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MCM8 (minichromosome maintenance 8 homologous recombination repair factor)

Identity

Alias (NCBI)C20orf154
POF10
dJ967N21.5
HGNC (Hugo) MCM8
HGNC Alias symbMGC4816
MGC12866
MGC119522
MGC119523
dJ967N21.5
REC
HGNC Alias nameREC homolog (Drosophila)
HGNC Previous nameC20orf154
HGNC Previous namechromosome 20 open reading frame 154
 minichromosome maintenance complex component 8
LocusID (NCBI) 84515
Atlas_Id 43359
Location 20p12.3  [Link to chromosome band 20p12]
Location_base_pair Starts at 5950652 and ends at 5998971 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FERMT1 (20p12.3) / MCM8 (20p12.3)IGF2 (11p15.5) / MCM8 (20p12.3)LRRN4 (20p12.3) / MCM8 (20p12.3)
MCM8 (20p12.3) / MCM8 (20p12.3)FERMT1 20p12.3 / MCM8 20p12.3IGF2 11p15.5 / MCM8 20p12.3
LRRN4 20p12.3 / MCM8 20p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MCM8   16147
Cards
Entrez_Gene (NCBI)MCM8    minichromosome maintenance 8 homologous recombination repair factor
AliasesC20orf154; POF10; dJ967N21.5
GeneCards (Weizmann)MCM8
Ensembl hg19 (Hinxton)ENSG00000125885 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125885 [Gene_View]  ENSG00000125885 [Sequence]  chr20:5950652-5998971 [Contig_View]  MCM8 [Vega]
ICGC DataPortalENSG00000125885
TCGA cBioPortalMCM8
AceView (NCBI)MCM8
Genatlas (Paris)MCM8
SOURCE (Princeton)MCM8
Genetics Home Reference (NIH)MCM8
Genomic and cartography
GoldenPath hg38 (UCSC)MCM8  -     chr20:5950652-5998971 +  20p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCM8  -     20p12.3   [Description]    (hg19-Feb_2009)
GoldenPathMCM8 - 20p12.3 [CytoView hg19]  MCM8 - 20p12.3 [CytoView hg38]
ImmunoBaseENSG00000125885
Genome Data Viewer NCBIMCM8 [Mapview hg19]  
OMIM608187   612885   
Gene and transcription
Genbank (Entrez)AI200387 AJ439063 AK022738 AK027644 AK297806
RefSeq transcript (Entrez)NM_001281520 NM_001281521 NM_001281522 NM_032485 NM_182802
Consensus coding sequences : CCDS (NCBI)MCM8
Gene ExpressionMCM8 [ NCBI-GEO ]   MCM8 [ EBI - ARRAY_EXPRESS ]   MCM8 [ SEEK ]   MCM8 [ MEM ]
Gene Expression Viewer (FireBrowse)MCM8 [ Firebrowse - Broad ]
GenevisibleExpression of MCM8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84515
GTEX Portal (Tissue expression)MCM8
Human Protein AtlasENSG00000125885-MCM8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJA3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJA3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJA3
PhosPhoSitePlusQ9UJA3
Domaine pattern : Prosite (Expaxy)MCM_2 (PS50051)   
Domains : Interpro (EBI)AAA+_ATPase    MCM    MCM_dom    MCM_lid    MCM_OB    NA-bd_OB-fold    P-loop_NTPase   
Domain families : Pfam (Sanger)MCM (PF00493)    MCM_lid (PF17855)    MCM_OB (PF17207)   
Domain families : Pfam (NCBI)pfam00493    pfam17855    pfam17207   
Domain families : Smart (EMBL)AAA (SM00382)  MCM (SM00350)  
Conserved Domain (NCBI)MCM8
PDB (RSDB)6L0O   
PDB Europe6L0O   
PDB (PDBSum)6L0O   
PDB (IMB)6L0O   
Structural Biology KnowledgeBase6L0O   
SCOP (Structural Classification of Proteins)6L0O   
CATH (Classification of proteins structures)6L0O   
SuperfamilyQ9UJA3
AlphaFold pdb e-kbQ9UJA3   
Human Protein Atlas [tissue]ENSG00000125885-MCM8 [tissue]
HPRD12186
Protein Interaction databases
DIP (DOE-UCLA)Q9UJA3
IntAct (EBI)Q9UJA3
