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MCM9 (minichromosome maintenance 9 homologous recombination repair factor)

Identity

Alias (NCBI)C6orf61
MCMDC1
ODG4
dJ329L24.1
dJ329L24.3
HGNC (Hugo) MCM9
HGNC Alias symbMGC35304
dJ329L24.3
FLJ20170
HGNC Previous nameMCMDC1
 C6orf61
HGNC Previous nameminichromosome maintenance deficient domain containing 1
 chromosome 6 open reading frame 61
 minichromosome maintenance complex component 9
LocusID (NCBI) 254394
Atlas_Id 52895
Location 6q22.31  [Link to chromosome band 6q22]
Location_base_pair Starts at 118910597 and ends at 118935162 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAV1 (7q31.2) / MCM9 (6q22.31)FAM184A (6q22.31) / MCM9 (6q22.31)FGFR1OP (6q27) / MCM9 (6q22.31)
FGFR1OP 6q27 / MCM9 6q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q22;q27) FGFR1OP/MCM9


External links

Nomenclature
HGNC (Hugo)MCM9   21484
Cards
Entrez_Gene (NCBI)MCM9  254394  minichromosome maintenance 9 homologous recombination repair factor
AliasesC6orf61; MCMDC1; ODG4; dJ329L24.1; 
dJ329L24.3
GeneCards (Weizmann)MCM9
Ensembl hg19 (Hinxton)ENSG00000111877 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111877 [Gene_View]  ENSG00000111877 [Sequence]  chr6:118910597-118935162 [Contig_View]  MCM9 [Vega]
ICGC DataPortalENSG00000111877
TCGA cBioPortalMCM9
AceView (NCBI)MCM9
Genatlas (Paris)MCM9
WikiGenes254394
SOURCE (Princeton)MCM9
Genetics Home Reference (NIH)MCM9
Genomic and cartography
GoldenPath hg38 (UCSC)MCM9  -     chr6:118910597-118935162 -  6q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCM9  -     6q22.31   [Description]    (hg19-Feb_2009)
GoldenPathMCM9 - 6q22.31 [CytoView hg19]  MCM9 - 6q22.31 [CytoView hg38]
ImmunoBaseENSG00000111877
genome Data Viewer NCBIMCM9 [Mapview hg19]  
OMIM610098   616185   
Gene and transcription
Genbank (Entrez)AK000177 AK122665 AK225233 AK299076 BC024976
RefSeq transcript (Entrez)NM_001378356 NM_001378357 NM_001378358 NM_001378359 NM_001378360 NM_001378361 NM_001378362 NM_001378363 NM_001378364 NM_001378365 NM_001378366 NM_001378367 NM_001378368 NM_001378369 NM_001378370 NM_001378371 NM_001378372 NM_017696 NM_153255
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MCM9
Alternative Splicing GalleryENSG00000111877
Gene ExpressionMCM9 [ NCBI-GEO ]   MCM9 [ EBI - ARRAY_EXPRESS ]   MCM9 [ SEEK ]   MCM9 [ MEM ]
Gene Expression Viewer (FireBrowse)MCM9 [ Firebrowse - Broad ]
GenevisibleExpression of MCM9 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)254394
GTEX Portal (Tissue expression)MCM9
Human Protein AtlasENSG00000111877-MCM9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NXL9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NXL9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NXL9
Splice isoforms : SwissVarQ9NXL9
PhosPhoSitePlusQ9NXL9
Domaine pattern : Prosite (Expaxy)MCM_2 (PS50051)   
Domains : Interpro (EBI)AAA+_ATPase    MCM    MCM_dom    MCM_lid    MCM_OB    NA-bd_OB-fold    P-loop_NTPase   
Domain families : Pfam (Sanger)MCM (PF00493)    MCM_lid (PF17855)    MCM_OB (PF17207)   
Domain families : Pfam (NCBI)pfam00493    pfam17855    pfam17207   
Domain families : Smart (EMBL)AAA (SM00382)  MCM (SM00350)  
Conserved Domain (NCBI)MCM9
DMDM Disease mutations254394
Blocks (Seattle)MCM9
SuperfamilyQ9NXL9
Human Protein Atlas [tissue]ENSG00000111877-MCM9 [tissue]
Peptide AtlasQ9NXL9
HPRD17472
IPIIPI00014977   IPI00855969   IPI00643533   IPI00966756   IPI00966438   
