [11p15.5/20p12.3]  [t(11;20)(p15;p12)]  
Fusion : MitelmanLRRN4/MCM8 [20p12.3/20p12.3]  [t(20;20)(p12;p12)]  
Fusion: TCGAFERMT1 20p12.3 MCM8 20p12.3 BRCA
Fusion: TCGAIGF2 11p15.5 MCM8 20p12.3 LUAD
Fusion: TCGALRRN4 20p12.3 MCM8 20p12.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCM8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM8
dbVarMCM8
ClinVarMCM8
1000_GenomesMCM8 
Exome Variant ServerMCM8
ExAC (Exome Aggregation Consortium)MCM8 (select the gene name)
Genetic variants : HAPMAP84515
Genomic Variants (DGV)MCM8 [DGVbeta]
DECIPHERMCM8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCM8 
Mutations
ICGC Data PortalMCM8 
TCGA Data PortalMCM8 
Broad Tumor PortalMCM8
OASIS PortalMCM8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMCM8
intOGen PortalMCM8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MCM8
DgiDB (Drug Gene Interaction Database)MCM8
DoCM (Curated mutations)MCM8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCM8 (select a term)
intoGenMCM8
Cancer3DMCM8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608187    612885   
Orphanet
MedgenMCM8
Genetic Testing Registry MCM8
NextProtQ9UJA3 [Medical]
TSGene84515
GENETestsMCM8
Huge Navigator MCM8 [HugePedia]
snp3D : Map Gene to Disease84515
BioCentury BCIQMCM8
ClinGenMCM8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84515
Chemical/Pharm GKB GenePA25696
Clinical trialMCM8
Miscellaneous
canSAR (ICR)MCM8 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCM8
EVEXMCM8
GoPubMedMCM8
iHOPMCM8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri May 19 12:24:29 CEST 2017

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