BioGRIDMCM8
STRING (EMBL)MCM8
ZODIACMCM8
Ontologies - Pathways
QuickGOQ9UJA3
Ontology : AmiGOdouble-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA helicase activity  chromatin binding  DNA replication origin binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  chromosome  cytosol  DNA replication  DNA replication  DNA replication initiation  cellular response to DNA damage stimulus  cell cycle  female gamete generation  hydrolase activity  enzyme binding  MutLbeta complex binding  MutSalpha complex binding  MutSbeta complex binding  DNA duplex unwinding  recombinational interstrand cross-link repair  pre-replicative complex assembly  MCM complex  male gamete generation  protein stabilization  protein localization to chromatin  MCM8-MCM9 complex  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA helicase activity  chromatin binding  DNA replication origin binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  chromosome  cytosol  DNA replication  DNA replication  DNA replication initiation  cellular response to DNA damage stimulus  cell cycle  female gamete generation  hydrolase activity  enzyme binding  MutLbeta complex binding  MutSalpha complex binding  MutSbeta complex binding  DNA duplex unwinding  recombinational interstrand cross-link repair  pre-replicative complex assembly  MCM complex  male gamete generation  protein stabilization  protein localization to chromatin  MCM8-MCM9 complex  
NDEx NetworkMCM8
Atlas of Cancer Signalling NetworkMCM8
Wikipedia pathwaysMCM8
Orthology - Evolution
OrthoDB84515
GeneTree (enSembl)ENSG00000125885
Phylogenetic Trees/Animal Genes : TreeFamMCM8
Homologs : HomoloGeneMCM8
Homology/Alignments : Family Browser (UCSC)MCM8
Gene fusions - Rearrangements
Fusion : MitelmanFERMT1/MCM8 [20p12.3/20p12.3]  
Fusion : MitelmanIGF2/MCM8 [11p15.5/20p12.3]  
Fusion : MitelmanLRRN4/MCM8 [20p12.3/20p12.3]  
Fusion : QuiverMCM8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCM8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM8
dbVarMCM8
ClinVarMCM8
MonarchMCM8
1000_GenomesMCM8 
Exome Variant ServerMCM8
GNOMAD BrowserENSG00000125885
Varsome BrowserMCM8
ACMGMCM8 variants
VarityQ9UJA3
Genomic Variants (DGV)MCM8 [DGVbeta]
DECIPHERMCM8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCM8 
Mutations
ICGC Data PortalMCM8 
TCGA Data PortalMCM8 
Broad Tumor PortalMCM8
OASIS PortalMCM8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMCM8
Mutations and Diseases : HGMDMCM8
intOGen PortalMCM8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMCM8
DgiDB (Drug Gene Interaction Database)MCM8
DoCM (Curated mutations)MCM8
CIViC (Clinical Interpretations of Variants in Cancer)MCM8
Cancer3DMCM8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608187    612885   
Orphanet
DisGeNETMCM8
MedgenMCM8
Genetic Testing Registry MCM8
NextProtQ9UJA3 [Medical]
GENETestsMCM8
Target ValidationMCM8
Huge Navigator MCM8 [HugePedia]
ClinGenMCM8
Clinical trials, drugs, therapy
MyCancerGenomeMCM8
Protein Interactions : CTDMCM8
Pharm GKB GenePA25696
PharosQ9UJA3
Clinical trialMCM8
Miscellaneous
canSAR (ICR)MCM8
HarmonizomeMCM8
DataMed IndexMCM8
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMCM8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:18:05 CEST 2021

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