Protein Interaction databases
DIP (DOE-UCLA)Q9NXL9
IntAct (EBI)Q9NXL9
FunCoupENSG00000111877
BioGRIDMCM9
STRING (EMBL)MCM9
ZODIACMCM9
Ontologies - Pathways
QuickGOQ9NXL9
Ontology : AmiGOdouble-strand break repair via homologous recombination  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA helicase activity  chromatin binding  DNA replication origin binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  chromosome  DNA replication  cellular response to DNA damage stimulus  female gamete generation  enzyme binding  MutLbeta complex binding  MutSalpha complex binding  MutSbeta complex binding  DNA duplex unwinding  recombinational interstrand cross-link repair  MCM complex  protein-containing complex binding  mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication  protein localization to chromatin  MCM8-MCM9 complex  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA helicase activity  chromatin binding  DNA replication origin binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  chromosome  DNA replication  cellular response to DNA damage stimulus  female gamete generation  enzyme binding  MutLbeta complex binding  MutSalpha complex binding  MutSbeta complex binding  DNA duplex unwinding  recombinational interstrand cross-link repair  MCM complex  protein-containing complex binding  mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication  protein localization to chromatin  MCM8-MCM9 complex  
NDEx NetworkMCM9
Atlas of Cancer Signalling NetworkMCM9
Wikipedia pathwaysMCM9
Orthology - Evolution
OrthoDB254394
GeneTree (enSembl)ENSG00000111877
Phylogenetic Trees/Animal Genes : TreeFamMCM9
HOGENOMQ9NXL9
Homologs : HomoloGeneMCM9
Homology/Alignments : Family Browser (UCSC)MCM9
Gene fusions - Rearrangements
Fusion : MitelmanFGFR1OP/MCM9 [6q27/6q22.31]  
Fusion PortalFGFR1OP 6q27 MCM9 6q22.31 BRCA
Fusion : QuiverMCM9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCM9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCM9
dbVarMCM9
ClinVarMCM9
1000_GenomesMCM9 
Exome Variant ServerMCM9
GNOMAD BrowserENSG00000111877
Varsome BrowserMCM9
Genetic variants : HAPMAP254394
Genomic Variants (DGV)MCM9 [DGVbeta]
DECIPHERMCM9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCM9 
Mutations
ICGC Data PortalMCM9 
TCGA Data PortalMCM9 
Broad Tumor PortalMCM9
OASIS PortalMCM9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCM9  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMCM9
Mutations and Diseases : HGMDMCM9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MCM9
DgiDB (Drug Gene Interaction Database)MCM9
DoCM (Curated mutations)MCM9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCM9 (select a term)
intoGenMCM9
Cancer3DMCM9(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610098    616185   
Orphanet23475   
DisGeNETMCM9
MedgenMCM9
Genetic Testing Registry MCM9
NextProtQ9NXL9 [Medical]
TSGene254394
GENETestsMCM9
Target ValidationMCM9
Huge Navigator MCM9 [HugePedia]
snp3D : Map Gene to Disease254394
BioCentury BCIQMCM9
ClinGenMCM9
Clinical trials, drugs, therapy
Protein Interactions : CTD254394
Pharm GKB GenePA162395071
Clinical trialMCM9
Miscellaneous
canSAR (ICR)MCM9 (select the gene name)
HarmonizomeMCM9
DataMed IndexMCM9
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCM9
EVEXMCM9
GoPubMedMCM9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:22:30 CEST 2020

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