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MCM9 (minichromosome maintenance 9 homologous recombination repair factor)

Identity

Alias_namesMCMDC1
C6orf61
minichromosome maintenance deficient domain containing 1
chromosome 6 open reading frame 61
minichromosome maintenance complex component 9
Alias_symbol (synonym)MGC35304
dJ329L24.3
FLJ20170
Other aliasODG4
dJ329L24.1
HGNC (Hugo) MCM9
LocusID (NCBI) 254394
Atlas_Id 52895
Location 6q22.31  [Link to chromosome band 6q22]
Location_base_pair Starts at 118910597 and ends at 118935162 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAV1 (7q31.2) / MCM9 (6q22.31)FAM184A (6q22.31) / MCM9 (6q22.31)FGFR1OP (6q27) / MCM9 (6q22.31)
FGFR1OP 6q27 / MCM9 6q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q22;q27) FGFR1OP/MCM9


External links

Nomenclature
HGNC (Hugo)MCM9   21484
Cards
Entrez_Gene (NCBI)MCM9  254394  minichromosome maintenance 9 homologous recombination repair factor
AliasesC6orf61; MCMDC1; ODG4; dJ329L24.1; 
dJ329L24.3
GeneCards (Weizmann)MCM9
Ensembl hg19 (Hinxton)ENSG00000111877 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111877 [Gene_View]  chr6:118910597-118935162 [Contig_View]  MCM9 [Vega]
ICGC DataPortalENSG00000111877
TCGA cBioPortalMCM9
AceView (NCBI)MCM9
Genatlas (Paris)MCM9
WikiGenes254394
SOURCE (Princeton)MCM9
Genetics Home Reference (NIH)MCM9
Genomic and cartography
GoldenPath hg38 (UCSC)MCM9  -     chr6:118910597-118935162 -  6q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCM9  -     6q22.31   [Description]    (hg19-Feb_2009)
EnsemblMCM9 - 6q22.31 [CytoView hg19]  MCM9 - 6q22.31 [CytoView hg38]
Mapping of homologs : NCBIMCM9 [Mapview hg19]  MCM9 [Mapview hg38]
OMIM610098   616185   
Gene and transcription
Genbank (Entrez)AK000177 AK122665 AK225233 AK299076 BC024976
RefSeq transcript (Entrez)NM_017696 NM_153255
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MCM9
Cluster EST : UnigeneHs.736853 [ NCBI ]
CGAP (NCI)Hs.736853
Alternative Splicing GalleryENSG00000111877
Gene ExpressionMCM9 [ NCBI-GEO ]   MCM9 [ EBI - ARRAY_EXPRESS ]   MCM9 [ SEEK ]   MCM9 [ MEM ]
Gene Expression Viewer (FireBrowse)MCM9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)254394
GTEX Portal (Tissue expression)MCM9
Human Protein AtlasENSG00000111877-MCM9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NXL9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NXL9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NXL9
Splice isoforms : SwissVarQ9NXL9
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
PhosPhoSitePlusQ9NXL9
Domaine pattern : Prosite (Expaxy)MCM_2 (PS50051)   
Domains : Interpro (EBI)AAA+_ATPase    MCM    MCM_dom    MCM_OB    NA-bd_OB-fold    P-loop_NTPase   
Domain families : Pfam (Sanger)MCM (PF00493)    MCM_OB (PF17207)   
Domain families : Pfam (NCBI)pfam00493    pfam17207   
Domain families : Smart (EMBL)AAA (SM00382)  MCM (SM00350)  
Conserved Domain (NCBI)MCM9
DMDM Disease mutations254394
Blocks (Seattle)MCM9
SuperfamilyQ9NXL9
Human Protein Atlas [tissue]ENSG00000111877-MCM9 [tissue]
Peptide AtlasQ9NXL9
HPRD17472
IPIIPI00014977   IPI00855969   IPI00643533   IPI00966756   IPI00966438   
Protein Interaction databases
DIP (DOE-UCLA)Q9NXL9
IntAct (EBI)Q9NXL9
FunCoupENSG00000111877
BioGRIDMCM9
STRING (EMBL)MCM9
ZODIACMCM9
Ontologies - Pathways
QuickGOQ9NXL9
Ontology : AmiGOdouble-strand break repair via homologous recombination  DNA binding  helicase activity  ATP binding  nucleus  DNA replication initiation  cellular response to DNA damage stimulus  female gamete generation  MCM8-MCM9 complex  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  DNA binding  helicase activity  ATP binding  nucleus  DNA replication initiation  cellular response to DNA damage stimulus  female gamete generation  MCM8-MCM9 complex  
NDEx NetworkMCM9
Atlas of Cancer Signalling NetworkMCM9
Wikipedia pathwaysMCM9
Orthology - Evolution
OrthoDB254394
GeneTree (enSembl)ENSG00000111877
Phylogenetic Trees/Animal Genes : TreeFamMCM9
HOVERGENQ9NXL9
HOGENOMQ9NXL9
Homologs : HomoloGeneMCM9
Homology/Alignments : Family Browser (UCSC)MCM9
Gene fusions - Rearrangements
Fusion : MitelmanFGFR1OP/MCM9 [6q27/6q22.31]  [t(6;6)(q22;q27)]  
Fusion: TCGA_MDACCFGFR1OP 6q27 MCM9 6q22.31 BRCA
Fusion PortalFGFR1OP 6q27 MCM9 6q22.31 BRCA
Fusion : QuiverMCM9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCM9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM9
dbVarMCM9
ClinVarMCM9
1000_GenomesMCM9 
Exome Variant ServerMCM9
ExAC (Exome Aggregation Consortium)ENSG00000111877
GNOMAD BrowserENSG00000111877
Genetic variants : HAPMAP254394
Genomic Variants (DGV)MCM9 [DGVbeta]
DECIPHERMCM9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCM9 
Mutations
ICGC Data PortalMCM9 
TCGA Data PortalMCM9 
Broad Tumor PortalMCM9
OASIS PortalMCM9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMCM9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MCM9
DgiDB (Drug Gene Interaction Database)MCM9
DoCM (Curated mutations)MCM9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCM9 (select a term)
intoGenMCM9
Cancer3DMCM9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610098    616185   
Orphanet23475   
DisGeNETMCM9
MedgenMCM9
Genetic Testing Registry MCM9
NextProtQ9NXL9 [Medical]
TSGene254394
GENETestsMCM9
Target ValidationMCM9
Huge Navigator MCM9 [HugePedia]
snp3D : Map Gene to Disease254394
BioCentury BCIQMCM9
ClinGenMCM9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD254394
Chemical/Pharm GKB GenePA162395071
Clinical trialMCM9
Miscellaneous
canSAR (ICR)MCM9 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCM9
EVEXMCM9
GoPubMedMCM9
iHOPMCM9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:22:41 CET 2018

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